Page 11234..1020..»

A protein puzzle game called Foldit turns up 99 promising ways to confound coronavirus – GeekWire

This is one of the high-scoring protein designs that will be turned into an actual protein binder for testing as an coronavirus-blocking agent. (Stomjoh via Foldit / UW Institute for Protein Design)

Who would have thought a video game could identify potential treatments for COVID-19? Researchers at the University of Washingtons Institute for Protein Design certainly thought so, and so far the game has produced 99 chances to win.

The game is a protein-folding puzzler called Foldit, which was created at UWs Center for Game Science more than a decade ago and has attracted nearly more than 750,000 registered players since then.

Foldits fans find ways to twist virtual protein structures into all sorts of contortions. Some of those contortions turn out to have therapeutic value, which can raise a players score in the game. And that can have real-world implications for countering the coronavirus.

On the cellular level, protein structures can switch on biological processes, or act as keys to spring open the locks that protect cells from harm. For example, the coronavirus that causes COVID-19, known as SARS-Cov-2, has a spike-like protein structure thats particularly well-shaped for unlocking a cells defenses and getting inside to do its dirty work.

Once researchers mapped the virus shape, the Institute for Protein Design set up a challenge for Foldits players. They were tasked with folding virtual proteins into shapes that could latch onto the coronavirus skeleton key and gum it up, rendering it useless for a cellular break-in.

Thousands of designs were submitted and scored over the course of three rounds of competition. Now the institutes researchers have selected 99 designs, 33 from each round, that will be turned into real-world proteins known as binders for testing as antiviral agents.

It will be a few more weeks before genes arrive and we can begin experiments on the Foldit designs, Brian Koepnick, a UW biochemist who focuses on Foldit, told players in blog post. In the meantime, well continue to work on designing better binders in Foldit.

In an earlier blog post, Koepnick cautioned players that the synthetic proteins dont always work as well in the real world as they do in Foldits computer-generated chemistry lab.

Protein binder design is a very hard problem one at the forefront of computational biology and there are other physical factors that are difficult to account for, he wrote. Even if our metrics look good on paper or on a computer, only laboratory testing will tell us whether these designer proteins actually fold and bind to the target.

But if the institute can turn one of the 99 designs into a workable drug that can stop coronavirus in its tracks, Foldit players wont be the only winners.

To get in on the game, head on over to the Foldit website, download the software and follow the instructions. After you get a feel for the game by playing the tutorials, check out this 49-minute video for tips on tackling the coronavirus puzzles.

Update for 11:35 p.m. PT April 1: Weve updated some outdated figures for the number of registered Foldit players.

View original post here:
A protein puzzle game called Foldit turns up 99 promising ways to confound coronavirus - GeekWire

Recommendation and review posted by Alexandra Lee Anderson

Read the Rest...

Q&A: Markus Buehler on setting coronavirus and AI-inspired proteins to music – MIT News

The proteins that make up all living things are alive with music. Just ask Markus Buehler: The musician and MIT professor develops artificial intelligence models to design new proteins, sometimes by translating them into sound. His goal is to create new biological materials for sustainable, non-toxic applications. In a project with theMIT-IBM Watson AI Lab, Buehler is searching for a protein to extend the shelf-life of perishable food. In anew studyin Extreme Mechanics Letters, he and his colleagues offer a promising candidate: a silk protein made by honeybees for use in hive building.

Inanother recent study, in APL Bioengineering, he went a step further and used AI discover an entirely new protein. As both studies went to print, the Covid-19 outbreak was surging in the United States, and Buehler turned his attention to the spike protein of SARS-CoV-2, the appendage that makes the novel coronavirus so contagious. He and his colleagues are trying to unpack its vibrational properties through molecular-based sound spectra, which could hold one key to stopping the virus. Buehler recently sat down to discuss the art and science of his work.

Q:Your work focuses on the alpha helix proteins found in skin and hair. Why makes this protein so intriguing?

A: Proteins are the bricks and mortar that make up our cells, organs, and body. Alpha helix proteins are especially important. Their spring-like structure gives them elasticity and resilience, which is why skin, hair, feathers, hooves, and even cell membranes are so durable. But theyre not just tough mechanically, they have built-in antimicrobial properties. With IBM, were trying to harness this biochemical trait to create a protein coating that can slow the spoilage of quick-to-rot foods like strawberries.

Q:How did you enlist AI to produce this silk protein?

