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Genetherapy | Cell Therapy | Conferences | Events | 2019 …

Cell Therapy

CellTherapy or Cytotherapy is the transfer of cells into a patient with a goal ofimproving the disease. From beginning blood transfusions were consideredto be the first type of celltherapy to be practiced as routine. Later, Bone marrow transplantation hasalso become a well-established concept which involves treatment of much kind ofblood disorders including anemia, leukemia, lymphoma and rareimmunodeficiencydiseases. Alternativemedical practitioners perform celltherapy in the form of several different names including xeno-transplanttherapy, glandular therapy, and fresh celltherapy. It has been claimed by the proponents of celltherapy that it has been used successfully to repair spinal cord injuries,strengthen weaken immune system, treatsautoimmunediseaseslike AIDS, helppatients with neurological disorders like Alzheimers disease, Parkinsons diseaseand epilepsy.

GeneTherapy

GeneTherapy basically involves the introduction or alteration of geneticmaterial within a cell or organism with an intention of curing the disease.Both celltherapy and gene therapy are overlapping fields of biomedical research withthe goals of repairing the direct cause ofGeneticdiseasesin DNA orcellular population respectively, the discovery of recombinant DNA technologyin the 1970s provided tools to efficiently develop genetherapy. Scientists use these techniques to readily manipulate viralgenomes, isolate genes and identify mutations involved in human disease,characterize and regulategeneexpressions, and engineer variousviral and non-viral vectors. Various long-term treatments for anemia,hemophilia, cystic fibrosis, muscular dystrophy, Gauschers disease, lysosomalstorage diseases, cardiovascular diseases, diabetes and diseases of bones andjoints are resolved through successful gene therapy and are elusivetoday.

StemCell Therapies

CellTherapy is defined as the therapy in which cellular material is injectedinto a patient in order to recover the healthy tissue. Celltherapy is targeted at many clinical indications in multiple organs bymeans of several modes of cell delivery.Stem-CellTherapyis the use ofstem cells to treat or prevent a disease or condition. Stemcells are a class of undifferentiated cells which are able to differentiateinto required or specialized cell types. Adult or somatic stem cells exist throughout the body after embryonic development and arefound available inside the different types of tissue. The stem cell methodologyincludes the phases of Stem cell or progenitor cell engraftment,differentiation followed by long term replacement of damaged tissue.

CellCulture and Bioprocessing

A Stem-Cell line is a group of undifferentiated stem cells which is culturedinvitro and can be propagated indefinitely. While stem cells can propagateindefinitely in culture due to their inherent cellular properties, immortalizedcells would not normally divide indefinitely but have gained this ability tosustain due to mutation. The Immortalized cell lines can be generated from cells by means of isolating cells fromtumors or induce mutations to make the cells immortal. An immortalizedcell line is a population of multicellular organism cells which has notproliferates indefinitely. Due to mutation, the cells evaded normal cellularsenescence and instead undergoing continuous celldivision. A key factor in reducing the production costs ofbiopharmaceuticals is the development of cell lines which in turn produce ahigh yield of product.

TissueScience & Regenerative Medicine

Regenerative Medicine is the branch of translational research deals with the processof replacing, engineering or regenerating human cells, tissues or organs inorder to restore or establish normal functionality of cell. Regenerativemedicine is the combination oftissueengineeringand Molecular Biology. CellTherapy mediate cell repair via five primary mechanisms: providing ananti-inflammatory effect, homing to damaged tissues and recruiting other cellssuch as endothelial progenitor cells for necessary tissue growth, supportingtissue remodeling over scar formation and inhibiting apoptosis programmablecell death and differentiating tissues into bone, cartilage, tendon andligament tissue.

ClinicalTrials on Cell & Gene Therapy

Clinical Trials of Celland Gene Therapy products often varying from the clinical trials design for other types of pharmaceutical products. Thesedifferences in trial design are necessitated by the distinctive features ofthese products. The clinical trials also reflect previous clinical experienceand evidence of medicine. Early experiences with Cell and Gene Therapy products indicate that some CGT products may posesubstantial risks to subjects due to effect at cellular and genetic level. Thedesign of early-phase clinical trials of Cell and Gene Therapy products ofteninvolves the following consideration of clinical safety issues, preclinicalissues and chemistry, manufacturing and controls (CMC) issues that areencountered.

NanoTherapy

Diseases can betreated using viruses as vector to deliver genes inGeneTherapy. Viruses as genevector however, can themselves cause problems in that they may initiateinflammation and the genes may be expressed at too high a level or for too longperiod of exposure. The goal of Nano Technology in genetherapy is delivery of therapeutic genes without a virus, usingnanoparticles as non-viral vector to deliver the genes. The particles canbe made with multiple layers so the outer layer with covering of peptide thatcan target the particles to cells of interest at specific site. The emergent Nanotechnologyin gene therapy is used to develop unique approaches in treating theretinopathies and the development of micro and Nano dimensional artificialantigen presenting cells forcancerimmunotherapy. These antigenpresenting cells mimic the natural signals in immunity that killer T-cellsreceive when there is an invader (bacteria, virus, cancer cell, etc.) in thebody.

AdvancedGene Therapeutics

Functionality ofbiomaterials for these forms is depends upon the chemical reaction such aslocalized or systemic response at the surface tethered moieties or encapsulatedtherapeutic factors such as drugs, genes, cells, growth factors, hormones andother active agents to specific target sites. The application of functional biomaterials is rehabilitation, reconstruction, regeneration, repair,ophthalmic applications and act as therapeutic solutions. It has the propertyof biocompatibility and produce inertness response to the tissue.Thebiomaterial-mediated gene therapy aim to use polymeric gene therapy systems tohalt the progression of neuron loss throughneuroprotectiveroutesand it combine stemcell therapy and biomaterial delivery system in order to enhance regeneration or repairafter ischemic injury.

