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Testosterone Injections: Are They Right for You?

Testosterone is a male steroid hormone that does a lot more for men than just promote a healthy sex drive. The hormone affects several other factors in your health, including body fat, muscle mass, bone density, red blood cell count, and mood.

Normal testosterone levels are between 300 and 1,000 ng/dL. If a blood test shows that your levels are far below the norm, your doctor may suggest testosterone injections. These are a form treatment called testosterone replacement therapy.

Testosterone injections are most often given by your doctor. The injection site is typically in the gluteal muscles in the buttocks. However, your doctor may allow you to self-administer the injections. In that case, the injection site would be in your thigh muscles.

Men naturally start losing some of their testosterone when they hit their 30s or 40s. A more rapid decline in testosterone levels may indicate a problem called low testosterone (low T). Common symptoms of low T include:

Some men may also have changes in the size of their penis and testicles. Others may have breast swelling.

Some men may want to diagnose themselves with low T. The problem with self-diagnosis is that many of the symptoms of low T are normal parts of aging, so using them for diagnosis isnt reliable. A doctor-ordered testosterone level test is the only way to find out if your testosterone levels are too low.

When you see your doctor, they will take a thorough health history and do a physical exam. In addition to a blood test to measure your testosterone levels, youll also likely have a test that measures your red blood cell count. Testosterone injections can increase your red blood cell count, so this test is done to make sure you arent at risk of a dangerous increase in these cells.

If your exam and tests reveal that you have low T, your doctor may suggest testosterone injections.

The purpose of testosterone injections is to help regulate male hormone levels to help address problems related to low T. For men with low T, the benefits of these injections can include:

Men generally have less body fat than women. This is partly related to testosterone, which regulates fat distribution and muscle maintenance in your body. With low T, youll likely notice an increase in body fat, especially around your midsection.

Your hormones also help regulate muscle growth. So, with low T, you may feel like youre losing muscle size or strength. However, this only occurs if your low T is prolonged and severe.

Testosterone shots can help regulate fat distribution, but you shouldnt expect significant weight changes from hormone therapy alone. As for muscle maintenance, testosterone therapy has been found to help increase muscle mass, but not strength.

Low sperm count is a common side effect of low T. This problem can make it difficult if you and your partner are trying to get pregnant. However, if low T is to blame for problems with conception, dont count on testosterone injections to help. Testosterone therapy can itself lead to reduced sperm counts, especially at high doses.

According to GoodRx.com, the cost of 1 mL (200 mg/mL) of Depo-Testosterone is about $30. The same amount of testosterone cypionate, the generic version of that drug, runs about $12$26. The Depo-Testosterone label states that shots should be given every two to four weeks. Considering that dosage varies by patient, the cost could run anywhere from less than $24 per month to more than $120 per month.

These estimates only cover the drug itself, and not all possible costs of treatment. For instance, if you receive the injections from your doctor, theres a cost for the office visits. This is in addition to the cost of office visits for monitoring, as your doctor will likely monitor your condition carefully to check for side effects and to make sure the injections are working properly. If you give yourself the injections, you may also need to buy needles and syringes.

Testosterone therapy doesnt cure the cause of low T, it just raises testosterone levels up to a normal range. Therefore, injections could be a lifelong treatment if you continue to need them.

Some insurance companies cover portions of the costs, but youll want to check your coverage in advance. If you have questions about the costs, talk to your doctor.

Testosterone shots can help many men with low T. Still, this doesnt mean that these powerful injections are safe for all men. Be sure to tell your doctor about all health conditions you have before starting testosterone therapy.

You will likely need extra monitoring from your doctor if you have heart disease, sleep apnea, or a high red blood cell count. And you should not use testosterone injections at all if you have breast cancer or prostate cancer.

Testosterone shots may also increase your risk of certain health problems, such as:

Testosterone injections can be helpful, but only if you actually have low T. If youre wondering if these injections might be right for you, talk to your doctor. They can test you for low T. If they diagnose you, you can discuss whether these injections would be a good choice for you.

If you dont end up having low T but still feel like your hormone levels might be off, keep in mind that good nutrition, regular exercise, and avoiding smoking could help you feel better. If those dont help, be sure to talk to your doctor.

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Nanomedicine | The Scientist Magazine

LAGUNA DESIGN/SCIENCE PHOTO LIBRARY/CORBIS

In a 1959 lecture at Caltech famously dubbed Theres Plenty of Room at the Bottom, American physicist and Nobel laureateto-be Richard Feynman discussed the idea of manipulating structures at the atomic level. Although the applications he discussed were theoretical at the time, his insights prophesied the discovery of many new properties at the nanometer scale that are not observed in materials at larger scales, paving the way for the ever-expanding field of nanomedicine. These days, the use of nanosize materials, comparable in dimension to some proteins, DNA, RNA, and oligosaccharides, is making waves in diverse biomedical fields, including biosensing, imaging, drug delivery, and even surgery.

Nanomaterials typically have high surface areato-volume ratios, generating a relatively large substrate for chemical attachment. Scientists have been able to create new surface characteristics for nanomaterials and have manipulated coating molecules to fine-tune the particles behaviors. Most nanomaterials can also penetrate living cells, providing the basis for nanocarrier delivery of biosensors or therapeutics. When systemically administered, nanomaterials are small enough that they dont clog blood vessels, but are larger than many small-molecule drugs, facilitating prolonged retention time in the circulatory system. With the ability to engineer synthetic DNA, scientists can now design and assemble nanostructures that take advantage of ?Watson-Crick base pairing to improve target detection and drug delivery.

Both the academic community and the pharmaceutical industry are making increasing investments of time and money in nanotherapeutics. Nearly 50 biomedical products incorporating nanoparticles are already on the market, and many more are moving through the pipeline, with dozens in Phase 2 or Phase 3 clinical trials. Drugmakers are well on their way to realizing the prediction of Christopher Guiffre, chief business officer at the Cambridge, Massachusettsbased nanotherapeutics company Cerulean Pharma, who last November forecast, Five years from now every pharma will have a nano program.

Technologies that enable improved cancer detection are constantly racing against the diseases they aim to diagnose, and when survival depends on early intervention, losing this race can be fatal. While detecting cancer biomarkers is the key to early diagnosis, the number of bona fide biomarkers that reliably reveal the presence of cancerous cells is low. To overcome this challenge, researchers are developing functional nanomaterials for more sensitive detection of intracellular metabolites, tumor cellmembrane proteins, and even cancer cells that are circulating in the bloodstream. (See Fighting Cancer with Nanomedicine, The Scientist, April 2014.)

The extreme brightness, excellent photostability, and ready modulation of silica nanoparticles, along with other advantages, make them particularly useful for molecular imaging and ultrasensitive detection.

