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Category : Human Longevity

121 Ways to Live 121 Years . . . And More: Prescriptions for Longevity – Anti Aging News

Chronological age has little to do with a person's biological age: some people are old at fifty, while others are still sharp and spry at ninety. This book is a guide for living a long and healthy life, providing hundreds of practical tips readers can implement today to help them live a satisfying and productive life.

Dr. Robert M. Goldman and Dr. Ronald Klatz, revolutionary thinkers, innovators, and co-founders of the American Academy of Anti-Aging Medicine, authored this handbook loaded with tips for living a long and healthy life. This book provides hundreds of practical tips readers can implement to help them live a satisfying and productive life through anti-aging medical techniques.

Nobody wants to get old. And why would we? The aging process eventually affects every one of our body systems-from mental function and sexual performance to physical appearance, ability, and strength. But chronological age has little to do with a person's biological age: some people are old at fifty, while others are still sharp and spry at ninety. While aging may be inevitable, that doesnt mean that we have to sit idly and just allow it to happen, there are steps we can take to slow the aging process to extend our healthspan and longevity.

The things we've always considered "normal aging" are actually caused by physiological problems that, in many cases, respond to medical treatment and healthy lifestyle habits. As a result, the human life span can be significantly increased while maintaining-or even improving-the quality of life! This contemporary approach to aging-known as anti-aging medicine-is a specialty practiced by more than 30,000 physicians worldwide. It uses advanced scientific and medical technologies for the early detection, prevention, treatment, and reversal of age-related dysfunction, disorders, and diseases. In the near future, we can look forward to boundless health and vitality thanks to these anti-aging approaches.

121 Ways to Live to 121 Years And More!, covers thirteen categories of topics that relate to improving the healthy human lifespan. With hundreds of individual tips on a wide variety of subjects, this book was written to help provide you with the knowledge you need to be your own health advocate and control your health destiny. Each of us must learn enough, and keep learning, about how to keep ourselves healthy. As Marcus Annaeus Seneca, Roman writer (c. 54 BCc. 39 AD) remarked, For the great benefits of our being our life, health, and reason, we look upon ourselves.

Tip 42: Fiber, The Anti-Fat: Fiber soaks up fat. A high-fiber diet can improve your digestion, relieve the strain on your liver and gallbladder, and reduce your risk of large bowel cancer, gallstones, diabetes, arteriosclerosis, colitis, hemorrhoids, hernia, and varicose veins. Your body will benefit from both soluble fiber (sources include dried beans, oats, barley, apples, citrus fruits, and potatoes) and insoluble fiber (found in whole grains, wheat bran, cereals, seeds, and the skins of many fruits and vegetables).

Remember, self-reliance is the key to our health, happiness, and well-being. Anti-aging medicine, a clinical specialty that embraces patient education and empowerment, represents the dawning of an exciting new era in medicine, one that will result with longevity intervention orders of magnitude greater than any other advancements made in medicine to-date. Enjoy a future of boundless health and vitality by implementing anti-aging approaches to help you feel, look, and perform better today by making simple lifestyle changes that can assist you on your way to living a long and healthy lifespan.

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121 Ways to Live 121 Years . . . And More: Prescriptions for Longevity - Anti Aging News

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Here’s how COVID-19 is reshaping medicine, according to experts – Fast Company

For Fast Companys Shape of Tomorrow series, were asking business leaders to share their inside perspective on how the COVID-19 era is transforming their industries. Heres whats been lostand what could be gainedin the new world order.

James Merlino,chief clinical transformation officer of the Cleveland Clinic

The old saying in crisis is never let the opportunity go to waste. Weve learned a couple things. One is that this has reemphasized the importance of safety. Were doing thermal screening for healthcare providers. Were testing any patient whos coming in for any surgery or ambulatory care. If theyre COVID-positive, well delay their procedure unless its an emergency.

The second thing is were seeing technology innovations, such as virtual rounding done on an iPad and virtual [visits]. Before COVID hit, we were doing 3,000 virtual visits a month. In March, we did 60,000. Then there are small things, such as putting IV pumps and ventilators outside the door in our COVID ICU.

We have to learn how to live with COVID. Some hospitals may suffer. But I want to believe that this is going to make us deliver care more efficiently. Weve been talking about social determinants and chronic health for a long time, but this is our opportunity to step in. COVID-19 preys on the elderly, on the socially disadvantaged. Going forward, we have to manage COVID-19 with more consistent care.

Nancy Lublin, CEO of Crisis Text Line, a nonprofit organization that provides free mental health texting services

If you were feeling things before, if you were struggling before, if you had an addiction or an eating disorder or anxiety or depression or a bad relationship, those things just became a lot harder. And even if you were perfect before, you are not perfect now.

53% of our texters before COVID were under the age of 17, and now the biggest age group were seeing is 18 to 34. Their lives have just been turned upside down. They were adulting, and now theyre home with their parents. Or theyre quarantined with roommates whom they didnt really know that well, or sheltering alone, and thats really hard. Or they have little children. Dating has been disrupted for the 18-to-34 age groupfor everybody.

When COVID first hit America, we saw a massive influx in anxiety. They were using words like freaked out, panic, and it was mostly about symptoms. That shifted into what we consider the second wave of feeling: the impact of the quarantines. Weve seen a 78% increase in domestic violence, a 44% increase in sexual abuse. Weve seen a huge increase in financial stress, people worried about homelessness, or thinking about financial ruin.

Mental health and well-being should be part of our education. One of the most important things is how to communicate with people, how to disagree with people, how to have productive relationships. And yet we dont learn any of this. Instead we learn calculuswhich I still havent used.

Christos Christou, international president of Doctors Without Borders

Because of COVID, it is now extremely challenging to move our resources and our people to those places that need them. Were not allowed to fly from Canada or Europe to Yemen, Tanzania, etc. And we are not allowed to export any material, because of nationalism, a very selfish approach by states, which are fighting against each other for supplies. They want to show that they can protect [their citizens]. They will ban any exportation of PPE and, in the event we get a new vaccine, they will make sure that they can stockpile it.

There are multiple crises within the COVID crisis. TB patients are not allowed to access any hospitals at the moment, and they need treatments every day. HIV patients, the same. We have war traumas. Some of the facilities have been repurposed, so its not easy for us to run surgeries. Malaria kills millions of people. We have the treatments, but [theyve] been affected a little bit because of all these debates about the chloroquine. We [also] have a rapid test for malaria. [But] the company that is producing this test has decided now that theres much more profit by repurposing it into a rapid test for COVID.

We have to rethink health systems. Its obvious that only public health systems and national health systems are going to provide the solution.

Im afraid for those places we cannot access. In Northwest Syria, [after] Idlib was bombed [in February], people were in desperate need of food, accommodation, and health services. All of a sudden, with COVID, everyone forgot about this situation. But this doesnt mean that their problems evaporated. Yemen is another place. In the past few days we have confirmed that theres a local transmission of COVID, and theres zero capacity. Im not talking about ventilators or ICU beds. They dont even have the test, the diagnostic. This is one of my nightmares.

[Source images: Videvo; _Aine_/iStock]The other one is related to those places where people live in high-density settlements. Im talking about communities like Coxs Bazar in Bangladesh, the Greek Islands, the favelas in Brazil, the [refugee] camps in Kenya. Anything related to good hygiene or stay-at-home policies in these place is just a luxury. [Its] not an option.

We have to rethink health systems. Its obvious that only public health systems and national health systems are going to provide the solution. If we leave it to the free market, their rules are different: Their driver is profit making. They have every right to do so, but you cannot ask for vaccines or therapeutics and diagnostics from those people. In this [pandemic], we should not allow anyone to profit from the solution.

Dr. Gianrico Farrugia,CEO of Mayo Clinic

COVID has enabled us to create virtual health as a new normal. Not only in terms of remote monitoring and acute medical care, but also for advanced care at home. For example, electrocardiograms can be done on a smartwatch to diagnose heart failure or to measure potassium.

As a nation, we have been promising and not delivering on telehealth now for several years, and that has had to do with licensure, regulation, billing, but also just healthcares reluctance to change. With those barriers removed, weve been able to move from maybe 400 to 35,000 virtual visits a week.

Some of the regulations that have been relaxed need to become permanentand in a way that can be enforced so patient safety does not suffer. We [shouldnt] go back to where we were, because we would have lost a huge opportunitythis tiny silver lining in the pandemic, which is the digital revolution of healthcare.

Yonatan Adiri,CEO of Healthy.io, a company that uses cellphone cameras to create clinical grade at-home tests for urinary tract infections and kidney disease

I dont buy that this has been the watershed moment for healthcare. The forces of status quo are very strong. Physicians can now practice across state lines; Medicare will reimburse remote patients sessions at the same price as in-person. People thought these things would take a decade to happen. We now have to work to keep this the new normal. All it takes is one company making false claims that creates a safety or efficacy issue and the whole thing will be rolled back.