Geneand Cell Therapy for Rare & Common Diseases

Gene therapy is a superior method to treat uncommon hereditary maladies; fixa solitary quality deformity by presenting a ‘right’ quality. The main qualitytreatment preliminaries were directed utilizing patients with uncommonmonogenetic issue, however these are presently dwarfed by the clinical testingof quality therapeutics for more typical conditions, for example, malignancy,AIDS and cardiovascular illness. This is halfway because of an inability toaccomplish long haul quality articulation with early vector frameworks, a basicprerequisite for amending numerous innate hereditary deformities. Presently, with the appearance ofadeno-relatedviral(AAV) and lent viral vectors, which show steady qualityarticulation in creature thinks about, this mechanical obstruction, may havebeen survived. These vectors are foreseen to shape the premise of numerous genetherapy protocols for acquired hereditary illnesses.

CellScience and Stem Cell Research

The extract derivedfrom the plant cell culture technology is being harnessed and utilized as anactive ingredient in anti-aging skincare products. In recent years, researchershave identified naturally occurring botanicals with substantial antioxidantactivity proven to protect skin stem cells from UV-induced oxidative stress,inhibit inflammation, neutralize free radicals and reverse the effects ofphoto-aging by means ofanti-oxidantactivity. Consequently,cosmeceutical products containing plant stem cell derived extracts have theability to promote healthy cell proliferation and protect against UV-induced dermatological cellular damage in humans. In contrast to epidermal stem cells,plant stem cells are totipotent that they are capable of regenerating anentirely new, whole plant. Through innovative plant stem cell technology,scientists are able to extract tissue from botanicals and regenerate stem cells can be harnessed for use in humans. The use of stem cellsderived from botanicals plant, rather than human stem cells, avoids thecontroversy surrounding the source or methods of extraction of human stem cellswhile still harnessing the potential of these intriguing cells and its effectin anti-photo aging.

MolecularBasis of Epigenetics

Epigenetics refers to changes in a chromosomewhich has influence on gene activity and expression. It is also used todescribe any heritable phenotypic change that doesn’t derive from amodification of the chromosome such as prions.Epigeneticsis the mechanism for storing andperpetuating or continuing indefinitely a memory at the cellular level. Thebasic molecular epigenetic mechanisms that are widely studied at present regulation of chromatin structure of cell through histone post-translationalmodifications and covalent modification of DNA principally through the methodof DNA methylation. Chromatin is a dynamic structure that integrates potentially hundreds ofsignals from the cell surface and has effects of coordinated and appropriate transcriptional response in cell. It is increasingly clear that epigenetic marking ofchromatin and DNA itself is an important component of the cell signalintegration of entire function that is performed by the genome. Moreover, thechanges in the epigenetic state of chromatin in cell can have lasting effectson behavioral changes.

Geneticsand Stem Cell Biology

An undifferentiated mass of cell in amulticellular animal which is prepared for offering rise to uncertain number ofcells of a comparable sort, and from which certain diverse sorts of cell riseby detachment. Undifferentiated life forms can isolate into specific cell creates. Thetwo describing characteristics of an undifferentiated cell are endlessself-restoration and the ability to isolate into a specific adult. There aretwo critical classes of youthful microorganisms: pluripotent that can end upbeing any cell in the adult body, and multipotent that is kept to transforminginto more limited masses of cells.

Regulatoryand Safety Aspects of Cell and Gene Therapy

Celltreatment things require a combination of prosperity examinations.Comparable living being and quality things are heterogeneous substances. Thereare a few zones that particularly ought to be tended to as it is extremely notthe same as that of pharmaceuticals. These range from making group consistency,thing soundness to thing prosperity, quality and sufficiency throughpre-clinical, clinical examinations and displaying endorsement. This reviewplots the present headings/administers in US, EU, India and the relatedchallenges in making SCBP with highlight on clinical point.

Markets& Future Prospects for Cell & Gene Therapy

The immense number of associations related withcell treatment has extended development incredibly in the midst of the pastcouple of years. More than 500 associations have been recognized to be lockedin with cell treatment and 305 of these are profiled 291 co-tasks. Of theseassociations, 170 are related with fundamental microorganisms. The Profiles of72 academic establishments in the US related with cell treatment close by theirbusiness facilitated efforts. Allogeneicdevelopment with in excess of 350 clinical preliminaries is prepared toorder the commercialization of cell medicines in publicize. Advance R&D incell and quality treatment is depended upon to bloom given the normally basedpurposes of intrigue.

CellBiology

Cell biology is the investigation of cell andhow the cell capacities. Cell consist of numerous organelles that performparticular capacities and assume an imperative part in the development andgrowth of an organism. Cells are of 2 composes Prokaryotic Cell and Eukaryotic Cell. Case of aProkaryoticCellincorporates,Bacteria, then again Animal Cell and Plant Cell are portrayed as EukaryoticCells

Geneediting and CRISPR based technologies

CRISPR (Clustered Regularly Interspaced ShortPalindromic Repeats) Technology is a champion among the most fit yet clearmechanical assembly for genome changing. It urges and empowers investigators toeasily change DNA groupings and modify quality limits. It has various potentialapplications that join helping innate disseminates, treating and keeping thespread of diseases and improving yields. CRISPR broadly used as CRISPR-Cas9whereCRISPRsare particular stretches out of DNA andCas9 is the protein which is an aggravate that exhibitions like a few nuclearscissors, fit for cutting DNA strands. The assurance of CRISPR advancementanyway raises moral stresses as it isn’t 100% compelling. Regardless, the progressionof CRISPR-Cas9 has disturbed the designed science industry these days, being aclear and great quality changing device.