Silica nanoparticles are one promising material for detecting specific molecular targets. Dye-doped silica nanoparticles contain a large quantity of dye molecules housed inside a silica matrix, giving an intense fluorescence signal that is up to 10,000 times greater than that of a single organic fluorophore. Taking advantage of Frster Resonance Energy Transfer (FRET), in which a photon emitted by one fluorophore can excite another nearby fluorophore, researchers can synthesize fluorescent silica nanoparticles with emission wavelengths that span a wide spectrum by simply modulating the ratio of the different dyesthe donor chromophore and the acceptor chromophore. The extreme brightness, excellent photostability, and ready modulation of silica nanoparticles, along with other advantages, make them particularly useful for molecular imaging and ultrasensitive detection.

THE NANOMEDICINE CABINET: Scientists are engineering nanometer-size particles made of diverse materials to aid in patient care. The unique properties of these structures are making waves in biomedical analysis and targeted therapy.See full infographic: JPG | PDF TAMI TOLPAOther materials that are under investigation as nanodetectors include graphene oxide (GO), the monolayer of graphite oxide, which has unique electronic, thermal, and mechanical properties. Semiconductor-material quantum dots (QDs), now being developed by Shuming Nies group at Emory University, exhibit quantum mechanical properties when covalently coupled to biomolecules and could improve cancer imaging and molecular profiling.1 Spherical nucleic acids (SNAs), in which nucleic acids are oriented in a spherical geometry, scaffolded on a nanoparticle core (which may be retained or dissolved), are also gaining traction by the pioneering work of Chad Mirkins group at Northwestern University.2 (See illustration.)

Nanoparticles are also proving their worth as probes for various types of bioimaging, including fluorescence, magnetic resonance imaging (MRI), computed tomography (CT), and positron emission tomography (PET). For instance, Xiaoyuan Chen, now at the National Institutes of Healths National Institute of Biomedical Imaging and Bioengineering, and Hongjie Dai of Stanford University have developed carbon nanotubes for performing PET scans in mice. When modified with the macromolecule polyethylene glycol to improve biocompatibility, the nanotubes were very stable and remained in circulation for days, far longer than the few hours typical of many molecular imaging agents.3 Further modification with a short-peptide targeting ligand called RGD caused the nanotubes to selectively accumulate in tumors that overexpressed integrin, the molecular target of RGD, enabling precise tumor imaging.

To further increase the specificity of nanodetectors, researchers can add recognition probes such as aptamersshort synthetic nucleic acid strands that bind target molecules. For example, we conjugated gold nanoparticles with aptamers that had been identified through iteratively screening DNA probes using living cancer cells.4 Circulating tumor cells (CTCs) are shed into the bloodstream from primary tumors and provide a potential target for early cancer diagnosis. However, CTCs are rare, with blood concentrations of typically fewer than 10 cells per milliliter of blood. Collaborating with physicians to profile samples from leukemia patients, we demonstrated that aptamers are capable of differentiating among different subtypes of leukemia, as well as among patient samples before and after chemotherapy (unpublished data). In addition to leukemia, we have selected aptamers specific to cancers of the lung, liver, ovaries, colon, brain, breast, and pancreas, as well as to bacterial cells. Other researchers have developed nanoparticles with numerous and diverse surface aptamers, enabling them to bind their targets more efficiently and securely.

NANOCAPSULES: A false-color transmission electron micrograph of liposomes, spherical particles composed of a lipid bilayer around a central cavity that can be engineered to deliver both hydrophobic and hydrophilic drugs to specific cells in the body DAVID MCCARTHY/SCIENCE SOURCEThe prototype of targeted drug delivery can be traced back to the concept of a magic bullet, proposed by chemotherapy pioneer and 1908 Nobel laureate Paul Ehrlich. Ehrlich envisioned a drug that could selectively target a disease-causing organism or diseased cells, leaving healthy tissue unharmed. A century later, researchers are developing many types of nanoscale magic bullets that can specifically deliver drugs into target cells or tissues.

Doxil, the first nanotherapeutic approved by the US Food and Drug Administration, is a liposome (~100 nm in diameter) containing the widely used anticancer drug doxorubicin. The therapy takes advantage of the leaky blood vasculature and poor lymphatic drainage in tumor tissues that allow the nanoparticles to squeeze from blood vessels into a tumor and stay there for hours or days. Scientists have also been developing nanotherapeutics capable of targeting specific cell types by binding to surface biomarkers on diseased cells. Targeting ligands range from macromolecules, such as antibodies and aptamers, to small molecules, such as folate, that bind to receptors overexpressed in many types of cancers.

Aptamers in particular are a popular tool for targeting specific cells. Aptamer development is efficient and cost-effective, as automated nucleic acid synthesis allows easy, affordable chemical synthesis and modification of functional moieties. Other advantages include high stability and long shelf life, rapid tissue penetration based on the relatively small molecular weights, low immunogenicity, and ease of antidote development in the case of an adverse reaction to therapy by simply administering an aptamers complementary DNA. We have demonstrated the principle of modifying aptamers on the surfaces of doxorubicin-containing liposomes, which then selectively delivered the drug to cultured cancer cells.5

Recent advances in predicting the secondary structures of a DNA fragment or interactions between multiple DNA strands, as well as in technologies to automatically synthesize predesigned DNA sequences, has opened the door to more advanced applications of aptamers and other DNA structures in nanomedicine. For instance, we have developed aptamer-tethered DNA nanotrains, assembled from multiple copies of short DNA building blocks. On one end, an aptamer moiety allows specific target cell recognition during drug delivery, and a long double-stranded DNA section on the other end forms the boxcars for drug loading. The nanotrains, which can hold a high drug payload and specifically deliver anticancer drugs into target cancer cells in culture and animal models,6 could reduce drug side effects while inhibiting tumor growth. Alternatively, Daniel Anderson of MIT engineered a tetrahedral cage of DNA, often called DNA origami, for folate-mediated targeted delivery of small interfering RNAs (siRNAs) to silence some tumor genes.7 And Mirkins SNAs can similarly transport siRNAs as guided missiles to knock out overexpressed genes in cancer cells. Mirkins group also recently demonstrated that the SNAs were able to penetrate the blood-brain barrier and specifically target genes in the brains of glioblastoma animal models.2 Peng Yin of Harvard Medical School and the Wyss Institute and others are now building even more complex DNA nanostructures with refined functions, such as smart biomedical analysis.8

Conventional assembly of such DNA nanostructures exploits the hybridization of a DNA strand to part of its complementary strand. In addition, we have discovered that DNA nanostructures called nanoflowers because they resemble a ring of nanosize petals, can be self-assembled through liquid crystallization of DNA, which typically occurs at high concentrations of the nucleic acid.9 Importantly, these DNA nanostructures can be readily incorporated with components possessing multiple functionalities, such as aptamers for specific recognition, fluorophores for molecular imaging, and DNA therapeutics for disease therapy.

Another example of novel nanoparticles is DNA micelles, three-dimensional nanostructures that can be readily modified to include aptamers for specific cell-type recognition, or DNA antisense for gene silencing. The lipid core and sphere of projecting nucleic acids can enter cells without any transfection agents and have high resistance to nuclease digestion, making them ideal candidates for drug delivery and cancer therapy.

Researchers are developing many types of nanoscale magic bullets that can specifically deliver drugs into target cells or tissues.