A:We trained a deep learning model on the Protein Data Bank, which contains the amino acid sequences and three-dimensional shapes of about 120,000 proteins. We then fed the model a snippet of an amino acid chain for honeybee silk and asked it to predict the proteins shape, atom-by-atom. We validated our work by synthesizing the protein for the first time in a lab a first step toward developing a thin antimicrobial, structurally-durable coating that can be applied to food. My colleague,Benedetto Marelli, specializes in this part of the process. We also used the platform to predict the structure of proteins that dont yet exist in nature. Thats how we designed our entirely new protein in the APL Bioengineering study.

Q: How does your model improve on other protein prediction methods?

A: We use end-to-end prediction. The model builds the proteins structure directly from its sequence, translating amino acid patterns into three-dimensional geometries. Its like translating a set of IKEA instructions into a built bookshelf, minus the frustration. Through this approach, the model effectively learns how to build a protein from the protein itself, via the language of its amino acids. Remarkably, our method can accurately predict protein structure without a template. It outperforms other folding methods and is significantly faster than physics-based modeling. Because the Protein Data Bank is limited to proteins found in nature, we needed a way to visualize new structures to make new proteins from scratch.

Q: How could the model be used to design an actual protein?

A: We can build atom-by-atom models for sequences found in nature that havent yet been studied, as we did in the APL Bioengineering study using a different method. We can visualize the proteins structure and use other computational methods to assess its function by analyzing its stablity and the other proteins it binds to in cells. Our model could be used in drug design or to interfere with protein-mediated biochemical pathways in infectious disease.

Q:Whats the benefit of translating proteins into sound?

A: Our brains are great at processing sound! In one sweep, our ears pick up all of its hierarchical features: pitch, timbre, volume, melody, rhythm, and chords. We would need a high-powered microscope to see the equivalent detail in an image, and we could never see it all at once. Sound is such an elegant way to access the information stored in a protein.

Typically, sound is made from vibrating a material, like a guitar string, and music is made by arranging sounds in hierarchical patterns. With AI we can combine these concepts, and use molecular vibrations and neural networks to construct new musical forms. Weve been working on methods to turn protein structures into audible representations, and translate these representations into new materials.

Q: What can the sonification of SARS-CoV-2's "spike" protein tell us?

A: Its protein spikecontains three protein chains folded into an intriguing pattern. These structures are too small for the eye to see, but they can be heard. We represented the physical protein structure, with its entangled chains, as interwoven melodies that form a multi-layered composition. The spike proteins amino acid sequence, its secondary structure patterns, and its intricate three-dimensional folds are all featured. The resulting piece is a form of counterpoint music, in which notes are played against notes. Like a symphony, the musical patterns reflect the proteins intersecting geometry realized by materializing its DNA code.

Q: What did you learn?

A: The virus has an uncanny ability to deceive and exploit the host for its own multiplication. Its genome hijacks the host cells protein manufacturing machinery, and forces it to replicate the viral genome and produce viral proteins to make new viruses. As you listen, you may be surprised by the pleasant, even relaxing, tone of the music. But it tricks our ear in the same way the virus tricks our cells. Its an invader disguised as a friendly visitor. Through music, we can see the SARS-CoV-2 spike from a new angle, and appreciate the urgent need to learn the language of proteins.

Q: Can any of this address Covid-19, and the virus that causes it?

A:In the longer term, yes. Translating proteins into sound gives scientists another tool to understand and design proteins. Even a small mutation can limit or enhance the pathogenic power of SARS-CoV-2. Through sonification, we can also compare the biochemical processes of its spike protein with previous coronaviruses, like SARS or MERS.

In the music we created, we analyzed the vibrational structure of the spike protein that infects the host. Understanding these vibrational patterns is critical for drug design and much more. Vibrations may change as temperatures warm, for example, and they may also tell us why the SARS-CoV-2 spike gravitates toward human cells more than other viruses. Were exploring these questions in current, ongoing research with my graduate students.

We might also use a compositional approach to design drugs to attack the virus. We could search for a new protein that matches the melody and rhythm of an antibody capable of binding to the spike protein, interfering with its ability to infect.

Q: How can music aid protein design?

A: You can think of music as an algorithmic reflection of structure. Bachs Goldberg Variations, for example, are a brilliant realization of counterpoint, a principle weve also found in proteins. We can now hear this concept as nature composed it, and compare it to ideas in our imagination, or use AI to speak the language of protein design and let it imagine new structures. We believe that the analysis of sound and music can help us understand the material world better. Artistic expression is, after all, just a model of the world within us and around us.