Genetics& Genomic Medicine

Genetics in Health and Disease in whichtherapy utilizesgenetics, imaging and biological indicators tounderstand predisposition to disease, what constitutes health during childhoodand throughout the life course. Gene and Protein Function are used to develop tools, skills and resources to elucidategene function and to inform development of new therapies using state-of the-arttechnologies. Personalized Medicine and Patient benefit is considered to ensurebasic science discoveries of disease mechanisms and patients genomes are usedto produce best effect to improve patients lives which include betterdiagnostics, identification of biomarkersand targeting of therapies.

BioengineeringTherapeutics

Tissue Engineering or Bioengineering is the combinational usage of cells,Engineering, materials methods, suitable biochemical and physicochemicalfactors in order to improve or replace the infected biological tissues. Thefield includes the development of materials, devices,techniques to detect and differentiate disease states, the treatmentresponse, aid tissue healing, precisely deliver treatments to tissues or cells,signal early changes in health status, and provide implantable bio-artificialreplacement organs for recover or establish of healthy tissue. Techniquesdeveloped here identify and detect biomarkers of disease sub-types,progression, and treatment response, from tissue imaging to genetic testing andSingle cell analysis, that aid the more rapid development of new treatments andguide their clinical applications in treating the disorder. It includes theusage of computational modeling, bioinformatics, andquantitativepharmacologyto integratedata from diverse experimental and clinical sources to discover new drugs andspecific drug targets, as well as to design more efficient and informativepreclinical, clinical safety and efficacy studies.

Immunogenetics& Transplantation

Immunogenetics and Transplantation providesspecialized diagnostic services for allogeneic transplantation and related research. It provides support for blood, bonemarrow, kidney, pancreas, liver, heart, lung, small bowel andcorneatransplantation. Currently Immunogenetics& Transplantation is hot topic of discussion.

Biomarkers

Biomarkersare evolving rapidly in the advance of personalized medicine and individualhealth. The identification & validation of biomarkers in drug discovery,development and in disease prognosis, diagnosis, prevention & treatmentplay an essential role in the genomic era.

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Genetherapy | Cell Therapy | Conferences | Events | 2019 …

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Sermorelin Cost & Benefits: Discover the Price of Monthly …

hGH Replacement Therapy has been a popular Anti-Aging and performance enhancing treatment since as early as 1990, but unfortunately, use of hGH does not come without risks.

Sermorelin Acetate has become a popular alternative as it enables you to obtain the benefits of hGH Therapy, without the associated risks.

This article looks more closely at the benefits of Sermorelin injections as a hGH alternative and the cost associated with it.

To begin with, it is a good idea to have an understanding of what Sermorelin Acetate is and what role it plays when administered via injection.

Scientifically Sermorelin acetate is referred to as growth hormone releasing factor 129 NH2-acetate, this is because it is a peptide which contains the first 29 amino acids that make up growth hormone produced in our bodies.

This contributes to Sermorelins function as a growth hormone secretagogue (a substance which causes another substance to be secreted Wikipedia) in this case, the substance whose secretion is promoted is growth hormone.

For this reason, Sermorelin is often also referred to as an hGH stimulator and is considered an excellent alternative to hGH.

One important thing to understand about Sermorelin is that it promotes healthy function of the pituitary (the gland responsible for our bodys production of hGH) during the aging process.

This is a far cry from aggressive administration of hGH which can, in fact, negatively impact normal pituitary function.

Another distinct advantage of using Sermorelin instead of hGH is the cost involved.

hGH typically costs $1000+ per month of treatment, Sermorelin is a much more affordable option with 3 months treatment of Sermorelin costing significantly less than just one month on hGH.

In fact, Sermorelin is available at as low as $290 per month for a 9mg vial.

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From $292 per month

Performance Peptides

Sermorelin 9mg

GHRP-2 9mg

GHRP-6 9mg

From $317 per month

Besides the obvious advantages of Sermorelin injections detailed above, you may want to know how you can benefit from using this therapy.

Perhaps the easiest way to understand the potential benefits of hGh replacement therapy is to look at the symptoms of hGH decline and the effect hGH replacement has on those symptoms.

These are detailed below:

Changes in body composition due to decreasing levels of hGH are reflected by a decrease in lean body mass (muscle) and an increase in fat mass.

Correcting hGH levels has been shown to reverse this state by improving muscle mass and reducing fat.

Research indicates that hGH deficiency in adults contributes to a reduction in bone density and therefore increased risk of osteoporosis.

It has also been shown that hGH replacement therapy for greater than 12 months results in improved bone mineral density and hence, lower risk of osteoporosis.

Due to changes in body composition detailed above, muscle strength is understandably compromised. As hGH therapy corrects body composition and improves muscle mass, muscle strength also improves.

The best results are gained after 12 months of hGH therapy.

By improving bone mineral density and increasing muscle mass and strength, hGH therapy can help to prevent joint deterioration that is a feature of arthritis.

Optimal growth hormone levels are also essential for health of connective tissue such as the Synovium found in joints.

