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Jatenzo, an Oral Testosterone Replacement Therapy, Now Available – Monthly Prescribing Reference

Jatenzo (testosterone undecanoate; Clarus Therapeutics), an oral testosterone replacement therapy, is now available for the treatment of hypogonadism.

Specifically, Jatenzo is indicated for testosterone replacement therapy in adult males for conditions associated with a deficiency or absence of endogenous testosterone:

Jatenzo is not intended for use in males with age-related hypogonadism and its safety and efficacy have not been established in males <18 years old.

The treatment carries a Boxed Warning related to blood pressure (BP) increases that could potentially increase the risk of major adverse cardiovascular events. In a clinical trial, Jatenzo increased systolic BP during 4 months of treatment by an average of 4.9 mmHg based on ambulatory BP monitoring and by an average of 2.8 mmHg from baseline based on BP cuff measurements. For this reason, baseline cardiovascular risk should be considered before initiating therapy and BP should be adequately controlled. Among study patients treated with Jatenzo, 7% were started on antihypertensive medications or required intensification of their antihypertensive medication regimen during the 4-month trial.

Jatenzo, a Schedule III controlled substance, is available in 158mg, 198mg, and 237mg softgels. Dosage should be individualized based on serum testosterone concentrations.

Jatenzo offers patients a convenient softgel formulation, and eliminates the worry of gel transference, skin irritation from patches, or pain from injections that other testosterone treatments carry, said Dr Ronald S. Swerdloff, lead investigator of the inTUne trial, the pivotal study that established the safety and efficacy of the treatment.

For more information visit jatenzo.com.

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Testosterone Replacement Therapy Market In-Depth Analysis by AbbVie, Inc., Bayer AG, Endo Pharmaceuticals, Inc., Eli Lilly and Company, Kyowa Kirin…

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Testosterone Replacement Therapy Market In-Depth Analysis by AbbVie, Inc., Bayer AG, Endo Pharmaceuticals, Inc., Eli Lilly and Company, Kyowa Kirin...

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Testosterone Replacement Therapy Market Ongoing Research by Top Manufacturers: AbbVie, Inc., Bayer AG, Endo Pharmaceuticals, Inc., Eli Lilly and…

Testosterone Replacement Therapy MarketReport provides a statistical analysis of Testosterone Replacement Therapy Market Global Industry Analysis, Size, Share, Growth, Trends, Outlook, and Forecasts 20202027 present in the industry space. The report helps the user to strengthen decisive power to plan their strategic moves to launch or expand their businesses by offering them a clear picture of this market.

Testosterone Replacement Therapy Market report provides key statistics on the market status of the Testosterone Replacement Therapy manufacturers and is a valuable source of guidance and direction for companies and individuals interested in the industry. The report also presents the vendor landscape and a corresponding detailed analysis of the major vendors operating in the market.

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Competitive landscape

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Key players analyzed in the Testosterone Replacement Therapy market study:AbbVie, Inc., Bayer AG, Endo Pharmaceuticals, Inc., Eli Lilly and Company, Kyowa Kirin International plc, Pfizer, Inc., Acerus Pharmaceuticals Corporation, and Perrigo Company plc.

This Testosterone Replacement Therapy report is very reliable as all the data and the information regarding the fnb industry is collected via genuine sources such as websites, journals, annual reports of the companies, and magazines. This global market research report is likely to show a considerable growth of market in percentage during the forecast period. Key insights of the report are complete and distinct analysis of the market drivers and restraints, major market players involved in this industry, detailed analysis of the market segmentation and competitive analysis of the key players involved.

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Competitive Rivalry-: The Testosterone Replacement Therapy report incorporates the detailed analysis of the leading organizations and their thought process and what are the methodologies they are adopting to maintain their brand image in this market. The report aides the new bees to understand the level of competition that they need to fight for to strengthen their roots in this competitive market.

Principal Research:

The research team works with industry experts from the Global Testosterone Replacement Therapy industry including the management organizations, processing organizations, value chain analytics by service providers of the Testosterone Replacement Therapy market.

Subordinate Research:

In the Secondary research vital information about the Testosterone Replacement Therapy industries value chain, total pool of key players, and application areas. Market separation is done as per the industrial drifts to the deepest level, terrestrial markets and key developments from both market place and technology-oriented viewpoints.

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Competitors

In this section, various Testosterone Replacement Therapy industry leading players are studied with respect to their company profile, product portfolio, capacity, price, cost, and revenue.

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Both, sales and revenue are studied for the different regions of the Testosterone Replacement Therapy Market. Another major aspect, price, which plays an important part in the revenue generation, is also assessed in this section for the various regions.

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In this study, the years considered to estimate the market size of 2018-2026 Keyword Market are as follows:History Year: 2014-2019Base Year: 2019Estimated Year: 2020Forecast Year 2020 to 2027

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Working In Science Was A Brutal Education. Thats Why I Left. – BuzzFeed News

Stephanie Singleton for BuzzFeed News

Do you miss being a scientist? some people ask.