Co-authors of the study in Extreme Mechanics Letters are: Zhao Qin, Hui Sun, Eugene Lim and Benedetto Marelli at MIT; and Lingfei Wu, Siyu Huo, Tengfei Ma and Pin-Yu Chen at IBM Research. Co-author of the study in APL Bioengineering is Chi-Hua Yu. Buehlers sonification work is supported by MITs Center for Art, Science and Technology (CAST) and the Mellon Foundation.

Q&A: Markus Buehler on setting coronavirus and AI-inspired proteins to music - MIT News

Recommendation and review posted by Alexandra Lee Anderson

Read the Rest...

Routines are healthy – Argonaut

During this challenging time within our community, it can be difficult to remain in a routine and stay motivated. With numerous benefits to maintaining a routine, one main benefit is preserving our mental health.

Even though students are not constrained to a consistent class schedule, it is important to keep a routine. This can be as easy as planning to have meals around the same time every day and sticking with a consistent sleep schedule. With so much uncertainty, it is easy to feel out of control, however, having a routine allows us to feel more in control. Sleep is crucial to our mental state and it affects all of our overall well-being. Making sure to have downtime for ourselves is necessary, and it is likely that our days will be more productive and happier.

The word routine may sound daunting to some, but having a routine to keep the important stuff a priority is extremely beneficial. Whether this be rest time, exercising, socializing with friends or family, these things are what keep our mental health in check.

Another addition to a good daily routine is exercise. Sometimes life can be hectic, and it can be hard to fit things in such as exercise and rest, but these aspects have a huge impact on our day to day lives.

Exercise can boost our mood and if we feel able to make time to be active, it can bring about many positive aspects. Many of our campus buildings such as the Student Recreation Center are closed, and as we continue to adjust to these challenging times it can be hard to switch things up. At home workouts or fun activities can substitute for these changes.

One last activity that is helpful is eating a healthy diet. Eating foods that provide energy and nutrition is essential to having a healthy lifestyle. Working extra time into a routine for cooking and eating enables us to focus on our eating habits. When times are busy it can be easy to avoid cooking nutritional meals and eating well at consistent times, but if theres time blocked in a daily routine, it becomes a priority.

Maintaining a routine is essential to maintaining mental well-being and it is something that is important to focus on during this hard time. Having a routine allows us to keep important things prioritized and it can provide a sense of control in this state we are all living in.

It is difficult adjusting to the new normal, so know that many resources available such as the Counseling and Testing Center and VandalCARE Report. As well as these resources, the Vandal Health Education social media pages are a great way to find tips on enhancing your mental well-being with topics focusing on coping, motivation, and routine building. We are all in this together!

Continued here:
Routines are healthy - Argonaut

Recommendation and review posted by Alexandra Lee Anderson

Read the Rest...

Exercise and enjoy healthy low carb snacks – kempercountymessenge

Compiled by Denise Swogetinsky

Kemper Messenger

Hope you are all practicing social distancing.

Use this time to begin working on you. Start exercising. If you don't know where to start, go to the internet and type in exercises in your search engine. Bad knees? Just say exercises for bad knees. You can taylor your search to fit your requirements.

Be sure to get outside and enjoy the sun and fresh air. You can trim your bushes, weed your flower beds, plant flowers and vegetables, or just sit quietly and enjoy the beauty of the day. While you do these things, don't forget about your Low-Carb snacks.

Just remember that living a healthy lifestyle takes planning and moderation.

Easy Baked Zucchini Chips

w/ avocado dip (6 carbs)

For the zucchini chips

23 mediums zucchini

2 tbsp avocado oil

2 tsp onion powder

2 tsp garlic powder

1/2 tsp sea salt (plus more to taste)

For the green

goddess dip

1 avocado

2 tbsp fresh basil

1 handful fresh parsley

1 handful fresh cilantro

2 sprigs green onion

1/4 cup olive oil

Juice of one lemon

Preheat the oven to 250 F and line two large baking sheets with parchment paper Using a mandolin slicer, carefully slice the unpeeled zucchinis in 1/8 slices, lightly patting the slices with a paper towel or napkin as you go to remove excess water.

Place the slices onto the baking sheets, add the avocado oil and season with garlic, onion, and sea salt. Bake in the oven for 1 hour and 15-30 minutes.

Check the chips frequently throughout the last 15-30 minutes as different slices cook faster depending on where they are in the oven. Remove the chips once crisped to liking and add more salt to taste if desired. Serve by themselves or with the dip.