Exercise performance is reduced in individuals with growth hormone deficiency. This appears to be partially due to reductions in bone density and muscle mass but also in part due to a reduction in oxygen uptake.

hGH therapy for 6 months has been shown to improve exercise performance by improving muscle mass and also oxygen uptake

There is evidence of a greater risk of heart disease in individuals with growth hormone deficiency and it has been hypothesized that this is due to a greater propensity to develop premature atherosclerosis (a build-up of plaque inside the arteries which increases risk of heart attack and stroke).

Growth hormone deficiency also results in changes in heart size and function. These changes have been demonstrated to be reversed after 6 months hGH therapy.

Growth hormone deficiency results in a reduced resting metabolism and replacement therapy reverses this decrease. hGH therapy has also been shown to increase protein synthesis, increase fat oxidation, normalize carbohydrate metabolism and reduce LDL (bad) cholesterol.

These favorable effects on metabolism may in part explain some of the other benefits of hGH including improved hearth health and body composition.

A reduction in skin thickness and all-important skin collagen is another result of growth hormone deficiency. Both conditions are improved by hGH therapy.

Although adults with growth hormone deficiency are not normally considered to have a compromised immune system, there is some evidence to suggest that hGH therapy can help regulate immune function.

It has been demonstrated that people with growth hormone deficiency have more difficulty with sexual relationships and reportedly, lower energy levels.

Many individuals have found an improvement in energy, libido and sexual performance following hGH therapy, some men even claiming an improvement in problems with premature ejaculation.

Reduced psychological well-being has been reported in individuals with growth hormone deficiency and hGH replacement has resulted in improvements in mood, energy and general feelings of well-being.

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Men’s T-Clinic: Testosterone Replacement: Dallas & Houston, TX

The founders of Mens T-Clinic, withseven convenient Texas locations Dallas, Frisco, The Colony, Houston, Cypress, Pearland, and Pasadena understand firsthand how devastating low testosterone can be. Founded by men afflicted with hypogonadism (commonly known as low testosterone, or Low T), the clinic has developed a thorough testosterone replacement therapy program for fast and effective relief. The founders established the Men’s T-Clinic with three objectives in mind:

The Mens T-Clinic team understands the debilitating effects Low T can have on everyday life. For years, these men went untreated or were misdiagnosed and treated for symptoms instead of the underlying cause. After trying several different treatments and doctors, each found best results with regular therapy.

The outcomes for these men have been nothing short of phenomenal. All have seen an increase in physical and mental drive, better moods, increased libido, and a decrease in belly fat. Men’s T-Clinic set out on a mission to improve men’s health by establishing conveniently located clinics with no appointment necessary to provide therapy.

They offer multiple treatment options to suit the patient, not the drug companies. Treatment can range from injection therapy to pharmaceutical gels and creams. You can begin on your first visit, and therapy is covered by most insurance plans.

The motto at Mens T-Clinic is “Get back to being you.”

Dr. Salvatore Campo directs the treatment plans at Men’s T-Clinic. Dr. Campo has more than two decades of treating hypogonadism for men of all ages. If you suspect that you suffer from hypogonadism and want relief, call one of the Mens T-Clinics convenient locations or schedule an appointment online today.

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Men’s T-Clinic: Testosterone Replacement: Dallas & Houston, TX

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Natural Testosterone Pellets | Testosterone Replacement …

BioTE Medical offers natural testosterone pellets for men and women. Learn more about our products and then Find a Provider to get started today.

Testosterone is a hormone naturally found inside both men and women that is responsible for many different critical body processes. Testosterone is produced in the testes and ovaries. Deficiency occurs as the body ages but suffering from the side effects of this is no longer unavoidable.

BioTE Medical provides bio-identical hormone replacement therapy in the form of pellets. Other forms of testosterone are tablets taken by mouth, tablets placed in the cheek and left to dissolve, muscle injections, patches applied to skin or as a gel. The forms of testosterone that do not release a consistent dosing may provide patients with inconsistent treatment or in the case of patches, short term consistent treatment. Pellets are the only form of testosterone replacement therapy that provides consistent dosing over a period of up to six months. This simple solution to testosterone supplementation has provided lifechanging results for BioTE Medical patients.

BHRT, or bio-identical hormone replacement therapy, uses hormones that most closely represent the ones found in the human body. The term bio-identical refers to how the hormones used in BHRT have a similar molecular structure to the ones found naturally. BHRT uses hormones from plant based sources rather than the animal based sources found in synthetic hormones.

Testosterone pellets are powdered testosterone fused together into a pellet using stearic acid and no chemical binders. The compound pharmacies used provide high-quality pellets, with ingredients that are tested. This testing process gives pharmacists, doctors and patients confidence that only the best pellets are being administered to our patients.

Testosterone pellets are intended to treat a wide range of reproductive, emotional and nonreproductive conditions. Some of these include low energy, chronic exhaustion, sexual dysfunction, mood swings, irritability and many others. How can I get started with testosterone pellet therapy? Do you suffer from any of the conditions listed above? Get started with testosterone pellet therapy by finding your local BioTE Medical provider on our Find a Provider page.

BioTE Medical only offers bio-identical hormone replacement therapy in the form of subcutaneous pellets and with over million insertions performed in the companys history, we have seen many lives changed with optimized hormones. If any of the hormone imbalance symptoms mentioned above ring a bell for you, or remind you of someone you love, BioTE Medical encourages you to use our Find a Provider tool or to nominate your provider to begin your journey to wellness today.

