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Category : Anti-Aging Medicine

IHS Pets: Bringing Cell And Gene Therapy To Cats, Dogs & Horses – Anti Aging News

Integrated Health System is bringing cell and gene therapy to cats, dogs, and horses. Recently IHS Pets has helped a paralyzed dog with a spinal cord injury to walk again after it was treated with experimental PRP and prolotherapy. Click here to see the video.

Telomeres

Aging is the root of virtually every complex noncommunicable disease in humans and animals. Telomeres are the protective end caps on the ends of our chromosomes, they are as important for the health of both humans and our pets, and they play roles in longevity.

One of the contributing factors in the lifespan in dog breeds is telomere length. As in humans researchers have found that telomere length is a strong predictor of average life span among 15 different breeds consistent with telomeres playing a role in life span determination. Dogs lose telomeric DNA ~10-fold faster than humans, which is similar to the ratio of average life spans between these species. As such telomerase therapy may be beneficial to pets as well as their human caretakers.

Telomerase gene therapy has been shown to extend lifespan in animals, this therapy may help to increase bone mineral density, improve motor performance, improve metabolism, and improve brain function.

Follistatin

The loss of muscle mass with age is just as problematic for animals as it is to humans; in cats for instance a study showed that for each 100g loss of lean body mass increased the risk of death by 20%. This is typically accompanied by frailty, and it is a contributing factor to metabolic syndrome, diabetes, heart disease, and overall mortality.

Diet and exercise have been shown to pay key roles in keeping pets healthy, but the loss of muscle mass is unavoidable without an effective intervention. Enter follistatin: myostatin blocks muscle growth, when it is inhibited then follistatin is able to let muscles grow freely to stop them from wasting away.

Follistatin gene therapy has been shown to be safe and effective in animals, this therapy may help to protect against frailty, increase muscle density, increase strength, and increase endurance.

Klotho: The Queen of Anti-Aging Proteins

1 in 3 cats will suffer from renal disease, but these numbers are under scrutiny with some suggesting that estimate may be too conservative. Chronic kidney failure can occur gradually over months or years, and it is one of the most common conditions affecting older cats with most cases progressing over time worsening the disease.

Klotho is known to play a significant role in the development of chronic kidney disease, and researchers are now turning to its broader role in the anging process as a whole; such as induces expression with gene therapy in mice has been shown to extend lifespan by targeting many of the same pathways as caloric restriction. Blocking Klotho has been shown to cause premature aging.

Klotho also helps to protect the brain, and contributes to more differences in intelligence than any one single gene. Research from the University of California has shown it to protect the brains of mice and improve brain function within 4 hours; and this result included young mice, old mice, and those that were models of Alzheimers disease.

In addition Klotho also plays a critical role in the inflammaging process. Inflammaging is the long term result of the chronic physiological stimulation of the innate immune system which can become damaging during the aging process.

Circulating levels of Kloto decreases with age, this decrease is associated with an increased risk of age related disease. Gene therapy with Klotho has been shown to increase lifespan in animal models, and it may improve kidney function, brain function, clear damage caused by oxidative stress, and protect against cardiovascular disease.

With the remarkable progress being made in genetics, gene therapy may play increasingly prominent and transformative roles in medicine for both humans and animals due to the potential to treat diseases and congenital disorders.

Pets can be an important part of life, they calm us, make us laugh, and create a bond of unconditional love. The company does note that all therapies are experimental, they are not approved by any regulatory body, and they make no claims that outcomes will be positive or beneficial.

IHS Pets is the veterinary wing of Integrated Health Systems, BioViva Sciences exclusive partner. IHS connects with doctors and patients who are interested in the power of gene therapy to pave the way to healthy aging and longevity.

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How Old Is Your Dog in Human Years? Scientists Develop Better Method than ‘Multiply by 7’ – UC San Diego Health

If theres one myth that has persisted through the years without much evidence, its this: multiply your dogs age by seven to calculate how old they are in human years. In other words, the old adage says, a four-year-old dog is similar in physiological age to a 28-year-old person.

But a new study by researchers at University of California San Diego School of Medicine throws that out the window. Instead, they created a formula that more accurately compares the ages of humans and dogs. The formula is based on the changing patterns of methyl groups in dog and human genomes how many of these chemical tags and where theyre located as they age. Since the two species dont age at the same rate over their lifespans, it turns out its not a perfectly linear comparison, as the 1:7 years rule-of-thumb would suggest.

To calculate your dogs age in human years based on epigenetics, find the dogs age along the bottom axis and trace your finger straight up until you reach the red curve. Then trace your finger straight over to the left to find the corresponding human age. Credit: Cell Press

The new methylation-based formula, published July 2 in Cell Systems, is the first that is transferrable across species. More than just a parlor trick, the researchers say it may provide a useful tool for veterinarians, and for evaluating anti-aging interventions.

There are a lot of anti-aging products out there these days with wildly varying degrees of scientific support, said senior author Trey Ideker, PhD, professor at UC San Diego School of Medicine and Moores Cancer Center. But how do you know if a product will truly extend your life without waiting 40 years or so? What if you could instead measure your age-associated methylation patterns before, during and after the intervention to see if its doing anything? Ideker led the study with first author Tina Wang, PhD, who was a graduate student in Idekers lab at the time.

The formula provides a new epigenetic clock, a method for determining the age of a cell, tissue or organism based on a readout of its epigenetics chemical modifications like methylation, which influence which genes are off or on without altering the inherited genetic sequence itself.

Epigenetic changes provide scientists with clues to a genomes age, Ideker said much like wrinkles on a persons face provide clues to their age.

Ideker and others have previously published epigenetic clocks for humans, but they are limited in that they may only be accurate for the specific individuals on whom the formulas were developed. They dont translate to other species, perhaps not even to other people.

Ideker said it was Wang who first brought the dog idea to him.

We always look at humans, but humans are kind of boring, he said. So she convinced me we should study dog aging in a comparative way.

To do that, Ideker and Wang collaborated with dog genetics experts Danika Bannasch, DVM, PhD, professor of population health and reproduction at UC Davis School of Veterinary Medicine, and Elaine Ostrander, PhD, chief of the Cancer Genetics and Comparative Genomics Branch at the National Human Genome Research Institute, part of the National Institutes of Health. Bannasch provided blood samples from 105 Labrador retrievers. As the first to sequence the dog genome, Ostrander provided valuable input on analyzing it.