If this had happened 10 years ago, it would have been a million-and-counting dead, and not 300,000 dead.

If this had happened 10 years agowithout computation, without DNA sequencing, without cloud, without bandwidth, without high-resolution selfie camerasit would have been a million-and-counting dead, and not 300,000 dead.

Andrew Diamond,chief medical officer at primary care company One Medical, which offers outdoor testing sites for COVID-19

We need a strategy to test enormous numbers of people, almost on a surveillance-like basis. And if you cant do that, then you need an alternative, like really robust contact tracing. I could see by the fall or maybe mid-winter that we could have technology where you couldat the door of your office building or apartment building or mass transit station or airport airline terminalspit into a disposable cup at a machine that gives you a readout in a matter of minutes.We also need to double down on taking care of hypertension, diabetes, and obesity. Some of the people who are most vulnerable to the worst effects of the infection are people with those conditions. Thats our bread and butter in primary care, but thats also how were actually going to contain the damage from COVID-19, as it lives with us for months and years to come.

Peter Diamandis,founder of the XPrize Foundation and several companies in the health space, including Cellularity, Human Longevity, and Covaxx

People feel abandoned by the healthcare system. They feel its dangerous to go to hospitals because theyre overloaded. There is a significant opportunity for new startups and for Apple, Google, and Amazon to step in and deliver much more efficient turnkey data-driven services.

The government should be pouring capital into research, but its going to be entrepreneurial companies that are in your home already that are delivering and collecting the data [that will] make you the CEO of your own health. How do you partner with AI to really understand whats going on and what your options are? I dont think health systems can innovate sufficiently [on their own].

Richard Park,cofounder of CityMD and CEO of Rendr Care

Whats going on now is this huge, bubbling, socioeconomic conflict or friction between the haves and the have-nots. COVID-19 is a real great reflection of that, especially in New York. If you look at CityMD and its hot spots, its the vulnerable population.

I was born here in the States, but to immigrant parents, who migrated here in the late 60s. They were grateful to be second-class citizens here in the greatest country on the planet. That humility, that you are always in debt to the greater society . . . was kind of an underlying theme at home.

Theres going to be more and more pressure to be efficient on healthcare, and so the baseline standards will get more and more meager.

[My family] would open stores and close stores and [have] terrible financial troubles. Not unlike so many other New Yorkers today, especially now with COVID. We had borrowed money from so many people to pay rent. It accentuated a tremendous amount of shame and guilt. I would, as a kid, walk around, knowing, That person lent us $5,000. That person lent us $10,000. That person lent $50,000, over the years. I couldnt even look them in the eye. The beautiful part of it was, as a community, they lent us money and they knew they were never getting it back. And I finally actually paid back everybody. Some of that debt was more than 35 years old. People were never expecting it.

[Source images: Videvo; _Aine_/iStock]At CityMd, the other founders are immigrants, and they understood this. We made a decision early on not to separate Medicaid [patients] from [those with] commercial [insurance plans]. People said, You cant mix the two populations. The Wall Street banker will not sit next to the Medicaid person. Maybe that was true in the past, but we said, Were not going to do that. Now we know, it absolutely does work together.

Concierge medicine is wrong. I consider that wrong. Its not how I want to roll. I dont want to participate in that. As the economy has difficulty, as Medicaid enrollment swells, revenue decreases at the state level. Its a bad mix: more enrollment, less revenue for it. This puts pressure on everybody. In the same way, employers have this impossible 5% year-over-year [increase in] healthcare costs. Its not sustainable. Theres going to be more and more pressure to be efficient on healthcare, and so the baseline standards will get more and more meager. Thats why the [concierge medical services] will arise. There are people who can afford it.

More from Fast Companys Shape of Tomorrow series:

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Here's how COVID-19 is reshaping medicine, according to experts - Fast Company

Recommendation and review posted by Alexandra Lee Anderson

Atomwise Partners with Global Research Teams to Pursue Broad-Spectrum Treatments Against COVID-19 and Future Coronavirus Outbreaks – Business Wire

SAN FRANCISCO--(BUSINESS WIRE)--Atomwise, the leader in using artificial intelligence (AI) for small molecule drug discovery, announced today it has fifteen research collaborations underway with leading global universities to explore broad-spectrum therapies for COVID-19 and other coronaviruses.

Coronaviruses are RNA viruses and include the causative SARS-CoV-2 strain of the current COVID-19 global pandemic as well as MERS and SARS-CoV-1 from prior regional outbreaks. Although drug repurposing may offer a rapid response to the current outbreak, the longevity of such an approach may be limited due to the accumulation of mutations and evolution of the virus. By using predictive models and AI, Atomwise and its collaborators seek to raise the probability of success for future therapies.

Each collaborative project will develop drug candidates with demonstrable broad-spectrum capability, providing potential long-term benefit for future coronavirus outbreaks. Overall, the 15 global research efforts span a wide variety of approaches, including different mechanisms of action, a mixture of viral and human/host target proteins, and targeting conserved regions of proteins that may be recognized even in mutated strains. In addition, many proteins targeted by the academic collaborators have previously been deemed undruggable due to their unknown structure or involvement in complex protein-protein interactions. Taken together, the combination of novel approaches could expand the repertoire of therapeutic approaches available for a future outbreak.

Several projects are part of Atomwises Artificial Intelligence Molecular Screen (AIMS) program, which enables researchers to accelerate the translation of their research into treatments. In support of each collaboration, scientists at Atomwise will use AtomNet, the companys patented AI screening technology, to predict the binding of millions or billions of small molecules to a protein of interest identified by the academic researcher as a potential target for COVID-19, narrowing down to a few hundred predicted hit molecules. Atomwise then sources and ships a subset of these predicted compounds to partnering laboratories for testing biochemical potency and selectivity, advancing the most promising compounds for further development as drug candidates.

Atomwises AI screening technology is used to predict the binding of more than 10 million small molecules to a protein of interest, and far exceeds what could be accomplished through traditional laboratory screening methods, said Dr. Stacie Calad-Thomson, vice president and head of Artificial Intelligence Molecular Screen (AIMS) Partnerships at Atomwise. With Atomwises AIMS Awards program, our hope is to democratize access to AI during the early stages of preclinical drug development and enable academics to contribute to the pandemic response who might not have the opportunity otherwise.

Research partners will include:

Target

Researcher

Institute

IL-6 Signaling Pathway

Dr. Mark Fry

University of Manitoba

Nucleocapsid (N-protein)

Dr. Luana Fioriti and Dr. Eric Kandel

Columbia University

NSP15

Dr. James L. Cole

University of Connecticut

Papain-Like Protease (PLpro)

Dr. Konstantin V. Korotkov

University of Kentucky

RdRp in NSP12

Dr. Jorg Stetefeld

University of Manitoba

Spike-ACE2

Dr. Gokhan Cildir

University of South Australia

Spike-ACE2

Dr. Alexander Freiberg

University of Texas Medical Branch (UTMB) Health

Spike (heptad region)

Dr. Abdullah Algaissi

Jazan University, Saudi Arabia

Undisclosed

Dr. Hari Arthanari

Dana-Farber Cancer Institute

Undisclosed

Dr. Yogesh Gupta

University of Texas Health Science Center at San Antonio

Undisclosed

Dr. Mel Fernand Bedi, Dr. Tim Mueser, and Dr. Amanda Bryant-Friedrich

University of Toledo

Atomwise and its partners will continue to focus research efforts on broad-spectrum approaches for COVID-19 and other coronaviruses so that drug discovery solutions are applicable for this pandemic, as well as for mutations, recurrences, or other coronavirus strains that may take place in the future.

Researchers interested in applying for the AIMS Awards program or pursuing industry partnerships with Atomwise are encouraged to contact academics@atomwise.com or partner@atomwise.com for more information.

About Atomwise

Atomwise Inc. invented the first deep learning AI technology for structure-based small molecule drug discovery. Created in 2012, today Atomwise performs hundreds of projects per year in partnership with some of the worlds largest pharmaceutical and agrochemical companies, as well as more than 200 universities and hospitals in 40 countries. Atomwise has raised over $50 million from leading venture capital firms to support the development and application of its AI technology. Learn more at atomwise.com or follow @AtomwiseInc.