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Testosterone Replacement Therapy | Phoenix | Scottsdale

Testosterone Replacement Therapy | Phoenix | Scottsdale

Testosterone is a steroid hormone naturally made by the body. Testosterone helps maintain reproductive tissues, stimulate sperm production, stimulate and maintain sexual function, increase muscle mass, and maintain bone strength. The proper amount of testosterone in your body is vital to your overall sense of well-being. Too little testosterone can lead to several health and wellness issues while a balanced hormone level can help you rediscover youthful vitality.

Do you have the following symptoms?

Testosterone Replacement Therapy

If you answered yes to at least 3 items above, you may be suffering from low testosterone. An easy blood test and confirm the testosterone levels in your body. If you do suffer from low testosterone Camelback Health Care provides treatment to increase your testosterone level and help you feel years younger. To schedule a consultation contact us at (602)368-5861.

This Internet site provides information of a general nature and is designed for educational purposes only. If you have any concerns about your own health or the health of your family please contact Camelback Health Care. Camelback Health Care is a family medical practice providing pro-active health care for the entire family, allergy testing and treatment, cosmetic skin and laser services, medically managed weight loss, and bio-identical hormone replacement therapy. Conveniently located on Camelback Road, Camelback Health Care is easily accessible from Phoenix, Paradise Valley, Scottsdale, and Tempe.

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Testosterone Replacement Therapy | Phoenix | Scottsdale

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Guide to Effective Testosterone Replacement Therapy Low T …

Testosterone replacement therapy has gained greater interest as a legitimate medical procedure as of late, due to it’s newly discovered benefits, both on physical health and increased quality of life.

The effects of testosterone can vary greatly; from increased energy and well-being, to greater muscle mass and sex drive, even improved cholesterol and cardiovascular profiles.

The administration of testosterone treatment is not as straight forward as many have been lead to believe. The male endocrine system requires a delicate balance to effectively manage side effects.

One needs to be aware, not only of testosterone but it’s interaction with estrogen and LH (luteinizing hormone) as well, to operate at peak performance.

Following the above best practices will help accentuate the positives of treatment while minimizing testosterone’s side effects.

Unfortunately most of the hormone’s demonization has been spurred on by ignorance and false claims from not so well meaning political groups and associated sports governing bodies.

However, the side effects of testosterone many men experience, generally comes from the mismanagement of it’s main metabolites; namely estradiol and DHT (dihydrotestosterone).

Androgel, Testim, and their associated compounded testosterone gels and creams have lately become an increasingly popular method to treat andropause.

However they come with both their supporters and detractors. Some championing their positives; ease of use (a doctor isn’t needed for administration), and short half-life which more closely mimics the body’s natural production.

Others harp on their unreliable results (absorbtion problems in some), patient compliance (may be sticky, stinky, with a worry of transferance to women and children), and expense (may be up to 4 to 5 times higher than other preparations).

Testosterone injections are currently the most reliable, efficient, and inexpensive method to administer replacement therapy.

Although as you can imagine, poking yourself with a needle isn’t exactly a positive selling point when trying to market to a large audience.

HCG injections are a common adjunct to testosterone replacement therapy among males. When combined with testosterone and estrogen control (aromatase inhibitor) as described in the testosterone trifecta plan, it can help maintain long term fertility and hormonal balance.

Testosterone pellets are marketed mainly under the brand name Testopel. I’m not much of a fan, as they’ve basically become a dated and inefficient means to increase testosterone levels.

However they have their fair share of supporters due to their infrequenct administration periods (up to 6 months) and may be inserted as a quick procedure by your physician.

Many men aren’t aware of a little known side effect, occuring in a small minority of men, after completing a vasectomy. The problem is that some men may experience an odd autoimmune side effect, which often can result in hypogonadism.

Your body’s immune system literally mistakes your gonads/testicles as foreign material and sets off to destroy the “offending” tissue.

If you’ve had the procedure and wondering why you’ve been feeling off or are considering a vasectomy in the future, it’s best you be aware of all the pros and cons before deciding on future treatment.

A place to ask questions on the finer points of testosterone replacement therapy.

From what kind of needle to use, whether to cycle your doses, to new and exciting developments in andropause research.

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Guide to Effective Testosterone Replacement Therapy Low T …

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Natural Alternatives to Testosterone Replacement Therapy …

Testosterone, touted as the manly hormone, is the most powerful androgen. Androgens are a group of steroid hormones whose name fittingly is derived from the Greek word for man-maker.

Testosterone is well-known for its role in muscle growth, male pattern hair growth, and plays a role in erection and sexual performance. It is also necessary for maintaining optimal bone density, a healthy pain response, regular sleep patterns, optimal energy levels, and red blood cell production. While the effects testosterone has on male behavior are not completely understood, it plays a role in energy levels, aggressiveness, and is necessary for sex drive.

As men age, testosterone levels typically decline. Low T is the term used when testosterone levels are low. While some experts believe that testosterone levels naturally decrease at a rate of 1 percent a year after age 40, there is recent research indicating that the decline in testosterone may be the result (not the cause) of deteriorating general health.

Some signs of Low T include decreased libido, shrinking testicles, reduced facial hair, osteoporosis, weight gain, hot flashes/night sweats, sleep issues, infertility, fatigue/decreased energy, muscle loss, depression, poor memory/lack of focus, and anemia.

It is evident that testosterone benefits the body in a plethora of ways and is necessary for optimal functioning. (While we are focusing on mens health, testosterone is an important hormone for womens health as well!) Luckily, there exist a vast variety of ways to increase testosterone levels in the body. There are both natural means as well as pharmaceutical testosterone therapy. Learning about these different testosterone-boosting methods will help you make an informed choice for yourself or your loved ones.