First author Tina Wang, PhD, (right) with her husband, Brandon, and their dog, Belli, who inspired the study. Photo courtesy of Tina Wang.

Dogs are an interesting animal to study, Ideker said. Given how closely they live with us, perhaps more than any other animal, a dogs environmental and chemical exposures are very similar to humans, and they receive nearly the same levels of health care. Its also important that we better understand their aging process, he said, as veterinarians frequently use the old 1:7 years ratio to determine a dogs age and use that information to guide diagnostic and treatment decisions.

What emerged from the study is a graph that can be used to match up the age of your dog with the comparable human age. The comparison is not a 1:7 ratio over time. Especially when dogs are young, they age rapidly compared to humans. A one-year-old dog is similar to a 30-year-old human. A four-year-old dog is similar to a 52-year-old human. Then by seven years old, dog aging slows.

This makes sense when you think about it after all, a nine-month-old dog can have puppies, so we already knew that the 1:7 ratio wasnt an accurate measure of age, Ideker said.

According to Ideker, one limitation of the new epigenetic clock is that it was developed using a single breed of dog, and some dog breeds are known to live longer than others. More research will be needed, but since its accurate for humans and mice as well as Labrador retrievers, he predicts the clock will apply to all dog breeds.

Next, the researchers plan to test other dog breeds, determine if the results hold up using saliva samples, and test mouse models to see what happens to their epigenetic markers when you try to prolong their lives with a variety of interventions.

Meanwhile, Ideker, like many other dog owners, is looking at his own canine companion a little differently now.

I have a six-year-old dog she still runs with me, but Im now realizing that shes not as young as I thought she was, Ideker said.

Co-authors of the study also include: Jianzhu Ma, Samson Fong, Katherine Licon, Brian Tsui, Jason F. Kreisberg, UC San Diego; Andrew N. Hogan, National Human Genome Research Institute, National Institutes of Health; Peter D. Adams, Sanford Burnham Prebys Medical Discovery Institute; and Anne-Ruxandra Carvunis, University of Pittsburgh School of Medicine.

Funding for this research came, in part, from the National Institutes of Health (grants ES014811, GM108865, GM008666, AG031862 and DE022532; NHGRI intramural program), California Institute for Regenerative Medicine (CIRM), and Maxine Adler Endowed Chair Funds.

An earlier version of this paper was shared as a preprint on BioRxiv on November 19, 2019, prior to peer-review and publication in Cell Systems.

Disclosure: Trey Ideker is co-founder of Data4Cure, Inc., is on the Scientific Advisory Board, and has an equity interest. He is also on the Scientific Advisory Board of Ideaya BioSciences, Inc., has an equity interest, and receives sponsored research funding. The terms of these arrangements have been reviewed and approved by the University of California San Diego in accordance with its conflict of interest policies.

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Key End use Industries to Surge Sales of Anti-Aging Medicine During the COVID 19 pandemic – 3rd Watch News

Longer life-expectancy is a cumulative effect of a healthy lifestyle and favorable environmental conditions. A trend of continuously increasing life expectancy has been a witness since a decade, primarily because of advances in medical sciences and treatment of chronic life-threatening diseases, availability of clean water and environment and other factors. This trend is projected to further show even more exponential growth graph owing to the anti-aging medicines, stem cell therapeutics, genetic screening and interventions, and high-tech biomedicines. American Academy of Anti-Aging Medicine claimed that anti-aging medicines can add up to 10-20 years to the life expectancy of a human. Today, a combination of calorie-restricted diet, regular exercise, and anti-aging medicines are claimed to slow the process of senescence and aging. Various medicines used against the treatment of acute or chronic diseases can be considered as anti-aging medicines, however, to define anti-aging medicine market we have considered only the drugs that are directly prescribed and used for delaying the effects of aging.

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The constantly growing demand to look young in old individuals and to remain young and youthful in young people drive the anti-aging market. The influence of aesthetics from the fashion and television industry propel the demand to retain the features and energy of younger age in old people. Additionally, the increasing number of anti-aging medicine manufacturers in the decade contribute to higher availability of the anti-aging medicine resulting in expansion of the global anti-aging medicine market. However, skeptical approach to anti-aging medicine as being an external stimulator of cell-cycles is a restraint to the expansion of anti-aging medicine market.

The global Anti-aging medicine market is segmented on basis of product type, age group, distribution channel, and region:

The rising demand for beauty consciousness amongst people and the desire to stay young is the primary factor fueling the growth of anti-aging medicines in the market. The acclaimed benefits of the products and affordability along with regional presence compel the demand for anti-aging medicine in the global market. Hormonal replacement therapy segment in product type is expected to account maximum market share in the terms of revenue in the global anti-aging medicine market. However, antioxidant therapy segment in product type is expected to grow with the highest CAGR over the forecast years owing to the rising awareness about the plethora of benefits of antioxidants in anti-aging among the public. On the basis of the route of administration, the global anti-aging medicine market is segmented as oral, injectable and topical, out of which oral segment is expected to generate maximum revenue share over the forecast period. As per the distribution channel, the global anti-aging medicine market is segmented as hospital pharmacies, retail pharmacies, e-commerce, and drug stores. The e-commerce segment in the distribution channel is estimated to grow with the highest CAGR over the forecast time.

Regionally, the global anti-aging medicine market is segmented into five key regions viz. North America, Latin America, Europe, Asia Pacific, and Middle East & Africa. North America anti-aging medicine market is projected to account for the largest market share in the terms of revenue in the global anti-aging medicine market owing to the higher healthcare expenditure and presence of numerous manufacturers.

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Europe is expected to hold the second largest share in the global anti-aging medicine market during the forecast period because of the growing geriatric population and higher spending on healthcare products and supplements. MEA anti-aging medicine market is expected to witness sluggish growth over the forecast time owing to the limited presence of manufacturers and lower healthcare expenditure. Asia Pacific is projected to grow with the highest CAGR over the forecast years in the global anti-aging medicine market due to higher demand from end users and regional penetration of the key players in the region.

Some of the players operating in the global anti-aging medicine market are Pfizer, Evolution GmbH, Himalaya Global Holdings Ltd., Cipla Limited, Mylan Laboratories, Novartis, Merck Group, Vitabiotics, William Ransom & Son Holdings Plc, Uni-Vite Healthcare and Health Made Easy Limited amongst others.