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Atomwise Partners with Global Research Teams to Pursue Broad-Spectrum Treatments Against COVID-19 and Future Coronavirus Outbreaks - Business Wire

Recommendation and review posted by Alexandra Lee Anderson

What Kind of Country Do We Want? | by Marilynne Robinson – The New York Review of Books

Magnum PhotosDoa Ana County, New Mexico, 2017; photograph by Matt Black

In my odd solitude I stream the America of recent memory. The pretext for drama, in the foreground, seems always to be a homicide, but around and beyond the forensic stichomythia that introduces character and circumstance there is a magnificent country, a virtual heaven. In a dystopian future, children would surely ask what it was like to live in such a country. Candid memory would say, By no means as wonderful as it should have been, even granting the broad streaks of pain in its history. Before there was a viral crisis whose reality forced itself on our notice, there were reports of declines of life expectancy in America, rising rates of suicide, and other deaths of despair. This is surely evidence of another crisis, though it was rarely described as such. The novel coronavirus has the potential for mitigation, treatment, and ultimately prevention. But a decline in hope and purpose is a crisis of civilization requiring reflection and generous care for the good of the whole society and its place in the world. We have been given the grounds and opportunity to do some very basic thinking.

Without an acknowledgment of the grief brought into the whole world by the coronavirus, which is very much the effect of sorrows that plagued the world before this crisis came down on us, it might seem like blindness or denial to say that the hiatus prompted by the crisis may offer us an opportunity for a great emancipation, one that would do the whole world good. The snare in which humanity has been caught is an economicsgreat industry and commerce in service to great markets, with ethical restraint and respect for the distinctiveness of cultures, including our own, having fallen away in eager deference to profitability. This is not new, except for the way an unembarrassed opportunism has been enshrined among the laws of nature and has flourished destructively in the near absence of resistance or criticism. Options now suddenly open to us would have been unthinkable six months ago. The prestige of what was until very lately the world economic order lingers on despite the fact that the system itself is now revealed as a tenuous set of arrangements that have been highly profitable for some people but gravely damaging to the world. These arrangements have been exposed as not really a system at allinsofar as that word implies stable, rational, intentional, defensible design.

Here is the first question that must be asked: What have we done with America? Over the decades we have consented, passively for the most part, to a kind of change that has made this country a disappointment to itself, an imaginary prison with real prisoners in it. Now those imaginary walls have fallen, if we choose to notice. We can consider what kind of habitation, what kind of home, we want this country to be.

No theoretical language I know of serves me in describing or interpreting this era of American unhappiness, the drift away from the purpose and optimism that generally led the development of the society from its beginnings. This can be oversimplified and overstated, but the United States did attract immigrants by the tens of millions. It did create great cities and institutions as well as a distinctive culture that has been highly influential throughout the world. Until recently it sustained a generally equitable, decent government that gave it plausible claims to answering to the ideals of democracy. This is a modest statement of the energies that moved the generations. Optimism is always the primary justification for its own existence. It can seem naive until it is gone. The assumption that things can get better, with the expectation that they should, creates the kind of social ferment that yields progress. If we want to avoid the word progress, then call it the creative unrest that made 2019 an advance on 1919.

In recent decades, which have been marked by continuous, disruptive change and by technological innovation that has reached assertively into every area of life, a particular economics has become a Theory of Everything, subordinating all other considerations to some form of cost-benefit analysis that silently insinuates special definitions of both cost and benefit. If neither of these is precisely monetizablecalories might have to stand in for currency in primordial transactionspersonal advantage, again subject to a highly special definition, is seen as the one thing at stake in human relations. The profit motive has been implanted in our deepest history as a species, in our very DNA.

This kind of thinking has discredited ideals like selflessness and generosity as hypocritical or self-deceived, or in any case as inefficiencies that impede the natural economy of self-interestsomehow persisting through all the millennia that might have been expected to winnow out inefficiencies, if the pervasiveness of this one motive is granted. I consider the American university to be among the highest achievements of Western civilization. And I know at the same time that varieties of nonsense that would not last ten minutes if history or experience were consulted can flourish there, and propagate, since our entire professional class, notably teachers, go to university. There has always been learned nonsense, of course. But when angels danced on the heads of pins, at least the aesthetic imagination was brought into play.

Much American unhappiness has arisen from the cordoning-off of low-income workers from the reasonable hope that they and their children will be fairly compensated for their work, their contribution to the vast wealth that is rather inexactly associated with this country, as if everyone had a share in it. Their earnings should be sufficient to allow them to be adequate providers and to shape some part of their lives around their interests. Yet workers real wages have fallen for decades in America. This is rationalized by the notion that their wages are a burden on the economy, a burden in our supposed competition with China, which was previously our competition with Japan. The latter country has gone into economic and demographic eclipse, and more or less the same anxieties that drove American opinion were then transferred to China, and with good reason, because there was also a transfer of American investment to China.

The terrible joke is that American workers have been competing against expatriated American capital, a flow that has influenced, and has been influenced by, the supposed deficiencies of American labor. New factories are always more efficient than those they displace, and new factories tend to be built elsewhere. And as the former presidential candidate Mitt Romney remarked, workers in China sleep in factory dormitories. Employing them in preference to American workers would sidestep the old expectation that a working man or woman would be able to rent a house or buy a car. The message being communicated to our workers is that we need poverty in order to compete with countries for whom poverty is a major competitive asset. The global economic order has meant that the poor will remain poor. There will be enough flashy architecture and middle-class affluence to appear to justify the word developing in other parts of the world, a designation that suggests that the tide of modernization and industrialization is lifting all boats, as they did in Europe after World War II.

In the recent environment, I was hesitant to criticize the universities because they are under assault now, as humanist institutions with antique loyalties to learning and to freedom of thought. But the universities have in general bent the knee to the devaluation of humane studies, perhaps because the rationale for that devaluation has come from their own economics departments and business schools. For decades scholars have read American history in these and related terms, excluding those movements and traditions that would challenge this worldview. Freedom of thought has valorized criticism, necessarily and appropriately. But surely freedom of thought is meant to encourage diversity of thinking, not a settling into ideological postures characteristic of countries where thought is not free. If the universities lose their souls to a model of human nature and motivation that they themselves have sponsored, there will be some justice in this and also great loss, since they are positioned to resist this decline in the name of every one of the higher values.

Any reader of early economics will recognize the thinking that has recently become predominant, that the share of national wealth distributed as wages must be kept as low as possible to prevent the cost of labor from reducing national wealth. This rationale lies behind the depression of wages, which has persisted long enough to have become settled policy, a major structural element of American society and a desolating reality for the millions it defrauds. Polarization is no fluke, no accident. It is a virtual institutionalization in America of the ancient practice of denying working people the real or potential value of their work.

Institutionalization may be less a factor here than inculcation. Long before the pandemic struck, the protections of the poor and marginalized that largely defined the modern Western state had been receding, sacrificed to the kind of policy that presents itself as necessity, discipline, even justice tendentiously defined. Wealth can be broadly shared prosperity, or it can be closely held, private, effectively underwritten by the cheapening of the labor of the nonrich, which reduces their demand for goods and services. When schools and hospitals close, the value of everything that is dependent on them falls. Austerity toward some is a tax cut for others, a privatization of social wealth. The economics of opportunism is obvious at every stage in this great shift. And yet Americans have reacted to the drove of presumptive, quasi, and faux billionaires as if preternatural wealth were a credential of some kind.

All the talk of national wealth, which is presented as the meaning and vindication of America, has been simultaneous with a coercive atmosphere of scarcity. America is the most powerful economy in history and at the same time so threatened by global competition that it must dismantle its own institutions, the educational system, the post office. The national parks are increasingly abandoned to neglect in service to fiscal restraint. We cannot maintain our infrastructure. And, of course, we cannot raise the minimum wage. The belief has been general and urgent that the mass of people and their children can look forward to a future in which they must scramble for employment, a life-engrossing struggle in which success will depend on their making themselves useful to whatever industries emerge, contingent on their being competitive in the global labor market. Polarization is the inevitable consequence of all this.

The great error of any conspiracy theory is the assumption that blame can be placed on particular persons and interests. A chord is struck, a predisposition is awakened. America as a whole has embraced, under the name of conservatism and also patriotism, a radical departure from its own history. This richest country has been overtaken with a deep and general conviction of scarcity, a conviction that has become an expectation, then a kind of discipline, even an ethic. The sense of scarcity instantiates itself. It reinforces an anxiety that makes scarcity feel real and encroaching, and generosity, even investment, an imprudent risk.

Lately, higher education has been much on the minds of journalists and legislators and, presumably, potential students and their families, who are given to understand that higher education is crucial to their financial prospects and also that the costs and debts involved may be financially ruinous. Worse, the press speaks of elite universities as if there were only a dozen or so institutions in the country where an excellent education can be had. In fact there are literally hundreds of colleges and universities in this country that educate richly and ambitiously. Many of the greatest of them are public, a word that now carries the suggestion that the thing described is down-market, a little deficient in quality. Anyone who notices where research and publishing are done knows that these schools are an immense resource, of global importance. In the midst of this great wealth of possibility, an imaginary dearth is created, and legislatorsout of an association between political courage and parsimonyrespond with budget cuts that curtail the functioning of these magnificent, prosperity-generating institutions. It should be noted that elite schools are also embracing the joylessly vocational emphasis that is the essence of these panicky reforms.

