Page 11234..1020..»

Nanomedicine Seen As A Promising Approach For Diagnosis and Treatment Against COVID – PRNewswire

PLAM BEACH, Fla., Sept. 16, 2020 /PRNewswire/ --The National Institute for Health (NIH) is at the heart of the emerging and rapidly evolving war against the global pandemic. They constantly update the public on the latest information on research for a vaccine and therapies to fight the virus. A recent report from them shone the light on a specific promising therapeutic approach nanomedicine. The NIH said that nanomedicine is a promising approach fordiagnosis, treatment and prophylaxis against COVID-19. They said that: "The COVID-19pandemic caused by the newly emerged severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) puts the world in an unprecedented crisis, leaving behind huge human losses and deep socioeconomic damages. Due to the lack of specific treatment against SARS-CoV-2, effective vaccines and antiviral agents are urgently needed to properly restrain the COVID-19 pandemic. Repositioned drugs such asremdesivir have revealed a promising clinical efficacy against COVID-19. Interestingly, nanomedicine as a promising therapeutic approach could effectively help win the battle between coronaviruses and host cells."Mentioned in today's commentary include: NanoViricides, Inc. (NYSE: NNVC), Immunomedics(NASDAQ: IMMU), Gilead Sciences, Inc. (NASDAQ: GILD), Inovio Pharmaceuticals, Inc. (NASDAQ: INO), Novavax, Inc. (NASDAQ: NVAX).

Due to a lack of approved vaccines and specific treatments only preventive measures can currently be applied. Currently, development of an effective vaccine and specific treatment is the main concern for researchers worldwide to fight the current COVID-19 and any future mutations. Understanding the coronaviral genome and the processes of viral replication and pathogenesis will enable researchers to develop specific drugs and vaccines. So researchers are turning to nanomedicine, one of the most important and emerging fields of modern science.

NanoViricides, Inc. (NYSE American: NNVC) Breaking News: NanoViricides Nominates a Novel Candidate for Advancing Into Clinical Trials for Treatment of COVID-19 NanoViricides, a global leader in the development of highly effective antiviral therapies based on a novel nanomedicines platform, today announced that it has nominated a clinical drug candidate for the treatment of COVID-19, thus further advancing its COVID-19 program closer to human clinical trials.

The Company has accelerated its drug development program for COVID-19 with the goal of creating the most effective medicine to obtain regulatory approval for emergency use in the COVID-19 pandemic in the shortest timeline feasible, after achieving proof of concept of broad-spectrum anti-coronavirus effectiveness of test candidates. The Company therefore aggressively worked to harness the full power of the nanoviricides nanomedicine platform to achieve these objectives.

A curative treatment for a virus such as SARS-CoV-2 coronavirus would require a multi-faceted attack that shuts down (i) ability of the virus to infect host cells and simultaneously, (ii) ability of the virus to multiply inside the host cells. The nanoviricide platform enables direct multi-point attack on the virus that is designed to disable the virus and its ability to infect new cells. At the same time, a nanoviricide is also capable of carrying payload in its "belly" (inside the micelle) that can be chosen to affect the ability of the virus to replicate. The nanoviricide is designed to protect the payload from metabolism in circulation. Thus, the nanoviricide platform provides an important opportunity to develop a curative treatment against SARS-CoV-2, the cause of COVID-19 spectrum of pathologies.

The clinical candidate the Company has chosen is identified as NV-CoV-1-R. It is made up of a nanoviricide that we have found to possess broad-spectrum anti-coronavirus activity, now identified as NV-CoV-1, and remdesivir encapsulated inside the core of NV-CoV-1. NV-CoV-1 itself is designed to attack the virus particles themselves, and possibly would also attack infected cells that display the virus antigen S-protein, while sparing normal (uninfected) cells that do not display the S-protein. Additionally, remdesivir is widely understood to attack the replication cycle of the virus inside cells. Thus the combined attack enabled by NV-CoV-1-R on the virus could prove to be a cure for the infection and the disease, provided that the necessary dosage level can be attained without undue adverse effects. Human clinical trials will be required to determine the safety and effectiveness of NV-CoV-1-R.

Remdesivir is a well-known antiviral drug (developed by Gilead) that has been approved for emergency use treatment of SARS-CoV-2 infection or COVID-19 in several countries. NV-CoV-1 is a novel agent that is being used as an adjuvant to remdesivir in creating NV-CoV-1-R, to improve the overall effectiveness. It is well known that remdesivir suffers from rapid metabolism in circulation that breaks down the prodrug to its nucleoside form which is not readily phosphorylated. The Company anticipates that encapsulation in NV-CoV-1 may protect remdesivir from this rapid metabolism. If this happens, the effective level and stability of remdesivir in the body would increase. This increase may lead to increased effectiveness if there are no adverse effects. Such increased effectiveness, if found, may also allow reduction in the required dosage of remdesivir in the encapsulated form, i.e. as NV-CoV-1-R. In this sense, NV-CoV-1 can be viewed to act as an adjuvant that enhances the effect of remdesivir, a known antiviral against SARS-CoV-2.

"This is an extremely important milestone for the Company," said Anil R. Diwan, PhD, President and Executive Chairman of the Company, adding, "We look forward to rapid development of the IND enabling core safety pharmacology studies and, thereafter, human clinical development on an accelerated timeline in these trying times of the pandemic." Read the full press release by going to:

In other biotech news in the markets this week:

Immunomedics(NASDAQ: IMMU) and Gilead Sciences, Inc. (NASDAQ: GILD)recently announcedthat the companies have entered into a definitive agreement pursuant to which Gilead will acquire Immunomedics for $88.00 per share in cash. The transaction, which values Immunomedics at approximately $21 billion, was unanimously approved by both the Gilead and Immunomedics Boards of Directors and is anticipated to close during the fourth quarter of 2020.

The agreement will provide Gilead with TrodelvyTM(sacituzumab govitecan-hziy), a first-in-class Trop-2 directed antibody-drug conjugate (ADC) that was granted accelerated approval by the U.S. Food and Drug Administration (FDA) in April for the treatment of adult patients with metastatic triple-negative breast cancer (mTNBC) who have received at least two prior therapies for metastatic disease. Immunomedics plans to submit a supplemental Biologics License Application (BLA) to support full approval of Trodelvy in the United States in the fourth quarter of 2020. Immunomedics is also on track to file for regulatory approval in Europe in the first half of 2021.