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4 home remedies that demonstrate the power of turmeric – Explica

For years the turmeric It is used by the traditional medicine of the India. It is characterized by being anti-inflammatory, antioxidant and anticancer, but it also has benefits for the digestive system, he nervous system, the skin and the eyes.

So turmeric is ideal for use on home remedies: a poultice for acne, a regenerating mask, a juice against anemia and a syrup that will help you if you are trying to lose a few extra pounds. Follow the step by step of the recipe you need, and uala!

Turmeric is not only a seasoning, it is also used in medicine. Turmeric, an ally for the digestive system and skin imperfections.

Basically turmeric stimulates the liver; added to certain preparations in the kitchen, it facilitates the metabolism of fats because it improves the quantity, quality and flow of bile. In addition, it has a anti-aging and balsamic effect for the skin; It is indicated for the healing of skin ulcers and wounds, and as a rejuvenating agent.

Poultice for acne: You will need 1 tablespoon of rose water, 1/2 teaspoon of agar-agar, 1 tablespoon of turmeric powder and 1 tablespoon of lemon juice. Let the agar-agar soak in the rose water for 15 minutes. Add the rest of the ingredients to the agar-agar gel until you obtain a paste.

Turmeric, an ally for the digestive system and skin imperfections.

Regenerating mask for the skin: Apply this mask for about 20 minutes and then rinse your face with fresh water. You will need: 1 tablespoon of turmeric, 1 tablespoon of maple syrup, and 1 tablespoon of thick soy yogurt.

Antianemia smoothie: Prepare it on the spot and drink it in the morning for three months. You require: 1 apple, 200 g of spinach, 4 teaspoons of sprouted alfalfa, 1 teaspoon of turmeric and 1 teaspoon of brewers yeast.

Syrup to lose weight: In weight loss diets we can add generous amounts of turmeric, to take advantage of improving liver function and helping to burn fat. This time, you will need: the juice of 2 lemons, 1 teaspoon of turmeric, 1 teaspoon of brewers yeast and 1 garlic.

Mix all the ingredients with a mixer so that the turmeric emulsifies and mixes well with all the ingredients. Take it once a day, preferably in the afternoon.

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The Future of Sports – Bleacher Report

Each night, around 7 o'clock, I drift off into a little daydream. This has been the case for weeks now. My beloved Mets are jogging onto the grass at Citi Field, taking their positions; their ace, Jacob deGrom, making a beeline to the mound. I am up out of my seat, applauding, gazing out onto the field. I look up to the sky, and that's it, really. The scene tends to slip away from there. I look down to see the gates of my apartment's window guard and the emptied streets of Manhattan beyond them. I really am clapping, but it's got nothing to do with baseball. It's in support of local nurses and doctors at work or changing shifts. Across New York City, this ritual plays out night after night (the clapping for health care workersnot the Mets fantasies, I don't think).

There's a crossing of wires at play, like my precious sports memories are mingling with the signatures of my life during the COVID-19 eraclapping, quarantining, boredom. Will it stay this way? For a while, at least, I think it will.

As MLB, the NBA and other leagues near their returns, I find myself fascinated by questions pertaining to the virus and the ways it will ripple through our leagues. How many players will contract it? How will leagues' models evolve as they move forward? Even for mea lifelong overcommitted fan who sends excessive, neurotic text threads (unresponded to) during regular-season gamesI think most of the drama in sports will come not from daily games but from daily tests results. This is the virus overpowering the once-invincible sports machine.

Already, so much of the mystique of sports has been lost. I miss the steady, circular rhythm of leagues in-season, the way they appeared day after day, overlapping only a few sacred times a year as if choreographed by the moon instead of computers and marketing teams. I miss the shameless self-importance of teams playing no matter what. (Spring training continued for 10 days after the first cases of COVID-19 appeared in Florida.) It was simply more fun back when we could view athletes as impervious superheroes rather than as bored video-gamersor, worse, as medical patients. There is something uncomfortable about having seen a dominant, intimidating player like Rudy Gobert briefly exposed as reckless and unhygienic. Games will return soon enough, but what about the underlying myths that lend them relevance and depth?

The NBA's bubble-based return, set for July 30, cuts against team fandomso driven by proximityby moving everyone to Disney World. It admits that the game could go on without us, the fans, rowdy old faithful, by playing in near silence. Game rules are changing, too, yielding to the virus' demands. There are smaller coaching staffs to protect older people from exposure, and expanded rosters for when the inevitable happens. Every league is making compromises: MLB might ban its most endearing prop, the sunflower seed, and tweak its most fundamental, unique feature, the nine-inning game.

These leagues are right to weigh these measures and to take them. They are preventing tragedies, not creating them. But the bending of tradition makes me wonder about the future of sports, about how things just changed overnight, and how they might change again in 10 years or 50. Maybe that will be the enduring impact of COVID-19 when it comes to sportsthat it opened the gates to change.

Naturally, this is where things get strange. Stick it out anyway. Consider the ways that fans and leagues are already adapting to this odd time, this time of no sports, and then imagine what comes next, and what after that. One small bit of innovation leads to an unpredictable new one, and on it goes. Very quickly, this evolution brings us into the realm of science fiction.

We might be there already. While games were on hold, the public embraced something that in the past seemed both silly and dystopian: game simulations. Las Vegas offered sim-game betting lines; we hosted virtual Madden watch parties right here at B/R. They were and are an obvious placeholder for real sports. Still, their popularity made me curious about their power down the road, if animated graphics improve enough to match real sports. Technologically speaking, could that day be coming? I asked an expert.

Nicholas Bostrom is a professor at Oxford and a pioneer of the simulation theory, which posits that we may be living in a knockoff version of Earth created by a more advanced (real-life) society. (Assuming that computers will someday be able to produce unlimited realistic simulations of life, we might be wise, he suggests, to already "think that we are likely among the simulated minds rather than among the original biological ones.") Bostrom published Are You Living in a Computer Simulation? way back in 2003. Today, few are better equipped to tell us about the future of sims. So, Professor, how good can they get?

"Eventually we will have completely realistic virtual reality simulations that would be indistinguishable from physical reality," he says. "I don't see why in theory you couldn't have a purely artificial creature that was competing against another in a way that would create a sports event."