Sometimes.

When people talk about science, they usually mean people in white lab coats doing things, like solving equations on the board or preparing solutions in beakers. What they mean is science as this crude mechanism of discovery by which humans refine over decades and centuries a small kernel of knowing. What they mean is grant dollars. What they mean is wild hair. What they mean is clean, aseptic, analytical. Brainy little robot people. White.

I try to be honest about my time in science about the feeling of satisfaction I had when I plotted all of my confocal data and there was a beautiful curve depicting the drop-off in signal as one moved further down the tissue of the gonad. I think about the calculations we did on scraps of paper to check the ratios of inheritance of the genes we introduced. I think of the little side room where we took our coffee and bagels. I think of the feeling of friendship and family that comes with being in a big lab, where everyone has a place, a role, an expertise, a skill. I remember the surprise I felt when people started to come to me because I knew something, because I could help. And how rare that was for me.

For the better part of several years, I saw my labmates every day. For hours and hours. Every holiday, every break, we stayed. We worked. We supported each other. We fought. We feuded. We gossiped. We threw parties for each other. We celebrated. We said goodbye at graduations and retirements. There were people who supported me and cherished me and looked after me. People who treated me like I mattered. A lab is a family. In a way.

Science was beautiful and it was wild and it was unknowable. Science was spending days and weeks on a single experiment with no way to know if it would work and no real way to tell if it had worked. Science was like trying to find your way to a dark forest only to realize that you had always been inside of the forest and that the forest is inside of another, greater, darker forest. Science was laughing with my labmates about television the night before, about the song of the summer, about tennis, about the unruly nature of mold growing on our plates, about cheap wings at Buffalo Wild Wings. Science was being taught to think. Taught to speak. Science was a finishing school. Science was a brutal education. Science made me ruthless. Science made me understand the vast beauty of the world.

But science was also working 15 hours a day for weeks or months. Science was working weekends and holidays. Science was being called lazy for taking a break. Science was the beat of doubting silence after I answered a question put to me. Science was being told that racism was not racism. Science was being told that I was fortunate that I had running water while growing up and that I was actually privileged because there are some places that do not. Science was being told that I was mistaken for a waiter at a party because I had worn a black sweater. Science was being told that I had to work harder despite working my hardest. Science was being told that I talked too much. Science was being told that I was too loud. Science was being told that I was behind, always behind. Science was being told that I had failed but had been gifted a pass by virtue of who you are. Science was being told that I had never once been to class despite attending every session and office hour because I was mistaken for someone else.

Science was being the only black person in the program for four years. Science was saying nothing because I was tired of being corrected about the particulars of my own experience. Science was being told that I should consider moving to the other side of town where more black people live. Science was someone suggesting that I find a church in order to find community. Science was having my hair stroked and touched. Science was being told that I was articulate. Science was watching peoples eyes widen slightly in surprise when I told them what program I was in. Science was the constant humiliation of wondering if I had justified my presence or if I had made it harder for the next black person to get admitted. Science was having to worry about that in the first place.

Science was a place I ultimately left, not so much because I wanted to, but because I had to. Science is not being able to say that because I reflexively feel the rebuttal waiting on the other end of that sentence: You could have made it work if you wanted it enough. Science is not knowing whether I wanted it enough.

Does science influence your writing?

Oh, sure. I guess.

Do you write science fiction?

No, I write domestic realism.

After the above exchange, people sometimes look at me like Im joking and at any moment will drop the faade to reveal that I do in fact write and love science fiction, after all.

But no, I do not write science fiction. I think that if people knew more scientists and spent significant time in their company, they would understand that the worst possible preparation for a career as a science fiction writer is an intensive science education. My training as a scientist makes it difficult to absent myself in the way I need to in order to write good fiction. I can never turn off the part of my brain that knows about protein folding or microscopy or tissue preparation or stem cells or physics or chemistry. Writing science fiction would be an extended exercise in pedantry.

People presume that science and writing are quite different. But they are both ways of knowing. They are ways of understanding the greater mystery of the world. They are systems of knowledge and inquiry. I do not understand something until I have written it, or more accurately put, until I have written my way through it.

Science was being the only black person in the program for four years. Science was saying nothing because I was tired of being corrected about the particulars of my own experience.

I think in many ways, the best preparation for a writer is a period of prolonged and rigorous thought about a difficult and complicated question. You learn to assemble your resources. You learn to fight with yourself. You learn to quarrel on the page with your worst ideas and with the ones you hold dearest. You treat your expectations with suspicion. You demand proof. You demand evidence. You think hard about the alternate hypothesis or other explanations, and you devise strategies to root these out. You learn to live with doubt. You try to prove yourself wrong. You look for places where you have been too soft. Too vague. You eliminate language that contains falsehoods. You eliminate language that can mislead your reader. You ask questions. You pursue answers with all the energy you can muster. You try to put language to what it is you observe. You develop a stamina for iteration. You develop a thick skin. You learn to seek criticism. You treat criticism like kindness. You churn the raw material of life into something that can be understood, and when you fail, you marvel at the mystery of things.