"This acquisition represents significant progress in Gilead's work to build a strong and diverse oncology portfolio. Trodelvy is an approved, transformational medicine for a form of cancer that is particularly challenging to treat. We will now continue to explore its potential to treat many other types of cancer, both as a monotherapy and in combination with other treatments," said Daniel O'Day, Chairman and Chief Executive Officer, Gilead Sciences. "We look forward to welcoming the talented Immunomedics team to Gilead so we can continue to advance this important new medicine for the benefit of patients with cancer worldwide."

INOVIO (NASDAQ: INO), a biotechnology company focused on bringing to market precisely designed DNA medicines to treat and protect people from infectious diseases and cancer, recently announced that Thermo Fisher Scientific, the world leader in serving science, has signed a letter of intent to manufacture INOVIO's DNA COVID-19 vaccine candidate INO-4800.

Thermo Fisherjoins other contract development and manufacturing organizations in INOVIO's global manufacturing consortium, enabling INOVIO to potentially scale commercial production of INO-4800. With its consortium of third-party manufacturers, INOVIO plans to have 1001million doses of INO-4800 manufactured in 2021, subject to FDA approval of INO-4800 for use as a COVID-19 vaccine.Thermo Fisherplans to manufacture INO-4800 drug substance as well as perform fill and finish of INO-4800 drug product at its commercial facilities in the US. At peak capacity,Thermo Fisherprojects that it could produce at least 100 million doses of INO-4800 annually.

Novavax, Inc. (NASDAQ: NVAX), a late-stage biotechnology company developing next-generation vaccines for serious infectious diseases, recently announced an amendment to its existing agreement with Serum Institute of India Private Limited (SIIPL) under which SIIPL will also manufacture the antigen component of NVXCoV2373, Novavax' COVID19 vaccine candidate. With this agreement, Novavax increases its manufacturing capacity of NVX-CoV2373 to overtwo billion doses annually, when all planned capacity has been brought online by mid-2021. NVXCoV2373 is a stable, prefusion protein made using Novavax' recombinant protein nanoparticle technology and includes Novavax' proprietary MatrixM adjuvant.

"Today's agreement with Serum Institute enhances Novavax' commitment to equitable global delivery of our COVID-19 vaccine. With this arrangement, we have now put in place a global supply chain that includes the recently acquired Praha Vaccines and partnerships with leading biologics manufacturers, enabling production on three continents," said Stanley C. Erck, President and Chief Executive Officer of Novavax. "We continue to work with extraordinary urgency to develop our vaccine, now in Phase 2 clinical trials, and for which we anticipate starting Phase 3 efficacy trials around the world in the coming weeks."

DISCLAIMER: FN Media Group LLC (FNM), which owns and operates and, is a third- party publisher and news dissemination service provider, which disseminates electronic information through multiple online media channels.FNM is NOT affiliated in any manner with any company mentioned herein. FNM and its affiliated companies are a news dissemination solutions provider and are NOT a registered broker/dealer/analyst/adviser, holds no investment licenses and may NOT sell, offer to sell or offer to buy any security.FNM's market updates, news alerts and corporate profiles are NOT a solicitation or recommendation to buy, sell or hold securities. The material in this release is intended to be strictly informational and is NEVER to be construed or interpreted as research material.All readers are strongly urged to perform research and due diligence on their own and consult a licensed financial professional before considering any level of investing in stocks. All material included herein is republished content and details which were previously disseminated by the companies mentioned in this release.FNM is not liable for any investment decisions by its readers or subscribers. Investors are cautioned that they may lose all or a portion of their investment when investing in stocks. For current services performed FNM was compensated twenty five hundred dollars for news coverage of current press release issued by NanoViricides, Inc. by a non-affiliated third party.FNM HOLDS NO SHARES OF ANY COMPANY NAMED IN THIS RELEASE.

This release contains "forward-looking statements" within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E the Securities Exchange Act of 1934, as amended and such forward-looking statements are made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. "Forward-looking statements" describe future expectations, plans, results, or strategies and are generally preceded by words such as "may", "future", "plan" or "planned", "will" or "should", "expected," "anticipates", "draft", "eventually" or "projected". You are cautioned that such statements are subject to a multitude of risks and uncertainties that could cause future circumstances, events, or results to differ materially from those projected in the forward-looking statements, including the risks that actual results may differ materially from those projected in the forward-looking statements as a result of various factors, and other risks identified in a company's annual report on Form 10-K or 10-KSB and other filings made by such company with the Securities and Exchange Commission. You should consider these factors in evaluating the forward-looking statements included herein, and not place undue reliance on such statements. The forward-looking statements in this release are made as of the date hereof and FNM undertakes no obligation to update such statements.

Contact Information:Media Contact email: [emailprotected]+1(561)325-8757


Read more here:
Nanomedicine Seen As A Promising Approach For Diagnosis and Treatment Against COVID - PRNewswire

Recommendation and review posted by Alexandra Lee Anderson

Read the Rest...

RNA Nanoparticles Rubbery Properties Help Them To Target Tumors – Technology Networks

A new study by researchers at The Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC James) shows that RNA nanoparticles have elastic and rubbery properties that help explain why these particles target tumors so efficiently and why they possess lower toxicity in animal studies.

RNA nanoparticles show great promise for the targeted delivery of anticancer drugs. Understanding their structure and behavior is essential for their possible future use.

This study, published in the journalACS Nano, reveals that RNA nanoparticles have elastic and rubbery properties that enable the molecules to stretch and return to their normal shape. Researchers say that these properties could help the particles target tumors by enabling them to slip through the poorly formed walls of tumor blood vessels and enter a tumor mass.

The researchers further proved that the same rubbery properties enable the RNA nanoparticle to slip through the kidney to excrete into the urine a half-hour after systemic injection, thereby eliminating them from the body relatively quickly. That, in turn, could reduce retention of the anticancer agent in vital organs, lowering an agents toxicity.

We show that RNA nanoparticles have a flexibility that allows for the assembly of molecular structures that have stretchable angles, says study leader and corresponding authorPeixuan Guo, PhD, professor in the College of Pharmacy and theSylvan G. Frank Endowed Chair in Pharmaceutics and Drug Delivery. Guo is also in the OSUCCC JamesTranslational Therapeutics Research Program.