For the dip

Using a high-speed blender, blend all of the ingredients until thoroughly combined. Add 1-2 tbsp of more olive oil if the dip is too thick.

Baked Cheese Crisp


Shredded cheese

To begin making crunchy baked cheese crisps recipe, preheat oven to 375 degrees. Line two Baking sheet with parchment paper. Lightly toast the cumin seeds and then coarsely grind it in a mortar and pestle. Add it to the shredded cheese in a bowl. Mix it gently.

Take two tablespoons of cheese mixture and spread it evenly on the lined baking sheet to form a 4 to 4.5 inch round. Repeat this step for the rest of the mixture leaving a 2-inch gap between the rounds. Bake the sheets one by one in the preheated oven for 6-8 minutes until it begins to brown slightly. Take out the baking sheet and lift the cheese using a spatula and fold it gently over a rolling pin or lay it flat on a kitchen paper towel. Allow it to cool complete to become crisp and then serve.

Serve as an appetizer with roasted tomato sauce or can be serve along a green vegetable salad.

Fruit Energy Balls

1 cup chopped almonds

1 cup dried figs

1 cup dried apricots

? cup unsweetened shredded coconut

Combine almonds, figs and apricots in a food processor; pulse until finely chopped. Roll the mixture into small balls and dredge in coconut. Cover and refrigerate for up to 3 days or freeze up to 3 months.

Cauliflower cheddar biscuits

1 pounds cauliflower florets (about 7 cups)

1 large clove garlic, quartered

1 cup plus 2 tablespoons shredded extra-sharp Cheddar cheese, divided

2 large eggs

3 tablespoons chopped fresh chives

1 tablespoon cornstarch

? teaspoon salt

Preheat oven to 425 degrees F. Line a large baking sheet with parchment paper or a silicone baking mat. Place cauliflower and garlic in a food processor. Process until finely grated. (You may need to do this in batches.) Transfer to a microwave-safe bowl.

Cover loosely and microwave on High for 4 minutes. Let cool slightly. Transfer the cauliflower to a clean kitchen towel and wring out excess moisture. Return to the bowl and stir in 1 cup cheese, eggs, chives, cornstarch, and salt until thoroughly combined. Using about 1/3 cup batter for each, mound into 2 1/2-inch biscuits on the parchment paper, leaving about 1 inch between each one, until you have 8 biscuits. Sprinkle tops with the remaining 2 tablespoons cheese. Bake until browned and crispy around the edges, about 30 minutes.

Read the original:
Exercise and enjoy healthy low carb snacks - kempercountymessenge

Recommendation and review posted by Alexandra Lee Anderson

Read the Rest...

World Health Day 2020: Beware, These 5 Habits Can Ruin Your Health – NDTV News

World Health Day 2020: Get rid of these habits to fight to ensure better health

World Health Day is observed on every 7th April. The theme for World Health Day 2020 is to support nurses and midwives. This World Healthy Day you can make promises for better health. You can fight the risk of several health issues with a healthy diet and lifestyle. You might not know but some habits can take a toll on your health. From lack of exercise to too much snacking, there are several things that you need to change for a healthy living. On the occasion of World Health Day, here are a few habits that you must get rid of for a healthy living.

Many take their mobile phones to the bedroom. It can disturb your sleeping pattern. Using phone for too long can is not just bad for your eyesight but can affect your overall health. Poor sleep is linked with several health issues. Keep your phone aside and make sure that you ensure better sleep.

World Health Day 2020: Reduce screen time and ensure proper sleepPhoto Credit: iStock

Sitting for too long can make you gain weight as well as increase the risk of chronic diseases like heart diseases, diabetes and certain cancers. More physical exercise throughout the day can help ensure better health. Exercise every day and take frequent breaks if you sit for too long.

Also read:World Health Day 2020: 5 Secrets To Stay Healthy And Disease Free; Make These Healthy Choices Today

When having a meal, eat slowly and chew your food properly. Eating quickly will not give you the satisfaction. It can also make you consume more calories than required. You should avoid all distractions while eating and chew food slowly.

Consumes your meals slowly for better satisfactionPhoto Credit: iStock

Many skip meals to lose weight. But it will not help you lose weight. To lose weight you should eat small and frequent meals. Skipping meals will make you consume more calories in the next. Also, add enough nutrients to your every meal.