Do you miss science?

Yes. No. Yes. No.

Sometimes, when I dont feel well, I consider the question of how to derive an expression for the degradation of a molecular species in a particular tissue under a given set of circumstances. Old calculus. I turn to YouTube lectures from MIT about thermodynamics. I think of my first winter in Madison, Wisconsin.

The first snowfall was in October. It had been a hot, rainy summer, so much so that the weather seemed to turn all at once with very little warning. I was either in the middle or at the start of my second rotation as a biochemistry graduate student, working in a biophysical chemistry lab and spending most of my day in the windowless instrument facility in the basement. My project was to deduce the effect of protein concentration on the ability of a polymer of DNA to wind itself. I spent a lot of time pipetting various liquids into each other in little cuvettes, slotting them into a machine, and then waiting for the reading. It was the kind of work to which I felt ideally suited, and I could have gone on that way forever. I had recently moved to the Midwest from Alabama to pursue a PhD, and it seemed as likely as anything else that I would go on pipetting and measuring the effect of things like DNA polymer length and protein concentration on DNA winding. It was as removed from the circumstances of my previous life as anything else, and so I didnt have a compelling reason to doubt that this would be the shape my life held.

But I remember sitting down at the desk in the lab and looking out the broad window. There was a large tree at the center of the courtyard that had recently turned yellow. Fall was there in name, but not in temperature. The labs were kept quite cold, and so I wore a sweater indoors and shucked it as soon as I got outside. But that day, I looked out of the window and saw snow drifting down. The flakes were thick and fluffy, and they seemed almost fake. It was the first time I had seen snow in years, and I was totally enamored by it. The other people in the lab were on edge because snow in October portended something dark and awful a hard winter, a long, brutal freeze. Where they saw inconvenient travel and slushy roads, I saw something beautiful if frivolous, a minor novelty. Winter came early that year, and it didnt end until the very beginning of the following summer. When I went to the lake on my birthday in early June, there was still ice in the water.

People presume that science and writing are quite different. But they are both ways of knowing.

When people ask me about my time in science, it is this day which presents itself to me in jewel-like clarity. It is the day something about my life altered irrevocably. Or perhaps it is that the snow has accumulated, the way all such moments do in life, the weight of meaning, of prophecy. Inevitability is an artifact of retrospection. It is because the snow represented a stark deviation from the previous course of events in my life, at the precise moment when my life was changing so wildly, that I remember it. It is not that the snow changed me, but it came at a point when I was starting not to resemble myself. I cannot use the snow to explain to people what my life was like in science. It has the whiff of superstition, folklore. It feels too much like a memory and not enough like an answer. I do not tell them about the snow or how it seemed a benediction at the outset of something I needed desperately to work.

It was only later that I realized this was wishful thinking, and that the snow was just snow.

Do you think youd ever go back to science?

That part of my life is over now.

Ive come to understand that what people want in such a situation is to have their own conceptions of the world confirmed. That is, they want me to say that when you leave science because you have written a novel and a book of stories and have decided to attend an MFA program in creative writing, you are doing something that is antithetical to science. People presume that it is akin to picking up and leaving your home in the middle of the night under great duress, never to return. What they want is the spectacle of the forgotten treasured item, the confirmation that something has been lost, perhaps forever.

I think if people knew what it was that I left, then theyd know better than to ask. It would be like asking someone if they were sad to have left their home with no prospect of returning. It would be like asking someone if they were sad to have left their faith behind. It would be like asking someone if they were sad to have given up some fundamental idea about who they are. It would be like asking someone if they were sad to have watched their life burn to the ground. It would be like asking someone if they were sad to have left their family and friends.

They would mind their own business if they knew.

But they do not know, and so they say things like Science, wow, thats so cool, like, do you miss it?

And I smile because that is what I have learned to do. Because explaining is too hard. Too messy. There is no clean or easy or simple way to make it known to others that I left because I had to, because it was necessary to leave that I do miss it, but I also dont because Im still that person but not that person, that every day I remind myself less of the person I was then. Its sad, like losing a memory of myself, and all those years are lost to me now, all the little tricks and habits of home dropping down and away, as I become this other person known for this other thing, and its too much in the moment to say that I miss it both more and less every day, that I become a person more capable of appreciating what is lost in the grand scheme of things but less a person who knows what it is Ive actually lost, and that there is some painful, brutal, awful misalignment in the scale of those two losses.

When people ask if I miss science, the only answer available to me is an incomplete solution to the problem: Yes. No. Sometimes. Its over now.

Brandon Taylor is the senior editor of Electric Literatures Recommended Reading and a staff writer at Literary Hub. His writing has earned him fellowships from Lambda Literary Foundation, Kimbilio Fiction, and the Tin House Summer Writer's Workshop. He holds graduate degrees from the University of Wisconsin-Madison and the University of Iowa, where he was an Iowa Arts Fellow at the Iowa Writers Workshop in fiction. Learn more about his first novel Real Life here.