These findings demonstrate the rubbery properties of RNA nanoparticles and why these molecules hold great promise for industrial and biomedical applications, especially as carriers for targeted delivery of anticancer drugs, says Guo, who directs Ohio StatesCenter for RNA Nanobiotechnology and Nanomedicine.

For this study, Guo and his colleagues tested the elasticity of nucleic acid polymers by stretching and relaxing individual RNA nanoparticle while subjecting RNA nanoparticles to elasticity studies using dual-beam optical tweezers built in Guo Lab. Finally, they used animal models to study the biodistribution, excretion and retention of RNA nanoparticles. This included measuring excretion of the particles in urine along with the study on the effect of their shape and size.

Key findings include:

Overall, Guo says, we believe these findings further support the development of RNA nanoparticles for targeted delivery of anticancer drugs or therapeutic RNA.

Reference: Ghimire C, Wang H, Li H, Vieweger M, Xu C, Guo P.RNA nanoparticles as rubber for compelling vessel extravasation to enhance tumor targeting and for fast renal excretion to reduce toxicity.ACS Nano 2020; doi:10.1021/acsnano.0c04863

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.

Continued here:
RNA Nanoparticles Rubbery Properties Help Them To Target Tumors - Technology Networks

Recommendation and review posted by Alexandra Lee Anderson

Read the Rest...

Pandemics and transhumanism – The Times of India Blog

The pandemic has forced authorities around the world to scramble for solutions within the realm of possibility. One of the more futuristic, radical solutions which is still relegated to the sidelines is transhumanism. It is a branch of philosophy that believes in transcending the limitations of the human population through technological augmentation. From hearing aids, pacemakers, bionic arms, the manifestations of transhumanism are very much present in our lives. However, the radical applications of being able to tweak biology to suit ones interests and needs at a commercial cost is yet to see the light of day. The basic tenet of transhumanism is extension of human life. Yet, eternal life comes across as a utopian thought where inadequate manufacturing of PPE kits for doctors and nurses have us jolted back to the harsh realities of current pandemic dwelling.

Since the globalized nature of modern capitalistic order and the consequent interconnectedness of our lives has made the possibility of frequent pandemics ever so plausible, we find ourselves at the juncture of a major shift towards increasing receptivity to transhumanist solutions. The famous American inventor and futurist Kurzweil wrote in his book The Singularity Is Near: When Humans Transcend Biology about a journey towards a meshing point of humans and machine intelligence The Singularity. He envisioned nanobots which allowed people to eat whatever they want while remaining healthy and fit, provide copious energy, ward off infections or cancer, replace organs and augment their brains. There will come a future where human bodies will carry so much augmentation that they would be able to alter their physical manifestation at will.

Even if the coronavirus fades off without wiping humans off the planet, it has given an eerie trailer of what future outbreaks might hold in store. Hence due security measures have to be pondered upon -whether in the labs, where deadly pathogens are being researched upon or in the malicious possibilities of a biowarfare. Frontline workers can be provided tech enhancements to ensure better armament against infectious, mutating viral diseases. Protective exoskeletons, real-time blood monitors for pathogens, can bid riddance to any temporary means of protection which are vulnerable against quality and efficacy issues.

In 2011, surgeons in Sweden had successfully transplanted a fully synthetic, tissue-engineered trachea into a man with late-stage tracheal cancer. The trachea was created entirely in a lab with tissue grown from the patients own stem cells inside a bioreactor designed to protect the organ and promote cell growth. Under transhumanism, artificial organs would be superior to ordinary donor organs in several ways. They can be made to order more quickly than a donor organ can often be found; would be grown from a patients own cells and hence wont require dangerous immunosuppressant drugs to prevent rejection.

As of 2018, prototypes of artificial lungs are also surfacing at the Galveston National Laboratory at the University of Texas Medical Branch, where the team spent the last 15 years developing the prototype. Upon completion, the bioengineered lungs were transplanted into four pigs. There was no indication of transplant rejection when the animals were examined at regular intervals for months after transplant. The researchers also observed that the bioengineered lungs became vascularized, establishing the necessary blood vessel networks to do its job. For diseases like covid-19, which affect a particular body organ, having an option of a bioengineered organ could very well be a safeguard.

But transhumanists are not just trying to extend human lives, they also want to revive them. They aim to merge bioengineering, AI capabilities, 3-D printing to resurrect the dead victims of any catastrophe much like the pandemic on our hands right now. Ways of dealing with grief at the loss of a loved one can possibly be placated with measures like interactive custom-holograms, social media feed powered by AI that could generate new messages based on the pattern of the old ones.

There are strong ethical considerations that also pop up in the discussion of transhumanism. Stefan Lorenz Sorgner, a German philosopher and bioethicist believes that processes like cryonics will go against most ecological principles given the amount of resources needed to keep a body in suspended animation post-death. Even though, transhumanism does not explicitly encourage breeding for the superiority of one specific group, the methods endorsed by some prominent transhumanists aim for physiological superiority. Considering that for the time being, solutions emanating will be heavy on the monetary end in the healthcare set-up, it could breed inequality in access. A huge gap in resources will be experienced in the society, as the affluent section amasses money and influence to set out an eternal timeline for themselves, coming at a lethal cost for the other half of the society.

Solving problems that will plague us in the future is a rising urge shared by leaders, philanthropists and billionaires around the world. This is why proponents like Zoltan Istvan fear the fact that the exponential rise of transhumanist technologies might leave governments fumbling to discuss and bring about policy directions to regulate and guard changes. Important questions like how far is too far? will need phased guidance as we have learnt from the chaotic response to systemic changes being implemented in the medical field during Covid-19. A conversation on transhumanism should not be put off any further and needs to permeate across different strata of stakeholders.

DISCLAIMER : Views expressed above are the author's own.

Pandemics and transhumanism - The Times of India Blog

Recommendation and review posted by Alexandra Lee Anderson

Read the Rest...

Testosterone Replacement Therapy Industry Market Current and Future Industry Trends, 2020 ? 2026 – AlgosOnline

The 'Testosterone Replacement Therapy Industry market' research report is latest addition by Market Study Report, LLC, that elucidates relevant market and competitive insights as well as regional and consumer information. In a nutshell, the research study covers every pivotal aspect of this business sphere that influences the existing trends, profitability position, market share, market size, regional valuation, and business expansion plans of key players in the Testosterone Replacement Therapy Industry market.

