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Category : Human Longevity

REVIEW: ‘The Dig’ is captivating, beautiful exploration of past The Daily Free Press – Daily Free Press

Combining the directorial skills of Simon Stone, the screenplay adaptation by Moira Buffini and the cinematography of Mike Eley, The Dig portrays a dynamic, true story intertwining themes of history and modern existential longing with dramatic scenes concerning life, death, love and family.

The Netflix film, released Jan. 29, is an adaptation of John Prestons 2007 novel of the same name and is based on a true story. Taking place in the rustic countryside of Suffolk, England on the eve of World War II, self-taught archaeologist Basil Brown, played by Ralph Fiennes, embarks on a dig to uncover whats believed to be ancient Anglo-Saxon ruins potentially dating as far back as the Vikings or further.

The site lies on the vast estate owned by Edith Pretty, played by 2013s The Great Gatsby star Carey Mulligan. Pretty is a widow left with one son and a dream to dig up three large, grassy, hill-like mounds located in the fields. Though the archaeologist is unconvinced theres anything significant to be found, attempted grave robberies have convinced Pretty theres something extremely valuable hidden within.

Brown, a local archaeologist with the Ipswich Museum, leads the Sutton Hoo excavation, with Peggy Piggott, played by Lily James. Hes portrayed as a modest working man with vast knowledge of the land. His soil expertise is what leads Pretty to hire him in the first place.

Given the politics of the time period, the dig site is seen as an area of national interest as Britain was preparing to protect the countrys ancient ruins from German air raids.

The story shifts toward a more intimate focus, concerned with family and belonging, when Prettys young son Robert, played by Archie Barnes, grows increasingly fond of Brown. The two are portrayed almost as father and son, bringing the narrative closer to one of community rather than national glory.

The Dig captures a unique perspective of existentialism, with the story taking place during Britains mobilization before wartime. It keeps audiences reflecting on the significance of human legacy, wondering what will be left of us after we are gone.

As the characters on screen are forced to come to terms with their own mortality in an age of destruction and uncertainty, we get a better understanding of the significance of these ancient runes that are still standing a testament of humanitys longevity.

Aside from matters of historical and ancestral significance, The Dig is a nod to the struggles that affect ordinary people of today, with overtones of love, lust and heartbreak.

What keeps viewers satisfied throughout the film is the unchanging and breathtaking scenery of the Suffolk countryside. Eley yields cinematographic mastery by capturing the lush wheat fields of eastern England, combined with enticing pan shots of the site to emphasize how massive this project is, yet also how seemingly small of a role it plays in the full history of the nation.

Stone keeps audiences holding their breaths by turning a story of national history into a heartfelt drama that so accurately touches on struggles that afflict people of all backgrounds.

Its worth mentioning the film has received some criticism for sexist portrayal of characters, for ageism despite the whimsical setting and for fictionalizing some of the truth.

Be that as it may, it was worth the watch.

At surface level, The Dig seems like a story of historical drama, but it takes audiences into deep-cutting, emotionally luring instances of love, loss, triumph and human connection.

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REVIEW: 'The Dig' is captivating, beautiful exploration of past The Daily Free Press - Daily Free Press

Recommendation and review posted by Alexandra Lee Anderson

Study examines why college education leads to healthier and longer lives – William & Mary News

Healthy lifestyle: Physical activities abound on college campuses like William & Mary. These healthy habits are among the benefits of college education that contribute to health and longevity, according to a study led by W&M Assistant Professor of Economics Peter Savelyev. Photo by Jim Agnew

by Nathan Warters | February 4, 2021

A study led by William & Mary Assistant Professor of Economics Peter Savelyev and funded by the National Science Foundation argues that college education leads to healthier and longer lives.

The study, Understanding the Mechanisms Linking College Education with Longevity, was published in September in Journal of Human Capital.

Researchers around the world still debate whether education affects health. Savelyev and his team support the claim that education improves heath by demonstrating the mechanisms behind this effect while using state-of-the art statistical analysis.

In our paper, we show that education increases health and longevity though healthier lifestyles, superior earnings and better work conditions, he said.

Savelyev and his co-authors examined data obtained from men and women who graduated from high school in Wisconsin in 1957. This specific timeframe was important to allow for data collection on at least a partially deceased U.S. cohort.

William & Mary News recently spoke to Savelyev about this study. The interview has been edited for length and clarity.

Variables related to healthy lifestyles that proved to be important are participating in physical exercise, maintaining a healthy body weight and abstaining from smoking tobacco. We also study the role of extremely dangerous work conditions, such as cutting trees or being exposed to infectious diseases. Educated people are less likely to face such jobs. The work conditions mechanism does not necessarily imply diminishing job-related risks for the general population, but it is a personal benefit for those who study hard and receive advanced degrees.

It is well known that many essential life determinants emerge early in life. Later in life, things are harder to change. College education is a powerful contributor to human development that increases health and longevity, among many other good effects, and it should be supported in situations when free market solutions do not work well enough.

Our simulations demonstrate that major health differences created by college education are hard to close later in life, even by strong hypothetical policy interventions, such as greatly increasing taxation of cigarettes.

Partly, this is because the effect of education is strong, and it works through many different mechanisms. It is not easy for an intervention that targets just one specific mechanism to overcome a strong effect created through dozens of mechanisms. Also, some policies, such as taxation of cigarettes, affect behavior of both the college-educated and those who did not go to college, so the effect on the difference between these two groups is small.

We find that obtaining a bachelors degree leads to about three additional years of life for men. However, we could not find any effect of college education for women, who live longer than men regardless of their education status. We identified from our data two mechanisms that partly explain the gender difference. One is that men tend to take more dangerous jobs than women. Another is that educated women of this historic cohort born in late 1930s in Wisconsin were less likely to be married, which created a negative contribution to their longevity that masked a positive contribution related to higher income. Marriage is good for your longevity. Since a negative effect of college education on marriage no longer takes place for more recent cohorts of women, we can expect a stronger effect of college on their longevity, as confirmed by our simulations.

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Study examines why college education leads to healthier and longer lives - William & Mary News

Recommendation and review posted by Alexandra Lee Anderson

Appointments, honors and activities – Purdue News Service

Thanos Tzempelikos, professor in the Lyles School of Civil Engineering, has received the prestigious Leon Gaster Award from the Society of Light and Lighting as a co-author of the paper, "Cross-validation and Robustness of Daylight Glare Metrics." This award is presented annually, naming the best paper of the year concerned with lighting applications. The award was presented at the societys Annual Awards evening in December in London.