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The Really Good And Really Bad News On Lifelong Learning – Forbes

There is light at the end of the tunnel for lifelong learning, but not for the reasons you may ... [+] think.

We are now closer to the year 2050 than the year 1990. Let that sink in for a bit and along with it try to contemplate the massive talent development revolution we will face in the next 30 years. With rapidly changing technology, the speed at which businesses must operate to be competitive in a global economy and with human life expectancy rising steadily, its clear that lifelong learning will become essential for humans to remain relevant in the workplace. The bad news is theres little evidence that lifelong learning can be taught and that any organization thus far has mastered it for their own human resource needs. The good news is that those hard truths might not matter anymore simply because lifelong learning will be thrust upon us as a staple of everyday work life. It will no longer be optional or aspirational; it will be a necessity and ubiquitous.

Weve already heard some of the statistics that project people will have as many 15 different jobs over their working lifetime. And we know the shelf-life of technical skills, such as software development, are getting shorter and shorter. Then theres the recent IBM report that predicts more than 120 million people will need up-skilling or re-skilling in the next three years and that the average length of training needed to close skills gaps has increased from 3 days to 36 days in just five years time. On top of the fast-changing marketplace of jobs and technology, theres also the coming impact of human longevity. Projections from a 2015 United Nations report indicate that average lifespans in the U.S. will reach 95 years for females and 90 years for males in the U.S. by 2050. Another report from 2012 indicated that 1/3 of babies born that year will live to 100. If it becomes common for people to live to 100 (or beyond), it will also become common for them to retire in their 80s extending their working years dramatically.

How will we grapple with all this? Its hard to fathom. But whats clear is that we need to build and operate a talent development system that is closer to the 2050 version than to the 1990 (or dare I say 1890) model we have now. Lifelong learning has long been a stated ambition of colleges and universities. The words lifelong learning are among the most commonly used in college mission statements. Given that, we ought to have ample outcome measures that demonstrate how graduates become lifelong learners. The truth is, we dont. Searching for evidence of lifelong learning is a little like the search for evidence of life on Mars; many scientists believe well eventually find it, but so far we havent.

Through an analysis of responses from more than 250,000 U.S. adults conducted by Gallup, there was no difference in the likelihood of respondents saying they learn or do something interesting each day across high school drop-outs, high school graduates, associates degree holders and bachelors degree holders. The only group that was statistically more likely to say so were those with post-graduate education. Other Gallup research arguably its most profound and influential of all on innate talent and strengths-based development, makes a strong case that some humans are born with learner talent. That is, learning comes more intuitively and naturally to them than it does to others. My current thesis about why post-graduate degree holders are more likely to report lifelong learning is two-fold. First, they are simply more likely to be those innate learners. And, second, post-graduate education involves more applied learning and in-depth research work than the typical undergraduate education.

If its the case that not even bachelors degrees are guarantees for becoming lifelong learners, how will we ever get our entire workforce there? The answer is a hopeful one because the question has rather suddenly been rendered moot. A quick look around our world today and a peek onto the horizon of 2050 tells us so. The expression necessity is the mother of invention is rather apropos here. Well bring the invention of lifelong learning to fruition once and for all because of outright necessity.

Colleges, for example, can no longer hope that lifelong learning magically happens for graduates after 4 years of study; they have to extend their roles by getting directly involved in delivering it for graduates next 40 to 60 years of their careers. Employers can no longer assume that a sprinkling of compliance training, some occasional professional development and some sporadic technical re-skilling will turn their human capital into lifelong learners. It will require them to transform everything from how hours are spent during the workday to how continual learning and education will be financed. What every CEO will soon realize is that business transformations require human capital transformations. And once that realization sinks in, we will all become lifelong learners whether we like it or not.

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Are stem cells really the key to making humans live longer? – Wired.co.uk

To some longevity acolytes, stem cells promise the secret to eternal youth. For a hefty fee, you can pay a startup to extract your own stem cells and cryogenically freeze them, in the hope that they can one day be used in a treatment to help extend your life.

Other firms let you bank stem cells from your babys umbilical cord and placenta after childbirth, if youre convinced the high cost represents an insurance policy against future illness. Or you can follow the example of Sandra Bullock and Cate Blanchett and opt for an anti-ageing cream made with stem cells derived from the severed foreskins of newborn babies in South Korea.

Stem cells are the parent cells which give rise to other cells in our bodies. Since scientists first isolated human embryonic stem cells in a lab and grew them over 20 years ago, they have been mooted as a source of great hope for regenerative medical treatments, including for age-related degenerative conditions such as Parkinsons, Alzheimers, heart disease and stroke.

But apart from a few small-scale examples, the only stem cell-based medical treatment practised in clinics uses haematopoietic stem cells found in the blood and bone marrow which only produce blood cells for transplants in blood cancer patients. These cells are taken from a patients sibling or an unrelated donor, before being infused into a patients blood, or theyre taken from a patients own blood before being reinfused. The procedure has been used to treat blood malignancies for almost half a century, and recently multiple sclerosis too. So how likely is it that the predictions about stem cells' longevity-enhancing powers will become a reality?

