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Category : Human Longevity

Can You Boost Your Metabolism? Here’s What the Science Says – Discover Magazine

Michal Mor hopes that one day, checking metabolism could be as routine as brushing your teeth. The vision is that everyone manages lifestyle based on their unique metabolism, she says. Its this metric that will help us live longer and healthier.

In May, Mor and her twin sister Merav both of them Ironman competitors with doctorates in psychology launched Lumen. The device, they say, helps users track and hack their metabolism. Its a simple concept: Breathe into the small black device, no bigger than an asthma inhaler, and receive a status report on what's called your metabolic flexibility. Then use that information to make lifestyle changes to boost performance and see an uptick in health.

The gadget has arrived among rising clamour from biohackers, intermittent fasting aficionados and rival tech developers (such as ketosis tracker Keyto) that insist the secret to a long, healthy life boils down to one major thing: our metabolism.

Are they right?

Loosely speaking, metabolism refers to the bodily processes that supply us with energy. These collective processes are designed to move primarily between two major states: absorptive (fed) and postabsorptive (fasting). In the former, usually after a meal, the body burns carbohydrates from food and stores excess as glycogen for later use. In the latter, it burns this stored fuel instead. (There is a third state, starvation, but it only occurs where the body is deprived of nutrients for an extended period of time and begins to break down muscle.) Metabolic flexibility is the term used to describe the efficiency and speed with which you move between the two states.

Despite throwing up 42 million search results on Google and acting as the main talking point at biohacking summits the world over, the concept of metabolic flexibility has only been circulating for about two decades. In 1999, endocrinologist David E. Kelley compared the effects of an overnight fast on lean versus obese patients. Leaner people, he found, adapted far more quickly, their bodies promptly switching to a postabsorptive state. Obese patients didnt adapt nearly as fast they were metabolically inflexible.

In the years since Kelley coined the term, its become very sexy, says Eric Ravussin, director of the Nutrition Obesity Research Center at the Pennington Biomedical Research Center. In fact, its been adopted as a sort of shorthand for optimal health. Red hot chilies, ice-cold showers and endless cups of green tea are just a few of the hacks recommended online by people who argue we can push our metabolism more efficiently between these two states to achieve goals in weight loss, exercise and overall health.

As Kelleys initial discovery would suggest, there is evidence of a link between metabolic flexibility and both weight management and exercise. A 2019 paper published in Cell Metabolism found the bodys ability to switch between fuels in response to the composition of diet was linked to a susceptibility to weight gain. And a review published in the same journal two years earlier highlighted evidence that efficiently matching fuel availability with metabolic machinery could help boost athletic performance.

But Merav Mor, and other advocates, go far beyond metabolic flexibility as a tool for weight loss or shaving a few seconds off a 100-meter sprint. They claim that it can help create a stronger immune system, improve sleep and boost longevity.

The science doesnt back up these broader health claims, though, says Ravussin. Not least because a robust human study would take 100 years, he points out. The only indicators we have of a link between metabolic flexibility and longevity right now are in mice. A 2015 review in Nature Cell Biology confirmed that studies have shown calorie restriction in mice can improve metabolic flexibility and increase lifespan.

It's like any other kind of bright, shiny object, says Susan Roberts, lead scientist of the Energy Metabolism Team at the Jean Mayer USDA Human Nutrition Research Center on Aging. Something new comes into science, and it sounds so attractive we think that maybe it's the solution to everybody's problem. But does metabolic flexibility account for 1 percent of health? 50 percent? 0.01 percent? That, for me, remains the question.

The other question is, what can we do about it?

The creators of Lumen say we all have the capacity to hack metabolic flexibility for optimal health. Its devices provide users with a metabolic level based on the composition of a single breath, or whats known as respiratory quotient (RQ). The idea is that when our metabolism is in a postabsorptive or fasted state, less carbon dioxide is released. Holding your breath for 10 seconds before exhaling into the device, Lumen say, captures this RQ and gives an accurate reading on your current metabolic state.

The premise is that a healthy body is one that relies on fat stores in the morning, says Mor. If the device detects this postabsorptive state first thing, then youre on the right track. If not, Lumen recommends lifestyle changes around sleep, exercise or diet, that help you improve it for next time. Easy.