Dr. David Waters is the recipient of the Center on Aging and the Life Course's (CALC) Outstanding Professor Award.Waters is professor emeritus in the College of Veterinary Medicine and a CALC faculty associate. Waters teaches biology of aging and received numerous student nominations for the award, which recognizesexceptional teaching and mentoring of emerging scholars in aging. He is director of the Center for Exceptional Longevity Studies at the Gerald P. Murphy Cancer Foundation.

* * * * *

Orr Fellowship, a postgraduate professional development program based in Indianapolis, has recently selected four Purdue seniors as Orr Fellows. The Orr Fellowship is one of Indianas most celebrated nonprofit talent programs. The students Miguel Diaz, Sean ODell, Eleanor Hamilton and Hannah Vanderbosch were chosen out of nearly 1,300 applicants and will begin at one of 46 Orr Fellowship partner companies upon graduating in May. They also will participate in Orr Fellowship programming dedicated to nurturing entrepreneurship and developing strong leadership skills.

Christine McCall, a graduate research and teaching assistant in the College of Health and Human Sciences, earned a top honor from the National Council on Family Relations for a paper. McCall won the Outstanding Student and New Professional Paper Award for her paper titled A Part of Our Family? Effects of Psychiatric Service Dogs on Quality of Life and Relationship Functioning in Military-Connected Couples.

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Appointments, honors and activities - Purdue News Service

Recommendation and review posted by Alexandra Lee Anderson

Around Town: UC Irvine to host a virtual celebration Monday to ring in the Year of the Ox – Los Angeles Times

The Lunar New Year will be welcomed Monday afternoon when UC Irvine hosts a special virtual celebration of the Year of the Ox.

The festivities are free and open to the public and are expected to include a dragon dance and feeding of the lion in addition to performances from artist Abigail Washburn and world-famous guzheng musician Wu Fei.

There will also be a virtual wishing tree and guests will be able to make a wish for prosperity, happiness and longevity by writing a wish on a red wishing card and taking a selfie with it. Wishing cards and more details on the event can be read at humanities.uci.edu.

Registration is required to attend and the event will begin at 4:30 p.m. on Feb. 8.

The Lunar New Year is on Feb. 12.

Laguna Beach hires recruiting firm for city manager searchLaguna Beach has begun the recruiting process in search of the seaside communitys next city manager.

John Pietig, the presiding city manager of Laguna Beach, announced the first week of January that he plans to retire in June. His service to the city has spanned 20 years.

The Laguna Beach City Council, which makes the appointment for the position of city manager, has hired the recruiting firm Bob Murray & Associates to carry out a search for candidates to serve as the citys top executive. City officials said the estimated cost for the executive recruiting firms services is less than $30,000.

This is one of the most important positions in the city, and hiring the recruiting firm will allow us to thoroughly evaluate both internal and external candidates for the City Manager position, Laguna Beach Mayor Bob Whalen said in a statement.

Pietig began his run with Laguna as assistant city manager, and he has served as city manager for the last decade. According to Whalen, the City Council aims to name his replacement in May.

Laguna Beach Dems to host OC Supervisor race talk Attorney Ashleigh Aitken will address the 6:30 p.m. Feb. 10 meeting of the Laguna Beach Democratic Club, a Zoom meeting that is open to the public. The events topic is the upcoming Orange County Board of Supervisors election, what role the board plays in running the county and how it allocates its $7.5 billion budget.

We should all be informed about and weigh in on how our tax dollars are being allocated by the Board of Supervisors, Gwen McNallan, president of the club, stated in a news release.

To learn more about the club, or to register for Wednesdays Zoom meeting, visit thelbdems.com.

OC emergency rental assistance program accepting applicationsThe County of Orange is accepting applications through the month of February for an Emergency Rental Assistance program for eligible renters struggling with unpaid rent or utilities bills during the COVID-19 pandemic.

Launched this week and funded by a $65.5 million allocation from the U.S. Department of Treasury, the program aims to provide financial assistance to those whose combined household income is at or below 80% of the countys average median income.

In Orange County, the median income is approximately $71,750 for an individual, $82,000 for a two-member household, $92,250 for three people and $102,450 for a four-person household. For more information on household size, visit era.211oc.org.

Residents of Anaheim, Santa Ana and Irvine may not participate in Orange Countys assistance program, as those cities have population sizes over 200,000 and maintain their own local city programs, according to a release issued last week by the Orange County Health Care Agency.

The Emergency Rental Assistance program does not apply to homeowners with past-due mortgage payments, utilities or energy costs. Funds may only be granted to renters.

Applicants will need to provide a photo ID, a copy of their lease agreement, proof of income affected by COVID-19, such as an unemployment letter or a letter from an employment detailing reduced hours or pay and proof of unpaid rent or utilities, such as documentation from a landlord or utility company stating an amount owed or overdue.

To learn how to apply, call 2-1-1 to receive assistance in multiple languages, visit era.211oc.org or text ERA to 898211.

Marine Corps Scholarship Foundation accepting applications through March 2A range of college scholarships are available to children or stepchildren of a Marine or Navy corpsmen, chaplain or religious programs specialist attached to a Marine unit who have a cumulative grade point average of 2.0 (on an unweighted 4.0 scale) and whose family has an adjusted gross income of $106,000 or less for 2021-22.

Scholarships are available for those pursuing an associates or bachelors degree, attending or planning to attend a college or career training school listed on the National Center for Education Statistics College Navigator website during the 2021-22 academic year.

Career and technical education scholarships are also available for students planning to attend a non-degree certificate program or vocational training 12 months or less at a community college or private career school listed on the College Navigator website.

Applications may be submitted through March 2. For more information, visit mcsf.org/apply.

Laguna Beach Festival of Arts 2021 grant applications due March 5Nonprofit organizations with programs promoting fine arts in and around the city of Laguna Beach are welcome to apply for a series of art grants through the Festival of Arts Foundation beginning Feb. 8.

The Foundation, established in 1989 to preserve and promote fine arts and other artistic endeavors in the area, will be accepting applications through March 5.

The FOA Foundation is proud to be able to assist local non-profit art organizations during these challenging times, Foundation President Bob Earl said in a statement. We hope that these funds will help to continue the programs that educate our community on the importance of art and cultural experiences.