You might be wondering what the point of this would be once sports return. Well, consider the NBA's most exhausting debate topic: load (or injury) management. Back when there were regularly scheduled games, we wasted much time meditating on the notion of, say, Kawhi Leonard taking a night off, letting his teammates dominate the lowly Cavaliers or Knicks in front of a crowd that paid to see him play. It's obvious that if there were fewer games, the need to skip some of them would decrease. Fewer games would also soothe another of the league's concerns: players' lack of sleep amid a busy travel schedule.

Simulations could merge these issues and resolve them at once. Why not simulate lopsided games like Clippers-Cavs, providing rest for Leonard and everybody else involved? Each year, each team could sim 10 or 12 games, allowing a 70- or 72-game schedule for playersalready a desired ballparkand a full 82-game slate for the league's partners, like TV networks and casinos, who would package the simulated visuals and box scores.

Maybe this idea seems a little far out, but the NBA rarely minds. It is already welcoming the ideas of the future, from the four-point shot to aerospace revolution.

Indeed, Commissioner Adam Silver has long seen supersonic flight as the key to a truly global league. With it, Portland could face Sydney and return four hours later, in time for bed. We already have an Atlantic Division with teams from America's Northeast; how about adding a Transatlantic Division featuring Brazil, Spain and Nigeria? For now, the problem is a logistical one. "Under existing airline technology, the planes aren't fast enough to at least play in the current framework of our regular season," Silver told USA Today in 2017. Fortunately, with help from Elon Musk, Richard Branson and more, supersonic jets are on their way. Just one of many game-changers to come.

Robots have perfected three-point shooting and will someday make flawless floor-spacers. Salaries paid in cryptocurrency will provide a cap loophole and threaten the league's financial structure. Augmented reality on-screen willsomehowincrease complaints about players' shot selection. Advanced tracking through biometric data will grow into a major concern regarding personal privacy. How much should bidding teams know about a free agent's body? Who gets to dictate the right body fat percentage for somebody else or whether a balky ankle is strong enough to play on? And, as the Wall Street Journal once asked: If a fan gains access to a player's medical status and uses it to wager on a game, is that insider trading? (If the answers to these questions seem like a privacy violation, then consider how quickly athletes' COVID-19 test results became expected public information, even though they're irrelevant so long as sports are on hold. If there is already a demand to know whether Ezekiel Elliott, a running back, is experiencing an inability to smell, then there's no doubting the future demand for intimate insight about his legs.)

Yes, the future can seem vast and spookythough not to Thomas Frey. Frey is an author and member of the Association of Professional Futurists. His job is to burst with ideas, and he's bursting all right, riffing on the future of medicine, tech, sports, you name it. He envisions not only the events of the future but also the issues that will counter those eventsthe future's future. "Drone racing is kind of a hot area right now," he says, "but my sense is that the drone racing eventually gets so fast that you can't even see it, and so I'm not sure that sport sticks around." Dang. What else? Frey wants to elevate existing sportsthe ones played on the groundthrough the control and reduction of gravity. (Think NFL meets Quidditch or Slamball with no need for trampolines.) He wonders about anti-aging, tooin this case, what 3,000-year lifespans might mean for athletic primes.

Other revolutions are impossible to imagine playing out (unless you happen to be a member of the APF). "We're close to reviving extinct species like woolly mammoths," Frey notes, before pondering the cruelty of secluding them from other, natural-born animals. An idea strikes him. "Creating a sport with woolly mammoth riders going around the trackthat would seem bizarre today," he says. "But I would definitely pay to go see that."

Of course, there is not only the matter of tweaking (or inventing) sports, but also that of tweaking the players themselves. One of Frey's favorite topics is genetic engineeringthe process of tinkering with human genes before birth. "We're reinventing people. We're making people more durable. We're giving rights to CRISPR [the bio-tech giant], who will give us superbabies who grow up to be superhumans," he says. OK then. Frey thinks it's inevitable that, someday, we'll be able to genetically manufacture superior athletes: bigger, faster, smarterto an uncanny degree. He wonders about "downloading the human brain" and uploading it into the mind of another person. In time, if this all gets easy and silly enough, a supertoddler could have the basketball IQ of LeBron James. (Just imagine the recruiting violations that would follow.)

Bostrom has explored genetic engineering as well. "The enhancement options being discussed," he wrote in 2003, "include radical extension of human health-span, eradication of disease, elimination of unnecessary suffering" and more. A superhuman ability to ward off illnesssay, a coronaviruswould certainly come in handy. So too would advancements that eliminate athletic limitations. Imagine how a perfect set of knees would have changed the careers of Greg Oden, Brandon Roy and others; imagine Shaquille O'Neal with a sprinter's endurance; imagine Jimmer Fredette at 7'3".

Sounds pretty greator actually it sounds like it would look pretty great, visually. But would this be good for sports? Is it ethical? Or the right spirit? And how would this impact the lives of the athletes we love?

Every tech innovation takes something away from the humans it replaces or (ostensibly) aids. Flawless three-and-D bots entering the NBA would not only change the game but also eliminate dozens or hundreds of lucrative jobs. Supersonic travel, alluring as it may be, could have untold effects on passengersespecially international-league athletes, flying overseas day after day. Genetic engineering could draw a devastating, permanent line between the haves and the have-nots.

When it arrives in full force, Frey says, crafting a given attribute"20/10 vision, a perfect heart"may well cost tens of thousands of dollars. There's no telling what else will be at the disposal of fortunate young athletes then (though Frey, of course, has some ideas, including advanced VR headsets).

Already, financial inequality pervades all of sports. Young basketball players need to be able to cover the costs of trainers and AAU travel teams to earn recognition; it's probably not a coincidence that the children of well-off former players are entering the league at a higher rate than ever. Young baseball players need not only training but also equipment, toomitts, balls, bats, helmets, cleats. (Cleveland pitcher Mike Clevinger recently blamed these costs for the sport's declining popularity among young athletes.) Golf, football, hockeyevery major sport operates behind a financial barrier to entry. In 2018, The Atlantic noted that "just 34 percent of children from families earning less than $25,000 played a team sport at least once a day in 2017, versus 69 percent from homes earning more than $100,000." (Those numbers came from a study by the Aspen Institute, which found that the gap was rapidly growing.)

Imagine a world in which the NBA MVP is an 8'6" trust-fund kid. It seems awfully shallow. Could a souped-up superhuman celebrate the award with the same tenderness as Kevin Durant did in 2014? Even if they did, would we bother to cry along with them? There is no great story in sports without long odds and a dash of relatability.Genetic engineering would destroy the enduring notion of the underdog. It would dull the sweetness of our games, the unpredictability, the misery, the reward. What, then, would be left?