Or is it?

There are links between lifestyle factors and metabolic performance. Sleep deprivation can damage overall metabolic health, for instance, while regular exercise can help prevent diseases linked to metabolism, such as type 2 diabetes.

But our ability to hack metabolism is limited. Your metabolism is mostly determined by your body composition and your genetic background, says Ravussin. Back in the 90s, Ravussin studied Pima Indians living in Arizona over an eight year period a group with the second highest prevalence of obesity in the world. Genes, he discovered, were crucial.

Even [which] Mor accepts that factors such as age and historic activity levels play into the extent to which you can tinker with metabolism. But theres no question about seeing improvement, she says.

For Roberts, of all the various ways we can boost health, painstakingly tracking metabolism isnt where she would focus efforts now. We need another couple of years of studies and then maybe it'll prove to be important, she says. But at this point, there are more important things. Do you eat junk food? Do you eat late at night? Do you stop eating at 6 p.m. and give your stomach time to recover? These are areas with really good evidence. This is all just a bit premature.

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Can You Boost Your Metabolism? Here's What the Science Says - Discover Magazine

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Apoplectic Eagles Announcer Merrill Reese Reacts to Back-Breaking Overtime Penalty – Sports Illustrated

You cant make this up. The way this team has shot itself in both feet.

The NFC East is shaping up to be quite the pillow fight. After three weeks, Dallas and Washington are tied at the top of the standings at 12, while the Giants and Eagles are winless.

The Eagles havent lost all their games, though. Sundays game against the Bengals ended in a tie, but only after Philadelphia threw away a chance to win the game.

Philly needed a game-tying drive from Carson Wentz in the final minutes to force overtime,and then neither team could get anything going in the extra period, as they just kept trading punts. Playing the field position game was eventually enough to give the Eagles a shot at a long, long field goal to win the game. With 19 seconds left, Jake Elliott lined up for a 59-yard attempt.

And then Eagles guard Matt Pryor committed a false start.

The penalty pushed the Eagles back five yards and head coach Doug Pederson decided he didnt want to take his chances on a 64-yard attempt (which would have tied the NFL record). Pederson punted and settled for the tie.

It was a maddening sequence of events and nobody was more enraged than longtime Eagles radio play-by-play man Merrill Reese. Reese was in sheer disbelief as he relayed the disaster to his listeners.

Thats inexplicable, how they cant line up for a field goalwith the game on the line, Reese said. Inexplicable. They cant line up for a field goal, ladies and gentlemen, with the game on the line. All they have to do is snap the ball to the holder.

You cant make this up, the way this team has shot itself in both feet, he added later.

Reese has called every single Eagles game since 1977. Hes a born-and-raised Philadelphian, and that absolutely comes through when hes calling a game. Theres never any doubt about who he wants to win the game.

There are those who will say Im a homer because I love this football team, Reese told Sports Illustrated in 2001.However, that doesnt affect my evaluation. That just puts me in tune with my audience.

His reaction to Sundays debacle, after the Eagles had already blown a big lead against Washington and gotten blown out at home against the Rams, was surely the reaction of every Eagles fanjust with less profanity.

By reaching his 10th NBA Finals, LeBron is setting a new standard for longevity of greatness. ... How much longer is Dan Quinn going to be the coach of the Falcons after another unfathomable collapse? ... Bam Adebayo came up huge for the Heat as they closed out the Celtics to advance to the NBA Finals.

Joe Montana reportedly fought off an intruder who tried to kidnap his nine-month-old granddaughter. ... A stranded motorist in Cleveland was shocked to discover that the guy who pulled over to help him out was Browns safety Ronnie Harrison. ... The Yankees D.J. LeMahieu won the batting title, becoming the first player in modern history to be crowned batting champ of both leagues. ... A Staten Island legislator told James Dolan to sell the Knicks, so Dolan responded by donating to his opponents campaign. ... Raiders defensive back Johnathan Abrams injuries from his collision with a TV cart on Monday Night Footballwere more severe than it initially appeared.

(He couldnt catch it because its six runs if he hits the ground with the ball outside the boundary.)

M. Night Shyamalans new movie is just called Old.... Human footprints discovered in Saudi Arabia could be 120,000 years old, the earliest evidence of human inhabitants in that part of the world. ... Workers in a gold mine in Colombia discovered 10,000-year-old fossils from a mastodon.