Applications can be submitted online at foapom.com/grants. For information on eligibility, grant awards and the application process, contact Bob Earl at (949) 494-4132.

Laguna Beach school board appoints Michael Conlon to assistant superintendentThe Laguna Beach Unified School District has named Michael Conlon its assistant superintendent of human resources and public communications, according to district officials.

Conlon, who was serving as the director of human resources for the district, was appointed to the role at the board meeting on Jan. 28, at which the board considered reorganizing into a format with three assistant superintendents.

A statement from the district said that the decision would not result in an increase in staff. Jeff Dixon is the assistant superintendent of business services, and the district plans to hire an assistant superintendent of instructional services.

Michael [Conlon] has continued to demonstrate his focus on continuous improvement for himself and our community, District Supt. Jason Viloria said in the release. He is committed to developing positive relationships with staff and problem-solving conflicts when they occur. He has proven to be an effective human resources leader and administrator whose work is characterized by a genuine concern for the entire school community.

Back Bay products Mo Kenney, Tanner Pulice earn mens water polo honorsNewport Harbor High alumnus Mo Kenney earned Mountain Pacific Sports Federation Player of the Week honors this week, while Corona del Mar High product Tanner Pulice was named the MPSF Newcomer of the Week.

Both Kenney and Pulice are freshmen for the UCLA mens water polo team.

In his collegiate debut, Kenney scored a game-high five goals on Jan. 30 to lead the No. 2-ranked Bruins to a 15-9 home win over No. 5 Pepperdine. Four of the goals were even strength, and one came on the power play. He needed just six shots to score the five goals.

Pulice had two goals and two assists in the victory, also winning a sprint and drawing an exclusion.

Cal senior football player Michael Saffell, an Edison High alumnus, has been named the Pac-12 Football Scholar Athlete of the Year.

Saffell, a center, started on the offensive line for the Golden Bears each of the last three years, earning honorable mention All-Pac-12 honors in 2020. He began his career at guard before moving to center as a junior.

Due to COVID-19, he is eligible for a fifth year of competition, and he has opted to return in 2021.

Saffell earned his bachelors degree from Cals Haas School of Business in three-and-a-half years, graduating in December with a 3.62 undergraduate GPA. He was accepted into the universitys Master of Information and Data Science program, which he began in January.

Orange County SC shirt sales to benefit OC Educational Arts AcademyThe Orange County Soccer Club has started the JuntosMsFuertes campaign, hoping to combine the communitys passion for soccer and the arts to support diverse nonprofit organizations.

A custom shirt has been created in collaboration with a local artist, and all net proceeds from its sale will go to the Orange County Educational Arts Academy.

Located in Santa Ana, the institution serves about 630 students, ranging from transitional kindergarten to eighth grade.

Hugo Cesar Chavarria was the Southern Californian artist called upon to create the design for the shirt, which depicts action in an Orange County Soccer Club game with landmarks like the Santa Ana Water Tower and the Great Park Balloon in Irvine in the background.

The shirts are limited edition and will be on sale through February. The cost is $20 per shirt, and they can be purchased at the following link: bit.ly/OCSCDASH.

Sage Hill School accepting applications for 2021-22 school year through Feb. 15Sage Hill School, a nonprofit, non-denominational independent high school is accepting applications for students in grades 9-12 for the 2021-22 school year through Feb. 15.

Having reopened its doors to students in September five days a week, Sage Hill offered classes virtually or in-person during the 2020-21 school year.

For more information on programs, or to apply online, visit sagehillschool.org and click on the Admission tab. For all candidates who apply by the Feb. 15 deadline, first-round decisions will be announced the last week of February.

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Around Town: UC Irvine to host a virtual celebration Monday to ring in the Year of the Ox - Los Angeles Times

Recommendation and review posted by Alexandra Lee Anderson

Global Longevity and Anti-senescence Therapy Market Report 2020 by Key Players, Types, Applications, Countries, Market Size, Forecast to 2026 (Based…

Overview for Longevity and Anti-senescence Therapy Market Helps in providing scope and definitions, Key Findings, Growth Drivers, and Various Dynamics.

Longevity and Anti-senescence Therapy Market Data and Acquisition Research Study with Trends and Opportunities 2019-2024The study of Longevity and Anti-senescence Therapy market is a compilation of the market of Longevity and Anti-senescence Therapy broken down into its entirety on the basis of types, application, trends and opportunities, mergers and acquisitions, drivers and restraints, and a global outreach. The detailed study also offers a board interpretation of the Longevity and Anti-senescence Therapy industry from a variety of data points that are collected through reputable and verified sources. Furthermore, the study sheds a lights on a market interpretations on a global scale which is further distributed through distribution channels, generated incomes sources and a marginalized market space where most trade occurs.

Along with a generalized market study, the report also consists of the risks that are often neglected when it comes to the Longevity and Anti-senescence Therapy industry in a comprehensive manner. The study is also divided in an analytical space where the forecast is predicted through a primary and secondary research methodologies along with an in-house model.

Download PDF Sample of Longevity and Anti-senescence Therapy Market report @ https://hongchunresearch.com/request-a-sample/113635

Key players in the global Longevity and Anti-senescence Therapy market covered in Chapter 4:Acorda TherapeuticsUnity BiotechnologyAntoxereneCelgeneCohbarSenex BiotechnologyHuman Longevity Inc.T.A. SciencesAgex TherapeuticsRecursion PharmaceuticalsCalico Life SciencesSpotlight BiosciencePowervision Inc.Sierra Sciences LlcRestorbioInsilico MedicineOisin BiotechnologySenolytic TherapeuticsProteostasis Therapeutics Inc.Prana Biotechnology Ltd.Cleara Biotech

In Chapter 11 and 13.3, on the basis of types, the Longevity and Anti-senescence Therapy market from 2015 to 2026 is primarily split into:Senolytic Drug TherapyGene TherapyImmunotherapyOthers

In Chapter 12 and 13.4, on the basis of applications, the Longevity and Anti-senescence Therapy market from 2015 to 2026 covers:LongevitySenescence InhibitionCardiovascular DiseasesNeural Degenerative DiseasesOphthalmology DisordersCancer

Geographically, the detailed analysis of consumption, revenue, market share and growth rate, historic and forecast (2015-2026) of the following regions are covered in Chapter 5, 6, 7, 8, 9, 10, 13:North America (Covered in Chapter 6 and 13)United StatesCanadaMexicoEurope (Covered in Chapter 7 and 13)GermanyUKFranceItalySpainRussiaOthersAsia-Pacific (Covered in Chapter 8 and 13)ChinaJapanSouth KoreaAustraliaIndiaSoutheast AsiaOthersMiddle East and Africa (Covered in Chapter 9 and 13)Saudi ArabiaUAEEgyptNigeriaSouth AfricaOthersSouth America (Covered in Chapter 10 and 13)BrazilArgentinaColumbiaChileOthersRegional scope can be customized

For a global outreach, the Longevity and Anti-senescence Therapy study also classifies the market into a global distribution where key market demographics are established based on the majority of the market share. The following markets that are often considered for establishing a global outreach are North America, Europe, Asia, and the Rest of the World. Depending on the study, the following markets are often interchanged, added, or excluded as certain markets only adhere to certain products and needs.