"I'm not particularly excited about sports enhancements," Bostrom says, speaking broadly. "We shouldn't make the mistake of thinking everything that makes the sport easier or makes performance better makes the sport more enjoyable. I think we should think of these things more as, You're designing a game. Think creatively about what would make the most fun game. It's not always the easiest thing."

So far, leagues have mostly welcomed new tech as it arrives, a concerning trend. Consider the modern obsession with instant replay.

Think back to the men's NCAA title game last April. With the season on the line, the ball was knocked out of a Texas Tech dribbler's hands and flew out of bounds. For anybody who has ever picked up a basketball and played a game on any level, it was instantly recognizable as Tech's ball. But after several minutes of replaywhich included referee consultant Gene Steratore saying, "At times, guys, I will tell you, when you start running replay really, really slow, you get a little bit of distortion in there as well, so you've gotta be cognizant to that," suggesting that looking more closely may bring us further from the truththe ball was given to Virginia, the underlying logic being that the most important thing is to get the call right. Is it? What about the flow of the game, the sanity of the viewer, the unspoken understandingsI knocked it out; it's your ballthat run between players and fans, deepening the sport?

This, I will always believe, is the good stuff. Even Bostromwho is so technical that he at one point connects sports fandom to ancient Greek war and says, "You can speculate that, from an evolutionary point of view, being able to detect small differences in fitness would be valuable"agrees these intangibles are worth protecting. Even at the cost of, say, letting simulations run wild.

"You can't predict how an actual game will play out just by sort of measuring the circumference of the biceps and the speed on the treadmill of the athletes," Bostrom says. "And I think if you could predict it, in some sense it could reduce interest. It's not the same as seeing the struggle, the human spirit, the grit, the audience cheering them on."

The question, then, is not so much whether replay or sims or any other technical advance are helpful or efficient but whether we have the ability to recognize when they are aiding sports versus when they are harming them, and when the time is right to rein them in.

"Rather than just allowing everything that makes the performance better," Bostrom says, "we should think more about changes that make the game more fun and rewarding for both the players and the audience."

Are we doing this now? It's hard to say. The COVID-19 pandemic is accelerating change and the acceptance of change. It is clouding the rule-changing thought process. Already, long-standing traditions and powerful illusions have been altered across sports. After years of debate within baseball about the designated hitter, it will be implemented leaguewide as part of MLB's plan for a safe return. It is but a footnote to a much more complex story, which is fine. But also, how does the DH protect anybody from the coronavirus?

The NBA's bubble league will introduce its own oddities, though not everyone will be there to experience them firsthand. Several players have already tapped out of the NBA reboot, some fearing the virus, some having tested positive for it, some unwilling to separate from their loved ones. Others are sitting out so they can focus on social justice reform after expressing concerns that basketball could detract from those efforts. For those traveling to Disney World, it will be a lonely undertaking. Players themselves "are not permitted to enter each other's hotel rooms." Card games, if they do occur, will be monitored closely, and decks will be swapped out frequently.

Every league is drawing its own unprecedented game plan. The NFL is planning to cover the seats closest to the sidelines to keep fans away from players (though the league of course will advertise on the tarp). The NHL will reportedly route its action through two hub cities, Toronto and Edmonton. The measures that college sports will need to takeassuming anybody is on campus come Septemberfigure to be the most drastic of all.

Tech innovation will accompany each return: temperature screenings, artificial crowd noise, broadcasting from home. As quarantine warps our collective sense of time, it feels as though we've known these quirks forever. But not long ago they would have seemed quite strange, impossible, unwelcome, like somebody somewhere out there was toying with our settings.

Leo Sepkowitz joined B/R Mag in 2018. Previously, he was a Senior Writer at SLAM Magazine. You can follow him on Twitter: @LeoSepkowitz.

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The Future of Sports - Bleacher Report

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LifeGaines Medical and Aesthetics Purchases 3 of the Latest and Best Lumenis Products to Serve Clients; a Laser Hair Removal System, a Tattoo Removal…

LifeGaines has been designated a 'Center of Excellence' by Lumenis for offering its new products such as Splendor X, PiQo4, and AcuPulse

Boca Raton, Florida--(Newsfile Corp. - June 30, 2020) - LifeGaines in Boca Raton just purchased 3 Lumenis products, a laser hair removal system and pigment lesion eraser called Splendor X, a tattoo removal device called the Piq04, and the AcuPulse, a CO2 laser system that removes "spider veins".

Schedule for a free consultation at (561) 931-2430 or go towww.lifegaines.comfor more information.

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LifeGaines has been just awarded the designation of "Center of Excellence" as they offer a collection of Lumenis services. These different services are described below.

Splendor X: Many people want to get rid of hair in certain places on their body. LifeGaines is administering the use of this product that helps people not happy with shaving, tweezing, or waxing to remove unwanted hair. The product guarantees uniform skin coverage in its application when removing hair.

PiQo4: When it comes to tattoos, many people regret getting them, but they don't know how to get rid of them. LifeGaines is using PiQo4 for those who want to remove tattoos. PiQo4 is used for Hyperpigmentation treatment for all skin tones. It provides high-energy light beams to treat skin, and for deeper pigmentation, such as melasma or tattoos. The Lasers shatter pigment deposits underneath the skin. This device is also used for unwanted age spots, sun damage, sun spots, or freckles. It is used for skin resurfacing.

PiQo4, a picture of tattoo removal: https://www.instagram.com/p/CB4KVQQAeKG/?igshid=18zl8kvud8kbl

AcuPulse is another product that LifeGaines is using for aesthetic resurfacing. It's an "ablative laser resurfacing workstation", which means it is used for the removal of a layer of tissue to treat discoloration, improve skin texture, or remove superficial lesions. AcuPulse is used for aesthetic resurfacing needs, such as getting rid of spider veins, uneven texture, sun damage, or acne scars.

AcuPulse is used to treat spider veins, like in this picture: https://www.instagram.com/p/CB5efJgAWi8/?igshid=3yqla5ftfa3h.