Email with any feedback or follow me on Twitter for approximately one half-decent baseball joke per week. Bookmark this page to see previous editions of Hot Clicks and find the newest edition every day. By popular request Ive made a Spotify playlist of the music featured here. Visit our Extra Mustard page throughout each day for more offbeat sports stories.

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Apoplectic Eagles Announcer Merrill Reese Reacts to Back-Breaking Overtime Penalty - Sports Illustrated

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Impact of COVID-19 on Global AI Medicine Software Market Size, Share, Segmentations and Forecast 2026 by Industry Key Players, Solutions and…

Overview for AI Medicine Software Market Helps in providing scope and definitions, Key Findings, Growth Drivers, and Various Dynamics.

AI Medicine Software Market Data and Acquisition Research Study with Trends and Opportunities 2019-2024The study of AI Medicine Software market is a compilation of the market of AI Medicine Software broken down into its entirety on the basis of types, application, trends and opportunities, mergers and acquisitions, drivers and restraints, and a global outreach. The detailed study also offers a board interpretation of the AI Medicine Software industry from a variety of data points that are collected through reputable and verified sources. Furthermore, the study sheds a lights on a market interpretations on a global scale which is further distributed through distribution channels, generated incomes sources and a marginalized market space where most trade occurs.

Along with a generalized market study, the report also consists of the risks that are often neglected when it comes to the AI Medicine Software industry in a comprehensive manner. The study is also divided in an analytical space where the forecast is predicted through a primary and secondary research methodologies along with an in-house model.

Download PDF Sample of AI Medicine Software Market report @

Key players in the global AI Medicine Software market covered in Chapter 4:Tempus Labs, Inc.Flatiron Health, Inc.Gene42, Inc.Sunquest Information Systems Inc2bPrecise LLCNantHealth, IncIBM Watson GroupHuman Longevity, Inc.N-of-One, Inc.Translational Software, IncSOPHiA GENETICS SASyapse, Inc.LifeOmic Health, LLCPierianDx, IncFabric GenomicsFoundation Medicine, Inc.Koninklijke Philips N.V.

In Chapter 11 and 13.3, on the basis of types, the AI Medicine Software market from 2015 to 2026 is primarily split into:Machine LearningNatural Language ProcessingOthers

In Chapter 12 and 13.4, on the basis of applications, the AI Medicine Software market from 2015 to 2026 covers:Drug DiscoveryPrecision MedicineOthers

Geographically, the detailed analysis of consumption, revenue, market share and growth rate, historic and forecast (2015-2026) of the following regions are covered in Chapter 5, 6, 7, 8, 9, 10, 13:North America (Covered in Chapter 6 and 13)United StatesCanadaMexicoEurope (Covered in Chapter 7 and 13)GermanyUKFranceItalySpainRussiaOthersAsia-Pacific (Covered in Chapter 8 and 13)ChinaJapanSouth KoreaAustraliaIndiaSoutheast AsiaOthersMiddle East and Africa (Covered in Chapter 9 and 13)Saudi ArabiaUAEEgyptNigeriaSouth AfricaOthersSouth America (Covered in Chapter 10 and 13)BrazilArgentinaColumbiaChileOthers

For a global outreach, the AI Medicine Software study also classifies the market into a global distribution where key market demographics are established based on the majority of the market share. The following markets that are often considered for establishing a global outreach are North America, Europe, Asia, and the Rest of the World. Depending on the study, the following markets are often interchanged, added, or excluded as certain markets only adhere to certain products and needs.

Here is a short glance at what the study actually encompasses:Study includes strategic developments, latest product launches, regional growth markers and mergers & acquisitionsRevenue, cost price, capacity & utilizations, import/export rates and market shareForecast predictions are generated from analytical data sources and calculated through a series of in-house processes.

However, based on requirements, this report could be customized for specific regions and countries.