Chances are you have seen commercials by the pharmaceutical industry promoting the use of testosterone replacement therapies, urging men to ask their doctors if they have possible signs of testosterone deficiency. FDA regulations allow for this pharmaceutical marketing (the US is one of only four nations that allows direct-to-consumer advertising).

According to Dr. Michael OLeary, a urologist at Harvard, Virtually everybody asks about this now because the direct-to-consumer marketing is so aggressive. Tons of men who would never have asked me about it before started to do so when they saw ads that say, Do you feel tired? Dr. OLeary states that being tired is low on his list when it comes to prescribing testosterone replacement therapy. If a client has significant low T symptoms, Dr. OLeary always performs a lab test- even then, most of the men who come to him have normal testosterone levels.

When men do have testosterone levels below the normal range, they usually end up on long-term testosterone replacement therapy. Dr. Carl Pallais, an endocrinologist at Harvard, agrees with Dr. OLeary in that the marketing of testosterone therapy has put men in the position of being informed of the benefits of testosterone therapy, without sufficient knowledge of its potential risks. He believes that men need to be more mindful of the long-term consequences. According to Dr. OLeary, the body stops making testosterone while on treatment, making it hard to stop taking it. Along with other experts, he airs on the side of caution, weary that the risks of testosterone replacement therapy add up over time.

According to Dr. OLeary, Men can often feel a big difference when they stop therapy because their bodys testosterone production has not yet recovered. This wouldnt matter so much if we were sure that long-term hormone therapy is safe. He refers to the treatment as a testosterone trap: men often feel better when they start treatment, but then there are side effects (dependency being a major one).

While most men feel better at the start of treatment, there are some who experience immediate side-effects, including acne, sleep apnea, breast swelling/tenderness, and swelling in the lower extremities. While on treatment, doctors monitor red blood cell counts, as increased counts could contribute to the risk of blood clots.

Unfortunately, the long-term effects of testosterone replacement are vague, as there has yet to be a large, definitive trail for testosterone therapy. The current research shows that men on testosterone treatment long-term have heightened risks of cardiovascular issues, including heart attacks, strokes, and death from heart disease. According to Dr. Pallais, the cardiac side effects are more immediate in older men.

While the evidence is mixed, and more research is needed for clarification, some experts worry that testosterone therapy could stimulate the growth of prostate cancer cells. Many experts believe that testosterone therapy should only be used by men with hypogonadism (except those with a history of breast or prostate cancer) or those enrolled in highly monitored clinical trials. Hypogonadism is a medical condition in which the testes stop producing and releasing adequate amounts of sex steroids (testosterone) and sperm. Hypogonadism can be congenital or acquired. It is most commonly acquired in late adulthood, presenting with co-morbidities including metabolic syndrome, obesity, and type 2 diabetes. Many physicians agree that low testosterone is often a sign of overall poor healththere are a handful of small studies displaying that lifestyle interventions can improve testosterone levels.

One expert in functional medicine, brings to light that other forms of hormone treatment have a history of dangerous side effects. For example, estrogen therapy has been linked to increased risk for breast cancer, and other synthetic hormone treatments have been shown to lower HDL cholesterol and increase the risk of stroke. With this in mind, this doctor recommends avoiding synthetic hormone treatment if possible.

The cost of testosterone replacement therapy will vary, depending upon your health insurance coverage. If you have insurance, there is typically a monthly co-pay ranging from $30-100 dollars. If paying out of pocket, you may pay upwards of 600 dollars per month, taking into account the blood tests and doctor visits needed to monitor your testosterone levels.

One doctor recommends intermittent fasting as a top lifestyle change for increasing natural testosterone. Intermittent fasting is a practice in which one eats all of their food within a smaller timeframe- leaving at least 12 hours between your last and first meal of the day. This gives the body a chance to digest, rest and balance. In fact, it has been shown that this practice can increase testosterone by up to 200 and even 400 percent. A study at the University of Virginia Medical School revealed that human growth hormone also increased, which is a hormone associated with increased T levels.

Lifting weights and working out are great ways to naturally increase testosterone production. In particular, HIIT (High-Intensity Interval Training) has been proven helpful in weight loss.

De-stress.Chronic stress means excess cortisol (the stress hormone). The bodys response to cortisol is initially to increase testosterone production, yet the body cannot keep up. A 2010 study published in the journal, Hormones and Behavior, revealed that testosterone levels bottom out after the initial increasein fact, testosterone levels become lower than they were prior to the cortisol spike.

Vitamin D3 is an important nutrient that boosts testosterone levels. Studies have shown that it can increase testosterone in men up to 30 percent. Spending 20-30 minutes in the sun is a great way to obtain vitamin D.

Decrease your sugar intake.Excess sugar intake puts you at risk for the co-morbidities associated with low T. When your sugar intake is increased, your body needs to produce more insulin to balance your blood sugar. Excess insulin overtime leads to insulin resistance, a condition in which your bodys cells no longer respond to insulin- this causes type II diabetes. People with type II diabetes are twice as likely to develop low T. Limiting your sugar levels can help your body to naturally balance your hormones.

Get your ZZZs.One doctor sites a study in which getting enough sleep (an average of 7 hours) and at the right time (sleeping between 10 pm to 2 am) is considered the most effective way to naturally raise testosterone levels. Our bodys circadian rhythms play a key role in overall hormonal balance. Getting enough sleep is also important for balanced weight maintenance.