About Dr. Gaines, founder of LifeGaines Medical and Aesthetic Center:

Dr. Richard Gaines graduated from Boston University School of Medicine in 1981. He completed his internship at Tufts University School of Medicine in 1981 and his residency at Harvard Medical School in 1985, where he was an anesthesiology fellow at Brigham and Women's Hospital. He served as a physician at Huntington General Hospital, as an anesthesiologist at Harvard Community Health Plan and at Sheridan Healthcorp. Dr. Gaines opened an age management and wellness practice, after a 40-year career as a physician and health care executive. He has a Fellowship in Anti-Aging and Regenerative Medicine (FAARM) from the American Academy of Anti-Aging Medicine, he's Board certified from the American Board of Anti-Aging & Regenerative Medicine (ABAARM) and he's certified as a Functional Medicine Practitioner with advanced training at The Institute for Functional Medicine.

Schedule for a free consultation at (561) 931-2430 or go to http://www.lifegaines.com for more information.

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Medical Wellness Market to Record Exponential Growth Owing to High Demand Through COVID 19 Pandemic – 3rd Watch News

Wellness describes itself as complete physical mental and social well-being. It comprises all the components used to lead a healthy life. Wellness is multidirectional and constitutes social, emotional, physical, spiritual, intellectual and emotional wellbeing. According to National Wellness Institute, two more component of wellness includes cultural and environmental wellness. Mental health and well-being are an integral and essential component of health. Wellness goes further than disease or disability and highlights the maintenance and improvement of health and well-being of the person. Wellness includes activities that improve health, enhance the quality of life and increase the levels of well-being of the person. Different types of wellness include workplace wellness, wellness tourism, lifestyle wellness and others. In order to help prevent disease, reduce stress, and enhance the overall quality of life Global Wellness Institute (GWI) organizes e Global Spa & Wellness Summit (GSWS) annually, that brings together leaders and visionaries to discuss various aspects of health and wellbeing.

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Nowadays, people are focusing on preventive, proactive aspects of wellness, wellness economy incorporates industrial sector that enables consumers to incorporate wellness into their lives. Consumers are inclining towards preventive measures to prevent diseases and maintain good health. The key sector of wellness includes wellness tourism, fitness, complementary & alternative medicine, lifestyle wellness, rejuvenation and spa industry, workplace wellness and others.

Wellness is self-responsibility and is opening new opportunities for wellness market as due to increase in geriatric population, rise in disease population due to sedentary lifestyle, new research on wellness procedures using alternative medicines, expansion of consumer base and wellness industries, tourism is growing, that will incorporate wellness into travel, shift of consumers towards personal care products are some of the factors that will drive the medical wellness market. The awareness about medical wellness will help consumers, spread wellness to homes and their workplace and help the right way to exercise, include healthy eating in their diet, focus on preventive and personalized health and others. Lack of awareness about medical wellness, rise in products and services of wellness industry, lack of workforce and others are some of the factors restraining the market growth.

The global medical wellness market is segmented on basis of wellness sector, distribution channel and geography:

Segment by Wellness Sector

Segment by Distribution Channel

The global medical wellness market is segmented into wellness sector and distribution channel. Based on the wellness sector, the medical wellness market is segmented into complementary and alternative medicine, beauty care and anti-aging (surgical and non-surgical), preventative and personalized medicine, healthy eating, nutrition and weight loss, rejuvenation and others. The beauty care and anti- aging segment will dominate the wellness market due to rise in number of aesthetics procedures and increase in number of beauty care wellness sectors. Based on the end user, the medical wellness market is segmented as franchise and company owned outlets. The global medical wellness market is going to increase significantly is near future due to shift of consumers towards proactive approaches and include wellness in day to day life.

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By regional presence, the global medical wellness market is segmented into five broad regions viz. North America, Latin America, Europe, Asia-Pacific, and the Middle East & Africa. North America market is expected to dominate in terms of revenue share, owing to the high availability of advanced products and services, wellness tourism, expenditures growth, , increasing penetration of leading companies in the region along with increase in patient population. Significant economic development has led to an increase in healthcare availability in Asia Pacific region, growing number of multi-specialty care centers, rejuvenation and fitness centers and penetration of global players in Asia is expected to fuel the medical wellness market

Some of the major players in medical wellness market are Enrich Hair & Skin Solutions, VLCC Wellness Center, Guardian Lifecare, Healthkart, WTS International, The Body Holiday, Bon Vital, Biologique Recherch, MINDBODY Inc., Massage Envy, ClearCost Health, Golds Gym International, Inc., World Gym, Spafinder Wellness 365, Kaya Skin Clinic, Body master and others

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Nutraceutical Products Market 2019 | How The Industry Will Witness Substantial Growth In The Upcoming Years | Exclusive Report By MRE – Cole of Duty

The Global Nutraceutical Products Market is expected to exceed more than US$ 404.48 Billion by 2024 at a CAGR of 7.32% in the given forecast period.

Market Research Engine has published a new report titled as Nutraceutical Products Market Size By Type (Food, Beverages, Dietary Supplements, Dairy Products, Infant Nutrition Products), By Distribution Channel (Conventional Stores, Specialty Stores, Drugstores & Pharmacies), By Source (Proteins & Amino Acids, Probiotics, Phytochemicals & Plant Extracts, Fibers & Specialty Carbohydrates, Omega-3 Fatty Acids, Vitamins, Prebiotics, Carotenoids, Minerals), By Region (North America, Europe, Asia-Pacific, Rest of the World), Market Analysis Report, Forecast 2018-2024.

FYI, You will get latest updated report as per the COVID-19 Impact on this industry. Our updated reports will now feature detailed analysis that will help you make critical decisions.

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The term nutraceutical has been derived from 2 terms, nutrition and pharmaceutical. It is a lot of an advert term that is employed for any food merchandise, or a part of food supplements that has a medical or health profit instead of simply basic nutrition. Such practical food merchandise contains varied minerals, vitamins, dietary fibers, hydrolysed proteins, prebiotics and probiotics that are terribly useful within the provision of nutrition to a persons body. Nutraceutical merchandise are offered within the sort of sports drinks, farm merchandise, snacks and pre-packaged diet meals. Nutraceuticals are terribly capable and versatile in nature as theyre utilized in various industries like pharmaceutical food & beverages, animal feed additives, and private care.

The global nutraceutical ingredients market is projected to register a major growth rate over a forecast amount because the demand for nutraceutical ingredients is hyperbolic thanks to the rising awareness and consciousness regarding the healthy diet as well as nutraceutical ingredients. Increasing prevalence of chronic diseases and rising aging population worldwide is that the major mode issue boosts the demand for the nutraceutical ingredient and drives the worldwide nutraceutical ingredients market. The increasing use of nutraceutical ingredients within the pharmaceutical medicine thanks to its effective properties like anti-aging conjointly drives the expansion of the worldwide nutraceutical ingredient market.