How is it that we can be told, and believe, that we are the richest country in history, and at the same time that we cannot share benefits our grandparents enjoyed? When did we become too poor to welcome immigrants? The psychology of scarcity encourages resentment, a zero-sum notion that all real wealth is private and is diminished by the claims of community. The entire phenomenon is reinforced by the fact that much of the capital that accumulates in these conditions disappears, into Mexico or China or those luridly discreet banks offshore.

The minimum wage has become the amount an employer can get away with paying. It is neither the amount a worker needs to sustain a reasonable life nor, crucially, to be important enough as a consumer for his or her interests to align with other interests. Because workers are underpaid, they are often treated as dependents, as a burden on the safety net, which is actually a public subsidy of the practice of underpayment. Workers often do not fall into the category of taxpayer, a word now laden with implication and consequence. It implies respectability, a more robust participation in citizenship, and, fairly or not, an extreme sensitivity to demands made on his or her assets for the public benefit. Equitable policies are often precluded in the name of the taxpayer so forcibly that the taxpayerthat is, a fair percentage of the publicis never really consulted. In this time of polarization, such language reflects an ugly, alienating division in our society, with bad faith at the root of it. Proud people are insulted, those same people we now call essential because they work steadily at jobs that are suddenly recognized as absolutely necessary.

Behind all this there is a scarcely articulated variant of an old model, once prevalent throughout the West, that invoked national wealth as the summum bonum of collective life. For the purposes of the theory in its present iteration, the absurd wealth that has accumulated at the top end of polarization is reckoned as part of the national wealth no matter how solidly it is based in poverty. In the eighteenth and nineteenth centuries, great engines of wealth built global empires that filled the world with colonialism, militarism, and racialism, as well as monuments and marching bands. These trappings of power generated the excited identification of the masses with the nation no matter how hostile the system was to their own interests.

As adapted for what was recently the present, this wealth is still a product of national policiesfavorable taxation, imaginative banking regulations, and low production costs, including depressed wages and lowered safety and environmental standards. The cinch that tightens such slack as remains in the lives of the underpaid is called austerity or fiscal discipline. Austerity has not touched the beneficiaries of these arrangements, nor has fiscal discipline. These policies amount to continuous downward pressure on the accommodations made to the fact that wages are not sufficient to meet basic needs. Austerity and discipline retain their brisk, morally coercive force, amazingly. The work ethic persists through impoverishment, unemployment, deindustrialization driven by pools of cheap labor elsewhere, and the de-skilling that is the effect of all these declines.

This is to say that the kind of shame suffered most sharply by proud people has been put to use to sustain this ugly economic and social configuration, too opportunistic and unstable to be called a system. It offers no vision beyond its effects. Obviously the depletions of public life, the decay of infrastructure, the erosions of standards affecting general health are not intended to make America great again. They are, in the experience of the vast majority of Americans, dispossessions, a cheapening of life.

The theory that supports all this is taught in the universities. Its terminology is economic but its influence is broadly felt across disciplines because it is in fact an anthropology, a theory of human nature and motivation. It comes down to the idea that the profit motive applies in literally every circumstance, inevitably, because it is genetic in its origins and its operations. Selfishness, its exponents call it, sometimes arguing that the word in this context has a special meaning, though the specifics of the sanitizing are unclear. Behind every act or choice is a cost-benefit analysis engaged in subrationally. This is to say that thinking itself is the product of this constant appraisal of circumstance, which is prior to thinking, therefore not subject to culture, moral scruples, and so on, which are merely a scheme of evolution to hide this one universal intention from the billions of us who, in our endless diversity, make up the human species. Greed is good, or at least good enough to have brought us this far. For an important part of any population, these would be glad tidingsmoral considerations not only suspended but invalidated, moralists revealed as hypocrites and fools as well, since they have no idea that the genius and force of evolution are against them. By its nature, this worldview is based in the moment, in any new occasion to seek advantage.

This view of things is radically individualistic, indifferent to any narrative of identity or purpose. It takes a cynical view of people as such, since no ones true motives are different from those of the consciously selfish. Because there is only one motiveto realize a maximum of benefit at a minimum of costthose who do not flourish are losers in an invidious, Darwinian sense. Winners are exempt from moral or ethical scrutiny since advance of any sort is the good to be valued. Progress is likewise exempt from the kind of scrutiny that would raise questions about the real value this process generates, reckoned against other value that is precluded or destroyed.

Americans never believe that Americans are actually influenced by the education they require of themselves and one another, on which they lavish much wealth. To do so would smack of intellectualism, a trait we do not grant ourselves. The same economic model is prevalent in Britain and France, perhaps Europe in general, though it is asserted in other terms. Austerity has prevailed there for decades. The issues raised by the Yellow Vest movement in France are highly consistent with the situation in America. The retraction of policies that acknowledged the claims of the population at large on the wealth of their nation can be described, historically, as the return of the ancien rgime, or as the final triumph of capitalism, or as proof of the waning of Judeo-Christianity, or as recognition of the fact that, when all is said and done, self-interest is indeed the one unvarying human motive. All these could be true simultaneously, each reinforcing the others.

This theory has all the power among us of an ideology, though it lacks any account of past or future, any vision of ultimate human well-being. It promotes itself as nationalism, though its operations are aggressively global. The supposed nationalism plays on a nostalgia for the postwar decades, when the prestige of countries and regions was measured by living standards. Perhaps it derives also from the myth of ideological conflict, the notion that if the Russians had communism, America must have an equal and opposite ideology. This would be called and in time would become capitalism, though the economy Marx critiques under that name is the highly exceptional colonial, industrial, and mercantilist Britain of the nineteenth century.

It is one of the stranger turns in modern history that, for the purposes of this epochal controversy, one man, Karl Marx, named and described both of these ideologies. This is a great concession made to someone whose thought his antagonists claimed to deplore, though it is fair to assume both that they had not read him and that they were simply content to be spared the effort of arriving at definitions of their own. Also, he had the chic of being dangerously European. The pastiche, or the motley, we are inclined to think of as American self-awareness is strange under scrutiny. If we are uniquely characterized by entrepreneurialism, for example, why is the only name we have for it a word of unassimilated French? That sort of thing is usually a signifier for pretentiousness or embarrassment. This little oddity is germane to the larger case against the status quo ante, in which many of our governing assumptions are flimsy and nonsensical, and have stood in the place of meaningful thought, especially in lofty circles, in institutions of great influence, the universities.

Because of this quaint adherence to Marxian categories a narrative has emerged over time that capitalism is the single defining trait of American civilization, the force that has propelled the country not only to unprecedented wealth but also to high levels of personal and political freedom. These assumptions are in need of scrutiny, not by comparison with other countries but of this country with itself a few generations ago. The other half of the great binary, communism, was never realized anywhere, never successful anywhere so far as it was attempted. That somehow legitimizes Marxs schema, even though this is not at all the result he predicted.

Never mind. We are left with the certainty that a civilization can be wholly described by its economy, and that ours is exhaustively and triumphally capitalistmaking anomalous the many well-established features of the culture to which the word public might attach: schools, lands, and, more generally, public works, public services, the public interest. If the furthest implications of the reign of selfishness are not yet fully actualized, no doubt custom, manners, image, shame, or the occasional laws are the obstacle, since the theory itself is so simple and natural in its operation that it should be as small an intrusion on the order of things as multiplying everything by one. It could be used to rationalize stealing the pennies from a dead mans eyes, true, even considering the nugatory value of the contemporary penny. Judgment as to whether it has reached this extreme must await a fuller knowledge of its global impact. Closer to home, it has scuppered the old habit of measuring wealth by standard of living. Averaging helicopters, yachts, and offshore accounts against imminent eviction would not yield a meaningful result.

The cult of cost/benefitof the profit motive made granular, cellularnot only trivializes but also attacks whatever resists its terms. Classic American education is ill-suited to its purposes and is constantly under pressure to reformthat is, to embrace as its purpose the training of workers who will be competitive in the future global economy. What this means, of course, is that universities and students themselves should absorb the cost to industry of training its workforce. Since no one knows what the industries of the future will be, a wrong guess about appropriate training could be costly, which means it would be all the smarter, from a certain point of view, to make colleges and students bear the risk. If this training produces skills that are relevant to future needs, their cost to the employer will be lowered by the fact that such skills will be widely available. In any case, the relative suitability of workers will be apparent in their school history, so industry will be spared the culling of ineffective employees. Those who fail to make the cut will be left with the pleasures of a technical education that is always less useful to them, skills that will be subject to obsolescence as industries change. Certain facts go unnoticed in all this. The great wealth that is presented as endorsing an American way of doing things was amassed over a very long period of time.