Brief about AI Medicine Software Market Report with [emailprotected]

Some Point of Table of Content:

Chapter One: Report Overview

Chapter Two: Global Market Growth Trends

Chapter Three: Value Chain of AI Medicine Software Market

Chapter Four: Players Profiles

Chapter Five: Global AI Medicine Software Market Analysis by Regions

Chapter Six: North America AI Medicine Software Market Analysis by Countries

Chapter Seven: Europe AI Medicine Software Market Analysis by Countries

Chapter Eight: Asia-Pacific AI Medicine Software Market Analysis by Countries

Chapter Nine: Middle East and Africa AI Medicine Software Market Analysis by Countries

Chapter Ten: South America AI Medicine Software Market Analysis by Countries

Chapter Eleven: Global AI Medicine Software Market Segment by Types

Chapter Twelve: Global AI Medicine Software Market Segment by Applications 12.1 Global AI Medicine Software Sales, Revenue and Market Share by Applications (2015-2020) 12.1.1 Global AI Medicine Software Sales and Market Share by Applications (2015-2020) 12.1.2 Global AI Medicine Software Revenue and Market Share by Applications (2015-2020) 12.2 Drug Discovery Sales, Revenue and Growth Rate (2015-2020) 12.3 Precision Medicine Sales, Revenue and Growth Rate (2015-2020) 12.4 Others Sales, Revenue and Growth Rate (2015-2020)

Chapter Thirteen: AI Medicine Software Market Forecast by Regions (2020-2026) continued