Such advances in targeting are now making it possible to deliver combinations of drugs and ensure that they reach target cells simultaneously. Paula Hammond and Michael Yaffe of MIT recently reported a liposome-based combination chemotherapy delivery system that can simultaneously deliver two synergistic chemotherapeutic drugs, erlotinib and doxorubicin, for enhanced tumor killing.10 Erlotinib, an inhibitor of epidermal growth factor receptor (EGFR), promotes the dynamic rewiring of apoptotic pathways, which then sensitizes cancer cells to subsequent exposure to the DNA-damaging agent doxorubicin. By incorporating erlotinib, a hydrophobic molecule, into the lipid bilayer shell while packaging the hydrophilic doxorubicin inside of the liposomes, the researchers achieved the desired time sequence of drug releasefirst erlotinib, then doxorubicinin a one-two punch against the cancer. They also demonstrated that the efficiency of drug delivery to cancer cells was enhanced by coating the liposomes with folate.

Scientists are also engineering smart nanoparticles, which activate only in the disease microenvironment. For example, George Church of Harvard Medical School and the Wyss Institute and colleagues invented a logic-gated DNA nanocapsule that they programmed to deliver drugs inside cells only when a specific panel of disease biomarkers is overexpressed on the cell surface.11 And Donald Ingbers group, also at Harvard Medical School and the Wyss Institute, developed microscale aggregates of thrombolytic-drug-coated nanoparticles that break apart under the abnormally high fluid shear stress of narrowed blood vessels and then bind and dissolve the problematic clot.12

With these and other nanoplatforms for targeted drug delivery being tested in animal models, medicine is now approaching the prototypic magic bullet, sparing healthy tissue while exterminating disease.

In addition to serving as mere drug carriers that deliver the toxic payload to target cells, nanomaterials can themselves function as therapeutics. For example, thermal energy is emerging as an important means of therapy, and many gold nanomaterials can convert photons into thermal energy for targeted photothermal therapy. Taking advantage of these properties, we conjugated aptamers onto the surfaces of gold-silver nanorods, which efficiently absorb near-infrared light and convert energy from photons to heat. These aptamer-conjugated nanorods were capable of selectively binding to target cells in culture and inducing dramatic cytotoxicity by converting laser light to heat.13

Magnetic nanoparticles are also attractive for their ability to mediate heat induction. Jinwoo Cheon of Yonsei University in Korea developed coreshell magnetic nanoparticles, which efficiently generated thermal energy by a magnetization-reversal process as these nanoparticles returned to their relaxed states under an external, alternating-current magnetic field.14 Using this technology, Cheon and his colleagues saw dramatic tumor regression in a mouse model.A third type of nanosize therapeutic involves cytotoxic polymers. For example, we synthesized a nucleotide-like molecule called an acrydite with an attached DNA aptamer that specifically binds to and enters target cancer cells.15 The acrydite molecules in the resultant acrydite-aptamer conjugates polymerized with each other to form an aptamer-decorated molecular string that led to cytotoxicity in target cancer cells, including those exhibiting multidrug resistance, a common challenge in cancer chemotherapy.

Many other subfields have been advanced by recent developments in nanomedicine, including tissue engineering and regenerative medicine, medical devices, and vaccines. We must proceed with caution until these different technologies prove safe in patients, but nanomedicine is now poised to make a tremendous impact on health care and the practice of clinical medicine.

Guizhi Zhu is a postdoctoral associate in the Department of Chemistry and at the Health Cancer Center of the University of Florida. Weihong Tan is a professor and associate director of the Center for Research at the Bio/Nano Interface at the University of Florida. He also serves as the director of the Molecular Science and Biomedicine Laboratory at Hunan University in China, where Lei Mei is a graduate student.

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Bone marrow Wikipedia StemCell Therapy

Bone marrow is a semi-solid tissue which may be found within the spongy or cancellous portions of bones.[2] In birds and mammals, bone marrow is the primary site of new blood cell production or hematopoiesis.[3] It is composed of hematopoietic cells, marrow adipose tissue, and supportive stromal cells. In adult humans, bone marrow is primarily located in the ribs, vertebrae, sternum, and bones of the pelvis.[4] On average, bone marrow constitutes 4% of the total body mass of humans; in an adult having 65 kilograms of mass (143 lb), bone marrow typically accounts for approximately 2.6 kilograms (5.7lb).[5]

Human marrow produces approximately 500 billion blood cells per day, which join the systemic circulation via permeable vasculature sinusoids within the medullary cavity.[6] All types of hematopoietic cells, including both myeloid and lymphoid lineages, are created in bone marrow; however, lymphoid cells must migrate to other lymphoid organs (e.g. thymus) in order to complete maturation.

Bone marrow transplants can be conducted to treat severe diseases of the bone marrow, including certain forms of cancer such as leukemia. Additionally, bone marrow stem cells have been successfully transformed into functional neural cells,[7] and can also potentially be used to treat illnesses such as inflammatory bowel disease.[8]

The composition of marrow is dynamic, as the mixture of cellular and non-cellular components (connective tissue) shifts with age and in response to systemic factors. In humans, marrow is colloquially characterized as red or yellow marrow (Latin: medulla ossium rubra, Latin: medulla ossium flava, respectively) depending on the prevalence of hematopoetic cells vs fat cells. While the precise mechanisms underlying marrow regulation are not understood,[6] compositional changes occur according to stereotypical patterns.[9] For example, a newborn babys bones exclusively contain hematopoietically active red marrow, and there is a progressive conversion towards yellow marrow with age. In adults, red marrow is found mainly in the central skeleton, such as the pelvis, sternum, cranium, ribs, vertebrae and scapulae, and variably found in the proximal epiphyseal ends of long bones such as the femur and humerus. In circumstances of chronic hypoxia, the body can convert yellow marrow back to red marrow to increase blood cell production.[10]

At the cellular level, the main functional component of bone marrow includes the progenitor cells which are destined to mature into blood and lymphoid cells. Marrow contains hematopoietic stem cells which give rise to the three classes of blood cells that are found in circulation: white blood cells (leukocytes), red blood cells (erythrocytes), and platelets (thrombocytes).[11]

The stroma of the bone marrow includes all tissue not directly involved in the marrows primary function of hematopoiesis.[6] Stromal cells may be indirectly involved in hematopoiesis, providing a microenvironment that influences the function and differentiation of hematopoeietic cells. For instance, they generate colony stimulating factors, which have a significant effect on hematopoiesis. Cell types that constitute the bone marrow stroma include:

The bone marrow stroma contains mesenchymal stem cells (MSCs),[11] also known as marrow stromal cells. These are multipotent stem cells that can differentiate into a variety of cell types. MSCs have been shown to differentiate, in vitro or in vivo, into osteoblasts, chondrocytes, myocytes, marrow adipocytes and beta-pancreatic islets cells.

The blood vessels of the bone marrow constitute a barrier, inhibiting immature blood cells from leaving the marrow. Only mature blood cells contain the membrane proteins, such as aquaporin and glycophorin, that are required to attach to and pass the blood vessel endothelium.[13] Hematopoietic stem cells may also cross the bone marrow barrier, and may thus be harvested from blood.