Lifetime earnings as well as longevity are adduced to demonstrate the value of university education. Obviously, these are measures of the well-being of people who were educated a generation or two ago. Otherwise, there would be no way of measuring workers peak earnings or their longevity. So there is clear evidence of the economic value of an education based on the humanist model that is now under siege. There is no evidence that education designed to train a workforce would be equally productive of wealth, but it would be profitable in another way, cheapening labor by diminishing the participation of the public in whatever wealth is produced. This is the embrace of inequality, accumulation on one side accelerated by deprivation on the other.

Historically, we have offered our youngthough never enough of themexposure to high thought and great art, along with chemistry and engineering. There is an opulence in all this that has no equivalent in the world. What were those earlier generations thinking when they built our great city-states of research and learning? All those arches and spires induce the belief in undergraduates that they have a dignified place in human history, something better than collaborating in the blind creep of a material culture that values only itself, that is indifferent on principle to the past, and inclined, when it considers a future, to imagine the ultimate displacement of the human worker and at the same time to develop systems of social control of which even Bentham could not dream. Why control people for whom no role or use is imagined? If these futures seem incompatible, the theory of cost/benefit does not admit of such criticism. Present trends, inevitably understood in light of emergent possibilities, are, in the nature of things, ineluctableor they were until a few weeks ago, when the system that had become more or less coextensive with our sense of reality abruptly collapsed.

Emergencies remind us that people admire selflessness and enjoy demands on their generosity, and that the community as a whole is revivified by such demands. Great cost and greater benefit, as these things are traditionally understood. If in present circumstances we are driven back on our primitive impulses, then we should be watching our collective behavior carefully, because it will be instructive with regard to identifying an essential human nature. In more senses than one we are living through an unprecedented experiment, an opportunity it would be a world-historical shame to waste.

Its value as experiment is enhanced by the near absence of leadership from the central government. In various forms, the crisis will persist indefinitely. Over time communities will organize themselves according to their senses of decency and need. Since this crisis is as novel as the virus that has caused it, and since the lack of a helpful central government is unique in the modern period, old thinking and new thinking will emerge over time, and the calculus of cost will be reckoned against the cost of failing to sustain the things that are valued. Benefit will be realized in the fact that needs are identified and served, with all the satisfactions this will entail. Allowing for regional variations, to the degree that democratic habits persist, the country will get by.

As Americans, we should consider our freedomsof thought, press, and religion, among othersthe basic constituents of our well-being, and accept the controversies that have always arisen around them as reflecting their vitality. Not so long ago they were something new under the sun, so if there is still a certain turbulence around them this should remind us that they are gifts of our brief history. We should step away from the habit of accepting competition as the basic model of our interactions with other countries, first because it creates antagonisms the world would be better off without, and second because recent history has shown that the adversary is actually us, and for ordinary people there is no success, no benefit.

And we have to get beyond the habit of thinking in terms of scarcity. We live in the midst of great wealth prepared for us by other generations. We inherited sound roads and bridges. Our children will not be so favored. Since the value of basic investments is not realized immediately, we cannot rationalize the expenditure. We are the richest country in history, therefore richer than the generations that built it, but we cannot bring ourselves even to make repairs. Our thrift will be very costly over time. The notion or pretense that austerity is the refusal to burden our children with our debts is foolish at best. But it is persuasive to those who are injured by it as surely as to those who look at a pothole and see a tax cut. Hiding money in a hole in the ground has seemed like wisdom to some people since antiquity. And there are many who are truly straitened and insecure, and are trusting enough to assume that some economic wisdom lies behind it. Legislators all over America, duly elected, have subscribed to this kind of thinking and acted on it.

We have seen where all this leads. It creates poverty, and plagues batten on poverty, on crowding and exhaustion. If the novel coronavirus did not have its origins in the order of things now in abeyanceother possibilities are even darkerthat order was certainly a huge factor in its spread.

As a culture we have spent a great deal of time in recent decades naming and deploring the crimes and injustices in our history. This is right and necessary. But the present crises have exposed crimes and injustices deeply embedded in the society we live in now. So we provide our descendants with a weighty burden of guilt to lament. This ironytoo mild a wordcasts grave doubt on the rigor of our self-examinations.

All this comes down to the need to recover and sharpen a functioning sense of justice based on a reverent appreciation of humankind, all together and one by one. The authenticity of our understanding must be demonstrated in our attempting to act justly even at steep cost to ourselves. We can do this as individuals and as a nation. Someday we will walk out onto a crowded street and hear that joyful noise we must hope to do nothing to darken or still, having learned so recently that humankind is fragile, and wonderful.

Continued here:
What Kind of Country Do We Want? | by Marilynne Robinson - The New York Review of Books

Recommendation and review posted by Alexandra Lee Anderson

UWA health and medical research receives $2.7 million funding boost – University News: The University of Western Australia

Wednesday, 20 May 2020

Two University of Western Australia research projects looking to improve health and patient outcomes have received a combined $2.7 million from the National Health and Medical Research Council (NHMRC).

They include a study that will examine Familial Hypercholesterolaemia, a condition where a gene alteration causes a high blood level of cholesterol to pass from one generation to the next and a research project that will look into ways of improving health and development outcomes in infants.

The NHMRC grants aim to support world-leading health and medical research projects to improve the lives of Australians and deliver better care as we look towards recovery from COVID-19.

Dr Jing Pang from the UWA Medical School has received $645,205 in funding to lead the study into Familial Hypercholesterolaemia and will be developing a tool to aid early diagnosis of the condition.

Those with Familial Hypercholesterolaemia are at very high risk of early coronary artery disease causing an estimated $4 billion burden on the Australian economy between 2017 and 2018.

Professor Jane Pillow from the UWA School of Human Sciences was awarded $2.06 million to examine ways of reducing global mortality and severity of disease in newborn infants.

Disruptions to normal growth and development can adversely affect lifelong health and longevity and affect multiple body organ systems in infants born prematurely.

Professor Pillows team will look into low-cost treatments that minimise the need for technology and technical skill.

Jess Reid (UWA Media and PR Adviser) 08 6488 6876

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UWA health and medical research receives $2.7 million funding boost - University News: The University of Western Australia

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Digital welfare states: boundaries and opportunities – Social Europe

A Dutch court case has set out a framework within which the emergent digital welfare state can respect the right to privacy.

Public authorities are increasingly using new technologies to perform public services. The latest ideas concern health-care apps to prevent the further spread of the coronavirus. Worldwide, there are many more examples of what the United Nations calls digital welfare states. Although governments argue new technologies make their services more efficient and cost-effective, many however express concern about the surveillance of citizens.

Such controversies tend to attach to individual episodes. Given the widespread emergence of digital welfare states, universal guidelines are needed to explore the opportunities they offer but also their legitimate boundaries. In a first court case, human rights have proved to offer relevant guidance.

Many welfare states have started using big data and algorithms in their social-security provision. Digital welfare states may be defined as having systems of social protection and assistance which are driven by digital data and technologies that are used to automate, predict, identify, surveil, detect, target and punish. For instance, data-driven tools are used to detect social-security fraud. Likewise, some governments use location data to track-and-trace the whereabouts of their citizens, aiming to halt the coronavirus.

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At first sight, such apps offer quick solutions to governments. Yet hasty decisions hinder proper research and in-depth debates on their effectiveness, necessity and side-effects. A suggestion by the Dutch government to create track-and-trace apps drew a public response from 60 experts. They warned against rapid implementation, urging that the purpose, necessity and effectiveness of such apps be weighed against the fabric of society, including fundamental rights and freedoms.

Quoting Michel Foucault, the experts wrote: Surveillance is permanent in its effects, even if it is discontinuous in its action. They expressed fear that the apps would set a precedent for future use of comparably invasive technologies, after the Covid-19 crisis had subsidedand so stressed that any app should be temporary, necessary, proportionate, transparent, completely anonymous, voluntary and managed by an independent body.

Other discussions of new technologies refer to similar principles. Universal guidelines are thus needed to underpin the development and functioning of any new technology used in digital welfare states. The recent judgment by the district court of the Hague shows that international human rights form a proper basis to create such guidelines.

The first ever court case using human rights to assess new technologies in digital welfare states focused on the Dutch System Risk Indication (SyRI). The SyRI lawsuit was taken against the Dutch state by a coalition of non-governmental organisations, supported by the then UN special rapporteur on extreme poverty and human rights, Philip Alston, who wrote an amicus brief to the court.