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List of tablesList of Tables and Figures Table Global AI Medicine Software Market Size Growth Rate by Type (2020-2026) Figure Global AI Medicine Software Market Share by Type in 2019 & 2026 Figure Machine Learning Features Figure Natural Language Processing Features Figure Others Features Table Global AI Medicine Software Market Size Growth by Application (2020-2026) Figure Global AI Medicine Software Market Share by Application in 2019 & 2026 Figure Drug Discovery Description Figure Precision Medicine Description Figure Others Description Figure Global COVID-19 Status Overview Table Influence of COVID-19 Outbreak on AI Medicine Software Industry Development Table SWOT Analysis Figure Porters Five Forces Analysis Figure Global AI Medicine Software Market Size and Growth Rate 2015-2026 Table Industry News Table Industry Policies Figure Value Chain Status of AI Medicine Software Figure Production Process of AI Medicine Software Figure Manufacturing Cost Structure of AI Medicine Software Figure Major Company Analysis (by Business Distribution Base, by Product Type) Table Downstream Major Customer Analysis (by Region) Table Tempus Labs, Inc. Profile Table Tempus Labs, Inc. Production, Value, Price, Gross Margin 2015-2020 Table Flatiron Health, Inc. Profile Table Flatiron Health, Inc. Production, Value, Price, Gross Margin 2015-2020 Table Gene42, Inc. Profile Table Gene42, Inc. Production, Value, Price, Gross Margin 2015-2020 Table Sunquest Information Systems Inc Profile Table Sunquest Information Systems Inc Production, Value, Price, Gross Margin 2015-2020 Table 2bPrecise LLC Profile Table 2bPrecise LLC Production, Value, Price, Gross Margin 2015-2020 Table NantHealth, Inc Profile Table NantHealth, Inc Production, Value, Price, Gross Margin 2015-2020 Table IBM Watson Group Profile Table IBM Watson Group Production, Value, Price, Gross Margin 2015-2020 Table Human Longevity, Inc. Profile Table Human Longevity, Inc. Production, Value, Price, Gross Margin 2015-2020 Table N-of-One, Inc. Profile Table N-of-One, Inc. Production, Value, Price, Gross Margin 2015-2020 Table Translational Software, Inc Profile Table Translational Software, Inc Production, Value, Price, Gross Margin 2015-2020 Table SOPHiA GENETICS SA Profile Table SOPHiA GENETICS SA Production, Value, Price, Gross Margin 2015-2020 Table Syapse, Inc. Profile Table Syapse, Inc. Production, Value, Price, Gross Margin 2015-2020 Table LifeOmic Health, LLC Profile Table LifeOmic Health, LLC Production, Value, Price, Gross Margin 2015-2020 Table PierianDx, Inc Profile Table PierianDx, Inc Production, Value, Price, Gross Margin 2015-2020 Table Fabric Genomics Profile Table Fabric Genomics Production, Value, Price, Gross Margin 2015-2020 Table Foundation Medicine, Inc. Profile Table Foundation Medicine, Inc. Production, Value, Price, Gross Margin 2015-2020 Table Koninklijke Philips N.V. Profile Table Koninklijke Philips N.V. Production, Value, Price, Gross Margin 2015-2020 Figure Global AI Medicine Software Sales and Growth Rate (2015-2020) Figure Global AI Medicine Software Revenue ($) and Growth (2015-2020) Table Global AI Medicine Software Sales by Regions (2015-2020) Table Global AI Medicine Software Sales Market Share by Regions (2015-2020) Table Global AI Medicine Software Revenue ($) by Regions (2015-2020) Table Global AI Medicine Software Revenue Market Share by Regions (2015-2020) Table Global AI Medicine Software Revenue Market Share by Regions in 2015 Table Global AI Medicine Software Revenue Market Share by Regions in 2019 Figure North America AI Medicine Software Sales and Growth Rate (2015-2020) Figure Europe AI Medicine Software Sales and Growth Rate (2015-2020) Figure Asia-Pacific AI Medicine Software Sales and Growth Rate (2015-2020) Figure Middle East and Africa AI Medicine Software Sales and Growth Rate (2015-2020) Figure South America AI Medicine Software Sales and Growth Rate (2015-2020) Figure North America AI Medicine Software Revenue ($) and Growth (2015-2020) Table North America AI Medicine Software Sales by Countries (2015-2020) Table North America AI Medicine Software Sales Market Share by Countries (2015-2020) Figure North America AI Medicine Software Sales Market Share by Countries in 2015 Figure North America AI Medicine Software Sales Market Share by Countries in 2019 Table North America AI Medicine Software Revenue ($) by Countries (2015-2020) Table North America AI Medicine Software Revenue Market Share by Countries (2015-2020) Figure North America AI Medicine Software Revenue Market Share by Countries in 2015 Figure North America AI Medicine Software Revenue Market Share by Countries in 2019 Figure United States AI Medicine Software Sales and Growth Rate (2015-2020) Figure Canada AI Medicine Software Sales and Growth Rate (2015-2020) Figure Mexico AI Medicine Software Sales and Growth (2015-2020) Figure Europe AI Medicine Software Revenue ($) Growth (2015-2020) Table Europe AI Medicine Software Sales by Countries (2015-2020) Table Europe AI Medicine Software Sales Market Share by Countries (2015-2020) Figure Europe AI Medicine Software Sales Market Share by Countries in 2015 Figure Europe AI Medicine Software Sales Market Share by Countries in 2019 Table Europe AI Medicine Software Revenue ($) by Countries (2015-2020) Table Europe AI Medicine Software Revenue Market Share by Countries (2015-2020) Figure Europe AI Medicine Software Revenue Market Share by Countries in 2015 Figure Europe AI Medicine Software Revenue Market Share by Countries in 2019 Figure Germany AI Medicine Software Sales and Growth Rate (2015-2020) Figure UK AI Medicine Software Sales and Growth Rate (2015-2020) Figure France AI Medicine Software Sales and Growth Rate (2015-2020) Figure Italy AI Medicine Software Sales and Growth Rate (2015-2020) Figure Spain AI Medicine Software Sales and Growth Rate (2015-2020) Figure Russia AI Medicine Software Sales and Growth Rate (2015-2020) Figure Asia-Pacific AI Medicine Software Revenue ($) and Growth (2015-2020) Table Asia-Pacific AI Medicine Software Sales by Countries (2015-2020) Table Asia-Pacific AI Medicine Software Sales Market Share by Countries (2015-2020) Figure Asia-Pacific AI Medicine Software Sales Market Share by Countries in 2015 Figure Asia-Pacific AI Medicine Software Sales Market Share by Countries in 2019 Table Asia-Pacific AI Medicine Software Revenue ($) by Countries (2015-2020) Table Asia-Pacific AI Medicine Software Revenue Market Share by Countries (2015-2020) Figure Asia-Pacific AI Medicine Software Revenue Market Share by Countries in 2015 Figure Asia-Pacific AI Medicine Software Revenue Market Share by Countries in 2019 Figure China AI Medicine Software Sales and Growth Rate (2015-2020) Figure Japan AI Medicine Software Sales and Growth Rate (2015-2020) Figure South Korea AI Medicine Software Sales and Growth Rate (2015-2020) Figure Australia AI Medicine Software Sales and Growth Rate (2015-2020) Figure India AI Medicine Software Sales and Growth Rate (2015-2020) Figure Southeast Asia AI Medicine Software Sales and Growth Rate (2015-2020) Figure Middle East and Africa AI Medicine Software Revenue ($) and Growth (2015-2020) continued