In September 2019, Google banned ads for unproven or experimental medical techniques such as most stem cell therapy, citing a rise in bad actors attempting to take advantage of individuals by offering untested, deceptive treatments [that can often] lead to dangerous health outcomes. The decision was welcomed by the International Society for Stem Cell Research, which emphasised that most stem cell interventions remain experimental. Selling treatments before well-regulated clinical trials have been done, the body said, [threatens public] confidence in biomedical research and undermines the development of legitimate new therapies.

Its easy to see how less scrupulous companies can exploit the allure of stem cells, which seem to occupy a place in our collective consciousness as a kind of magical elixir. High hopes for stem cell-based therapies have grown since 2006, when the Japanese biologist Shinya Yamanaka created a new technology to reprogram adult cells, such as skin cells, into a similar state to embryonic stem cells, which are pluripotent, meaning they can develop into any tissue in the body. The Nobel prize-winning breakthrough was hailed as a major step in the study of stem cells without the need for controversial embryo research, and towards the use of these human induced pluripotent stem cells to regenerate damaged or diseased organs or effectively grow new spare parts which could treat the life-limiting and life-shortening illnesses associated with ageing.

Gerontologist Aubrey de Grey, whose Strategies for Engineered Negligible Senescence (SENS) research foundation aims to eliminate ageing-related diseases, thinks the chances well soon have stem cell based therapies are high. For anything that's in clinical trials, you're talking about maybe five years before it's available to the general public, he says, citing stem cell treatments for Parkinsons disease, currently being tested in phase two clinical trials, as one of the developments he thinks is likely to come soonest.

However, given that these trials involve a relatively small number of participants and most clinical trials ultimately fail, his predictions might be overly optimistic. Often described as a maverick, De Grey believes that humans can live forever and there is a 50 per cent chance medical advances of which stem cell therapies will play an important part will make this a reality within the next 17 years. Though living forever, he says, is not the ultimate goal but a rather large side effect of medicine which will successfully prevent or repair the damage that comes with ageing.

For New Jersey-based Robert Hariri, who co-founded Human Longevity Inc, which set its sights more modestly on making 100 the new 60, stem cells derived from placentas present especially exciting opportunities. A biomedical scientist, surgeon and entrepreneur, Hariri says his current venture Celularity which is focused on engineering placental cells, including stem cells, to create drugs for cancer and other conditions is not as concerned about the actual age number, but about preserving human performance as we age and treating the degenerative diseases that rob us of our quality of life.

Many of those working in the field, however, remain cautious in their optimism. Researchers have highlighted the potential risks of giving pluripotent cells to patients, whether they are induced or embryonic, as these cells can develop cancer-causing mutations as they grow.

Davide Danovi, a scientist at Kings College Londons Centre for Stem Cells & Regenerative Medicine, says the path to stem cell-based therapy is very long and full of hurdles. The supply chain involves challenges, he says. On the one hand, allogeneic treatments those with stem cells derived from one individual and expanded into big batches to create cells to treat many individuals have the advantage of being similar to the traditional pharmaceutical business models. The product is clear, its something that comes in a vial and can be scaled up and mass produced, Danovi says. But this treatment can present a greater risk of rejection from the patient, as opposed to the more bespoke autologous option which is more expensive and time-consuming as it involves extracting a patients own stem cells before reprogramming them.

Danovi is most excited by the potential of stem cells to treat age-related macular degeneration. In 2017 Japanese scientist Masayo Takahash led a team that administered transplants of artificially grown retinal cells created from induced pluripotent stem cells taken from donors to five patients with the eye condition, which can cause blindness, and theyre reported to be doing well. The eye, he says seems to be a place where immunity plays less of a role relative to other issues, so you can host cells which come from another individual with fewer problems [of rejection]. But, with other organs such as the liver, he says there are major conceptual problems with creating enough tissue. Its like the clean meat burger - you're talking about a production that is, in many cases, not easy to reach with the current technology.

Hariri believes placentas will solve some of the production challenges crucially, theyre an abundant commodity, with the vast majority thrown out after childbirth. His interest was sparked 20 years ago when his oldest daughter was in the womb: When I saw her first ultrasound in the first trimester, the placenta had already developed into a relatively sizable organ, even though she was just a peanut-sized embryo. Id been taught that the placenta was nothing more than an interface, but [if that was the case], you would expect that it would grow at the same rate as the embryo. His curiosity piqued, he began to see the placenta not as an interface but as a biological factory, where stem cells could be expanded and differentiated to participate in the development of that foetus. That intrigued me and I started to collect placentas and just, you know, basically disassemble them.

Placentas have numerous benefits, he says they dont carry the same ethical controversy as embryonic stem cells, for one thing. Scientists working on embryonic stem cells have to destroy an early embryo, and that option yields them a dozen cells, which have to be culture-expanded in the laboratory into billions of cells. In contrast, the placenta houses, billions and hundreds of billions of cells, which can be expanded as well, but you're starting out with a dramatically larger starting material.