SyRI was established to detect welfare fraud, collating no less than 17 categories of personal data gathered by different public agencies. These included information on employment, detention, sanctions, finances, education, pensions, childcare allowances, benefit receipt and health insurance. SyRI has been used recurrently, especially in neighbourhoods with poorer and more vulnerable people. It has analysed data using an algorithm with risk indicators, thus selecting potentially fraudulent claimants. The algorithm and its indicators were kept secret out of fear citizens would start gaming the system.

The court ruled that SyRI violated important human rights and therefore should be ended immediately. For the UN this was nothing less than a landmark rulingfor the first time arresting, on grounds of human rights, the use of digital technologies and abundant information-processing by welfare authorities. It set an important legal precedent and could inspire NGOs across the globe to influence the public debate or even to go to court themselves.

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The court stressed the right to respect for private and family life, home and correspondence in article 8 of the European Convention on Human Rights, and paid special attention to achieving a fair balance between the collective importance for society to fight fraud and thereby limiting the individual right to respect for private life. The state had a special responsibility to safeguard this fair balance when using new technologies, the court said.

SyRIs lack of transparency about its functioning prevented scrutiny of whether there was such a balance. It could even result in unfair judgments involving discriminatory distinctions between people, for instance based on socio-economic or migrant status. This might have severe negative consequences, not only for the individuals concerned but also for society at large. Not only fraudsters were caught up in large data processing but, in the case of SyRI, everyone living in a certain neighbourhood and anyone flagged as potentially claiming illegitimately.

The court did not say that the government could never use new technologies. It found fighting fraud a legitimate aim. Equally, however, new technologies sparked questions on the right to protection of personal data. Adequate protection of privacy contributed to trust in government, whereas inadequate protection and too little transparency had the opposite effect: they could make citizens afraid and less willing to share their data. In addition, SyRI did not convince in terms of its necessity and proportionality and the purpose of data-processing.

Here, the court used European Union data-protection regulations to explain the principles of a fair balance between rights and purposes: transparency, purpose limitation and data minimisation. Such principles also appear in the guidelines for contact-tracing apps recently promulgated by the EUs eHealth Network.

All these sources could be used to convert similar messages into universal guidelines for digital welfare states, enabling them to benefit from new technologies in a responsible manner. Then, new technologies could contribute to the economic and social wellbeing of all citizens.

An article on the SyRI court case will appear in the Netherlands Yearbook of International Law, vol 50.

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Digital welfare states: boundaries and opportunities - Social Europe

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Expert Jason Hope on using AI to learn from pandemic – Augusta Free Press

Published Thursday, May. 14, 2020, 8:33 pm

Front Page Business Expert Jason Hope on using AI to learn from pandemic

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Since the initial recognition of COVID-19, and throughout the remarkable trajectory of the global pandemic to date, the scientific community has sought to garner unprecedented insight regarding the connection between Coronavirus, and a myriad of human connections. From the Epidemiologists investigating patterns of infection throughout the world to the Biologists seeking an effective vaccination, the scientific community is brimming with brilliant minds searching for ways to gain an understanding of the pandemic, the human body, modern disease mitigation, and the impacts of COVID-19 on other aspects of the general lifespan. For Jason Hope, along with researchers in the niche field of longevity studies, the Coronavirus pandemic has opened a breadth of new considerations, topics of study, and important connections that could impact the quest for long-term wellness and preservation.

As a widely renowned thought leader and champion within the realm of human longevity research, expert Jason Hope has dedicated his breadth of time, experience, and knowledge to propel technology, public understanding, and research needed to propel the field. With a firm belief in the potential benefits that a broader understanding of human longevity can provide, the entrepreneur and mentor, who previously developed a successful mobile communications company, now focuses on leveraging his skills to drive the field forward. Recently, shed light on the connection between artificial intelligence, human longevity, and the COVID-19 pandemic.

In discussing the impact of COVID-19 within the field of longevity studies, Hope sat down with the Director of Aging Research at Kings College London, Dr. Richard Siow. After his own firsthand experience with battling Coronavirus-like symptoms, Siow spoke at length about the experience, his understanding of the pandemic as it related to human longevity, and what the scientific community can learn from the current Coronavirus pandemic.

In speaking about his experience, Siow shared that he did stop taking the immunosuppressives for the two weeks to try and recover, so Ive also had an increase in my arthritis symptoms. So you can see that there are consequences for my Longevity by having an underlying health condition. According to Hope, it can be surmised that individuals who test positive for COVID-19 may experience a myriad of symptoms, potentially more difficult to deal with in the presence of other already present healthcare conditions. Thus, when utilizing medications or treatments to combat the symptoms of Coronavirus, these individuals may experience a resurgence of symptoms related to their other existing conditions, sparked by medication interaction, or a push-and-pull effect of the human body. In this sense, the presence of COVID-19 in any individual can directly impact overall wellness, the aging of the body, and the prospect of increasing longevity.

With these vastly important conclusions in play, it is important for professionals within the field of anti-aging and human longevity to research ways to mitigate the negative impacts of infectious diseases like COVID-19 in terms of longevity. While Dr. Siows previous studies focused primarily on cardiovascular aging, the current pandemics interference with human longevity has motivated him to pivot his studies. Dr. Siow has stated, my interest now is to align my research background and the longevity consequences of COVID-19 and see how my research might be able to mitigate and prevent some of these long term impacts on health and wellness and also future infections. As a trusted thought provider in the field, Hope touts that this increased focus on maintaining longevity efforts for individuals affected by infectious conditions like COVID-19 will undoubtedly create a much more informed, efficient, and successful blueprint for action, in the event of a future pandemic outbreak.

While the presence of Coronavirus presents immediate risks and dangers to individuals, it also poses long-term concerns and can exacerbate conditions that may remain dangerous long after the virus leaves the individual. While a full recovery may signal the disappearance of immediately related COVID-19 symptoms, it doesnt account for the potentially grim aftermath that the presence of Coronavirus may leave behind. Experts like Jason Hope ponder the notion that COVID-19 could potentially predispose individuals to the future emergence of age-related conditions, including dementia, heart disease, and other serious medical considerations. Thus, increasing overall human resilience may be the key to boost overall wellness, longevity, and health, which could minimize the seriousness of symptoms for future outbreaks.

In seeking scientifically backed answers to these very current considerations, Dr. Siow looks to personalization, technology, and artificial intelligence to customize prevention to meet the needs of every individual. At the Longevity AI Consortium, a Kings College initiative focused on marrying industry and academic personnel to create personalized aging insights, garnering insight from healthy individuals is the first step to creating a roadmap for maintaining wellness. To do this, Dr. Siow looks at specific biomarkers for wellness to create proactive planning to retain health and wellness through positive intervention. Championing the potential impact of this proactive approach, Hope notes that creating a bespoke and effective proactive regimen for individuals to follow could greatly impact their ability to harness an efficient immune system and be best prepared to stave off potential complications throughout another outbreak like the current Coronavirus pandemic.

Bridging the tech-based advancements with the practical consumer-facing application will be the key to generating universal data sets that can then be analyzed, and utilized to create trustworthy statistics, recommendations, and information that can undoubtedly help individuals across the globe. While this sector remains fragmented, philanthropists and investors like Jason Hope believe that through constant advancement, the marriage of AI, technology, science, and medicine, will be able to propel the field of anti-aging and human longevity forward. With broad considerations for the myriad of ways that different facets of human functionality impact longevity on a long-term basis, growth within the field can unlock answers that can help countless individuals to remain healthy well into the geriatric age. Furthermore, in times of a global healthcare crisis, the field of longevity can offer unparalleled insight into how conditions like COVID-19 can impede longevity, exacerbate tertiary conditions, and create long-term negative effects.

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Expert Jason Hope on using AI to learn from pandemic - Augusta Free Press

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SOLIUS Announces Investment from Human Longevity Inc. to Support Mission of Improving Health, Performance, and Longevity. – PRNewswire

SEATTLE, May 13, 2020 /PRNewswire/ --SOLIUS, a developer of innovative light therapy technologies focused on mitigating vitamin D deficiency, today announced investment from Human Longevity, Inc. (HLI) into its Series B financing.

The SOLIUS technology stimulates the production of vitamin D in the skin using a narrow spectrum of ultraviolet B (UVB) light. Vitamin D has a wide range of impact on systemic health, and supports physical, mental and immune function. SOLIUS delivers safe and effective light therapy using a personalized dosing system while filtering out nearly all other ultraviolet light. The SOLIUS technology can produce 10x more vitamin D than the sun, using 100x less ultraviolet energy. This technology is also an effective solution for at risk populations unable to absorb vitamin D orally.