About HongChun Research: HongChun Research main aim is to assist our clients in order to give a detailed perspective on the current market trends and build long-lasting connections with our clientele. Our studies are designed to provide solid quantitative facts combined with strategic industrial insights that are acquired from proprietary sources and an in-house model.

Contact Details: Jennifer GrayManager Global Sales+ 852 8170 0792[emailprotected]

NOTE: Our report does take into account the impact of coronavirus pandemic and dedicates qualitative as well as quantitative sections of information within the report that emphasizes the impact of COVID-19.

As this pandemic is ongoing and leading to dynamic shifts in stocks and businesses worldwide, we take into account the current condition and forecast the market data taking into consideration the micro and macroeconomic factors that will be affected by the pandemic.

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Impact of COVID-19 on Global AI Medicine Software Market Size, Share, Segmentations and Forecast 2026 by Industry Key Players, Solutions and...

Recommendation and review posted by Alexandra Lee Anderson

USMS’s 50th Anniversary: Expanding the Age Range | US Masters Swimming – U.S. Masters Swimming

Over the years, certain contentious issues have vexed the leadership and tested the ability of U.S. Masters Swimming to grow and develop. One of the most debated of these issues to hit the House of Delegates floor was the simple question of how old swimmers needed to be to participate in Masters Swimming.

For the first two decades or so of USMSs existence, swimmers had to be at least 25 to become members. Adult swimming, it seemed, was something you couldnt do until years after you were legally allowed to have a drink or cast a vote in an election. And a lot of that goes back to how swimmings international governing body, FINA, was set up.

FINAs official rules for Masters swimming do not extend to cover swimmers under the age of 25. USMS was in step with this until the mid-1980s when some folks began advocating for adding a younger age group. This faction wanted to see that change made so that the organization could be more inclusive and reach a segment of the swimming population that didnt have other options for swimming.

But simply adding an age group turned out to be a lot more difficult than we might expect looking back now.

We had huge arguments over this, says Tom Boak, a longtime member of the Woodland Masters Swim Club in Texas who also served as USMSs president from 1981 through 1985. One segment of the USMS leadership believed that because FINA didnt recognize swimmers younger than 25, USMS simply couldnt have swimmers younger than 25 involved either.

There was another faction that said, Thats crazy. We have all these people out here, we need to service this group, Boak recalls. The huge gap between collegiate swimmers leaving college and when they can start swimming with Masters made no sense.

To help address this issue, Boak recalls that proposals were floated starting in the mid-1980s, but it was an uphill battle to get it passed.

Nancy Ridout, longtime Masters swimmer and volunteer who served as president of the organization from 1997 to 2001, remembers the anti-younger age group faction really used scare tactics to try to sway more people to their side.

There was a rule that prohibited amateur swimmers from being tainted by professionals, Ridout says. The rule stated that an amateur swimmer couldnt swim in a pool or a meet or competition with a professional. Because Masters were considered professional, they figured that if college kids came home for the summer and wanted to work out, and the best place to do that was with a Masters group, they would forfeit their opportunity to swim in college or in the Olympics. They were afraid that leadership within FINA would not look kindly on this and it would jeopardize our American swimmers on the world and collegiate stages.

After much lobbying on both sides, a final vote was held at USMSs annual meeting in 1990. It was such a contentious issue and such a close vote that we counted the votes like five different times and every time it came out different, Boak says.

To break the stalemate and arrive at an accurate count, we had to actually physically divide the House of Delegates at the annual meeting, Boak recalls. Everybody in the House of Delegates had to stand up from their chairs and move to one side or the other of the room so that we could count the votes.

On that final vote, the proposal to add a 19- to 24-year-old age group passed by two votes, which is unbelievable, he says.

Looking back now, Boak says the opposition to adding the younger swimmers was totally illogical. But it was a hot-button issue that required a lot of time and effort to work through. In the end, however, that decision was monumental in terms of what Masters Swimming became.