Increasingly, scientists in the anti-ageing sphere are focusing on an approach that seems like the opposite of planting fresh stem cells into our bodies. Experts such as Ilaria Bellantuono at Sheffield Universitys Healthy Lifespan Institute are working towards creating senolytics medication that could kill off our senescent cells, the zombie cells that accumulate in tissues as we age and cause chronic inflammation. I think stem cells are very good for specific disease, where the environment is still young, Bellantuono says, but the data in animal models tells us that senolytics are actually able to delay the onset and reduce the severity of multiple diseases at the same time for example, there is evidence for osteoarthritis, osteoporosis, cardiovascular disease, Alzheimer's, Parkinson's, and diabetes. She explains that while human trials are still in their early stages, senolytics are likely to be more cost-effective than stem cell therapy and the status quo of older patients taking multiple pills for multiple diseases, which can interact with each other. Besides, she adds, they may actually work in tandem with stem-cell based therapies in the future, with senolytics creating a more hospitable environment in tissues to allow stem cells to do their work.

And as for the so-called penis facial? Its far from the only ultra-expensive stem cell skincare making bold anti-ageing claims but youre probably better off saving your money, as you are with the experimental medical treatments on offer. Stem cells are definitely exciting but theyre not the key to eternal youth. At least, not yet.

Robert Harari will be one of the speakers at WIRED Health in London on March 25, 2020. For more details, and to book your ticket, click here

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Marketing To 100-Year-Olds: How Longevity Will Transform Finance, Healthcare And Education – Forbes

Right now, Stanford University is addressing a pressing and fascinating question:

What happens to society when everyone starts living to 100? How will we stay physically fit, financially stable and mentally sharp, especially in that back half?

Exploring these questions is the goal of the Stanford Longevity Project. To answer them, theyve partnered with major brands like Wells Fargo, Instructure, and Principal to help research key elements like financial security, lifelong learning, and healthcare.

Despite Americas average life expectancy declining the past couple years due to more overdoses, suicides and alcohol-related illnesses, people are going to be able to live longer. Strong advancements have been made in cancer. This month, the U.S. saw its sharpest one year decline in cancer death rate. That will save millions of lives alone.

But this isnt just a health and wellness conversation. What this presents are multiple opportunities in multiple verticals for marketers.

One of the biggest trends at CES this month was a new generation of healthcare wearables. There were earbuds designed to detect blood pressure for those with hypertension, temporary tattoos that tell you when to get out of the sun, smart glasses that assist people with dyslexia and watches that detect sleep apnea. These technologies are all discreet, easy to use, and built in to everyday things we already use.

We are heading toward a near future in which every human body will have a functioning check engine light. You can imagine how much better healthcare will be when a sensor will tell you something needs attention, rather than panicked scrolling through WebMD.

We will have the ability to know when something is wrong and immediately trigger tests, medication and treatment. Imagine if that sensor, using the IoT, could immediately send and fill a prescription for you.

This is all coming down the pipeline, and its going to help us live longer. Its also going to change the way marketers do their jobs and open up countless new opportunities to reach new audiences.

Heres what some of those opportunities will look like.

Cincinnati has one of the best healthcare startup scenes in the country. Cincinnati Childrens Hospital is ranked #3 nationally. CincyTech has raised nearly a billion in healthcare follow-on investment over the past ten years.

The common thread these organizations share is they are tackling high-use issues in different ways. That includes everything from small, wearable, injectable devices (Enable Injections) that can be used for a multitude of conditions, to analyzing peoples sweat to ensure proper medication dosing (Eccrine Systems).

One of the most interesting might be Sense Diagnostics because their simple device addresses a huge need: stroke detection. Right now there isnt a good way to tell which kind of stroke (transient ischemic, ischemic, or hemorrhagic) someone is having in the field. An ambulance with this non-invasive device will be able to quickly diagnose which stroke is occuring, allowing them to begin the best possible treatment immediately.

As people begin living longer, well see that the traditional approach to education and work must change. A longer living workforce will be more likely to need to reskill for second and third careers.

Private equity firm Thoma Bravo is buying Instructure (makers of the popular Canvas Learning Management System) for $2 billion, precisely because of the projected growth and opportunity in education as people extend their careers.

Of course, four-year higher education will still exist. But new avenues and approaches to learning will emerge as supplemental or alternative ways of reskilling for jobs that will target people in their 60s, 70s, and 80s.

Curricula will obviously also have to adapt, becoming more flexible, personalized, and life-long. Being able to brush up every three months on relevant skills via a subscription model may be a better future model for education than entering a full-time program. Most of the marketing opportunities will be around aiding employers, because they have the budgets and the competition for retention.

Living longer changes a persons entire financial strategy.