The Testosterone Replacement Therapy Industry market report provides a broad perspective of this business landscape and elaborates on the various factors that are impacting the revenue generation and growth. The study also enlists exhaustive analysis of the regional landscape as well as regulatory outlook. A detailed SWOT analysis alongside market drivers are analyzed and offered in the document.

Request a sample Report of Testosterone Replacement Therapy Industry Market at:

Other details such as challenges & restraints faced by market players as well as new entrants in tandem with their individual impact on the remuneration of companies is highlighted. The study also analyzes the effect of COVID-19 disease outbreak on future remuneration and overall growth of the market.

Underlining the competitive scenario of the Testosterone Replacement Therapy Industry market:

Additional information comprised in the Testosterone Replacement Therapy Industry market report:

Ask for Discount on Testosterone Replacement Therapy Industry Market Report at:

Highlighting the geographical landscape of Testosterone Replacement Therapy Industry market:

TOC of Testosterone Replacement Therapy Industry Market Report Includes:

For More Details On this Report:

Related Reports:

1. Global Frozen Ready Meals Market Report 2020 by Key Players, Types, Applications, Countries, Market Size, Forecast to 2026 (Based on 2020 COVID-19 Worldwide Spread)Read More:

2. Global Retailing Market Report 2020 by Key Players, Types, Applications, Countries, Market Size, Forecast to 2026 (Based on 2020 COVID-19 Worldwide Spread)Read More:

Contact Us:Corporate Sales,Market Study Report LLCPhone: 1-302-273-0910Toll Free: 1-866-764-2150 Email: [emailprotected]

Read more:
Testosterone Replacement Therapy Industry Market Current and Future Industry Trends, 2020 ? 2026 - AlgosOnline

Recommendation and review posted by Alexandra Lee Anderson

Read the Rest...

Kenergy Scientific, Inc. Announces New Added Location and Telemedicine to Their Florida-Based Men’s Healthcare and Anti-Aging Company – Stockhouse

BAY HARBOR, FL / ACCESSWIRE / September 14, 2020 / Kenergy Scientific, Inc. (OTC PINK:KNSC) is pleased to announce MedSmart Group, Inc's, (MSGI) subsidiary MedSmart Men's Wellness and Antiaging centers is focused on Men's health, and well-being. MedSmart is Well Established in the operations of Clinics from Start up to market dominance. The company has added a new location in Aventura Florida for a brand new 2,000sq ft. state of the art facility. The Center is located a few minutes away from some of the most high-end neighborhoods in South Florida. Coral Gables, Sunny Isles, Golden Beach, Hallandale, to name a few. We are estimating the grand opening by November 2020.

MSGI is progressing extremely well on the integration of Telemedicine and being HIPPA compliant. MedSmart has already contracted for the development of our online presence with some of the top firms in the field, in social marketing, SEO, Google adds, key words, Instagram, and Face book adds.

"In cooperation with our own Compound Pharmacy and our marketing department, we will facilitate direct delivery and prescribing of the necessary medication to our patients. This will intern add to the revenue stream from the Medical Centers" said Calvin Lewis President.

While MedSmart, is continuing to lay the groundwork for expansion in other areas and creating the most exclusive patient Doctor encounter available online today. This will be one of the most impressive sites developed today for Physicians offices, bringing the latest in technology for anti-aging and men's health direct to the patient.

About MedSmart Group, Inc.

MedSmart Group Inc. is a professional network of Medical Centers specializing in "Anti-Aging Treatments" that improve the overall health and quality-of-life of male patients in a comfortable, casual and discreet setting. All of our procedures are administered by licensed physicians and other medical professionals that specialize in the latest treatment options available for the unique needs of men, through our centers along with the availability of face to face visits through Telemedicine, and overnight delivery of Meds.

Our unique Non-invasive treatment plans include: Testosterone Replacement, Erectile Dysfunction (ED), Hypothyroidism, Allergies, High Cholesterol, Hypertension, Diabetes, Physicals Lab on Site - Immediate Results, Hair Loss, Vein Treatment, Cryogen Therapy, Weight loss and Laser Hair Removal. Presently the marketplace for anti-aging products and services is valued at $250 billion, and with an annual growth rate of 9.5%, it is projected to reach $331 billion by 2025. To capture a share of the "Anti-Aging Market", Med Smart Group, Inc. intends to open and operate a nationwide chain of Men's Health and Wellness Centers, along with Telemedicine

Safe Harbor Statement:

The information posted in this release may contain forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. You can identify these statements by use of the words "may," "will," "should," "plans," "explores," "expects," "anticipates," "continue," "estimate," "project," "intend," and similar expressions. Forward-looking statements involve risks and uncertainties that could cause actual results to differ materially from those projected or anticipated. These risks and uncertainties include, but are not limited to, general economic and business conditions, effects of continued geopolitical unrest and regional conflicts, competition, changes in technology and methods of marketing, and various other factors beyond the Company's control.

MedSmart Group, Inc. 844 544 4014

SOURCE: Kenergy Scientific Inc.

View source version on

The rest is here:
Kenergy Scientific, Inc. Announces New Added Location and Telemedicine to Their Florida-Based Men's Healthcare and Anti-Aging Company - Stockhouse

Recommendation and review posted by Alexandra Lee Anderson

Read the Rest...

Penny Stocks To Watch If You Like Biotech; 1 Up 287% Year To Date – Penny Stocks

Putting Together Your List Of Penny Stocks To Watch?

Do you like biotech penny stocks? Youre likely among a unique group of investors that can handle risk if you said yes. When it comes to these cheap stocks, not only does volatility play a role, so does speculation. Most small-cap biotech stocks tend to experience extremes.

This goes for extreme jumps and extreme drops. It usually involves 1 of a few things. First, when biotech stocks are on the move higher, theres usually a news catalyst to look for. It might stem from something the company just announced. For more info on different ways to trade penny stocks, download our 60+ page eBook for free.

On the flip side biotech companies pre-announce important dates. So it could have something to do with an upcoming announcement. Usually, these entail things like phase trial results, data readouts, or new patient enrollment. You may also see things like PDUFA dates, IND submission or approvals, and NDA submission or approvals. These all have to do with different FDA events. Dont worry if you dont understand what these acronyms mean, Ill explain, briefly.