The addition of the younger age group meant there would be no gap at all for someone who wanted to continue swimming after they got out of high school or college, and it helped increase USMSs membership numbers. With the more recent addition of College Club Swimming as a USMS program, the ranks of younger USMS members continue to grow.

In 2002, the age at which a swimmer could register with USMS was again loweredto 18but these 18-year-olds would have to wait until age 19 to compete. That rule was changed in 2005 when 18-year-olds were granted permission to register and compete just like any other adult.

At the other end of the age spectrum, it appears human longevity may be the only limiting factor in how many age groups get added. In 1989, the 9094 age group was added. Although FINA still doesnt recognize Masters swimmers younger than 25, it defines Masters age groups in five-year increments starting at age 25 and going as high as necessary. The organization spells out age groups through 9094 in its rule book.

USMSs rule book lists out all age groups running from 1824 right up though 100104 and includes a provision for additional five-year age groups to be added as high as is necessary. As humans continue to find ways of living longer and healthier, look for additional defined age groups to be added in the future.

USMS's 50th Anniversary: Expanding the Age Range | US Masters Swimming - U.S. Masters Swimming

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Longevity app calculates your life expectancy but will it make us healthier? – The Conversation UK

Would knowing the date of your death influence your actions? It did for Tiberius Caesar. Convinced by the court astrologer Thrasyllus that he had many years of life ahead of him, the paranoid old emperor chose to postpone the murder of his heir Caligula.

But by believing Thrasylluss prediction and letting his guard down, Tiberius inadvertently gave Caligula enough time to poison him first. The rest, as they say, is history which Thrasyllus had altered by deliberately overestimating his employers life expectancy.

While many of us are unlikely to find ourselves in Caesars position, knowing how many years we have left may influence many aspects of our life including when to retire, whether to take a long-awaited vacation, and even whether to opt for certain medical treatments.

My Longevity, a newly developed app from researchers at the University of East Anglia, now allows each of us to be our own life expectancy astrologer. But how much trust should we place in these predictions?

Simply put, life expectancy is how long, on average, members of any given population can expect to life. This is different from lifespan, which is the maximum length of time any member of the species can survive.

Although lifespan has changed very little if at all global life expectancy has soared by more than 40 years since the beginning of the 20th century. This was achieved through a combination of scientific discoveries and public health measures that drove down infant mortality. In the UK, life expectancy at birth is now over 80 years.

Life expectancy depends a lot on where you grow up or live. So the more a disparate population can be broken down into sub-populations who have traits in common but which are still large enough to be statistically significant the more accurate predictions become. Doing this might involve subdividing the population by sex (on average females live longer than males) or smoking status (for obvious reasons) or both.

The team of researchers used a sophisticated version of this approach when developing their app, informed by its previous research. This allows its app to factor in the life expectancy effects of controlled and uncontrolled high blood pressure, the presence of related illnesses such as cardiovascular disease or rheumatoid arthritis, ongoing treatment with statins, and serious risk factors, such as high cholesterol.

Developing the app has involved dealing with some problems along the way in estimating potential health benefits for the overall population based on those seen in clinical trials. This is because discrepancies exist between trial subjects and populations for a number of reasons but usually they are cases of what is known as tight segmentation working against you.

For example, a clinical trial of the effects of orange juice in sailors with scurvy will show profound benefits because they are a tight segment with vitamin C deficiency. But anyone expecting to see the same beneficial effects on health from prescribing orange juice to everyone taking a boat trip today is going to be deeply disappointed.

How seriously you should treat the predictions from an app of this type is basically a function of how accurately it reflects the sub-population into which you best fit. I compared my life expectancy prediction from My Longevity with calculators provided by the UK Office for National Statistics and those of two insurance companies. The predictions varied from 84-90 years. As Im 54, this may not have been a completely fair test of My Longevity because the data the team has used makes the app most accurate for the over 60s.

The major reason life expectancy calculators spit out such different figures is because there are a wide range of factors influencing the results. Being married increases your life expectancy compared to being single, as does being happy. In addition to smoking, levels of fruit and vegetable intake influence life expectancy. Perhaps unsurprisingly, levels of alcohol consumption and exercise make a profound difference to life expectancy. These are concrete lifestyle changes people can make which can add years to their lives.