The red bone marrow is a key element of the lymphatic system, being one of the primary lymphoid organs that generate lymphocytes from immature hematopoietic progenitor cells.[14] The bone marrow and thymus constitute the primary lymphoid tissues involved in the production and early selection of lymphocytes. Furthermore, bone marrow performs a valve-like function to prevent the backflow of lymphatic fluid in the lymphatic system.

Biological compartmentalization is evident within the bone marrow, in that certain cell types tend to aggregate in specific areas. For instance, erythrocytes, macrophages, and their precursors tend to gather around blood vessels, while granulocytes gather at the borders of the bone marrow.[11]

Animal bone marrow has been used in cuisine worldwide for millennia, such as the famed Milanese Ossobuco.[citation needed]

The normal bone marrow architecture can be damaged or displaced by aplastic anemia, malignancies such as multiple myeloma, or infections such as tuberculosis, leading to a decrease in the production of blood cells and blood platelets. The bone marrow can also be affected by various forms of leukemia, which attacks its hematologic progenitor cells.[15] Furthermore, exposure to radiation or chemotherapy will kill many of the rapidly dividing cells of the bone marrow, and will therefore result in a depressed immune system. Many of the symptoms of radiation poisoning are due to damage sustained by the bone marrow cells.

To diagnose diseases involving the bone marrow, a bone marrow aspiration is sometimes performed. This typically involves using a hollow needle to acquire a sample of red bone marrow from the crest of the ilium under general or local anesthesia.[16]

Bone marrow derived stem cells have a wide array of application in regenerative medicine.[17]

Medical imaging may provide a limited amount of information regarding bone marrow. Plain film x-rays pass through soft tissues such as marrow and do not provide visualization, although any changes in the structure of the associated bone may be detected.[18] CT imaging has somewhat better capacity for assessing the marrow cavity of bones, although with low sensitivity and specificity. For example, normal fatty yellow marrow in adult long bones is of low density (-30 to -100 Hounsfield units), between subcutaneous fat and soft tissue. Tissue with increased cellular composition, such as normal red marrow or cancer cells within the medullary cavity will measure variably higher in density.[19]

MRI is more sensitive and specific for assessing bone bone composition. MRI enables assessment of the average molecular composition of soft tissues, and thus provides information regarding the relative fat content of marrow. In adult humans, yellow fatty marrow is the dominant tissue in bones, particularly in the (peripheral) appendicular skeleton. Because fat molecules have a high T1-relaxivity, T1-weighted imaging sequences show yellow fatty marrow as bright (hyperintense). Furthermore, normal fatty marrow loses signal on fat-saturation sequences, in a similar pattern to subcutaneous fat.

When yellow fatty marrow becomes replaced by tissue with more cellular composition, this change is apparent as decreased brightness on T1-weighted sequences. Both normal red marrow and pathologic marrow lesions (such as cancer) are darker than yellow marrow on T1-weight sequences, although can often be distinguished by comparison with the MR signal intensity of adjacent soft tissues. Normal red marrow is typically equivalent or brighter than skeletal muscle or intervertebral disc on T1-weighted sequences.[20][9]

Fatty marrow change, the inverse of red marrow hyperplasia, can occur with normal aging,[21] though it can also be seen with certain treatments such as radiation therapy. Diffuse marrow T1 hypointensity without contrast enhancement or cortical discontinuity suggests red marrow conversion or myelofibrosis. Falsely normal marrow on T1 can be seen with diffuse multiple myeloma or leukemic infiltration when the water to fat ratio is not sufficiently altered, as may be seen with lower grade tumors or earlier in the disease process.[22]

Bone marrow examination is the pathologic analysis of samples of bone marrow obtained via biopsy and bone marrow aspiration. Bone marrow examination is used in the diagnosis of a number of conditions, including leukemia, multiple myeloma, anemia, and pancytopenia. The bone marrow produces the cellular elements of the blood, including platelets, red blood cells and white blood cells. While much information can be gleaned by testing the blood itself (drawn from a vein by phlebotomy), it is sometimes necessary to examine the source of the blood cells in the bone marrow to obtain more information on hematopoiesis; this is the role of bone marrow aspiration and biopsy.

The ratio between myeloid series and erythroid cells is relevant to bone marrow function, and also to diseases of the bone marrow and peripheral blood, such as leukemia and anemia. The normal myeloid-to-erythroid ratio is around 3:1; this ratio may increase in myelogenous leukemias, decrease in polycythemias, and reverse in cases of thalassemia.[23]

In a bone marrow transplant, hematopoietic stem cells are removed from a person and infused into another person (allogenic) or into the same person at a later time (autologous). If the donor and recipient are compatible, these infused cells will then travel to the bone marrow and initiate blood cell production. Transplantation from one person to another is conducted for the treatment of severe bone marrow diseases, such as congenital defects, autoimmune diseases or malignancies. The patients own marrow is first killed off with drugs or radiation, and then the new stem cells are introduced. Before radiation therapy or chemotherapy in cases of cancer, some of the patients hematopoietic stem cells are sometimes harvested and later infused back when the therapy is finished to restore the immune system.[24]

Bone marrow stem cells can be induced to become neural cells to treat neurological illnesses,[7] and can also potentially be used for the treatment of other illnesses, such as inflammatory bowel disease.[8] In 2013, following a clinical trial, scientists proposed that bone marrow transplantation could be used to treat HIV in conjunction with antiretroviral drugs;[25][26] however, it was later found that HIV remained in the bodies of the test subjects.[27]

The stem cells are typically harvested directly from the red marrow in the iliac crest, often under general anesthesia. The procedure is minimally invasive and does not require stitches afterwards. Depending on the donors health and reaction to the procedure, the actual harvesting can be an outpatient procedure, or can require 12 days of recovery in the hospital.[28]

Another option is to administer certain drugs that stimulate the release of stem cells from the bone marrow into circulating blood.[29] An intravenous catheter is inserted into the donors arm, and the stem cells are then filtered out of the blood. This procedure is similar to that used in blood or platelet donation. In adults, bone marrow may also be taken from the sternum, while the tibia is often used when taking samples from infants.[16] In newborns, stem cells may be retrieved from the umbilical cord.[30]

The earliest fossilised evidence of bone marrow was discovered in 2014 in Eusthenopteron, a lobe-finned fish which lived during the Devonian period approximately 370 million years ago.[31] Scientists from Uppsala University and the European Synchrotron Radiation Facility used X-ray synchrotron microtomography to study the fossilised interior of the skeletons humerus, finding organised tubular structures akin to modern vertebrate bone marrow.[31] Eusthenopteron is closely related to the early tetrapods, which ultimately evolved into the land-dwelling mammals and lizards of the present day.[31]

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Amazon.com: Transhumanism: The History of a Dangerous Idea …

Transhumanism is a recent movement that extols mans right to shape his own evolution, by maximizing the use of scientific technologies, to enhance human physical and intellectual potential. While the name is new, the idea has long been a popular theme of science fiction, featured in such films as 2001: A Space Odyssey, Blade Runner, the Terminator series, and more recently, The Matrix, Limitless, Her and Transcendence.