The FDAs IND or Investigational New Drug program allows pharmaceutical companies permission to begin human clinical trials and ship experimental drugs across state lines before a marketing application for the drug has been approved. Essentially it is a starting point for clinical investigations in the US. The main idea of an initial IND submission is to ensure the safety and rights of clinical trial participants.

In business, you generally see and NDA as a non-disclosure agreement. However, when it comes to biotech, NDA means something completely different. This refers to a New Drug Application. The NDA application sponsors formally propose that the FDA approve a new pharmaceutical for sale and marketing in the U.S. The data gathered during the animal studies and human clinical trials of an IND become part of the NDA.

PDUFA or Prescription Drug User Free Act was passed in the 90s and authorizes the FDA to receive fees from drug manufacturers. These fees are used to fund the drug approval process. The PDUFA date is a deadline for the FDA to review a new drug application. The typical review period can be anywhere from 6-10 months depending on priority.

Read More

Ok, so now youve got a basic understanding of some of the basic FDA forms. As I said above favorable outcomes to data readouts or any of these forms can trigger momentum in the market. On the flip side, if a company isnt granted permissions or misses trial endpoints, then the other side of the coin is a move to the downside. One thing to consider during times of negative readouts is managements commentary.

It can be a big blow to any stock, including penny stocks, but how management reacts is important. Are they fully giving up on the treatment or did they find some positives that suggest that theres still something to build upon? While the road may be long, many biotech penny stocks end up recovering in the end as they rework their trials. With this in mind, here are a few biotech penny stocks to watch right now.

VYNE Therapeutics (VYNE Stock Report) might appear as a new biotech company. However, it is one that weve discussed in the past under the name Menlo Therapeutics. While Menlo had its ups and downs throughout the year, it did experience several bouts of bullishness. This month, the name and symbol changes went into effect and now weve got VYNE stock.

The companys focus remains on dermatology treatments. In light of this, CEO David Domzalski explained, Having achieved FDA approval for our two commercial products AMZEEQ and ZILXI in a period of less than eight months is a testament to the value of our proprietary technology and is aligned to the symbolic meaning behind our new name strength, growth, endurance, and resilience.

Domzalski also filed a Form 4 recently showing the purchase of 75,000 of the companys stock. The average price per share was $1.38. CFO Andrew Saik also picked up a chunk as well. He purchased 40,000 at an average of $1.462. This week, VYNE appointed a new Director to its board, Patrick LePore. Considering the recent activity, will VYNE stock be on your watch list in September?

Unity Biotechnology Inc.(UBX Stock Report) is another one of the trending biotech penny stocks to watch. If youre unfamiliar with the company theres a reason for that. For most of this year, UBX stock rarely came close to penny stock territory. That all came to an end after shares plummeted from around $12.50 to recent lows of $2.72 in August. Remember what I was saying about the outcome of meeting or missing endpoints? In this case, Unity Biotech announced that its UBX0101, osteoarthritis treatment missed its primary endpoint.

After several weeks of sideways trading, volume began picking up this week. Price has also followed. Aside from participating in a few industry conferences this month, Unity also announced new developments. The company announced the initiation of a restructuring. Unity said it is to align programs in ophthalmology and neurology.

[Read More] Should Your List Of Penny Stocks Include These 3 Names?

The company said it will advance its UBX1325 to Phase 1 clinical development in patients with diabetic macular edema. Furthermore, it expects to dose the first patient in the second half of 2020. This corporate restructuring is also said to extend the companys cash runway through mid-2022.

Lipocine Inc. (LPCN Stock Report) is another one of the biotech penny stocks weve watched for months. In fact, year-to-date, LPCN stock is up more than 280%. A lot of the lead-in to the recent price movement came in light of its TLANDO treatment. This is the companys oral testosterone replacement therapy. Lipocine originally had its Prescription Drug User Fee Act goal date ofAugust 28, 2020. However, that was pushed back by the FDA. In light of this extension, the market lost a bit of its thunder and shares have slid nearly $1 a share in the course of about a month.

Although the FDA did not provide a timeline on a new action date, the FDA informed the Company that the review is expected to be completed in the coming weeks. The FDA has not asked for any additional data and the Company has provided the FDA with all information requested to date.

It has now been more than a few weeks since then. The company also just presented at the H.C. Wainwright Investment Conference on Monday. While trading volumes and price have picked up, is this just general speculation on that coming weeks statement? Obviously, well follow this closely, but its also important to note that this could also remain a high-risk situation depending on the PDUFA outcome whenever that may be.

Midam Ventures, LLC | (305) 306-3854 | 1501 Venera Ave, Coral Gables, FL 33146 |

Visit link:
Penny Stocks To Watch If You Like Biotech; 1 Up 287% Year To Date - Penny Stocks

Recommendation and review posted by Alexandra Lee Anderson

Read the Rest...

Testosterone Replacement Therapy Market Size and Share Forecast Analysis, Top Key Players, Latest Developments, Growth Factors till 2020 to 2026 -…

The Testosterone Replacement Therapy Market (2020-2026) Research Report provides key analysis on the market status of the Testosterone Replacement Therapy manufacturers with best facts and figures, meaning, definition, SWOT analysis, expert opinions and the latest developments across the globe. The Report also calculate the market size, Testosterone Replacement Therapy Sales, Price, Revenue, Gross Margin and Market Share, cost structure and growth rate. The report considers the revenue generated from the sales of This Report and technologies by various application segments.

Request a Sample Copy of the Report

Testosterone Replacement Therapy Market 2020 Industry Research Report is a professional and in-depth study on the current state of the Global Testosterone Replacement Therapy industry. Moreover, research report categorizes the global Testosterone Replacement Therapy market by top players/brands, region, type and end user. Testosterone Replacement Therapy Market report also tracks the latest market dynamics, such as driving factors, restraining factors, and industry news like mergers, acquisitions, and investments. It provides market size (value and volume), Testosterone Replacement Therapy market share, growth rate by types, applications, and combines both qualitative and quantitative methods to make micro and macro forecasts in different regions or countries.

This study also contains company profiling, product picture and specifications, sales, market share and contact information of various international, regional, and local vendors of Global Testosterone Replacement Therapy Market. The market competition is constantly growing higher with the rise in technological innovation and M&A activities in the industry.

Major Key Players of Testosterone Replacement Therapy Market:

Moreover, many local and regional vendors are offering specific application products for varied end-users. The new vendor entrants in the market are finding it hard to compete with international vendors based on quality, reliability, and innovations in technology.