Here is a short glance at what the study actually encompasses:Study includes strategic developments, latest product launches, regional growth markers and mergers & acquisitionsRevenue, cost price, capacity & utilizations, import/export rates and market shareForecast predictions are generated from analytical data sources and calculated through a series of in-house processes.

However, based on requirements, this report could be customized for specific regions and countries.

Brief about Longevity and Anti-senescence Therapy Market Report with [emailprotected]https://hongchunresearch.com/report/longevity-and-anti-senescence-therapy-market-size-2020-113635

Some Point of Table of Content:

Chapter One: Report Overview

Chapter Two: Global Market Growth Trends

Chapter Three: Value Chain of Longevity and Anti-senescence Therapy Market

Chapter Four: Players Profiles

Chapter Five: Global Longevity and Anti-senescence Therapy Market Analysis by Regions

Chapter Six: North America Longevity and Anti-senescence Therapy Market Analysis by Countries

Chapter Seven: Europe Longevity and Anti-senescence Therapy Market Analysis by Countries

Chapter Eight: Asia-Pacific Longevity and Anti-senescence Therapy Market Analysis by Countries

Chapter Nine: Middle East and Africa Longevity and Anti-senescence Therapy Market Analysis by Countries

Chapter Ten: South America Longevity and Anti-senescence Therapy Market Analysis by Countries

Chapter Eleven: Global Longevity and Anti-senescence Therapy Market Segment by Types

Chapter Twelve: Global Longevity and Anti-senescence Therapy Market Segment by Applications 12.1 Global Longevity and Anti-senescence Therapy Sales, Revenue and Market Share by Applications (2015-2020) 12.1.1 Global Longevity and Anti-senescence Therapy Sales and Market Share by Applications (2015-2020) 12.1.2 Global Longevity and Anti-senescence Therapy Revenue and Market Share by Applications (2015-2020) 12.2 Longevity Sales, Revenue and Growth Rate (2015-2020) 12.3 Senescence Inhibition Sales, Revenue and Growth Rate (2015-2020) 12.4 Cardiovascular Diseases Sales, Revenue and Growth Rate (2015-2020) 12.5 Neural Degenerative Diseases Sales, Revenue and Growth Rate (2015-2020) 12.6 Ophthalmology Disorders Sales, Revenue and Growth Rate (2015-2020) 12.7 Cancer Sales, Revenue and Growth Rate (2015-2020)

Chapter Thirteen: Longevity and Anti-senescence Therapy Market Forecast by Regions (2020-2026) continued