The proteins & amino acids section is projected to carry the most important market share throughout the forecast amount. Proteins area unit chiefly utilized in industrial applications because of their nutrition ARY and useful properties. Their potential to extend nutrition ARY levels makes them one among the key ingredients within the nutraceutical merchandise market. Additionally, intensive R&D on proteins and therefore the edges of their properties have semiconductor diode to the identification of innovative uses within the attention and pharmaceutical industries. what is more, the role of amino acids within the growth of organisms to make sturdy muscular tissues, development of organs, and best functioning of the system has semiconductor diode to their increasing usage in snacks, ready-to-eat, and convenience foods.

The global Nutraceutical Products market is segregated on the basis of Type as Food, Beverages, Dietary Supplements, Dairy Products, and Infant Nutrition Products. Based on Distribution Channel the global Nutraceutical Products market is segmented in Conventional Stores, Specialty Stores, and Drugstores & Pharmacies. Based on Source the global Nutraceutical Products market is segmented in Proteins & Amino Acids, Probiotics, Phytochemicals & Plant Extracts, Fibers & Specialty Carbohydrates, Omega-3 Fatty Acids, Vitamins, Prebiotics, Carotenoids, Minerals, and Others.

The global Nutraceutical Products market report provides geographic analysis covering regions, such as North America, Europe, Asia-Pacific, and Rest of the World. The Nutraceutical Products market for each region is further segmented for major countries including the U.S., Canada, Germany, the U.K., France, Italy, China, India, Japan, Brazil, South Africa, and others.

Competitive Rivalry

Kraft Heinz Company, The Hain Celestial Group, Conagra, General Mills, Kelloggs, Nestl, Natures Bounty, Amway, Hero Group, Barilla, and others are among the major players in the global Nutraceutical Products market. The companies are involved in several growth and expansion strategies to gain a competitive advantage. Industry participants also follow value chain integration with business operations in multiple stages of the value chain.

The Nutraceutical Products Market has been segmented as below:

Nutraceutical Products Market, By Type

Nutraceutical Products Market, By Distribution Channel

Nutraceutical Products Market, By Source

Nutraceutical Products Market, By Region

Nutraceutical Products Market, By Company

The report covers:

Report Scope:

The global Nutraceutical Products market report scope includes detailed study covering underlying factors influencing the industry trends.

The report covers analysis on regional and country level market dynamics. The scope also covers competitive overview providing company market shares along with company profiles for major revenue contributing companies.

The report scope includes detailed competitive outlook covering market shares and profiles key participants in the global Nutraceutical Products market share. Major industry players with significant revenue share include Kraft Heinz Company, The Hain Celestial Group, Conagra, General Mills, Kelloggs, Nestl, Natures Bounty, Amway, Hero Group, Barilla, and others.

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DXIN Joins Hands with TCI to Develop a Variety of Premium Functional Foods for Beauty Purposes – PRNewswire

DXIN, since 2014, has launched numerous sought-after products and achieved considerable sales growth with social commerce, so far the hottest e-commerce trend worldwide. Social commerce connects consumers around the world based on interpersonal communication of user experience and users' direct feedback on social media platforms. The key to the success of this trending business model lies in that consumers can truly feel the effectiveness of products and that the products really help improve their lives. Thus, DXIN thoroughly investigates market expectations, rigorously controls product quality, and collaborates withTCI (TWE:8436),international ODM supplier to develop competitive products of exceptional quality and make the brand widely recognized by consumers, who are willing to recommend products by DXIN to their friends and followers on social networks.

2020 is a crucial year for DXIN's further business expansion. DXIN, from its' years of experience in social commerce, has discovered that the combination of internal and external treatment, a highly-valued strategy in traditional Chinese medicine, is the ultimate skincare solution. Therefore, DXIN joins hands with TCI, a world-famous scientific R&D manufacturer sophisticated in health and skin care, to develop a variety of premium functional foods for beauty purposes, including the anti-aging Collagen Cubilose Drink, the skin-whitening Pomegranate and Rosa roxburghii Tablet, the fat-burning Vegetable Fruits and Vegetables Baking Powder, and the immunity-boosting Coniferous Cherry Probiotic Powder. Exceeding consumers' expectations, these groundbreaking products with incredible health effects have literally made DXIN a market leader whose launches of new products are always expected by consumers. Currently, DXIN and TCI have embarked on the co-development of the energy-boosting Polygonatum sibiricum drink for males, the blueberry eye care jelly, which will be produced at the Sunrise Park in Pingtung, Taiwan, and the blood-enriching red jinseng drink.

DXIN has indicated in an interview that its products, such as the Cubilose Drink easy to take in modern life, the fermented Fruits and Vegetables Powder, and Probiotic Powder, are produced based on the integration of Chinese traditional herbal treatment and the R&D partner TCI's unique extraction technology. DXIN believes that with the strict quality control in accordance with international standards and innovative strategy in formula design, its brand-new collection of functional foods will again take social commerce platforms by storm and create a better future for the health and beauty of consumers and that DXIN is definitely becoming a China-based pioneer navigating the global skin care market.

SOURCE TCI

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Overnight Face Mask Market 2020: Global Industry Analysis By Size, Share, Growth, Trends And Forecast To 2026 – Cole of Duty

Trusted Business Insights answers what are the scenarios for growth and recovery and whether there will be any lasting structural impact from the unfolding crisis for the Overnight Face Mask market.

Trusted Business Insights presents an updated and Latest Study on Overnight Face Mask Market 2019-2026. The report contains market predictions related to market size, revenue, production, CAGR, Consumption, gross margin, price, and other substantial factors. While emphasizing the key driving and restraining forces for this market, the report also offers a complete study of the future trends and developments of the market.The report further elaborates on the micro and macroeconomic aspects including the socio-political landscape that is anticipated to shape the demand of the Overnight Face Mask market during the forecast period (2019-2029).It also examines the role of the leading market players involved in the industry including their corporate overview, financial summary, and SWOT analysis.