Enquire Before Purchasing This Report

Global Testosterone Replacement Therapy market 2020 research provides a basic overview of the industry including definitions, classifications, applications, and industry chain structure. The Global Testosterone Replacement Therapy market analysis is provided for the international markets including development trends, competitive landscape analysis, and key regions development status. Development policies and plans are discussed as well as manufacturing processes and cost structures are analyzed. This report also states import/export consumption, supply and demand Figures, cost, price, revenue, and gross margins.

Testosterone Replacement Therapy Market Forecast (2020-2026):

Market Size Forecast:Global Testosterone Replacement Therapy market segmented by overall size, by type/product category, by applications/end users, by regions/geography.

Key Data (Revenue):Market size, market share, growth rate, growth, product sales price, and opportunity.

Trend and forecast analysis:Market trend, forecast and analysis to 2026 by segments and geographical regions.

Segmentation analysis:Global fat burn supplements market size by various applications such as product, material, shape, and end use in terms of value and volume shipment.

Regional analysis:Global Testosterone Replacement Therapy Market Breakdown by North America, Europe, Asia Pacific, And The Rest of the World.

Growth opportunities:Analysis of growth opportunities in different applications and regions in the global Fat Burn Supplements Industry

Strategic analysis:This includes new product development and competitive landscape in the global Fat Burn Supplements

Testosterone Replacement Therapy Market Include the Following Manufacturers Based on Testosterone Replacement Therapy Sales, Revenue, Price and Gross Margin. The analysis of the Testosterone Replacement Therapy Market is a thorough study that offers a select combination of skillful market realities. The study shows changing trends of the market as well as the size of each separate segment in this market. Various product types and application are shown below.

Application of Testosterone Replacement Therapy Market:

Types of Testosterone Replacement Therapy Market:

Purchase This Report (Price 3350 USD For Single User License)

In this study, the years considered to estimate the market size of Video Surveillance Storage are as follows:

History Year: 2015-2019

Base Year: 2019

Estimated Year: 2020

Forecast Year: 2020 2026

Key questions answered in the report:

-What will the market growth rate of Testosterone Replacement Therapy market in 2026?

-What are the key factors motivating the global Testosterone Replacement Therapy market?

-Who are the important key players in Testosterone Replacement Therapy market space?

-What are the market opportunities, market risk and market overview of the Testosterone Replacement Therapy market?

-What are sales, revenue, and price analysis by types and applications of Testosterone Replacement Therapy market?

-What are sales, revenue, and price analysis by regions of Testosterone Replacement Therapy industries?

Table of Contents:

1 Report Overview

1.1 Study Scope

1.2 Key Market Segments

1.3 Players Covered

1.4 Market Analysis by Type

1.4.1 Global Testosterone Replacement Therapy Market Size Growth Rate by Type (2020-2026)

1.4.2 Major-Type

1.4.3 Independent-Type

1.4.4 Administrator-Type

1.5 Market by Application

1.5.1 Global Testosterone Replacement Therapy Market Share by Application (2020-2026)

1.5.2 Commercial

1.5.3 Commonweal

1.5.4 Other

1.6 Study Objectives

1.7 Years Considered

2 Global Growth Trends

2.1 Testosterone Replacement Therapy Market Size

2.2 Testosterone Replacement Therapy Growth Trends by Regions

2.2.1 Testosterone Replacement Therapy Market Size by Regions (2020-2026)

2.2.2 Testosterone Replacement Therapy Market Share by Regions (2015-2020)

2.3 Industry Trends

2.3.1 Market Top Trends

2.3.2 Market Drivers

2.3.3 Market Opportunities

3 Market Share by Key Players

3.1 Testosterone Replacement Therapy Market Size by Manufacturers

3.1.1 Global Testosterone Replacement Therapy Revenue by Manufacturers (2014-2020)..

3.4 Date of entering into Testosterone Replacement Therapy Market

3.5 Mergers & Acquisitions, Expansion Plans

4 Breakdown Data by Type and Application

4.1 Global Testosterone Replacement Therapy Market Size by Type (2015-2020)

4.2 Global Testosterone Replacement Therapy Market Size by Application (2015-2020)


About Us:

Market Reports World is an upscale platform to help key personnel in the business world in strategizing and taking visionary decisions based on facts and figures derived from in-depth market research. We are one of the top report resellers in the market, dedicated to bringing you an ingenious concoction of data parameters.

Contact Us:

Name: Ajay More


Phone: +1 408 520 9750/+44 203 239 8187

Other Reports Here:

Global Laboratory Circulator Market 2020 Global Industry Size, Share, Revenue, Business Growth, Demand and Applications by Market Research Report to 2024

Jet Injector Device Market Size, Share 2020 Global Industry Current Trends, Top Companies, Application, Growth Factors, Development and Forecast to 2024 Research Report

Automotive Side Airbags Market Size, Share 2020 Global Industry Trends, Demand, Growth Opportunities, Industry Revenue, Future and Business Analysis by Forecast 2023

Linear Cutter Staplers Market Size, Share 2020 Explosive Factors of Revenue by Key Vendors, Demand, Development Strategy, Future Trends and Industry Growth Research Report

Low Smoke Halogen Free Flame Retardant Polypropylene Market Size, Share 2020 |Global Industry Analysis by Trends, Company Overview, Growth and Forecast by 2024 | Latest Research Report by Market Reports World

Visit link:
Testosterone Replacement Therapy Market Size and Share Forecast Analysis, Top Key Players, Latest Developments, Growth Factors till 2020 to 2026 -...

Recommendation and review posted by Alexandra Lee Anderson

Read the Rest...

Global Gymnastic Equipment Market – Post Pandemic Recovery Plan, Strategies and Processes | Increased Awareness About Healthy Lifestyle to Boost…

LONDON--(BUSINESS WIRE)--The global gymnastic equipment market size is expected to grow by USD 12.68 million during 2020-2024. The report also provides the market impact and new opportunities created due to the COVID-19 pandemic. We expect the impact to be significant in the first quarter but gradually lessen in subsequent quarters with a limited impact on the full-year economic growth.