HIL is a pioneer and leader in the delivery of data-driven, predictive precision health intelligence. Wei-Wu He, PhD, Executive Chairman, HLI stated: "We are excited to invest in SOLIUS as its mission is to provide the benefits of the sun without the harmful rays to unlock the healing powers of the human body. Investing in SOLIUS is another example of HLI's expertise in aggregating and leveraging technologies designed to demonstrably increase health, performance and lifespan. I welcome SOLIUS to our emerging ecosystem of longevity and performance-focused companies."

Bob Wise, SOLIUS CEO, said "Humans need sun exposure to stay healthy, and the benefits of the sun cannot be fully replicated with hormone replacement, such as oral vitamin D supplements. We are excited to partner with HLI in developing technologies that prevent disease and improve human health."

ABOUT SOLIUSSOLIUS was founded to advance the understanding of photobiology and the impact that ultraviolet light has on the human body. SOLIUS is dedicated to developing light therapies that stimulate the production of hormones via the skin. The SOLIUS products aim to improve health for people affected by conditions scientifically correlated with a reduction in sun exposure and vitamin D deficiency. For more information, visit http://www.solius.com.

About HLIHuman Longevity, Inc. (HLI) is a genomics-based, health intelligence company empowering proactive healthcare and enabling a life better lived. HLI's business focus includes the Health Nucleus, a genomic-powered, precision medicine center which uses whole-genome sequencing analysis, advanced imaging, and blood analytics, to deliver the most complete picture of individual health.

Contact: [emailprotected]

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SOLIUS Announces Investment from Human Longevity Inc. to Support Mission of Improving Health, Performance, and Longevity. - PRNewswire

Recommendation and review posted by Alexandra Lee Anderson

Longevity and Anti-senescence Therapy Market Projected to Experience Major Revenue Boost During the Forecast Period Between 2020-2026 | Covid-19…

ReportsnReports recently added a detailed overview and industry professional survey report on the global Longevity and Anti-senescence Therapy Market. In this report, titled Longevity and Anti-senescence Therapy Market Size, Share and Industry Analysis by Technologies, By Product, By Application, By Distribution Channel, and Regional Forecast 2019-2026.

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The scope of the report encompasses the major types of Longevity and Anti-senescence Therapy Market that have been used, as well as the major applications being developed by industry, academic researchers and their commercialization offices, and government agencies. It analyzes the current market status, examines future market drivers, and presents forecasts of growth over the next five years. Technology developments, including the latest trends, are discussed. Other influential factors such as screening strategies for pharmaceuticals have also been included.

The global Longevity and Anti-senescence Therapy Market is comprehensively profiled in the report, including a detailed study of the markets key drivers and restraints, major market players, and leading segments.

Report Scope:

The scope of this report is broad and covers various therapies currently under trials in the global longevity and anti-senescence therapy market. The market estimation has been performed with consideration for revenue generation in the forecast years 2018-2023 after the expected availability of products in the market by 2023. The global longevity and anti-senescence therapy market has been segmented by the following therapies: Senolytic drug therapy, Gene therapy, Immunotherapy and Other therapies which includes stem cell-based therapies, etc.

Revenue forecasts from 2028 to 2023 are given for each therapy and application, with estimated values derived from the expected revenue generation in the first year of launch.

The report also includes a discussion of the major players performing research or the potential players across each regional longevity and anti-senescence therapy market. Further, it explains the major drivers and regional dynamics of the global longevity and anti-senescence therapy market and current trends within the industry.

The report concludes with a special focus on the vendor landscape and includes detailed profiles of the major vendors and potential entrants in the global longevity and anti-senescence therapy market.

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Report Includes:

71 data tables and 40 additional tables An overview of the global longevity and anti-senescence therapy market Analyses of global market trends, with data from 2017 and 2018, and projections of compound annual growth rates (CAGRs) through 2023 Country specific data and analysis for the United States, Canada, Japan, China, India, U.K., France, Germany, Spain, Australia, Middle East and Africa Detailed description of various anti-senescence therapies, such as senolytic drug therapy, gene therapy, immunotherapy and other stem cell therapies, and their influence in slowing down aging or reverse aging process Coverage of various therapeutic drugs, devices and technologies and information on compounds used for the development of anti-ageing therapeutics A look at the clinical trials and expected launch of anti-senescence products Detailed profiles of the market leading companies and potential entrants in the global longevity and anti-senescence therapy market, including AgeX Therapeutics, CohBar Inc., PowerVision Inc., T.A. Sciences and Unity Biotechnology

Summary:

Global longevity and anti-senescence therapy market deals in the adoption of different therapies and treatment options used to extend human longevity and lifespan. ?Human longevity is typically used to describe the length of an individuals lifetime and is sometimes used as a synonym for ?life expectancy in the demography. ?Anti-senescence is the process by which cells stop dividing irreversibly and enter a stage of permanent growth arrest, eliminating cell death. Anti-senescence therapy is used in the treatment of senescence induced through unrepaired DNA damage or other cellular stresses.

Global longevity and anti-senescence market will witness rapid growth over the forecast period (2018-2023) owing to an increasing emphasis on Stem Cell Research and an increasing demand for cell-based assays in research and development.

An increasing geriatric population across the globe and a rising awareness of antiaging products among generation Y and later generations are the major factors expected to promote the growth of global longevity and anti-senescence market. Factors such as a surging level of disposable income and increasing advancements in anti-senescence technologies are also providing traction to the global longevity and anti-senescence market growth over the forecast period (2018-2023).

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According to the National Institutes of Health (NIH), the total geriatric population across the globe in 2016 was over REDACTED. By 2022, the global geriatric population (65 years and above) is anticipated to reach over REDACTED. An increasing geriatric population across the globe will generate huge growth prospectus to the market.

Senolytics, placenta stem cells and blood transfusions are some of the hot technologies picking up pace in the longevity and anti-anti-senescence market. Companies and start-ups across the globe such as Unity Biotechnology, Human Longevity Inc., Calico Life Sciences, Acorda Therapeutics, etc. are working extensively in this field for the extension of human longevity by focusing on study of genomics, microbiome, bioinformatics and stem cell therapies, etc. These factors are poised to drive market growth over the forecast period.

Global longevity and anti-senescence market is projected to rise at a CAGR of REDACTED during the forecast period of 2018 through 2023. In 2023, total revenues are expected to reach REDACTED, registering REDACTED in growth from REDACTED in 2018.

The report provides analysis based on each market segment including therapies and application. The therapies segment is further sub-segmented into Senolytic drug therapy, Gene therapy, Immunotherapy and Others. Senolytic drug therapy held the largest market revenue share of REDACTED in 2017. By 2023, total revenue from senolytic drug therapy is expected to reach REDACTED. Gene therapy segment is estimated to rise at the highest CAGR of REDACTED till 2023. The fastest growth of the gene therapy segment is due to the Large investments in genomics. For Instance; The National Human Genome Research Institute (U.S.) had a budget grant of REDACTED for REDACTED research projects in 2015, thus increasing funding to REDACTED for approximately REDACTED projects in 2016.

The latest Longevity and Anti-senescence Therapy Market report provides readers with a deeper understanding of potential target consumers to create a lucrative marketing strategy for the 2019-2026 forecast period. For entrepreneurs seeking information about potential customers, it will be particularly helpful. Selective statements provided by leading vendors would allow entrepreneurs to gain a deeper understanding of the local market and prospective customers.

Table of Contents:

Chapter 1 Introduction

Study Background

Study Goals and Objectives

Reasons for Doing This Study

Scope of Report

Methodology and Information Sources

Geographic Breakdown

Market Breakdown

Analysts Credentials

.Continued

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Eight O&M steps to extend the longevity of hydropower plants – ESI Africa

The cost of implementing a robust operations and maintenance (O&M) strategy for hydropower accounts for a relatively small percentage of the value of electricity generated. However, failure to implement adequate and sufficient O&M can result in very high costs due to increased losses of production (direct and indirect) and higher needs for rehabilitation and equipment replacement.

This article first appeared inESI AfricaIssue 2-2020.Read thefulldigimaghereorsubscribe to receive a print copy here.

The development of hydropower continues throughout the world, with some 22GW of hydropower being added in 2018, bringing the worlds hydropower capacity to around 1,290GW. In 2018, the estimated generation from these facilities amounted to 4,200TWh, or some 16% of the worlds electricity production.

A key distinguishing feature of hydropower is its potential longevity. A hydropower facility can operate for 100 years or more, compared with 20-30 years for most other generation technologies. This article outlines the best O&M strategies that can be applied to maintain the longevity of hydropower plants through a step-by-step approach.

Step 1: Diagnose existing O&M arrangements, budgets and owner/operator capabilities

For existing hydropower fleets, assess the condition and performance of theassets and services, including risks related to major equipment and need for replacement and repairs. The intended outcome of the diagnosis is toidentify what aspects of O&M need to be improved, and to establish whether the owner needs external assistance for operation of its assets.