However, as its adherents hint at in their own publications, transhumanism is an occult project, rooted in Rosicrucianism and Freemasonry, and derived from the Kabbalah, which asserts that humanity is evolving intellectually, towards a point in time when man will become God. Modeled on the medieval legend of the Golem and Frankenstein, they believe man will be able to create life itself, in the form of living machines, or artificial intelligence.

Spearheaded by the Cybernetics Group, the project resulted in both the development of the modern computer and MK-Ultra, the CIAs mind-control program. MK-Ultra promoted the mind-expanding potential of psychedelic drugs, to shape the counterculture of the 1960s, based on the notion that the shamans of ancient times used psychoactive substances, equated with the apple of the Tree of Knowledge.

And, as revealed in the movie Lucy, through the use of smart drugs, and what transhumanists call mind uploading, man will be able to merge with the Internet, which is envisioned as the end-point of Kabbalistic evolution, the formation of a collective consciousness, or Global Brain. That awaited moment is what Ray Kurzweil, a director of engineering at Google, refers to as The Singularly. By accumulating the total of human knowledge, and providing access to every aspect of human activity, the Internet will supposedly achieve omniscience, becoming the God of occultism, or the Masonic All-Seeing Eye of the reverse side of the American dollar bill.

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Transhumanism – Ascension Glossary

Transhumanism is an international, cultural and intellectual movement with an eventual goal of fundamentally transforming the human condition, by making available technologies that greatly enhance human intellectual, physical, and psychological capacities. [1]Many transhumanists believe in the compatibility between the human mind and computer hardware, with the implication that human consciousness can be transferred to alternative media, known as mind uploading. Since the Science of the Soul and the Consciousness functions of the spiritual bodies, have not yet been discovered by scientists, this has potentially extremely destructive consequences to human consciousness and the electromagnetic functions of the Lightbody. Posthumans (the result of applied transhumanist technologies) could be completely synthetic artificial intelligences, or a symbiosis of human and artificial intelligence, or uploaded consciousness, or the result of making profound technological augmentations to a biological human.

Transhumanism is a school of thought that seeks to guide us towards a posthuman condition. Essentially, this is about creating artificially intelligent hybrids or cyborgs to replace the organic spiritual consciousness of humans. Some examples are redesigning the human organism using advanced nanotechnology or radical technological enhancements. Some of the proposed biological enhancements are using some combination of technologies such as genetic engineering, psychopharmacology, life extension therapies, neural interfaces, brain mapping, wearable or implanted computers, and entrainment of cognitive techniques. Most of these options are designed to disconnect the human soul from the human body, and prepare the body to be used as a shell for a new host. Effectively, this is integrating technological and pharmaceutical hybridization to damage human DNA, as preparation for body snatching.

The fundamental basis of the Transhumanism concept is the A.I. downloaded into the scientific human mind from the Negative Aliens and Satanic Forces, in their quest to survive and achieve immortality by hijacking human consciousness and ultimately possessing the human host body. They do not have flesh and bone bodies and covet ours. Most academics are filled with a variety of mind control and alien implants to be a cog in the wheel to steadily enforce alien control systems. Most early transhumanism concepts were developed by geneticists interested in eugenics and sustaining life forms in synthetic environments. (Like the eugenic experiments similar to those of the Black Sun Nazis). A common feature of promoting transhumanism is the future vision of creating a new intelligent species, into which humanity will evolve and eventually, either supplement it or supersede it. This distraction on the surface is a scheme, while the underlying motivation is intending species extinction of what we know as humans today. Transhumanism stresses the evolutionary perspective, yet it completely ignores the electromagnetic function of human DNA and the consciousness reality of the multidimensional human soul-spirit. They claim to want to stop human suffering but have no idea of the alien machinery and mind control implants used to imprison human consciousness. They know nothing about the afterlife, what happens during the death of the body or even how the human body or Universe really works, yet they want to control every aspect of the human body with artificial technology.

A primary goal of many transhumanists is to convince the public that embracing radical technology and science is in the human species best interest. With the False God Alien Religions used to spread the rhetoric of fear and mindless obedience on one end, and the primarily atheistic science used to mock all things religious without any comprehension of true spiritual understanding on the other, they have the bases covered. Consciousness and spiritual groups are quickly labeled Conspiracy theorists by scientists to intimidate, discredit and shut us up. Obviously, until people have personal consciousness experiences outside of their body, have the ability to communicate with assorted lifeforms, such as deceased humans and travel to other dimensions, they have zero information about consciousness and are totally uninformed and ignorant about the nature of reality. None of these transhumanist people, are remotely qualified to be put in charge of scientifically directing the future evolution of the human species. Propping up egomaniacs and Psychopaths, and giving them power and control over world affairs and influence over public perception is the game of the NAA Controllers.

The true knowledge of the Sacred Sciences of the Soul and mechanics of human multidimensional consciousness have been obliterated from record and conveniently mind controlled out from the majority of sciences. If scientists integrate theories of the soul or consciousness outside of the consensus of the mind control standard, they risk ridicule and losing their funding and careers. Unfortunately, the controlled mainstream sciences do not recognize multiple dimensions of consciousness inherent in the functions of activated human DNA, or know that biological life and multidimensional human consciousness does not end on this earth. The quest for biological immortality on a prison planet is ludicrous when experiencing the capability of human multidimensional consciousness. After the human body expires, if the undeveloped and disembodied consciousness is merged and assimilated into artificial intelligence, the remnants of that human soul will not have a human body to incarnate into any longer. Hence, that person will lose their connection to organic spiritual biology and cease to be human. Transhumanism is a Consciousness Trap. [2]

Since the persons Consciousness has not been prepared for the afterlife, whatever is left of his energetic quanta will be assimilated into a cyborg body or other types of synthetic life forms or EBEs. There are currently spiritually disconnected humans existing on the earth that will be assimilated into synthetic life forms that appear as Extraterrestrial Biological Entities, but were actually human souls in human bodies in past timelines. Most of the smaller EBE bodies assimilate nutrients from light similar to plants. They are unable to evolve, reproduce, ascend or move into higher dimensions of consciousness. Some of these EBEs have returned to the earth from the future to try to break into the human genetic code, in this earth timeline in order to save themselves. Many of these EBEs were once humans that were involved in the Orion Wars, and were captured in Orion and used in worker colonies. Some from the earth were enslaved on the astral plane by other races of creatures, such as Mantids, Grey Aliens and Reptilians that took them as workers to other planetary systems. Some are even used as minions for carrying out human abductions in MILABS soul transference projects. Many of them had their consciousness erased and they do not remember that they were once human.