Tongkat Ali is also referred to as Malaysian Ginseng. It is an ancient herb with traditional use as an anti-aging remedy. In modern times it is used as an adaptogen and is well-regarded for its ability to improve libido, energy, athletic performance and weight loss. In fact, it may be one of the most effective herbs for increasing free testosterone levels in the body!

Nettle Root Extracthas long been appreciated as a nourishing tonic it is touted as being high in minerals. The nettle root is particularly indicated for male hormone and prostate health. Studies show that nettle root can inhibit sex-binding globules from binding to testosterone, resulting in higher levels of free testosterone in the body. Nettle root has also been shown to support overall urinary tract and prostate health. It both nourishes and tones the male reproductive tract. Nettle root also has anti-inflammatory effects and has been shown to decrease swelling of the prostatewhich can result in enhanced sexual satisfaction.

Pine Pollen is known for supporting male health and has been used in TCM for thousands of years. Pine Pollen is known for containing phyto-androgens (including testosterone), which is fitting as it is the male spore of the pine tree after all! Experts believe that the structure of these phyto-androgens allows them to work similarly to the bodys own hormones in an adaptogenic way. As a hormonal balancer, pine pollen can also support liver health and detoxification. It is also high in phytonutrients and antioxidants!

Ashwagandha is considered an adaptogen and has long been appreciated as a hormonal balancing herb in Ayurveda. It has been shown to reduce cortisol levels in the body and increases blood flow to the sexual organs. Taking this herb in a spagyric form also means that there are more minerals than a typical Ashwagandha tincture, due to the enhanced processing technique.

Black Maca has long been used as a remedy for sexual dysfunction and infertility. It is not a surprise that it is often used as an aphrodisiac. Maca is a tuber, which is filled with phytonutrients, including zinc and other important micronutrients. It can help build bone density, muscle, and is also touted for increasing energy. The powder is tasty too! It can easily be added to smoothies.

As you can see, when it comes to testosterone there are a plethora of lifestyle, dietary and herbal supports. Working with your body naturally can help increase your testosterone without being subject to a long list of side-effects. Your testosterone levels are important to your health and wellbeing. The way in which you choose to increase your testosterone levels has an impact on your overall health and wellbeing as well, so take the time to make the choice that is right for you.

References

Corona, Giovanni, et al. Advances in Pediatrics. Aug. 2017. Retrieved from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583373/

Gilbert, Brandon. Mens Sexual Health: The Power of Nettle Root. Retrieved from: http://www.elephantjournal.com/2014/06/mens-sexual-health-the-power-of-nettle-root-brandon-gilbert/

Hackett, Geoffrey. Advances in Pediatrics. Apr. 2016. Retrieved from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772354/

Is Testosterone Therapy Safe? Take a Breath before You Take the Plunge. Retrieved from: http://www.health.harvard.edu/mens-health/is-testosterone-therapy-safe-take-a-breath-before-you-take-the-plunge

Testosterone Replacement: A Cautionary Tale Harvard Health. Retrieved from: http://www.health.harvard.edu/mens-health/testosterone-replacement-a-cautionary-tale

Older Age Does Not Cause Testosterone Levels to Decline in Healthy Men. ScienceDaily.2011 June 07. Retrieved from: http://www.sciencedaily.com/releases/2011/06/110607121129.htm

Talbott, Shawn M, et al. Advances in Pediatrics. 2013. Retrieved from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669033/

Erin Henry

The complexity and connection in nature inspire Erins study of herbalism. She is fascinated by the healing capacity of the body. Spending good time in the woods and her garden brings her joy. You can read more about her journey with herbalism at: empoweredterrains.com

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What you should know about testosterone replacement therapy

Bryant Stamford, Special to Courier Journal Published 6:49 a.m. ET May 17, 2018 | Updated 6:50 a.m. ET May 17, 2018

A study suggests that exercise can reduce the risk of heart damage for middle-aged adults and seniors. According to the study, even those who are obese will benefit from physical activity. Wochit

Senior man working in a greenhouse(Photo: Alistair Berg, Getty Images)

Millions of middle age and older men feel themselves slowing down and they wonder, is it simply age or is it something more, like a low testosterone level? If your testosterone is low, is testosterone replacement therapythe answer?

This seems like a simple question. Unfortunately, its not. The diagnosis process is challenging, plus there is the issue of safety. Yes, TRT can downplay symptoms, but at the same time can it be harmful? Lets take a look.

Testosterone is responsible for governing many important functions in the male body. Production typically peaks in early adulthood, then declines at the rate of about 1 percent per year from about age 35. As testosterone production in the testicles declines, muscle and bone mass are lost and body fat increases around the midsection. Red blood cell production may decline, along with a drop in libidoand sperm production, plus erectile dysfunction. When testosterone drops substantially, there can be disruption of sleep and increased lethargy throughout the day, depressed moods, lack of motivation, poor concentration and loss of memory.

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These symptoms become more obvious as testosterone levels go lower and lower. This raises the question: Is it time for TRT? That depends. How many symptoms do you have (very few men will have all of them)? Beyond that, how severe are the symptoms and how persistent? Next, how low is your testosterone level?

Testing for testosterone levels in the blood and using results for a diagnosis is not as straightforward as it might seem. Results can vary for a number of reasons, and its best to conduct tests on more than one day. But its more complicated than that because testosterone circulates in the bloodstream in three forms.

First is free testosterone that is readily available for use by the body. Second is testosterone loosely bound to albumin (a protein in the blood) which can be used but is not as immediately available as free testosterone. And third, most of the testosterone is bound tightly to another protein, sex hormone binding globulin (SHBG). Testosterone bound to SHBG is not available, but it is important because it regulates the amount of free testosterone in the blood.