Also read:World Health Day 2020: What Happens When Your Diet Is Low In Protein? Nutritionist Explains

Do you consume a pain killer whenever you experience pain or minor discomfort? This is also linked with several health issues. You should not consume pills without your doctor's consultation. Also, try to skip the use of painkillers as much as possible.

Also read:World Health Day 2020 Honours Nurses And Midwives: Here's Everything You Need To Know

Disclaimer: This content including advice provides generic information only. It is in no way a substitute for qualified medical opinion. Always consult a specialist or your own doctor for more information. NDTV does not claim responsibility for this information.

Read the rest here:
World Health Day 2020: Beware, These 5 Habits Can Ruin Your Health - NDTV News

Recommendation and review posted by Alexandra Lee Anderson

Read the Rest...

Op-Ed: The COVID-19 Messages I Wish We Were Hearing – NJ Spotlight

Robert Schwaneberg

My fellow Americans, we all need to be aware of a deadly menace in our midst. It is a new virus to which none of us is immune. The vast majority of us will recover on our own, but it could infect so many that if we do nothing, the death toll could be very high. We have a plan, however, and with your cooperation, we can minimize the damage. And let us keep our faith and perspective: We all are mortal. There are 330 million of us, and in a normal year, death takes 2.8 million. With this virus that might rise to 2.9 million or 3 million.

Do you wish this is what our president had told us months ago, when this pandemic was just hitting our shores? Does suddenly being told that COVID-19 could kill 240,000 of us motivate or paralyze you? With good reason, the campaign against this pandemic is being called a war. Whether or not it is fair to say truth has been one of the first casualties, context and perspective certainly have. We could use more of both. COVID-19 is deadlier than seasonal flu, but neither is it a biblical plague that will kill one-third of us.

In the short term, your lives will change dramatically. Almost all of you will be working or attending school from home, as we must eliminate all gatherings and minimize in-person contact to slow the spread of this virus. But that does not mean you should become couch potatoes. Regular aerobic exercise is protective against almost all of our major health threats, including heart disease and stroke, which together kill 793,840 Americans each year. Now is no time for a marathon or cross-country vacation, but aerobic fitness is vital. Stay home, but stay in shape.

We have all heard Stay home. Stay in shape deserves equal emphasis. To his credit, Gov. Phil Murphy has recognized that exercise is essential, allowing us outside for a walk, run or bike ride close to home. But we are not being told we need to do these things, and too many local officials are making it nearly impossible. Beaches, boardwalks and entire park systems have been closed, when access could have been limited. Establish one-way loop trails and a website for citizens with camera phones to report social-distance violators. Auction beach badges online, with proceeds going to the New Jersey Pandemic Relief Fund.

We know that in our urban areas, providing opportunities for outdoor exercise while maintaining 6 feet of separation is a challenge. Therefore, we will be converting numerous city streets to pedestrian malls and highways to biking and hiking paths. And these changes will be permanent. The result will be a healthier and more livable New Jersey.

As usual, we are letting a crisis go to waste. The Blue Zones Project promotes healthy-living practices based on lessons learned from communities around the globe that enjoy exceptionally long and healthy lives. One of its tenets is that good health depends not so much on self-discipline as on living in an environment that makes physical activity unavoidable. It would be a big step forward if we could just make it safe; too many of us risk our lives just going for a jog. With the president calling for $2 trillion in infrastructure spending, now is the perfect opportunity to fix that.

We recognize that the steps we are taking to slow the spread of this virus jeopardize other vital public health initiatives. We understand that the stress of prolonged isolation risks increases in substance use disorder, smoking, domestic violence, depression and suicide. We ask experts in these fields for their suggestions on how to minimize these unintended consequences.

As with any war, this one risks inflicting collateral damage. We need to plan now to mitigate it.

On an individual basis, we need to assess our personal health risks, some of which may be deadlier than COVID-19. If you have a family history of heart disease, a drink with dinner might be beneficial. If your family history includes alcoholism, probably not. Alcohol kills 88,000 Americans a year. Living on junk food? That contributes to 678,000 deaths each year. Feeling stressed by all of this? Please dont start or return to smoking. Smoking-related diseases kill 1,300 of us every day.

At the level of national and statewide planning, we need to remember that COVID-19 is far from our only public health menace. Nationwide, we lose 67,000 lives annually to drug overdoses and another 47,000 to suicide. If we are not careful, we could unintentionally make those statistics worse.

There are probably hundreds of ways that could happen, so I will suggest just one scenario. A residential program for women in recovery from substance use disorder has banned all visits, including family and class instructors, and canceled all social programs outside and inside the facility. Without such social supports, how many will slide back into addiction? What if this goes on for seasons rather than weeks? What if COVID-19 never goes away, but returns each year like the flu?