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List of tablesList of Tables and Figures Table Global Longevity and Anti-senescence Therapy Market Size Growth Rate by Type (2020-2026) Figure Global Longevity and Anti-senescence Therapy Market Share by Type in 2019 & 2026 Figure Senolytic Drug Therapy Features Figure Gene Therapy Features Figure Immunotherapy Features Figure Others Features Table Global Longevity and Anti-senescence Therapy Market Size Growth by Application (2020-2026) Figure Global Longevity and Anti-senescence Therapy Market Share by Application in 2019 & 2026 Figure Longevity Description Figure Senescence Inhibition Description Figure Cardiovascular Diseases Description Figure Neural Degenerative Diseases Description Figure Ophthalmology Disorders Description Figure Cancer Description Figure Global COVID-19 Status Overview Table Influence of COVID-19 Outbreak on Longevity and Anti-senescence Therapy Industry Development Table SWOT Analysis Figure Porters Five Forces Analysis Figure Global Longevity and Anti-senescence Therapy Market Size and Growth Rate 2015-2026 Table Industry News Table Industry Policies Figure Value Chain Status of Longevity and Anti-senescence Therapy Figure Production Process of Longevity and Anti-senescence Therapy Figure Manufacturing Cost Structure of Longevity and Anti-senescence Therapy Figure Major Company Analysis (by Business Distribution Base, by Product Type) Table Downstream Major Customer Analysis (by Region) Table Acorda Therapeutics Profile Table Acorda Therapeutics Production, Value, Price, Gross Margin 2015-2020 Table Unity Biotechnology Profile Table Unity Biotechnology Production, Value, Price, Gross Margin 2015-2020 Table Antoxerene Profile Table Antoxerene Production, Value, Price, Gross Margin 2015-2020 Table Celgene Profile Table Celgene Production, Value, Price, Gross Margin 2015-2020 Table Cohbar Profile Table Cohbar Production, Value, Price, Gross Margin 2015-2020 Table Senex Biotechnology Profile Table Senex Biotechnology Production, Value, Price, Gross Margin 2015-2020 Table Human Longevity Inc. Profile Table Human Longevity Inc. Production, Value, Price, Gross Margin 2015-2020 Table T.A. Sciences Profile Table T.A. Sciences Production, Value, Price, Gross Margin 2015-2020 Table Agex Therapeutics Profile Table Agex Therapeutics Production, Value, Price, Gross Margin 2015-2020 Table Recursion Pharmaceuticals Profile Table Recursion Pharmaceuticals Production, Value, Price, Gross Margin 2015-2020 Table Calico Life Sciences Profile Table Calico Life Sciences Production, Value, Price, Gross Margin 2015-2020 Table Spotlight Bioscience Profile Table Spotlight Bioscience Production, Value, Price, Gross Margin 2015-2020 Table Powervision Inc. Profile Table Powervision Inc. Production, Value, Price, Gross Margin 2015-2020 Table Sierra Sciences Llc Profile Table Sierra Sciences Llc Production, Value, Price, Gross Margin 2015-2020 Table Restorbio Profile Table Restorbio Production, Value, Price, Gross Margin 2015-2020 Table Insilico Medicine Profile Table Insilico Medicine Production, Value, Price, Gross Margin 2015-2020 Table Oisin Biotechnology Profile Table Oisin Biotechnology Production, Value, Price, Gross Margin 2015-2020 Table Senolytic Therapeutics Profile Table Senolytic Therapeutics Production, Value, Price, Gross Margin 2015-2020 Table Proteostasis Therapeutics Inc. Profile Table Proteostasis Therapeutics Inc. Production, Value, Price, Gross Margin 2015-2020 Table Prana Biotechnology Ltd. Profile Table Prana Biotechnology Ltd. Production, Value, Price, Gross Margin 2015-2020 Table Cleara Biotech Profile Table Cleara Biotech Production, Value, Price, Gross Margin 2015-2020 Figure Global Longevity and Anti-senescence Therapy Sales and Growth Rate (2015-2020) Figure Global Longevity and Anti-senescence Therapy Revenue ($) and Growth (2015-2020) Table Global Longevity and Anti-senescence Therapy Sales by Regions (2015-2020) Table Global Longevity and Anti-senescence Therapy Sales Market Share by Regions (2015-2020) Table Global Longevity and Anti-senescence Therapy Revenue ($) by Regions (2015-2020) Table Global Longevity and Anti-senescence Therapy Revenue Market Share by Regions (2015-2020) Table Global Longevity and Anti-senescence Therapy Revenue Market Share by Regions in 2015 Table Global Longevity and Anti-senescence Therapy Revenue Market Share by Regions in 2019 Figure North America Longevity and Anti-senescence Therapy Sales and Growth Rate (2015-2020) Figure Europe Longevity and Anti-senescence Therapy Sales and Growth Rate (2015-2020) Figure Asia-Pacific Longevity and Anti-senescence Therapy Sales and Growth Rate (2015-2020) Figure Middle East and Africa Longevity and Anti-senescence Therapy Sales and Growth Rate (2015-2020) Figure South America Longevity and Anti-senescence Therapy Sales and Growth Rate (2015-2020) Figure North America Longevity and Anti-senescence Therapy Revenue ($) and Growth (2015-2020) Table North America Longevity and Anti-senescence Therapy Sales by Countries (2015-2020) Table North America Longevity and Anti-senescence Therapy Sales Market Share by Countries (2015-2020) Figure North America Longevity and Anti-senescence Therapy Sales Market Share by Countries in 2015 Figure North America Longevity and Anti-senescence Therapy Sales Market Share by Countries in 2019 Table North America Longevity and Anti-senescence Therapy Revenue ($) by Countries (2015-2020) Table North America Longevity and Anti-senescence Therapy Revenue Market Share by Countries (2015-2020) Figure North America Longevity and Anti-senescence Therapy Revenue Market Share by Countries in 2015 Figure North America Longevity and Anti-senescence Therapy Revenue Market Share by Countries in 2019 Figure United States Longevity and Anti-senescence Therapy Sales and Growth Rate (2015-2020) Figure Canada Longevity and Anti-senescence Therapy Sales and Growth Rate (2015-2020) Figure Mexico Longevity and Anti-senescence Therapy Sales and Growth (2015-2020) Figure Europe Longevity and Anti-senescence Therapy Revenue ($) Growth (2015-2020) Table Europe Longevity and Anti-senescence Therapy Sales by Countries (2015-2020) Table Europe Longevity and Anti-senescence Therapy Sales Market Share by Countries (2015-2020) Figure Europe Longevity and Anti-senescence Therapy Sales Market Share by Countries in 2015 Figure Europe Longevity and Anti-senescence Therapy Sales Market Share by Countries in 2019 Table Europe Longevity and Anti-senescence Therapy Revenue ($) by Countries (2015-2020) Table Europe Longevity and Anti-senescence Therapy Revenue Market Share by Countries (2015-2020) Figure Europe Longevity and Anti-senescence Therapy Revenue Market Share by Countries in 2015 Figure Europe Longevity and Anti-senescence Therapy Revenue Market Share by Countries in 2019 Figure Germany Longevity and Anti-senescence Therapy Sales and Growth Rate (2015-2020) Figure UK Longevity and Anti-senescence Therapy Sales and Growth Rate (2015-2020) Figure France Longevity and Anti-senescence Therapy Sales and Growth Rate (2015-2020) Figure Italy Longevity and Anti-senescence Therapy Sales and Growth Rate (2015-2020) Figure Spain Longevity and Anti-senescence Therapy Sales and Growth Rate (2015-2020) Figure Russia Longevity and Anti-senescence Therapy Sales and Growth Rate (2015-2020) Figure Asia-Pacific Longevity and Anti-senescence Therapy Revenue ($) and Growth (2015-2020) Table Asia-Pacific Longevity and Anti-senescence Therapy Sales by Countries (2015-2020) Table Asia-Pacific Longevity and Anti-senescence Therapy Sales Market Share by Countries (2015-2020) Figure Asia-Pacific Longevity and Anti-senescence Therapy Sales Market Share by Countries in 2015 Figure Asia-Pacific Longevity and Anti-senescence Therapy Sales Market Share by Countries in 2019 Table Asia-Pacific Longevity and Anti-senescence Therapy Revenue ($) by Countries (2015-2020) Table Asia-Pacific Longevity and Anti-senescence Therapy Revenue Market Share by Countries (2015-2020) Figure Asia-Pacific Longevity and Anti-senescence Therapy Revenue Market Share by Countries in 2015 Figure Asia-Pacific Longevity and Anti-senescence Therapy Revenue Market Share by Countries in 2019 Figure China Longevity and Anti-senescence Therapy Sales and Growth Rate (2015-2020) Figure Japan Longevity and Anti-senescence Therapy Sales and Growth Rate (2015-2020) Figure South Korea Longevity and Anti-senescence Therapy Sales and Growth Rate (2015-2020) Figure Australia Longevity and Anti-senescence Therapy Sales and Growth Rate (2015-2020) Figure India Longevity and Anti-senescence Therapy Sales and Growth Rate (2015-2020) Figure Southeast Asia Longevity and Anti-senescence Therapy Sales and Growth Rate (2015-2020) Figure Middle East and Africa Longevity and Anti-senescence Therapy Revenue ($) and Growth (2015-2020) continued

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Global Longevity and Anti-senescence Therapy Market Report 2020 by Key Players, Types, Applications, Countries, Market Size, Forecast to 2026 (Based...