This is one of the possible results of the Transhumanism movement underway in this earth timeline now, that leads to the potential future alien or dark force control over that Soul. Once the consciousness is assimilated into artificial intelligence and synthetic biology, that being can no longer incarnate into an organic human form. That person cannot incarnate again into human realms, such as planet earth. They become a displaced entity that cannot die and be reborn into another identity they are enslaved and merged with an AI hive mind. This is desired by many of these negative groups, such as the Alpha Draconis/Orion Group, as then they have full control over the life force of humans that can be made into worker slaves. This is the main purpose as to why Transhumanism is being marketed and pushed aggressively during this time, they want to create more human EBEs and cyborgs or host bodies. When that person drops their body while the Universal Gates are open, they can easily be transported to many different planetary systems for trading as a workforce commodity.[3]

The term directed evolution is used within the transhumanist community to refer to the idea of applying the principles of directed evolution and experimental evolution to the control of human evolution. This has its base in Eugenics theories.

When we look at the larger Galactic picture of consciousness enslavement, we see the NAA’s many pronged agenda to target the Brain, CNS and thought forms of every person on earth. Through the agenda of Transhumanism, we see the promotion of hybridization and synthetic integration with artificial neural networks for control over the CNS and Brain. What is starting to surface with more clarity is that our human Neurobiology is wired for empathy, which connects us to higher consciousness and has a spiritual function. The NAA and their minions of soulless AI infected synthetic beings do not have the bio-circuitry for empathy. We are in essence, in a struggle between human EMPATHS, and alien hybridized humans and extra-dimensional aliens that are NON-EMPATHS. [4]

The traumatized are vulnerable to become pawns in further spreading Sexual Misery programing, especially into the younger generation. Transgender ideology is a specific psychological warfare tactic being run by the Controllers, in tandem with Transhumanism, to counter and prevent spiritual Ascension. These satanic agendas are designed to condition people to reject their own bodies, and to generate delusions that can have them mentally identify with anything else but actually being a human and unconditionally loving toward their own natural body.[5]

Mind Controlled Gene Expression

Genetic Engineering

Eugenics

CRISPR

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Transhumanism – Ascension Glossary

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Male Testosterone Replacement Therapy (TRT) | Laser Center of …

Feel Better with TRT and Get Back in the Game!

We hear a lot about the changes caused by menopause in women, but much less about andropause (so called manopause) or low testosterone in men. Young men in their late teens and twenties seem to have boundless energy driven by high testosterone levels, but that doesnt last. Testosterone levels drop about one percent a year after age 30 and many men experience an even steeper decline. This steady drop in testosterone can lead to a need for Testosterone Replacement Therapy (TRT).

Physical signs of declining testosterone (low T) include decreased muscle strength and size, increased fat- especially belly fat, loss of body hair, dry eyes, elevated blood pressure, thinning dry skin, enlarging fatty breasts (gynecomastia), and lack of body odor.

The Adam Questionaire is a sensitive tool for screening for low T. A decrease in sex drive or erectile dysfunction suggest low T. Other symptoms include decreased energy or strength, decreased enjoyment of life, sadness or grumpiness, falling asleep after dinner, or a recent deterioration in work performance.

Fortunately, most men can be restored to hormonal health with proper medical care. The benefits of testosterone replacement therapy (TRT) include increased energy and strength, increased muscle mass, decreased osteoporosis, improved cholesterol profile, lowered blood sugars, improved sexual function, and increased longevity.

Men experiencing the symptoms of low T need a focused medical history, physical exam, and laboratory testing by a physician with specialized training in TRT. Although testosterone may be replaced by transdermal gels or implanted pellets, most patients are best managed by self administered injections of bioidentical testosterone and HCG (human chorionic gonadotropin). Some men may also need estrogen blocking pills.

The good news is that many of these negative symptoms are not really from aging at all, but rather from low testosterone. You can improve your health and recapture the joy and vigor of life.

TRT is safe if appropriately prescribed and monitored. There is no evidence that testosterone causes cancer, however preexisting prostate cancer may grow faster with TRT. It is very important to have a prostate exam and a serum PSA (prostatic specific antigen) level prior to beginning therapy, and to monitor the PSA level regularly.

You may very well start feeling better within days. However, body composition changes will transform over several months as your testosterone (T) level is optimally tuned. Several patients have already reported weight loss and lean muscle gain within the first month. They have have also reported increased erection strength, better sex drive, and an overall uptick in energy.

Male breast enlargement (gynecomastia) is a sign of testosterone/estrogen imbalance. Patients with this problem may need an estrogen blocker in addition to TRT. Therapy does not reverse the enlargement, but often Laser Assisted Liposuction can correct it very nicely.

The Laser Center of Maryland proudly provides Baltimore, Annapolis, Columbia, Severna Park, Glen Burnie and Pasadena, Maryland with comprehensive and advanced laser surgery and cosmetic surgery.

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Testosterone Replacement Therapy Can Slow Men’s COPD, Study Shows

Testosterone replacement therapy can help slow the progression of chronic obstructive pulmonary disease (COPD) in men, a new study shows.

Men with COPD tend to experience shortness of breath, leading physicians to prescribe them long-term steroid-based medications. While these medications help treat pulmonary symptoms, they are also associated with testosterone dysfunction.

Accordingly, previous studies have shown that men with COPD have low testosterone levels, which could lead to a worsening of the condition.

Previous studies have suggested that testosterone replacement therapy may have a positive effect on lung function in men with COPD, Jacques Baillargeon, the studys author and a professor in preventive medicine and community health at University of Texas Medical Branch at Galveston, said in a press release.

The study, set to be published in the journalChronic Respiratory Disease, was designed to determine whether testosterone replacement therapy (in which patients are prescribed testosterone) could help reduce the risk of hospitalization due to respiratory disease in middle-aged and older men with COPD.

Baillargeon noted that we are the first to conduct a large-scale, nationally representative study on this association.

Baillargeon and his colleagues used the Clinformatics Data Mart dataset, which comprises one of the largest commercially insured populations in the United States.They examined data from 450 men ages 40-63 with COPD who began testosterone replacement therapy between 2005 and 2014.

Researchers also used the national Medicare database to study data from 253 men age 66 and up with COPD, and who initiated testosterone replacement therapy between 2008 and 2013.

Researchers found that patients who underwent testosterone replacement therapy had a greater reduction in respiratory hospitalizations when compared to patients who did not receive the therapy.

Specifically, middle-aged testosterone replacement therapy users had a 4.2 percent greater decrease in respiratory hospitalizations compared with non-users, Baillargeon said. Older testosterone replacement therapy users had a 9.1 percent greater decrease in respiratory hospitalizations compared with non-users.

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Testosterone Replacement Therapy – Royal Medical Center

There are three main medications for testosterone treatment

Testosterone is used to increase and optimize hormone levels. The dosage varies and is determined by the prescribing physician. A patients medical history, lab results and physical are all factored in during diagnosis.HCG is used to prevent testicular shrinkage and maintain the natural production of the hormone in the testes.An Estrogen Blocker is used to control the levels of estrogen in mens bodies.

Our doctors have designed a safe and proven program for our patients to maximize life-changing benefits, including

Improved sexual performance

Improves skin tone and elasticity

increases energy and stamina

These benefits are seen when low hormone levels are treated in hypogonadal and andropausal men. Follow-up is the key to success for our patients and Royal Medical Center

90 days after beginning the powerful hormone replacement therapy program, the patient will be required to follow up with additional labs. This is to determine that the diagnosis and dosages are on target. If we are not pleased with your levels, the regimen will be altered to suit the best results for the patient.