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Doctors use two tests. One is for total testosterone, and the other is for free testosterone. Total testosterone includes all testosterone (free testosterone as well as all the testosterone bound to the two proteins in the blood, albumin and SHBG). As to which test is more useful and reliable, some experts believe free testosterone is the better indicator of clinical status. Unfortunately, this is not true for all patients. Also, some experts contend that free testosterone results can vary too much from day to day.

Another problem is, you can have symptoms of low testosterone even though your free and total testosterone levels are in the normal range. Whats more, although symptoms become more likely with decreasing levels of testosterone, according to the Endocrine Society of the United States, there is no clear-cut testosterone threshold that can be reliably applied to all patients.

Obviously, getting an accurate diagnosis and deciding whether or not TRT is right for you is complicated. For that reason, experts urge working with an experienced physician who fully understands the complexities associated the issues and with testosterone tests. I have found that seeing a urologist is a good way to go. Since folks always ask me, let me put in a plug for my urologist, Dr. Greg Steinbock. Hes really on top of things, plus hes a good listener and communicator.

Overall, its very important that your doctor sees the big picture, because its possible that symptoms are caused by something other than low testosterone levels. For example, obesity and being sedentary may be the root cause of lack of energy, a low libido and other symptoms.

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There is no one right approach to obtaining an accurate diagnosis and subsequent treatment, but some experts suggest assessing the impact of a trial dose of TRT for three to six months. In other words, the patient is closely monitored while taking a low dose of testosterone to see if it alleviates symptoms. One problem with this is the potential for a placebo effect, feeling better because you know you are being treated, but this usually doesnt last long.

The bottom line is, unlike prescribing medications for high blood pressure or high cholesterol, your doctor may be hesitant to have you quickly jump on board and start TRT. Instead, smart money says take a cautious approach and cover all the bases before proceeding.

Next week I will discuss potential health risks and benefits associated with TRT, and alternative treatments for low testosterone levels.

Reach Bryant Stamford, a professor of kinesiology and integrative physiology at Hanover College, at stamford@hanover.edu.

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Testosterone Replacement Therapy Cost – tctmed.com

Low T Treatment, also known as Testosterone replacement therapy or TRT, has become a much more common treatment for both men and women in recent years.

Because of this, options for treatment of Low T have also grown, but what can one expect testosterone replacement therapy to cost?

Most of the testosterone replacement therapy cost is covered by insurance, and affordable cash plans are also available.

Your choices are numerous, and Low T clinics and centers seem to be everywhere.

However, not all treatments and clinics are created equal. When we say that we are Setting the Standard, we are stating that we are committed to giving you the highest quality of care.

This goes beyond the standard testosterone replacement therapy cost beyond the mere dollar amount. The value of that is substantial, and it is something you will see once you meet with our dedicated providers.

At Testosterone Centers of Texas we will always work hard to provide superior service that places solid patient care atop a long list of priorities that keep our standards high.

With TCT, you receive personalized care that improves your quality of life without sacrificing your overall healthand you receive all of this in an efficient and streamlined manner.

We believe that men and women who suffer from the symptoms of Low T should expect a high level of care and expertise alongside affordability of treatment.

Consultations for prospective patients are free!

You can call or come by at any time to speak with one of our knowledgeable providers about your symptoms and whether or not TRT might be right for youjust click here to set up a free consultation.

To make sure that men and women who need treatment can get treatmentand not avoid contacting us because of a potentially high testosterone replacement therapy cost we do accept insurance, and we also have an affordable cash plan.

If you expect testosterone replacement therapy to cost a lot, you might be in for a surprise.

For insured patients, your benefits can be verified before your first visit and your pricing will be dependent upon your individual plan.

For those patients paying out-of-pocket, we offer an initialevaluation of total and free testosterone for just $25.

If you decide that the testosterone replacement therapy cost is outweighed by all the benefits of feeling like yourself again, and you want to proceed with treatment, the cost of the initial evaluation is applied to the month-to-month cash fee of $299/month, and this pricing covers visits, injections, and in-house labs.

Contact us today to schedule your free consultation!

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Healthy Me Medical Therapies | Chelation Therapy | Hormone …

Dr. Carlos Sanchez is board-certified in emergency medicine. He received his medical degree from Nova Southeastern University College of Osteopathic Medicine and completed his residency in Emergency Medicine at Newark Beth Israel Medical Center in New Jersey.

Dr. Sanchez has been practicing Emergency Medicine since 1999 and has treated thousands of patients with many different conditions. He has served in many leadership and administrative capacities at North Shore Medical Center. He is also owner and medical director of Medi-Station Urgent Care in Miami Shores.

In addition to practicing Emergency Medicine, Dr. Sanchez also has a special interest and passion inRegenerative and Integrative Medicine. He has seen the devastating results of chronic disease in manypatients presenting to the emergency department. It was obvious to him that there is an existingdeficiency in medicine to promote preventative care and lifestyle education.

Dr. Sanchez has completed his Certification with the Academy of Anti-Aging Medicine. His focus is in onBio Identical Hormone Replacement Therapy, IV Nutritional Replacement, Chelation Therapy andWeight Management. Dr. Sanchez created HealthyMe Medical Therapies to help his patients achieveoptimal health and healthier lifestyles. So whether it is IV Nutritional Therapies, Chelation Therapy,Hormone Optimization, or weight loss; you can be sure Dr. Sanchez and his dedicated staff will workclosely with you so you can achieve your goals and live a healthier life.

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