Request challenges and opportunities influenced by COVID-19 pandemic - Request a Free Sample Report on COVID-19 Impacts

The increase in sedentary lifestyles and physical inactivity exposes individuals to various health conditions such as anxiety, obesity, type 2 diabetes, and osteoporosis. As a result, individuals are increasingly looking to adopt healthy lifestyles. Moreover, social media is playing a pivotal role in creating awareness about healthy lifestyles and the ways to achieve it through various fitness and training activities such as gymnastics. Gymnastics offers several benefits such as better coordination and body awareness and increased strength of abdominal muscles. Strengthening these muscles can help relieve back pain, which is a common malady in todays generation. Thus, the increasing awareness about healthy lifestyle is expected to drive the gymnastic equipment market growth.

To learn more about the global trends impacting the future of market research, download a free sample:

As per Technavio, the increasing popularity of e-commerce channels will have a positive impact on the market and contribute to its growth significantly over the forecast period. This research report also analyzes other significant trends and market drivers that will influence market growth over 2020-2024.

Gymnastic Equipment Market: Increasing Popularity Of E-commerce Channels

The increasing popularity of e-commerce channels is one of the major trends being witnessed in the global gymnastic equipment market. The online sales of gymnastic equipment have witnessed significant growth over the past decade due to the retailers' and manufacturers' efforts toward educating customers, streamlining the online retail process, providing better aftersales services and targeted marketing campaigns. The growing penetration of smartphones and the internet worldwide will further increase the sale of gymnastic equipment through online portals, thereby, driving market growth.

Other factors such as the high prevalence of gymnastic associations, and increase in disposable income across emerging economies will have a significant impact on the growth of the gymnastic equipment market value during the forecast period, says a senior analyst at Technavio.

Register for a free trial today and gain instant access to 17,000+ market research reports

Technavio's SUBSCRIPTION platform

Gymnastic Equipment Market: Segmentation Analysis

This market research report segments the gymnastic equipment market by distribution Channel (offline and online) and geography (North America, Europe, APAC, South America, and MEA).

The North America region led the gymnastic equipment market in 2019, followed by Europe, APAC, South America, and MEA respectively. During the forecast period, the APAC region is expected to register the highest incremental growth due to factors such as the rising young population, the increase in disposable income, and the growing awareness of the need to invest in health and fitness activities.

Technavios sample reports are free of charge and contain multiple sections of the report, such as the market size and forecast, drivers, challenges, trends, and more. Request a free sample report

Some of the key topics covered in the report include:

Market Drivers

Market Challenges

Market Trends

Vendor Landscape

About Technavio

Technavio is a leading global technology research and advisory company. Their research and analysis focuses on emerging market trends and provides actionable insights to help businesses identify market opportunities and develop effective strategies to optimize their market positions.

With over 500 specialized analysts, Technavios report library consists of more than 17,000 reports and counting, covering 800 technologies, spanning across 50 countries. Their client base consists of enterprises of all sizes, including more than 100 Fortune 500 companies. This growing client base relies on Technavios comprehensive coverage, extensive research, and actionable market insights to identify opportunities in existing and potential markets and assess their competitive positions within changing market scenarios.

Read the original post:
Global Gymnastic Equipment Market - Post Pandemic Recovery Plan, Strategies and Processes | Increased Awareness About Healthy Lifestyle to Boost...

Recommendation and review posted by Alexandra Lee Anderson

Read the Rest...

Coping and Hoping: Mental Health Tips for Trying Times | University of Michigan – Michigan Medicine

Even before 2020 began, many Americans of all ages had mental health conditions and alcohol or drug issues that werent getting the attention and care that they deserved.

Now, six months into the COVID-19 pandemic, three months into a major social justice movement, two months away from a national election and with school starting, hurricanes blowing, wildfires burning and the economy slumping, its a fair bet that many more people are struggling with mental health concerns.

Thats why Michigan Medicine assembled a panel of experts for a recent webinar to offer concrete steps that might help, and links to further resources for helping to manage overall well-being.

This recording has a wealth of tips, from breathing exercises to family activities to advice about the kinds of healthy lifestyle choices that can bolster mental health and keep alcohol use in check. The U-M Department of Psychiatry also offers a wide range of resources and helpful links in its COVID-19 Toolkit.

If youre feeling overly stressed, depressed, anxious or concerned about your alcohol use or someone close to you is showing such signs you dont have to start with a specialist. In fact, primary care providers such as family doctors, general internists, pediatricians and primary care nurse practitioners, are trained to handle many mental health symptoms, says Jill Schneiderhan, M.D., a U-M family medicine doctor and mental wellness specialist.

So just as you would start by contacting them for a new physical symptom, dont be afraid to contact them about changes to your mental health and substance use. That includes a persistent low mood, finding things less enjoyable, and anxious thoughts that intrude on your everyday life.

Several of the experts focused on the things you can do to improve your mental state, including more regular bed times and wake times, cutting out screen use in bed, keeping up social connections even if its via video chat or phone calls, eating a healthy diet, getting regular physical activity, engaging in a hobby, spending time outside, and engaging with art and music.

Elizabeth Duval, Ph.D., a clinical psychologist in the U-M Department of Psychiatry, offers some specific breathing exercises and mindfulness activities that anyone of any age can do, almost anywhere.

Box breathing: Breathe in for a few seconds, hold for a few seconds, breathe out for a few seconds, and hold for a few seconds before breathing in again.

Try the 54321 exercise: Sitting or standing wherever you are, take a moment to notice and name out loud or to yourself five things you can see right now, four things you can touch, three things you can hear, two things you can smell and one thing you can taste.

When talking with someone, say what you are feeling inside. Just speaking it out loud can actually help defuse the feeling itself

If youre a parent, keep in mind that your children are noticing and reacting to the way youre handling these times, says Polly Gipson, Ph.D., a pediatric psychologist who heads U-Ms Trauma and Grief Clinic. Thats especially true if your family has lost someone to COVID-19, or you belong to a group or live in an area thats being especially affected by current events.

But you can be a model to them by engaging in healthy mental wellbeing self-care and finding ways to focus on positive memories, things to be grateful for, family togetherness because of the lack of scheduled activities, and more. She recommends the CALM method: Communicate with the child to share information, find out what they know and validate their feelings; help them stay Active and creative; Learn how children in general, or your child in particular, show distress; and Model self-care by using positive strategies and sharing them with children.

Childrens future mental health depends in part on how theyre affected by adverse experiences now, both their own and those that their larger community is going through. If you notice troubling behavior in the children in your life, speaking up to get help can make a major difference.