Right now, we need all available protective gear for our frontline health care workers, first responders and essential employees like grocery cashiers. When more becomes available, who will be first in line to get it to facilitate a return to normal? Will it be ambulatory surgery centers, assisted living facilities, domestic violence and homeless shelters, residential treatment programs, schools for disabled children who cannot be taught online, schools without the technology to conduct online learning?

These are difficult decisions. We need to keep reminding ourselves: No life is expendable, but we all are mortal.

No life is expendable. The corollary is that the life of a COVID-19 patient, actual or potential, is not more valuable than the life of someone grappling with substance use disorder, a despondent teenager flirting with suicide, a cancer patient whose treatment is delayed, or someone whose heart disease or diabetes goes undiagnosed.

We all are mortal. We will all die of something. We must not allow a myopic focus on killing this virus (something we have only ever done once, with smallpox) to blind us to other public health threats and the victories against them that are achievable.

We must keep the health and well-being of all of us paramount. We need to stay calm and maintain our perspective.

View post:
Op-Ed: The COVID-19 Messages I Wish We Were Hearing - NJ Spotlight

Recommendation and review posted by Alexandra Lee Anderson

Read the Rest...

Take control of your health using the latest technology – Gulf News

Philips' VitalHealth is a cloud-based patient-centered population healthcare management platform Image Credit: supplied

As we celebrate World Health Day today, let us first thank our healthcare professionals at the forefront of providing quality care, especially now as we face the Covid-19 pandemic.

Healthcare systems are under pressure like never before, and young and old alike have never been more eager to take control of their health evolving from passive healthcare recipients into active health consumers. Empowering people to take control of their own health is critical to transforming healthcare. Consumers are asking for it. Demographic developments demand it. And technology enables it.

Philips takes a holistic view of peoples health journeys, starting from healthy living and prevention, precision diagnosis and personalised treatment, through to care in the home, where the cycle to healthy living begins again.

Home healthcare solutions are a broad range of health services that can be provided at a patients home. This can be especially useful in the management of chronic diseases where a patient is enabled to lead their best possible life either through the regular use of technology support or by keeping track of their own health with the support of a connected group of physicians.

Philips has many solutions in this area including population health management systems such as VitalHealth and sleep and respiratory care such as the Respironics portfolio.

VitalHealth is a cloud-based patient-centered population healthcare management platform that allows caregivers to keep an overview of their patients and advise them individually without coming into the clinic. It also aggregates data from different information systems to provide quick insights for an entire patient population which help drive strategic decisions around improving health while reducing costs.

Philips Respironics empowers patients to rediscover confidence and the freedom to live a fulfilling life by restoring the ability to sleep and breathe naturally. Whether at home or on the go, Philips Respironics solutions makes it easy for the young and the old to take control of illnesses such as obstructive sleep apnea (OSA) and other respiratory diseases by integrating care in their everyday life.

From birth to old age, health is a state to be treasured, promoted and supported. At Philips, we believe peoples health journeys should be connected, offering seamless, integrated and highly personalised experiences. These are journeys in which people are increasingly engaged with their own health and get support from professional care teams, as and when needed, journeys in which every single bit of information adds to a greater body of knowledge that patients, their care professionals, and science and society at large can benefit from.

Health technology solutions will become increasingly personalised, adapting to peoples needs and preferences, helping them to achieve their health goals. By connecting different data points from different sources over time, we will be able to develop a true continuum of care, bridging the hospital and the home.

Read more:
Take control of your health using the latest technology - Gulf News

Recommendation and review posted by Alexandra Lee Anderson

Read the Rest...

What is the secret to a long, healthy and meaningful life? – News – The University of Sydney

Here, we asked Professor Fontana to elaborate on just a few of the many questions and myths his book tackles.

The first step is to acknowledge our health problems and limitations and challenge the underlying assumptions. Most of us will reshape our behaviours only if we have a clear understanding of why it is important to change, and we approve of it. Then we just need to set our goals, pursue them and have faith in them.

Smart people never stop learning, because they know that this is the way to deeper insights and revolutionary changes.

None of these: many are just fads, oversimplifications of a complex reality. Our society has become obsessed with losing weight, but the real question we should ask is not How can I drop some extra kilos?, but How can I avoid developing chronic diseases as I age, and possibly live a much longer and healthier life?