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PerkinElmer’s Horizon Discovery CHOSOURCE Cell Line Supports Trinomab Biotech’s Development of the World-First, Tetanus Toxin mAb Drug for Clinical…

WALTHAM, Mass.--(BUSINESS WIRE)--PerkinElmer, a global leader committed to innovating for a healthier world, today announced that its Horizon Discovery CHOSOURCE CHO-K1GS knockout cell line licensed by Trinomab Biotech. Co., Ltd. (www.trinomab.com), of Guangzhou, China was used to help produce and bring to clinical trial the worlds first, fully native human monoclonal neutralizing antibody (mAb) drug candidate to fight tetanus toxin.

Officially approved by the Australian Therapeutic Goods Administration (TGA) and Human Research Ethics Committee (HREC), the phase I clinical trial in Australia is expected to be completed in August 2021. Leveraging Horizons CHOSOURCE cell line, which includes a gene-edited Glutamine Synthetase (GS) knockout Chinese Hamster Ovary (CHO) K1 cell line and well-established GS expression system, Trinomab was able to get its drug candidate from DNA sequence to clinical manufacturing more quickly and easily.

Trinomab Biotech explained: Since implementing the CHOSOURCE CHO-K1 knockout cell line in our drug development workflow in March 2019, we have been able to hit the ground running and develop this mAb drug candidate against different diseases including the first in-human mAb in phase I trial in Australia against tetanus toxin. These efforts have shown how easy and effective the Horizon cell line was to implement and adapt to our processes. We are pleased with the results and continue to build our drug pipeline using the CHOSOURCE CHO-K1 cell line.

We are delighted that the CHOSOURCE cell line has been part of Trinomabs pioneering efforts to combat disease and are pleased to be working with other organizations in China and around the globe to move drug science and new therapeutic candidates forward, commented Jess Zurdo, Global Head Bioproduction in PerkinElmers Horizon business.

The CHOSOURCE platform, designed for pharmaceutical, biotechnology and biosimilar companies of all sizes, is recognized by the industry and regulators as optimized for high yield bioproduction and is licensed by more than 80 organizations globally. More than nine biotherapeutics expressed in these cell lines, including Trinomabs, have progressed to investigational new drug (IND) filings.

For further information on PerkinElmers Horizon Discovery CHOSOURCE technology please visit: https://horizondiscovery.com/en/chosource.

About PerkinElmer

PerkinElmer enables scientists, researchers, and clinicians to address their most critical challenges across science and healthcare. With a mission focused on innovating for a healthier world, we deliver unique solutions to serve the diagnostics, life sciences, food, and applied markets. We strategically partner with customers to enable earlier and more accurate insights supported by deep market knowledge and technical expertise. Our dedicated team of about 14,000 employees worldwide is passionate about helping customers work to create healthier families, improve the quality of life, and sustain the wellbeing and longevity of people globally. The Company reported revenue of approximately $3.8 billion in 2020, serves customers in 190 countries, and is a component of the S&P 500 index. Additional information is available through 1-877-PKI-NYSE, or at http://www.perkinelmer.com.

About Trinomab

Trinomab is a biopharmaceutical start-up focused on the research and development of new, fully native human antibody drugs to fight infectious, autoimmune, and other diseases as well as malignant tumors. The core technology of the company is a fourth-generation antibody HitmAb, a proprietary technology platform. Additional information is available at http://www.trinomab.com.

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PerkinElmer's Horizon Discovery CHOSOURCE Cell Line Supports Trinomab Biotech's Development of the World-First, Tetanus Toxin mAb Drug for Clinical...

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Who wants to live for ever? – Ageing can be curedand, in part, it soon will be | Books & arts – The Economist

That is Andrew Steeles thesis in Ageless

Feb 6th 2021

Ageless. By Andrew Steele. Doubleday; 352 pages; $29. Bloomsbury; 20

OLD AGE is a massacre, wrote Philip Roth, long before the pandemic underscored its hazards. Even those who count as young must often watch the ineluctable drift of loved ones into decrepitude. Andrew Steele has a hopeful message for all those facing this prospect (ie, everyone). Old age neednt be a massacre; in fact, old age neednt even be old.

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Mr Steeles thesis in Ageless is that ageing can be curedand, at least in part, that it very soon will be. The giant tortoises of the Galapagos Islands show no age-related decline, in some ways seeming as youthful at 170 as at 30. Mr Steele thinks this phenomenon, known as negligible senescence, is within humanitys grasp, too.

Whether or not readers are persuaded that ageless humans could ever be more than a theoretical possibilityand it is a stretchthis book will convince them that discounting the theoretical possibility altogether is based on nothing but prejudice. Western art may have something to do with it, bristling as it is with morality tales about the folly of wanting to turn back the clock; but there is actually no good reason to assume an upper limit to longevity, or that ageing must come with decline. And there is quite a lot of evidence to the contrary. Without the rich worlds denizens really noticing, a life that ends after the biblical three score years and ten has already come to seem a life cut short; instead, 90 is now seen as a good innings.

This prejudice held back the field of biogerontology for a very long time, but in the past few decades some scientists have cast it aside. This has enabled them to see that the real folly lies in the attempt to cure the diseases of old age one by one, rather than tackling their underlying causeageing itself. Now they are trying to understand that process in all its extraordinary complexity, and to intervene much earlier.

They have many tools at their disposal, and Mr Steele, who has a background in computational biology, evaluates them expertly and with verve. They range from drugs that mimic the life-extending effects of dietary restriction to gene-editing tools such as CRISPR and computer models that simulate whole biological systems. Such models may eventually prove the key that unlocks the inner Methuselah in everyone, by revealing both the limits to these systems and their redundancies: what can be tweaked, and what had best be left alone.

Temporarilyand with a bitter ironycovid-19 has slammed the brakes on this burgeoning area of research. But Mr Steele thinks its first dividends will emerge within a couple of years, perhaps in the form of senolytic drugs that clear the accumulating cellular detritus of a long life. He makes the valid point that if, for every year of scientific endeavour, a year could be added to the average human lifespan, old age would recede into the future at the same rate as todays population approached it. That would itself be quite a milestone on the road to negligible senescence.