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Industry Insights, Market Size, CAGR, High-Level Analysis: Overnight Face Mask Market

The global overnight face mask market size was valued at USD 18.2 billion in 2018 and is anticipated to expand at a CAGR of 7.1% over the forecast period. Growing incidences of various skin conditions such as ageing, wrinkles, and dryness are driving the consumers to increasingly spend on various skin care solutions that offer prolonged treatment. Overnight face masks have been gaining an increasing traction among consumers who look for convenient skin care products at home that do not demand additional time investment. Moreover, increased consumer demand for mental relaxation is expected to drive the manufacturers to develop overnight face products infused with functional ingredients, thereby propelling the growth of the global market in the near future.Impact of busy and modern lifestyles due to long work hours, pollution, work life pressures, and inappropriate diets is taking a visible toll on the skin, thereby resulting in premature damage. Considering the fact that adequate sleep is an essential remedy, consumers are also looking for skin care products including overnight face masks that penetrate more effectively when at rest.

This scenario has triggered the increasing application of sleep masks among the consumers. In the last few years, bubble masks had gained significant popularity in the Asian beauty trends, which resulted in manufacturers creating their own unique formulas. For instance, brands such as Origins and e.l.f. Cosmetics introduced their hydrating bubble mask and foaming deep cleansing masks respectively that included deep hydration and cleansing agents. These product innovations are anticipated to drive the market for overnight face masks.Increasing preference for overnight masks infused with essential oils and natural and fruit based ingredients is driving continuous product innovations. For instance, ESPA Overnight Hydration Therapy is made of relaxing essential oils and seaweeds extracts that revive the skin moisture content overnight. Lanieges Sleeping Mask is a popular fruit based overnight face rejuvenating product. Laniege offers few varieties in the night mask category.Women have been the major demand generators in the overnight face mask market. However, men are increasingly considered to be the high potential consumers by brand managers, particularly who are into online distribution or have high-end product positioning. Shaving often leads to roughness and dryness, hence sheet masks are generally preferred by men for a well moisturized skin. Moreover, a wide range of overnight face masks for men are available with specific solutions such as anti-aging, wrinkle free, and skin lightening. Some of the common overnight face masks include watermelon glow sleeping mask, Elizabeth Ardens superstart probiotic boost skin renewal bio cellulose mask, and Saturn sulfur acne treatment mask by Sunday Riley.Distribution Channel InsightsConvenience stores accounted for the largest share of 46.8% in 2018. These include beauty, drug, and general stores. Growth of the skin care industry has driven the manufacturers to distribute their products widely across their retail beauty stores and independent beauty and drug stores. These stores are easily accessible to the customers and ensure high visibility of products including overnight face masks. Moreover, presence of an in-store associate guides the customers in choosing the correct product, thereby easing out their purchase decisions.Online distribution channel is expected to expand at the fastest CAGR of 8.8% over the forecast period. Growing demand for beauty care products has been driving the existing as well new manufacturers to introduce their online distribution channels to cater to the large customer base. Moreover, high demand for Korean as well as other international based overnight face mask products is expected to popularize the use of online shopping sites. Moreover, online retailers such as Sephora and e.l.f Cosmetics have started creating their own formulas in this category in order to cater to the continuous demand of the consumers.

Product Insights of Overnight Face Mask Market

Cream and gel based masks accounted for the largest share of more than 55.0% in 2018. This is the most preferred type due to its easy and hassle free application. Creams and gel forms penetrate deeply in the skin, thereby resulting in effective skin repair. Companies are investing in introducing lightweight cream and gel based masks to provide a relaxing effect on the skin while sleeping. For instance, LOreal Paris had introduced a jelly based mask made with French grape seed extracts. This product repairs the dullness and enhances the hydration level of the skin with its double hyaluronic acids, thereby giving a soft and supple effect to the face.

Sheet based overnight face masks are expected to witness significant growth in the next few years due to its quick and hassle free application. Face sheets are usually infused with cooling ingredients that relaxes the muscles and effectively revives the damaged skin. These overnight face sheets usually include hyaluronic acid and enriching vitamins in high content that seep in quickly as compared to creams. These face sheets provide easy hydration and add extra moisture content to energize dry skin. Sheet masks can be used as a daily skincare routine as compared to creams, hence it is expected to witness increased application in the near future.

Regional Insights of Overnight Face Mask Market

Asia Pacific dominated the global market, accounting for a share of more than 35.0% in 2018 primarily due to increased use of overnight face masks in countries such as China and Korea. Growing demand for skin care products such as face masks in these countries has been driving the product innovations. Consumers in these countries prefer intensive skin care solutions and daily grooming routines, wherein application of overnight sheet based masks serve as an essential product. The market includes a wide variety of masks with an array of enriching ingredients derived from traditional Chinese medicine extracts, coupled with vitamins and minerals.North America is expected to expand at the highest CAGR of 7.5% over the forecast period. Companies are emphasizing on increasing the product penetration in U.S. owing to growing consumer awareness about skin care solutions and high demand for Korean beauty products. Moreover, celebrity influencers are playing a crucial role in popularizing the skin care trends in this region, which is expected to contribute to this market growth.

Market Share Insights of Overnight Face Mask Market

The global market is highly competitive in nature. Some of the major players operating in the market for overnight face mask are LOreal Paris; Laniege; e.l.f. Cosmetics; Inc.; The Body Shop; Peter Thomas Roth Labs LLC.; Lotus Herbals; Lakme Cosmetics; Innisfree; The Estee Lauder Companies Inc.; Vichy Laboratories; and Avon Products, Inc. Companies dealing in this beauty care category are actively involved in introducing new products to cater to the varied needs of the customers. Continuous research and development is carried out to introduce products based on natural ingredients. For instance, Innisfree is a naturalism oriented cosmetic brand that offers a wide range of sleeping or overnight face masks infused with natural ingredients, such as its green tea sleeping pack is made of green tea seed oil.

Segmentations, Sub Segmentations, CAGR, & High-Level Analysis overview of Overnight Face Mask Market Research ReportThis report forecasts revenue growth at the global, regional, and country levels and provides an analysis of the latest industry trends in each of the sub-segments from 2014 to 2025. For the purpose of this study, this market research report has segmented the global overnight face mask market report on the basis of product, distribution channel, and region:

Product Outlook (Revenue, USD Billion, 2019 2030)

Creams & Gels

Sheets

Distribution Channel Outlook (Revenue, USD Billion, 2019 2030)

Supermarkets & Hypermarkets

Convenience Stores

Online

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