Most standard retirement principles assume that retirement will last a maximum of 30 years. The commonly-used "4% rule" of retirement is an example of this. However, if you live to 100 or beyond, your retirement could last 35 years, 40 years, or longer, said Nathan Hamilton, director and industry analyst at The Ascent from The Motley Fool.

A deferred annuity could be worth a look. Essentially, you put some money into an annuity when you first retire (or earlier), but that won't start paying out until a certain agesay, 80 or 85. The idea is that even if your retirement nest egg is getting low as you get older, this move guarantees you a predictable income stream for life.

How we invest may also change as we look to create steady income streams that kick in throughout retirement rather than just upfront. This also may inevitably cause people to work later and longer especially as our workforce trends farther away from physical labor to more mental and creative labor.

The biggest takeaway here isnt that living longer will impact one thing. It will impact everything.

As humans, we need to think about that for ourselves and our future generations. And as marketers and entrepreneurs, we can start thinking about ways we can make that reality better, more productive, and more secure for people.

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6 habits of highly healthy brains – Ladders

The relationships between our brain and body and the world around us are complex. What you do or dont do can significantly change how your health and wellbeing.

A healthy brain is determined by both biological and physiological factors genes, hormones, the immune system, nutrition, exercise, and other lifestyle choices.

Social, psychological and environmental factors including relationships, stress, emotions, mindset, life events and current circumstances also contribute to your brain health.

Each element can impact others in a multi-directional and dynamic way. Example, your thoughts can influence your physical health (which is why chronic stress can lead to abnormal heart rhythms or heart attacks).

Everyone wants to live an active, vibrant life for as long as possible. And that goal depends on robust brain health. You cant do much about your genes, but other physiological, social and environmental factors can be modified to improve your brain.

Our brains naturally decline if we do nothing to protect them. However, if we intervene early, we can slow the decline process its easier to protect a healthy brain than to try to repair damage once it is extensive.

You can improve your lifestyle habits to promote a highly healthy brain one free of physical or mental illness, disease, and pain. We have more control over our ageing brains than we realise.

These habits are just a reminder you already know the importance of these lifestyle choices. It pays to make a conscious effort to help yourself your brain will thank you.

That means eating lots of foods associated with slowing cognitive decline blueberries, vegetables (leafy greens kale, spinach, broccoli), whole grains, getting protein from fish and legumes and choosing healthy unsaturated fats (olive oil) over saturated fats (butter).

The connection between what goes into your body and how your brain performs is a strong one. The best diet should also be good for your brain, your heart and blood vessels.

Omega-3 fats from fish or nuts fight inflammation associated with neurodegeneration. Fruit and vegetables combat age-related oxidative stress that causes wear and tear on brain cells, says Dr Gary Small, a professor of psychiatry and ageing, and director of the Longevity Center at the Semel Institute for Neuroscience & Human Behavior, University of California, Los Angeles.

Find your moment or place of calm and separate yourself from chronic stress.

Chronic stress can change the wiring of our brains.Stress shrinks the brains memory centres, and the stress hormone cortisol temporarily impairs memory, says Dr Small.

To reverse stress and improve your mood and memory, adopt relaxation methods like meditation. Meditation even rewires the brain and improves measures of chromosomes telomere (protective cap) length, which predicts longer life expectancy argues Dr Small.

Find your place or moment of calm, and do something pleasurable that makes you come alive a personal passion project can help you destress.

Physical activity is one of the best things you can do for your brain and body. You already know the countless benefits of exercising.

Dozens ofresearchhave found that that nearly any type of physical activity walking, running, cycling, minimal weight-lifting and even mindful exercise such as yoga contribute to improved cognitive performance.

Exercise stimulates the brain to release brain-derived neurotrophic factor (BDNF), a molecule essential for repairing brain cells and creating connections between them.

Physical activity also boosts endorphins, which can lift your mood. Aerobic exercise helps improve the health of brain tissue by increasing blood flow to the brain and reducing the chances of injury to the brain from cholesterol buildup in blood vessels and from high blood pressure, says Dr Joel Salinas, a neurologist at Harvard-affiliated Massachusetts General Hospital.

A simple walk outdoors gets you away from digital devices and into nature. Youll do your best thinking when walking.

Stimulating and challenging the brain helps it stay fit and firing. Spend some time in new thoughts.

To improve your brain health, try to do one activity that challenges the mind every day spend some time in new thoughts. The desire to learn and understand other people, ideas, cultures and concepts can boost your brain.

higher cognitive activity endows the brain with a greater ability to endure the effects of brain pathologies compared to a person with lower cognitive engagement throughout life, says David S. Knopman, M.D., a clinical neurologist involved in research in late-life cognitive disorders.

Lifelong learning and mentally challenging work build cognitive reserve. Find reasonably challenging activities you can practice regularly try activities that combine mental, social and physical challenges.

Were social creatures meaningful social connections make us happier. Happiness makes your brain work better.

Psychological studies show that conversation stimulates the brain. It may seem effortless to many, but it requires a complex combination of skills including attention, memory, thinking, speech and social awareness.