This interim goal is easily within reach, he claims. Many scientists agreeand are among those who have chosen to take experimental anti-ageing drugs. For some of these treatments they have calculated that the risks are small, compared with the potential benefits. The true sign that a scientific revolution is in the offing is that the scientists themselves have bought into it. Whether that revolution is desirable is a different question, which it may fall to a new generation of artists to answer.

This article appeared in the Books & arts section of the print edition under the headline "Who wants to live for ever?"

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Who wants to live for ever? - Ageing can be curedand, in part, it soon will be | Books & arts - The Economist

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Oh! How the stay at the top has changed Comrade Museveni – The East African

By TEE NGUGI

I was amazed to hear Yoweri Museveni lamenting about foreign interference in the internal affairs of Uganda. These fellows, he said, in reference to foreign news networks in particular and the West in general, have a primitive culture that allows interference in other peoples affairs. He intimated that African culture would never allow him to interfere in other peoples business.

Now, this was exactly the sentiment voiced by African leaders in the 1980s when they were faced with agitation for a return to democracy. They castigated news networks and the West for trying to impose a foreign ideology on otherwise peace-loving Africans. Democracy, they said, was a system alien to African culture, because it was adversarial while African traditional democracy was consentaneous. They dismissed those calling for democracy as foreign stooges.

Human rights originations, such as Amnesty International, were accused of trying to bring about a re-colonisation of Africa.

When Museveni took power in 1986, he represented a new kind of leadership. He brought stability to a country ravaged by murderous chaos for decades. He revived an economy ruined by corrupt regimes, beginning with Milton Obotes in the 1960s. In the rest of Africa, his progressive ideas were a beacon of hope on a continent in the vicious grip of tyranny and consequent poverty. He supported progressive forces in Kigali when the rest of Africa looked the other way. Likewise, he gave support to forces attempting to overthrow Mobutu Sese Sekos rapacious dictatorship.

Kenyan dissidents, facing death or jail, found safe passage through Uganda. He memorably called the Organisation of African Unity, the predecessor body to the African Union, a trade union of dictators. He advocated for a new Africa where leaders served the people, not their stomachs. He did not object when the West and human rights organisations, which he now criticises for interfering in the internal affairs of Africa, praised the new breed of African leadership he represented.

But oh, how years at the top change everything! Critics and oppositions members like Bibi Wine are regularly arrested. Elections are accompanied by intimidation and violence.

In the region, Museveni is a defender of the old order. He is now an ardent supporter of the AU which, like its predecessor body, looks the other way as leaders terrorise and impoverish their citizens, but is quick to condemn ill-treatment of African-Americans in America. Museveni, who once said that the problem of Africa was leaders not wanting to leave power, now says that longevity in power has made him an expert in governance.

Now, if he Museveni were a Lee Kuan Yew, the man who presided over Singapores spectacular rise, perhaps his longevity in power could be justified. But like last weeks column argued, his continuation in power is detrimental to the economic and social welfare of Uganda in particular and Africa in general. Who would have thought back then that Museveni, like Mugabe, would transform from liberator to oppressor.

Tee Ngugi is a Nairobi-based political commentator

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Oh! How the stay at the top has changed Comrade Museveni - The East African

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Research Roundup: COVID-19 Recovery & the Vaccine and More – BioSpace

Every week there are numerous scientific studies published. Heres a look at some of the more interesting ones.

People Recovered from COVID-19 May Only Require One Dose of mRNA Vaccines

A study published on the preprint server medRxiv, meaning it has not yet been peer-reviewed, suggests that people who have had a strong case of COVID-19 may only require a single mRNA vaccine, such as that produced by Pfizer-BioNTech or Moderna, in order to generate sufficient immune response for protection. The study was conducted by scientists at Mount Sinai Hospital. The findings were partially described after noting that people who had previous cases of the disease appeared to have much more severe reactions to the first dose of the vaccines.

I think one vaccination should be sufficient, said Florian Krammer, a virologist at the Icahn School of Medicine at Mount Sinai and one of the study authors. This would also spare individuals from unnecessary pain when getting the second dose and it would free up additional vaccine doses.

It was supported by a second study published on medRxiv by researchers at the University of Maryland School of Medicine in healthcare workers. This study didnt evaluate symptom response to the vaccine, but instead looked at antibody responses. In that study, they found that previously infected people generated high antibody levels after the first dose of the vaccines, comparable to the levels seen after second doses in individuals who had not previously had COVID-19.

Although the data is interesting, its a significantly long way from proving that the second doses should be abandoned in people already diagnosed with COVID-19. And there are cases where people with mild COVID-19 cases seemed to generate much lower antibody levels, which may not offer enough protection, particularly against the new more contagious variants.

Random DNA Change Reversed Rare Inherited Immune Condition

DOCK8 immunodeficiency is a rare autosomal recessive type of hyperimmunoglobulin E syndrome. It is caused by a mutation in the DOCK8 gene and is marked by elevated immunoglobulin E levels, eosinophilia, and recurrent staph and viral infections. Investigators at the Garvan Institute of Medical Research identified three patients whose bodies spontaneously repaired the mutation and restored normal immune function over time. Two of the patients were in France and one in Australia. Analyzing the genome of the patients immune cells, they observed that some cells had undergone somatic reversion, which is to say, they accumulated random mutations within the DOCK8 gene and when it was copied, they reverted to normal DNA code.

Why Some Psychiatric Drugs Help Some but Not Others

Scientists with the University of Colorado at Boulder found that a specific protein in the brain called AKT appears to function differently in males than females. AKT was identified in the 1970s and is known for causing cancer when mutated, but it was more recently found to be a key player in promoting synaptic plasticity, which is the brains ability to strengthen connections between neurons in response to experience. Mutations in the AKT gene are linked to schizophrenia, post-traumatic stress disorder, autism and Alzheimers. This research found that there are different forms of AKT that have different functions in the brain, for example, AKT2, which is implicated in brain cancer, is found only in the star-shaped astroglia. AKT3 is involved in brain growth and development, while AKT2 and AKT1 are critical for learning and memory. But the finding that there are sex differences, and it was a significant difference, they hope it will lead to more nuanced treatments for these diseases.