As I have tried to explain in this book, the knowledge we have acquired over the past couple of decades about the metabolic and molecular mechanisms that regulate ageing is allowing us to more accurately choose what to eat, how much of it and when, to meet our nutrient needs.

Sleep regenerates the brain, improves the efficiency of the immune system and reduces the risk of infections, while also playing a vital role in consolidating memories and reducing the risk of dementia.

There is no magic number of hours that works for everyone. The most important thing is that sleep is deep and restful, and you wake feeling restored. This can be difficult for some so the book explores strategies like endurance exercise to improve sleep quality or using yoga and meditation.

One of the features of centenarians living in Okinawa and Sardinia is the strong sense of belonging to the family and to a broader social group of friends. One of the Okinawans mottos is Shikinoo chui shiihii shiru kurasuru, which means: We live in this world by helping one another.

Positive social relationships and friendship play a key role in promoting metabolic, emotional and mental health so seek them out as challenging as that may be in current times.

Originally posted here:
What is the secret to a long, healthy and meaningful life? - News - The University of Sydney

Recommendation and review posted by Alexandra Lee Anderson

Read the Rest...

Multifunctional nanomedicine: Developing smarter therapeutics – Advanced Science News




Althoughthe medical and pharmaceutical fields have come a long way in diagnosing diseasestates and producing highly potent drugs, the lack of effective delivery ofsuch therapeutics to the target organ with desired pharmacokinetics remains oneof the major challenges in this process.

The advent of nanotechnology, along with advances in protein engineering and materials science, have brought new hope to patients. The impact of nanotechnology on medicine nanomedicine is recognized by the development of novel nanoscale therapeutics and diagnostic and imaging modalities.

Ina recent review published in WIREs Nanomedicine and Nanobiotechnology, Professor Joerg Lahann and his team from the University of Michigan discuss state-of-the-art nanoparticle drug delivery platforms, their advantages and shortcomings, and future directions towards clinical translation.

The ability to impart multiple functions to a single delivery system, engineering both bulk and surface properties, provides a means to answer some of the greatest remaining challenges in the field of drug delivery, said Jason Gregory, a PhD student in the Lahann Lab.

In fact, approaches to address this conundruminclude the development of multifunctional particles, cell-mediated transportmechanisms, and the use of biologically derived materials. Multifunctionalparticles can possess two or more dissimilar properties through surface or bulkanisotropy.

For example, the electrohydrodynamic co-jetting process, which was pioneered in the Lahann lab, permits the creation of multicompartmental particles. Independently engineering individual compartments of the nanoparticle leads to an ability to incorporate materials with orthogonal properties that may offer a solution to simultaneously address multiple biological barriers.

Multicompartmental particles provide a set ofunique features for nanoparticle targeting and controlled release ofcombination drugs, said Dr. Joerg Lahann, the Wolfgang Pauli CollegiateProfessor of Chemical Engineering and Director of the Biointerfaces Instituteat the University of Michigan.

While traditional nanoparticles fail to efficiently deliver the drug to target sites, our bodys circulatory cells as natural carriers of many substances have evolved properties to optimally perform delivery functions. Imparting these properties into the design of the drug delivery platforms by combining nanoparticles with circulatory cells enhances the overall outcome of the system, added Nahal Habibi, a PhD student in the Lahann Lab working on cell-mediated drug delivery strategies.

Leukocytes are particularly good candidates because they can naturally migrate to disease-relevant regions that are often inaccessible by traditional nanoparticles, and have been used to carry therapeutic nanoparticles to cross the bloodbrain barrier in a Parkinsons disease model.

Synthetic protein nanoparticles are another emerging trend in nanomedicine.

Advances in designing novel multicompartmental polymer/protein nanoparticles utilizing the intersection of polymer chemistry and protein biochemistry offers promise in engineering the next generation of nanoparticle formulations, said Daniel Quevedo, another PhD candidate in Prof. Lahanns group.

Reference: Nahal Habibi et al. Emerging methods in therapeutics using multifunctional nanoparticles. WIREs Nanomedicine and Nanobiotechnology (2020). DOI: 10.1002/wnan.1625

Excerpt from:
Multifunctional nanomedicine: Developing smarter therapeutics - Advanced Science News

Recommendation and review posted by Alexandra Lee Anderson

Read the Rest...

Nanomedicine Market Size Analysis, Top Manufacturers, Shares, Growth Opportunities and Forecast to 2026 – Science In Me

New Jersey, United States: Market Research Intellect has added a new research report titled, Nanomedicine Market Professional Survey Report 2020 to its vast collection of research reports. The Nanomedicine market is expected to grow positively for the next five years 2020-2026.