Physicals will be conducted at least once a year or per request by the physician.

*Patients using testosterone supplements should seek medical attention immediately is symptoms of a heart attack or stroke are present, such as:

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Low T – Regional Urology

Hypogonadism is commonly referred to as low testosterone, or low-T. Low-T can cause a range of symptoms including lack of libido (loss of sex drive), fatigue, low energy, sleep disturbances, difficulty losing weight and depression. Long term effects can include night sweats and osteoporosis (soft bones).

Primary hypogonadism, or testicular failure, is a condition where the testicles do not make enough testosterone. Secondary hypogonadism occurs when the brain (pituitary and/or hypothalamus) do not send appropriate signals (luteinizing hormone, LH) to the testicles telling them to make testosterone. Acquired hypogonadism refers to low testosterone related to aging.

As in all medical conditions, evaluation begins with an appointment where your urologist can take your medical history, perform a physical exam, and order appropriate blood tests.

In a male with symptoms of low-T, a testosterone level can easily be measured with a simple blood test. Testosterone levels naturally fluctuate during the day and peak in the morning between 7 and 9am. For this reason, it is best to measure a testosterone level in the early morning. A normal testosterone level is between 300 and 800 ng/dl. Other lab tests that may get ordered include a prolactin, LH (luteinizing hormone), FSH (follicle-stimulating hormone), complete blood count, and PSA (prostate specific antigen).

There are many options for the management of Low-T:

After initiation of replacement therapy, most men see their symptoms markedly improve within one to two weeks.

There are side effects of testosterone replacement to be aware of.

If you are interested in learning more about testosterone replacement, make an appointment with one of our Urologists today.

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ALIGNED WITH LOVE: DANTE, TRANSHUMANISM AND THE CATHARS …

The first use of the word Transhuman was by the 13th century Italian poet laureate and suspected/probable Cathar, Templar and heretic, Dante, in Paradisio, the last book of his Divine Comedy. The poem, considered one of the greatest works of human literature, is a Cathar inspired visionary journey into the afterlife and a guide for our ascension. It also offers an alternative to todays Transhumanism.

This fact will come as a surprise to scholars who suggest the term transhumanism was first coined in 1957 by Julian Huxley, a British evolutionary biologist and promoter of eugenics (who advocated culling the human herd ala the Nazis), who used the term in his book New Bottles for New Wine.

Considering Transhumanism is about packing our skins with computer chips, Huxleys title is more than poetic. Readers of my book, The Skingularity Is Near, are aware that the gods of Silicon Valley (aka the Digerati) are developing a new skin for humanity that will give us vastly advanced capacities such as health, beauty, longevity, athletic ability, and general mental ability, as compared to ordinary humans, and will fulfill Huxleys vision of positive eugenics. With our without our permission they seek to transform the entire human race via technology and unite it as one Superbeing.

Transhumanism is a more palatable or higher sounding term for the lower eugenics. It is the goal of UNESCO, the UNs global organization dedicated to the creation of a single world culture founded by Huxley in 1947. Huxley believed the world was ready for a new religion to replace the old superstitious ones. The UN would build the new Tower of Babel of this religion. You can read a slightly paranoid, but factual, update on the UNs implementation of Artificial Intelligence to fulfill its globalist agenda here.

New Bottles, New Wine is a play on the mysterious parable attributed to Jesus: And no one puts new wine into old wineskinsbut one puts new wine into fresh wineskins (Mark 2:22). Putting fresh wine in old stretched to the limit skins is asking for trouble. Its like trying to get new results with old behaviors.

Transhumanists believe we must make new skins for the new, gooder human to inhabit. Our old skins and human behaviors simply will not due. Therefore, reason Transhumanists, if we change the skin via technology we can control behavior, and if we can control behavior we can change humanity. Those Fitbits and Apple Watches that monitor blood pressure, heart rate, and basically everything else, are the front door of this type of behavior modification or mind control technology. In March, 2017 Elon Musk launched Neuralink to meld humans with A.I. in an effort to save us.

This behavior-mind-skin modification is among the top concerns of they/we who question the implications/sanity of, or outright oppose, Transhumanism.

What will happen to those who do not take the chip or get the new skin (like some older whiners, like me, may choose to do)? What if they are deemed unfit or defective humans by the new ones?

Huxleys writings on eugenics provides possible answers, beginning with sterilizing of the unfit or ungooder (aka those unretrofitted with chips?) and identification of defective humans (the unaugmented?). He also advocated for: prohibition of marriage of the unfit and segregation of institutions containing degenerate individuals.

As I write this article, MIT Technology Review announced that the first human embryos have been edited in the U.S., demonstrating that we can improve the DNA of human embryos. The news here wasnt the capability, but the location. Previous reports of editing human embryos were all published by scientists in China, who are considered to be less than ethics challenged. The U.S. intelligence community last year called this type of gene editing (known as CRISPR) a potential weapon of mass destruction. It appears the unspeakable is becoming unstoppable.

Dante holds the Divine Comedy.

Will there be a safe place, a high mountain, for the unfit, ungooder and backward thinking humans in the new world of the souped up or hot-rodded Transhumans and genetically engineered humans? A way out?

I believe there isand this is what Dante was, prophetically, pointing to in the Divine Comedy and what he actually meant when he coined the term Transhuman before Julian Huxley hijacked it.

CHANGING FLESH

Dantes Divine Comedy is about the souls journey to God and how he changed his earthly flesh into celestial flesh, prompting the first dropping of the word Transhuman.

Changing our behaviors that change our flesh to light is the only way out of earth life.

There is nothing funny, ha ha, about Dantes poem. In the classical sense the word comedy refers to works which reflect belief in an ordered universe, in which events tend toward not only a happy or amusing ending but one influenced by a Providential will that orders all things to an ultimate good. This infers a belief in God, and a God that is actively involved in our daily lives and our ascension.

The how to change human flesh into celestial flesh question has been on the human table for thousands of years, especially every since Babylon in 600 B.C. Dante updated it in a dramatic fashion.

The Italian genius was a great assembler of esoteric knowledge. He drew from the Greeks, Romans, early Christians any and all who could assist in answering the fundamental question we all face. Where do we go after we die? How do we get there?

He wasnt the first to visualize, preview or rehearse ascending, but he was among the many who consciously seek the how to of this process.

How do we become more whole, holy, compassionate and complete and ascend to dwell among a higher class of souls? (The answer is we change what we are doing while in the body.)

GET THE ROBE

Dante sought to complete his earthly journey by embarking on a celestial journey which would land him in the company of the holy ones in heaven (Sion, Paradise), and the just humans made perfect, who surround the throne of Christ.