Subgroup of COVID-19 Patients at High-Risk for Severe Bleeding

A study by researchers at the University of Michigan published in Scientific Reports of a subgroup of COVID-19 patients found increased risk of bleeding. This is related to the well-known incidences of COVID-19 patients having high risk of blood clots, which could result in strokes or heart attacks. In this subgroup, they appear to have an unbalanced ability to break down blood clots, which is good for removing the clots, but then provides a greater risk of uncontrolled bleeding. The study included 118 COVID-19 patients and 30 healthy controls. The investigators expected to observe high levels of plasminogen activator-inhibitor-1 in the COVID-19 patients, which is associated with stabilizing blood clots. But, they found high levels of tissue-type plasminogen activator, a molecule responsible for removing clots.

How Exercise Improves Metabolism

Researchers with USC Leonard Davis School of Gerontology and the University of Ulsan College of Medicine in Seoul, South Korea, showed how moderate exercise stimulates cells in the hypothalamus to release a hormone called MOTS-c. The hormone is encoded in cells smaller mitochondrial genome. The hypothalamus is the part of the region that controls metabolism. The research suggests that low-grade stress in mitochondria promotes health and longevity, which is called mitohormesis. They conducted research on mice homodeficient in Crif1, which controls how cells use proteins encoded by mitochondria. The mice without Crif1 experienced severe mitochondrial stress and had metabolic problems at adulthood, such as weight gain and decreased energy expenditure. They also had insulin resistance and high blood sugar, similar to type 2 diabetes in humans. But mice that were heterodeficient in the Crif1 gene, meaning they produced some of the appropriate protein, had mild mitochondrial stress and protection against obesity or insulin resistance.

Super Responder Memory B Cells Attack COVID-19 Virus, but Not Necessarily the Spike Protein

Immunome, a biotech company in Exton, Pennsylvania, published preclinical research from its COVID-19 research program. The study found that 50% of the antibodies isolated from so-called super-responders are directed at non-Spike antigens. This suggests that non-Spike-related antibodies may play a big role in effectively clearing the virus. The most prevalent non-Spike targets were nucleocapsid proteins and the open reading frame-encoded (ORF) proteins, ORF8 and ORF10. They also found that the antibody response against both neutralizing and non-neutralizing epitopesparticular parts of the Spike proteinare committed to B-cell memory. The research is yet to be peer-reviewed but has been posted on the bioRxiv preprint server.

The company received a $13.3 million agreement from the U.S. Department of Defenses Joint Program Executive Office for Chemical, Biological, Radiological and Nuclear Defense (JPEO-CBRND), in collaboration with the Defense Health Agency, to support its COVID program.

We believe that the broad response we observed to multiple viral proteins beyond just the Spike protein points towards an approach for developing an antibody cocktail, which could better mimic the natural human immune response against the SARS-CoV-2 infection, said Purnanand Sarma, chief executive officer of Immunome. Furthermore, an optimized combination of antibodies could potentially overcome the high level of mutational drift we are seeing in the Spike protein.

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Research Roundup: COVID-19 Recovery & the Vaccine and More - BioSpace

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Turn Biotechnologies Expands the Potential of its mRNA Platform by Licensing Unique Artificial Niche Technology – PRNewswire

MOUNTAIN VIEW, Calif., Feb. 3, 2021 /PRNewswire/ --Turn Biotechnologies, a company developing medicines for currently untreatable age-related conditions, announced that it has acquired the global rights for new artificial niche (AN) technology that can be used to restore muscle stem cells damaged by aging.

The company licensed its AN technology from Stanford University, where it was developed by a researcher who serves as an advisor to Turn. AN technology is used to create a microenvironment that maintains stem cells in a quiescent state to repair or replace specific types of damaged tissue. The stem cell niche provides structural and trophic support and the appropriate homeostasis to regulate stem cell function.

Turn will use the niche technology in combination with its mRNA-based epigenetic reprogramming of age (ERA) technology to restore specific cells' youthful functionality, to trigger the body's ability to fight age-related diseases.

"Our artificial niche technology expands the applicability of our ERA technology to a variety of diseases involving tissue that requires a microenvironment to maintain cell quiescence," said Anja Krammer, Turn CEO. "By enveloping our ERA technology in the protective matrix of an artificial niche, we can reactivate muscle stem cells, as well as stem cells in tissues where quiescence is necessary to maintain stem cell functions."

The combined use of Turn's AN and ERA technologies may be able to restore function in hematopoietic, liver, brain, certain mesenchymal stem cells across different tissues and within the hair follicle.

This is Turn's second licensing announcement since the start of the year. Earlier, the company revealed that it acquired the global rights for its ERA technology from Stanford University, where it was developed by three researchers who founded Turn. It is the first technology to maintain cellular identity while restoring specific cells' youthful functionality, to trigger the body's ability to fight age-related diseases.

As with ERA, the company announced that it has filed for patents to protect its AN technology in major-market nations on six continents.

"This is significant for our pipeline because the combination of AN with our ERA technology in murine models shows increased potency," said Jay Sarkar, Turn's chief technology officer and a company founder who helped to develop the ERA technology. "The studies show that aged muscle stem cells treated with this combination therapy fully regenerate age-related muscle dysfunctions."

Turn's technology uses messenger RNA to produce instructions that induce cells to treat or prevent disease. Use of mRNA, which led to the quick development of two COVID-19 vaccines, promises to revolutionize the development of therapeutics by making that development safer, faster, more efficient and extremely tunable to patient need.

Turn is currently completing pre-clinical research on tailored therapies targeting indications in dermatology, ophthalmology, osteo-arthritis and cartilage damage and musculature.

ABOUT TURN BIOTECHNOLOGIES

Turn is a pre-clinical-stage company focused on repairing tissue at the cellular level. Our proprietary mRNA technology combats the effects of aging in the epigenome, thus restoring optimal gene expression and enabling cells to function as vigorously as when they were younger. Our technology provides a platform from which to attack a variety of diseases related to age. The company has the financial backing of Methuselah Fund, which focuses its investments to extend the healthy human lifespan; Formic Ventures, which invests in biotech start-ups focused on human longevity; and Shanda Group, a private global investment firm. For more information, see http://www.turn.bio.

FOR MORE INFORMATION, CONTACT:Jim Martinez, rightstorygroup[emailprotected] or (312) 543-9026

SOURCE Turn Biotechnologies

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Turn Biotechnologies Expands the Potential of its mRNA Platform by Licensing Unique Artificial Niche Technology - PRNewswire

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