The Nanomedicine market report studies past factors that helped the market to grow as well as, the ones hampering the market potential. This report also presents facts on historical data from 2011 to 2019 and forecasts until 2026, which makes it a valuable source of information for all the individuals and industries around the world. This report gives relevant market information in readily accessible documents with clearly presented graphs and statistics. This report also includes views of various industry executives, analysts, consultants, and marketing, sales, and product managers.

Market Segment as follows:

The global Nanomedicine Market report highly focuses on key industry players to identify the potential growth opportunities, along with the increased marketing activities is projected to accelerate market growth throughout the forecast period. Additionally, the market is expected to grow immensely throughout the forecast period owing to some primary factors fuelling the growth of this global market. Finally, the report provides detailed profile and data information analysis of leading Nanomedicine company.

Nanomedicine Market by Regional Segments:

The chapter on regional segmentation describes the regional aspects of the Nanomedicine market. This chapter explains the regulatory framework that is expected to affect the entire market. It illuminates the political scenario of the market and anticipates its impact on the market for Nanomedicine .

The Nanomedicine Market research presents a study by combining primary as well as secondary research. The report gives insights on the key factors concerned with generating and limiting Nanomedicine market growth. Additionally, the report also studies competitive developments, such as mergers and acquisitions, new partnerships, new contracts, and new product developments in the global Nanomedicine market. The past trends and future prospects included in this report makes it highly comprehensible for the analysis of the market. Moreover, The latest trends, product portfolio, demographics, geographical segmentation, and regulatory framework of the Nanomedicine market have also been included in the study.

Ask For Discount (Special Offer: Get 25% discount on this report) @

Table of Content

1 Introduction of Nanomedicine Market1.1 Overview of the Market1.2 Scope of Report1.3 Assumptions

2 Executive Summary

3 Research Methodology3.1 Data Mining3.2 Validation3.3 Primary Interviews3.4 List of Data Sources

4 Nanomedicine Market Outlook4.1 Overview4.2 Market Dynamics4.2.1 Drivers4.2.2 Restraints4.2.3 Opportunities4.3 Porters Five Force Model4.4 Value Chain Analysis

5 Nanomedicine Market, By Deployment Model5.1 Overview

6 Nanomedicine Market, By Solution6.1 Overview

7 Nanomedicine Market, By Vertical7.1 Overview

8 Nanomedicine Market, By Geography8.1 Overview8.2 North America8.2.1 U.S.8.2.2 Canada8.2.3 Mexico8.3 Europe8.3.1 Germany8.3.2 U.K.8.3.3 France8.3.4 Rest of Europe8.4 Asia Pacific8.4.1 China8.4.2 Japan8.4.3 India8.4.4 Rest of Asia Pacific8.5 Rest of the World8.5.1 Latin America8.5.2 Middle East

9 Nanomedicine Market Competitive Landscape9.1 Overview9.2 Company Market Ranking9.3 Key Development Strategies

10 Company Profiles10.1.1 Overview10.1.2 Financial Performance10.1.3 Product Outlook10.1.4 Key Developments

11 Appendix11.1 Related Research

Complete Report is Available @

We also offer customization on reports based on specific client requirement:

1-Freecountry level analysis forany 5 countriesof your choice.

2-FreeCompetitive analysis of any market players.

3-Free 40 analyst hoursto cover any other data points

About Us:

Market Research Intellect provides syndicated and customized research reports to clients from various industries and organizations with the aim of delivering functional expertise. We provide reports for all industries including Energy, Technology, Manufacturing and Construction, Chemicals and Materials, Food and Beverage and more. These reports deliver an in-depth study of the market with industry analysis, market value for regions and countries and trends that are pertinent to the industry.

Contact Us:

Mr. Steven FernandesMarket Research IntellectNew Jersey ( USA )Tel: +1-650-781-4080

Email: [emailprotected]

Get Our Trending Report

Tags: Nanomedicine Market Size, Nanomedicine Market Growth, Nanomedicine Market Forecast, Nanomedicine Market Analysis, Nanomedicine Market Trends, Nanomedicine Market

Read this article:
Nanomedicine Market Size Analysis, Top Manufacturers, Shares, Growth Opportunities and Forecast to 2026 - Science In Me

Recommendation and review posted by Alexandra Lee Anderson

Read the Rest...

Page 11234..1020..»