Alcohol and cannabis sales have shot up during the past six months, and jokes about drinking or using marijuana-derived products to cope with these times are rampant on social media. This is typical during stressful times, says Mark Ilgen, Ph.D., the addiction psychologist who directs the U-M Addiction Treatment Services. But he warns that as time goes on, what was once a short-term coping mechanism could develop into a substance-use problem.

Fortunately, he says, support groups, twelve-step groups and addiction care specialists have pivoted to offer online help. And newer medications can help people who have developed a dependence on alcohol, opioids and more. If youre not sure you need this level of help, he notes that many people can cut back on their substance use on their own, by setting targets for themselves including limits on daily or weekly alcohol or cannabis intake. If you find you cant stay within these self-imposed limits, thats a time to seek help. Find more information on the U-M Addiction Treatment Services COVID-19 Addiction & Recovery Resources page.

Above all else, the experts note, if you or someone youre in contact with have been feeling hopeless or even suicidal, its crucial to get help. Dont shy away from discussing the topic, and get in touch with a primary care provider if its not an urgent situation. For urgent or life-threatening situations, contact the National Suicide Prevention hotline at 800-273-8255 or call 911.

See more here:
Coping and Hoping: Mental Health Tips for Trying Times | University of Michigan - Michigan Medicine

Recommendation and review posted by Alexandra Lee Anderson

Read the Rest...

I Learned Proper Portion Control Through WW And Lost 107 Pounds In 2 Years – Women’s Health

My name is Katy Allen (@kallen_cooks), and I am 23. I currently live in St. Louis, Missouri, where I work as a labor and delivery nurse. I joined WW (formerly Weight Watchers) and learned proper portion controland I feel like my healthiest, happiest self.

My weight has fluctuated up and down my entire life. As a child and throughout middle school, I was heavier than my close friends and family members, and very aware of it. I was told I was just "big boned" and born "the opposite" of my tall and skinny sister.

My self worth revolved around my body image and how I was perceived by others, even at a young age. I would put myself on cleanses or fad diets, and spend hours exercising in the evening. Then I would binge on anything I could find in the pantry. This was a revolving cycle, and it was just my normal.

Once I began high school, I got into dance and joined the competitive poms team. I was in better shape those years but still had a very poor relationship with my body image. I saw myself as bigger than the other girls, and always felt self conscious in group settings. Throughout this time I had a poor sense of portion control and continued to eat mindlessly.

My senior year of high school through the end of my freshman year of college, I kicked it into high gear with exercise and healthier eating. I lost around 20 pounds. This was the first time I was ever able to lose a significant amount of weight, and I was hooked. I was running more than five miles a day, tracking my calories, and going to the gym before school at 6 a.m.

But gradually this lifestyle became less feasible with nursing classes, an ankle injury, and my first experiences with depression and anxiety. I stopped exercising and returned to an unhealthy diet of fast food, sugar, and whatever was accessible. By the end of college, I had gained around 80 pounds. I graduated college at my heaviest weight ever, 253 pounds at 21 years old.

This content is imported from Instagram. You may be able to find the same content in another format, or you may be able to find more information, at their web site.

I hardly slept and was chronically fatigued. Walking up a flight of stairs would leave me breathless and my joints would ache. My ankles and knees were in pain to the point that I was taking Aleve most days of the week and wearing a brace.

My blood pressure and blood glucose levels were high as well. My doctor was concerned that I was developing prediabetes and hypertension that would need to be managed with medication. These health problems, in my case, were preventableand uncommon for someone in their early 20s.

This content is imported from Instagram. You may be able to find the same content in another format, or you may be able to find more information, at their web site.

Aside from the physical health problems I had encountered, I was extremely uncomfortable in my own body. My clothes no longer fit, and I was wearing sizes bigger than those I was used to. I was also getting ready to begin my career as a nurse, where I would be constantly on my feet and expected to take care of multiple patients at a time. How could I take great care of others when I wasn't taking care of myself?

This content is imported from Instagram. You may be able to find the same content in another format, or you may be able to find more information, at their web site.

I was moving to a new city and starting fresh. I decided that the day I took my nursing boards my journey would begin. I began WW (Wellness Wins, formerly known as Weight Watchers) on June 26, 2018.

I knew that I was going to be in this for the long haul, so a quick cleanse or restrictive diet plan was not going to work for me. I heard of WW from family members and had seen it advertised at work, so I decided to give it a try. What has been the most helpful is adding the foods I eat to a daily tracker. Every food or recipe is assigned a SmartPoint value based on the ingredients and serving size.

With WW, no foods are off limits or considered "bad" foods, regardless of their SmartPoint value. This system has motivated me to measure my foods, rather than mindlessly eating from the bag or dumping a random amount into a recipe.

This content is imported from Instagram. You may be able to find the same content in another format, or you may be able to find more information, at their web site.

This content is imported from Instagram. You may be able to find the same content in another format, or you may be able to find more information, at their web site.

This content is imported from Instagram. You may be able to find the same content in another format, or you may be able to find more information, at their web site.

For the first year of my weight loss journey, I went to a conventional gym and took yoga classes here and there. I took my first Pure Barre class with a friend in June of 2019 and have been going regularly ever since!

I prefer low impact workouts rather than more strenuous activities such as HIIT or running. Pure Barre, combined with regular yoga, has helped improve my muscle tone, endurance, and self confidence.

This content is imported from Instagram. You may be able to find the same content in another format, or you may be able to find more information, at their web site.

This content is imported from Instagram. You may be able to find the same content in another format, or you may be able to find more information, at their web site.

I want other women to know that my weight loss and overall wellness journey has not been linear. There have been highs and lows, physically and emotionally, throughout this entire process. And there will continue to be!

Living a healthy lifestyle is a choice, and it is one that I make every single day. There is a small chance that I will stay this weight for the rest of my life, and that is okay. I now know that I have the tools to remain healthy and make the best choices for my body.

This content is imported from Instagram. You may be able to find the same content in another format, or you may be able to find more information, at their web site.

This content is created and maintained by a third party, and imported onto this page to help users provide their email addresses. You may be able to find more information about this and similar content at

Read more from the original source:
I Learned Proper Portion Control Through WW And Lost 107 Pounds In 2 Years - Women's Health

Recommendation and review posted by Alexandra Lee Anderson

Read the Rest...

Page 11234..1020..»