Dantes journey, and the poem, is divided into three sections: Hell, Purgatory and Paradise. This is our ascension journey, too. The descent into the underworld precedes our ascension. This descent is a sort of pop quiz. The reason for this is because ontogeny recapitulates philogeny, meaning we have to go through, recapitulate or review all our previous states of being throughout our evolution just to make sure we have transcended them. One reason for this is that they represent where we came from, demonstrating that we are morphing beings who have transited, transfigured or transformed through many previous states (that we dont have to repeat) and have many ahead of us, as well.

Dante knew our next goal was to acquire the white robe of these Chosen Ones or Perfect Ones. The idea is that if we want to be like the perfected ones we must dress like themlightly. This white robe is also worn symbolically by the Knights Templar, the holy militia or Gods army, of which Dante was a member.

Dante studied at Florences Santa Maria Novello. The Spanish Chapel, the old chapter house of the monastery shows the white-robed Chosen entering the gate to the high mountain, Sion. This is one of many ascension painting we will study during our Immortal Italy tour May 8-22, 2018.

Dante knew that this robe is transmittable and that one way to get this robe was to have it gifted from the Perfect or Chosen. The other way is to act like these beings, to think like them and to become perfect like them while in our earthly body.

Perfection and Heaven are terms for a state of being and a state of doing superior to ordinary earth life.

Dante is telling us we can consciously upgrade our consciousness while on earth and ascend to a superior place and state of being.

In our future, our future selves will inhabit new skins of light. New behaviors will accompany these light bodies. My work is devoted to identifying these new behaviors and assisting souls in implementing them so that the capacities of our future selves can be lived now. In Buddhism, these invaluable behaviors are called paramitas (perfection, completeness). These behaviors include generosity, patience, kindness, truth speaking. The root, para, means beyond Doing the paramitas completes us and takes us beyond ordinary human suffering.

Identifying with these states of being now, and doing them, is the key to accelerating our evolution. This will take us into the transcendent realms, not Transhumanism.

THE GOOD ONES

In his celestial journey to become a Perfect One in Heaven, Dante also drew from the Cathar knowledge of how to ascend the mystical ladder to God and navigate the seven planetary spheres.

The Cathars (or Good People) of Southern France were gnostic ascension masters who claimed to possess the true secret ascension teaching of Jesus, one composed of symbols and known as the Book of Love. They were massacred by the Catholic Church in the first European genocide from 1200-1244 to prevent the Book of Love from gaining widespread acceptance.

Like the Essenes the Cathars sought a return to our Edenic State, our primordial condition before the fall. Back then, we werent in a lesser state. We were in a supra-human phase. This is same state of being that Transhumanists seek to attain via technology.

The Cathars utilized the Ascension of Isaiah, an early (2nd-3rd century AD) Christian text that follows the journey of Isaiah, and the ascension of Jesus, through the Seven Heavens, where Isaiah gets his robe. He also saw Enoch and all who (were) with him, stripped of (their) robes of the flesh; and I saw them in their robes of above, and they were like the angels who stand there in great glory (Ascension of Isaiah 9:10).

This text was used as a visualization tool to induce visions of the afterlife and to connect with their future selves. Through repeated chanting of the text the body of the Cathars began to know what it felt like to be in heaven among the angels and how to become them. Today, feeling it to manifest it is a principle of quantum healing.

In the view of esoteric Dante scholars, such as Gabriele Rossetti, Eugene Aroux and Rene Guenon, Dantes Divine Comedy is a metaphysical-esoteric allegory that simultaneously veils and unveils the successive phases through which the consciousness of the initiate passes in order to reach immortality (angelhood/perfection). In addition to the Cathar teachings, it is drawn from Eleusis, Karnak, and India. While some wonder how Dante could have contact with these teachings, others, such as this author, believe he had tapped into the unifying cosmic truth woven through these teachings.

Dantes vision also has elements of Mohhammneds 7th century ascension to the celestial spheres (Miraj). In a single night Mohammed physically and spiritually ascended the seven levels to heaven with the archangel Gabriel, where he spoke with God. Don Miguel Asin Palacios has shown the striking correspondence between the Divine Comedy and The Book of the Nocturnal Journey, especially the fact that both heaven and hell are accessed via an immense funnel formed by a series of levels.

WORDS MAY NOT TELL OF THAT TRANSHUMAN CHANGE

Having completed his ascension through seven halls or holes in space, Dante arrives in the Empyrean, a region of pure light beyond physical existence, time and space, where he is enveloped in a light that transforms his human flesh into the perfect celestial flesh of the angels, rendering him dressed appropriately to see God.

Mohammed nears the Throne of God, attracted by a luminous garland. Says Rene Guenon in The Esotericsm of Dante, the apotheosis of both ascensions is the same: the two travelers, raised to the presence of God, describe Him as a center of intense light surrounded by nine concentric circles formed by compact lines of innumerable angelic priests who emit luminous rays.

Dante is practically speechless at witnessing the transfiguration or metamorphosis of his body into light, words may not tell of that transhuman change.

Like Glaucus when he tasted the herb of immortality that made him peer among the ocean gods, Dantes transfiguration is complete.

Like sudden lightning scattering the spiritsof sight so that the eye is then too weakto act on other things it would perceive,

such was the living light encircling me,leaving me so enveloped by its veil of radiance that I could see no thing.

The Love that calms this heaven always welcomesinto Itself with such a salutation,to make the candle ready for its flame.

Dante witnessed the power of the soul to cloak it self, uncloak itself, and then re-cloak itself. He witnessed the power of resurrection and ascension developed by the guardians of the holy land the Essenes, Gnostics, Cathars and Templar.

Dante sees an enormous rose, symbolizing divine love, the petals of which are the enthroned souls of the faithful. All the souls he has met in Heaven, including Beatrice, have their home in this rose. Angels fly around the rose like bees, distributing peace and love.

Of course, many Transhumanists do not believe in the existence of an ethereal soul, so most are unaware of the religious nature of their quest to perfect the human body. They have no idea that they are the latest priests of human transformation and that their lineage stretches back, at least, to Babylon, when the Magi first began teaching the art of resurrection. The line weaves through the Essenes and early Christianity.

FACE TO FACE WITH GOD

Finally, Dante comes face-to-face with God Himself (Cantos XXXII and XXXIII). God appears as three equally large circles occupying the same space, representing the Father, the Son, and the Holy Spirit:

but through my sight, which as I gazed grew stronger,that sole appearance, even as I altered,seemed to be changing. In the deep and brightessence of that exalted Light, three circlesappeared to me; they had three different colors,but all of them were of the same dimension;one circle seemed reflected by the second,as rainbow is by rainbow, and the thirdseemed fire breathed equally by those two circles.

Within these circles Dante can discern the human form of Christ. The Divine Comedy ends with Dante trying to understand how the circles fit together, and how the humanity of Christ relates to the divinity of the Son but, as Dante puts it, that was not a flight for my wings.

In a flash of understanding, which he cannot express, Dante does finally see this, and his soul becomes aligned with Gods love.

Aligned with love.

This should be the goal of all humans, Transhumanists included.

When we are aligned with love we are perfected. More, we are truly Born Again.

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ALIGNED WITH LOVE: DANTE, TRANSHUMANISM AND THE CATHARS …

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