Astudypublished in theAmerican Journal of Public Healthfound that better social interaction can help protect the brain against dementia and Alzheimers.

Social connections are as important to our flourishing as the need for food, safety, and shelter. The urge to connect is a life-long human need.

Matthew Lieberman, a social psychologist, neuroscientist, and author ofSocial: Why Our Brains Are Wired to Connect,sees the brain as the center of the social self. He writes in his book, Its hard to find meaning in what we do if at some level it doesnt help someone else or make someone happier.

Researchers at the Oregon Health & Science University and the University of Michigan havesuggestedthat human interaction and conversation could be the keys to maintaining brain function as we grow older.

Supportive friends, family and social connections helps you live longer, happier and healthier. Socialising reduces the harmful effects of stress

Sleep is the number one, fundamental bedrock of good health. A good night sleep every night should be a priority, not a luxury.

Without good sleep, we see increased anxiety and stress. Sleep is restorative, helping you be more mentally energetic and productive, advises Sandra Bond Chapman, Ph.D., founder and chief director of the Center for BrainHealth at the University of Texas at Dallas and author ofMake Your Brain Smarter.

Apart from getting a good and quality night sleep, make time for wakeful rest it pays to plan breaks in between your busy schedule. Plan downtime on your calendar.

After a busy day, give your brain time to recover sit back, close your eyes and let your mind wander (spontaneous thought in our wakeful life) in the knowledge that your brain is busy consolidating information.

In a study onBoosting Long-Term Memory via Wakeful Rest,the authors found that wakeful rest without any external stimulation allows the brain to consolidate the memories of what it has learned.

It is never too early or too late to start living more healthily. Your daily habits have more impact on how long and how well you live plan to eat well, take short walks, engage in mental stimulation, and manage your social connections for better brain health.

This article first appeared on Medium.

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Rising stress levels will drop the average body temperature – The Daily Titan

Between December and February, the flu is at an all-time high. There are some who are coughing, sneezing or going through terrible headaches as they get through their everyday lives.

According to the United States Centers for Disease Control and Prevention, people are most likely to experience the flu for three to four days. In that time span, there is a correlation between handling illness and the way body temperature reflects on this notion.

The average human body temperature is 98.6 degrees Fahrenheit. However, recent studies have analyzed the average human body temperature has dropped to 97.5 to 97.9 degrees Fahrenheit.

Scientists question whether the change in body temperature is the result of the change in physical longevity and body type of the normal human body.

Although the research is still developing, a change in body temperature clearly reflects a persons health given their current environment and could possibly show the immune systems ability to adapt.

According to the International Journal of Biometeorology, the change in core body temperature correlates to heart rate and skin temperature affected through different environmental and working conditions.

A study by Stanford Medicine stated that the decline in body temperature goes back to after the events of the Civil War. During that time, those who were born in the early 1800s had a much higher body temperature by 1.06 degrees Fahrenheit than the average human born during the 1990s.

In the case of the academic environments, such as college, there is a heavy correlation to students ways of coping to get over the flu with their studies and their overall body temperature.

The concept of health and academics clash. With the way students study for finals, projects and other forms of assignments that need to be finished at a discrete deadline, a healthy lifestyle is usually not followed.

The stresses of everything in life tend to weaken your immune system. (Students are) getting less sleep dealing with everything else that theyre going to end up weakening their immune system where they get sick and are just exacerbating the problem, said Richard Coulter, history major.

The idea of putting too much stress on studying not only damages a students psychological health, but also their physical health.

Todays academic culture thrives with succeeding in classes at the cost of students physical well-being. Whether were arrogant in not taking the right medication or not sleeping enough, the idea of self-care seems non-existent within the academia.

Coulter also said students shouldnt take their academics too harshly in the face of coming down with the flu while studying.

Dont overwork yourself because those stresses (with your academics) are whats going to make that time of year so much more miserable, Coulter said.

There are ways the cold or flu can be remedied for a persons health so they dont have to further get sick or catch another flu virus; especially when there are people who are always busy throughout the day.

Though methods of feeling better may vary, there are some who say medicine, such as Tylenol, gets the job done.

Marketing major Maxwell Baranoff said, Go to the store, get some Tylenol, get over it, when asked about his method of getting over the flu.

Yet there are those who say hot drinks and various forms of health devices help battle the flu.

Ive been drinking so much tea, I got a humidifier for my throat, said Shantay Alvarez, psychology major.

Considering the correlation with body temperature and health, its important for anyone, especially college students, to consider their body temperature next time they come down with the flu.

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Anti-Senescence Therapy Market- A comprehensive assessment of current dynamics and emerging avenues – News Parents

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The key players profiled in this report include: Unity Biotechnology, Siwa Therapeutics, Calico LLC, AgeX TherapeuticsInc, Numeric Biotech, Human Longevity Inc. (HLI), Cleara Biotech, OisinBiotechnologies, Recursion Pharmaceuticals, Sierra Sciences, Proteostasis Therapeutics, Senolytic Therapeutics, Allergan

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