Carrying out the diagnosis is also a good preliminary tool for assessing the status of the existing equipment, prioritising rehabilitation and, if needed, launching related feasibility studies to improve performance and ensure future safe operation. Diagnosis of an existing fleets performance can focus on contractual or standard industry key performance indicators (KPIs).

When financing a new facility to be added to an existing fleet, considerationshould be given to the current fleets O&M performance record. This will help guide the O&M strategy for the new facility, and possibly trigger changes to the O&M strategy for the existing fleet. Where the new project is a stand-alone facility, including those developed by an independent power producer (IPP), the same KPIs can be assessed on past or existing facilities for which the IPP team has or had responsibility.

Step 2: Define the objectives to be achieved through the implementation of the O&M strategy

Meeting the define objectives based on the diagnosis in Step 1 should be seen as a long-term goal that may require multiple iterations, such as changes in the operational management of facilities, short- and medium-term maintenance, and refurbishment, or the upgrading of the facilities. In order to ensure that a companys business plan does not become too focused on only one or two performance areas (such as finance or reliability), multiple goals and objectives are required.

The objectives of the strategy must be defined by indicators to be applied at all levels, including technical, financial, human resource services, and management, among others. Vision and mission statements may be used, if they exist, or formulated, if they do not, as an anchor point for the O&M strategy. Their primary objective is to communicate the companys strategic goals and is often linked to operational performance. Such vision and mission statements only have value if they are used by management as guiding principles for the business.

Step 3: Explore various activities to be undertaken to achieve these objectives

Considerations to be addressed while preparing the list of activities for the O&M strategy should go beyond assessment of asset repairs and refurbishment to examining root causes and long-term and sustainable solutions. The output from this step includes identification of the core activities and measures required in order to achieve the strategic objectives established in Step 2, based on the diagnosis completed in Step 1.

Step 4: Examination of O&M contractual models

Depending on the capabilities identified in Step 1, along with the activities selected in Step 3, explore O&M contractual models to identify which activities will be implemented internally and which will be outsourced. This can be broken down into three models to identify which model works best, namely:

Model one: Owner retains sole responsibility for O&M. Model two: Owner outsources some O&M responsibilities to consultants, contractors, or suppliers. Model three: Owner outsources all O&M responsibility to an independent operator.

Step 5: Training and human resources management

Explore organisation and staffing options (and organograms) according to owner capacity and requirements for external training and human resources. The success of the organisation depends on the quality of its employees (skills, knowledge, and experience) at all levels of the company and how well the human resources are selected, trained, and managed.

The differences between the performance of well-run and poorly performing utility fleets are evident at multiple levels. The greatest responsibility rests at the senior and management levels. Shortcomings should be identified during the diagnosis in Step 1 and through a more detailed operational audit.

Step 6: Financing for the implementation of the O&M strategy

Estimate financial resources required for implementing the selected model, including any external contracting. For the purposes of validating the O&M strategy, the costs are often estimated in USD. However, local or other international currencies may also be used, matching the currency that was adopted for estimating the benefits in Step 2. The costs of hydropower facility O&M vary considerably due to a range of factors including:

Nature of the facilities: complex facilities with multiple units, extensive civil works, and extensive associated infrastructure cost more to operate than simple compact facilities.

Age: older hydropower facilities with manual controls, analogue systems, and outdated equipment cost more to operate than modern, fully automated, remotely operated digitalised plants.

Condition: facilities in poor condition requiring continuous attention and suffering frequent failures cost more to operate than facilities in good condition. Facilities in poor condition are likely to require significant capital investment programmes.

Location: facilities in remote locations, especially where accommodation, utilities, and other facilities need to be provided for O&M staff, cost more than hydropower facilities in urban locations.

Country: since staff costs form a significant portion of OPEX, the labour costs and available skill levels in the country have a significant impact on O&M costs, especially if lack of skills means that expatriates are required. Some other input costs (vehicles, fuel, etc.) also vary by country.

Regulatory regime: the cost of permits, licences, registrations, rents, and other administrative outgoings varies from facility to facility and by country.

Owners approach to staffing: many traditional public utilities carry larger staff resources than commercial organisations with leaner operations.

The cost schedules from this Step will be used in the cost-benefit analysis to validate the strategy and check whether the proposed strategy is sustainable and bankable.

Step 7: Cost-benefit analysis of proposed strategy

Carry out cost-benefit analysis to assess the economic viability of the proposed strategy. If the strategy does not pass the test for economic viability, it may be necessary to go back to Step 2 to adjust objectives, activities, and resources. Once financial viability of the proposed strategy is achieved, internal and external validation can be sought. This Step also includes a check that adequate funding will be available.

Step 8: Monitoring and key performance indicators

Implement the strategy and prepare annual and rolling five-year operating plans and longer-term capital programmes. Overall performance of the strategy will be monitored through KPIs specified in appropriate agreements and contractual arrangements. The terms and conditions in the O&M contract will need to reflect the obligations of the owner under its concession agreement and PPA in the case of an IPP, or the requirements of the electricity regulator in the case of a public utility.

Model 3 case study: Nalubaale-Kiira Hydropower Complex, Uganda

The Ugandan government, working with the Uganda Electricity Generation Company (UEGCL), awarded a 20-year operational, management and maintenance concession to Eskom Uganda Limited (EUL), a subsidiary of Eskom, to cover both the Nalubaale Power Station and the adjacent Kiira Power Station.

The concession agreement commenced in 2003, with the electricity generated being sold to UETCL; the agreement expires on April 1, 2023. In this Model 3 concession arrangement, all O&M responsibilities are assumed by EUL, the private operator, for a fixed duration. UEGCL supervises the asset health and assumes all risks that are deemed to be catastrophic in nature. The owner reports to Electricity Regulatory Authority (ERA) to enforce performance standards, especially during the periodic renewal of generation licence performance targets.

EUL, the O&M operator, assumes all operational risks and mobilises all the required capital funding to keep the assets in good condition under an investment incentive structure, based on a 12% return on investment on all verified investments (any capital replacement made by EUL is recovered through asset depreciation plus a 12% ROI) during the contract period. Utility Prudent Practices are generally the yardstick by which the assets are to be maintained. So far, no specific details of these practices have been defined in the existing contract between EUL and UEGCL due to the broad definition of prudent practices.

Under the current 20-year O&M contract with Eskom Uganda, UEGCL hasexperienced challenges and successes, which include:

Transfer of knowledge Eskom Uganda has facilitated knowledge and skills transfer to a number of trainees from academic institutions as part of the usual industrial practice of internship programmes.

Modernisation the operator has modernised some of the critical plantsystems, albeit at a slower pace than what was anticipated at contractsigning. These improvements reduced the number of forced outages at the Nalubaale Power Plant.

Due to the generic definition of prudent practices, the success of the O&M contractual arrangement with Eskom Uganda cannot be fully appraised in the absence of appropriate qualitative or quantitative assessment. Discussions are ongoing to amend the contract to improve the contractual performance measures with a focus on asset management.

Due to rapidly advancing technologies and long procurement lead times, there is an ongoing requirement to stock spare components to avoid loss ofgeneration due to forced outages.

Alkali Silicate Reaction (concrete expansion) at the Nalubaale HPP has been (and continues to be) a technical issue since 1964 when the first crack appeared, resulting in a significant reduction in the expected life of the civil structure. Therefore, a programme has been undertaken to carry out a comprehensive rehabilitation of the power station, beginning with the feasibility study already underway.

Skills retention continues to be a challenge due to ongoingindustrialisation where skilled staff are in high demand by competitors.Therefore, there is a need to continuously provide on-board training and competitive salaries to retain skilled workers.

In general, the emergence of private sector-led investment in other forms ofrenewable energy, mainly from solar PV and other small hydropower projects on seasonal rivers, has resulted in an increase in peaking requirements and start/stop cycles for the large hydropower projects on the Nile River.

This additional demand for peaking will ultimately lead to a reduction in the design life of the hydro units, particularly for Kiira HPP which was designed for baseload conditions. The impact on Nalubaale units is not seen to be as significant because the units are Kaplans and can easily follow demand; i.e., each unit has an operating range from as low as 6MW up to 18MW, providing a healthy margin of spinning reserve.

In view of these challenges, a modernisation plan for the Nalubaale-Kiira Hydropower Complex is in preparation, focusing mainly on the optimisation of the two power plants to improve their plant factor, and to find a permanent solution to concrete expansion problems at Nalubaale Power Plant. ESI

This is article is based on an adaption of the Operation and MaintenanceStrategies for Hydropower handbook, compiled by the World Bank with thesupport of the Swiss State Secretariat for Economic Affairs and in collaboration with the International Hydropower Association. License: CC BY 3.0 IGO.

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Eight O&M steps to extend the longevity of hydropower plants - ESI Africa

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