The East Anglia research team hopes that access to its calculator will encourage users to adopt healthier lifestyles. Although there is some evidence that framing behaviours in terms of their effects on life expectancy is an effective way of encouraging people to embrace healthier lifestyles, superficial discussions of health and longevity often assume that everyone will seek to maximise life expectancy if only they are fed enough of the facts about it.

However, human motivation is emotional and intuitive at its core and is shaped by what a person most values in life. Propositions that accord with a persons values are typically supported. Those that dont are either ignored or rejected.

Another common mistake made by those promoting behaviour change is to assume their own dominant values are shared by the people they want to adopt the behaviour in question. This approach will only convince people who already think and feel like them. But the more developers of such apps recognise that users will only adopt certain behaviours according to their values and beliefs, the more useful these apps will be.

Longevity app calculates your life expectancy but will it make us healthier? - The Conversation UK

Recommendation and review posted by Alexandra Lee Anderson

Award-winning Austrian supplement containing "spermidine" is now available to consumers in the US – PRNewswire

Until recently, fasting has been considered the most efficient method to trigger the critical cellular renewal process, called "autophagy;" however, European aging scientists have discovered that autophagy is also triggered through a substance found in the human body, called spermidine. As the body ages, spermidine levels decrease, along with the self-renewing power of its cells. In search of a way to offset the effects of decreasing spermidine levels, Longevity Labs developed a method to isolate spermidine from plants (wheat germ) and to make it available to humans as a dietary supplement - spermidineLIFE.

TLL The Longevity Labs GmbH ("TLL") launched its first flagship product, spermidineLIFE in the EU 2019, bringing the first commercially available, safety-tested, lab-verified, spermidine-rich supplement to the global market. Quickly becoming a phenomenon in Austria and Germany, in September 2020, TLL has begun distribution of spermidineLIFE in the United States, through its subsidiary, Longevity Labs Inc., via its US website at

"We began with a common vision to support healthy aging. Spermidine was completely unknown in Austria but the scientific research, quality of our product and its effectiveness convinced the public.spermidineLIFE was voted one of the top 3 OTC product innovations in Austria in 2019 and interest has only continued to grow worldwide," says Vedran Bijelac, CEO of Longevity Labs Inc and Director of Sales and Marketing of TLL.

"We are proud to be the first scientifically tested and naturally-extracted spermidine supplement," says Daniel Dietz, COO of Longevity Labs Inc. "Not only do we want to present the health benefits of spermidine to the American population, we also want to find additional research partners. We are already working with more than 10 research institutions in Europe but the opportunity to work with top US scientists is very exciting."

spermidineLIFE is naturally extracted from European non-GMO wheat germ using TLL's proprietary extraction process in its state-of-the-art manufacturing facility in Graz, Austria. spermidineLIFE is lab-tested to ensure consistently rich spermidine content and has been tested for safety and tolerability in humans.

spermidineLIFE is available to consumers via its website via a monthly subscription model starting at $99. The supplement will also be available for one or more monthly package orders starting at $109. Wholesale pricing is available for practitioners.

For additional information or questions, please contact [emailprotected].

For more information about spermidineLIFE or to place an order, please visit

About TLL The Longevity Labs, GmbHTLL The Longevity Labs, GmbH is based in Graz, Austria. With the goal of translating scientific findings into natural solutions for a longer and healthier life, TLL worked with european university research partners to develop its novel product spermidineLIFE, with EU sales launching in 2019 and expanding worldwide. TLL continues to perform best-in-class research on life-extending products and services to bring to the global marketplace. For more information, visit or States).

No governmental agency has reviewed, approved or disapproved the content of this news release.

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

SOURCE Longevity Labs Inc.

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Award-winning Austrian supplement containing "spermidine" is now available to consumers in the US - PRNewswire

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The Three Main Benefits of Ecotourism and How to Promote It – TravelPulse

Although traveling to new places and experiencing new adventures is a great way to see the world, it is no secret that there are negative environmental effects of mass tourism. As you begin to think about your next vacation, perhaps look into a lower-impact alternative to mass tourism, which is ecotourism.

Ecotourism is a carefully curated way to see fragile, undisturbed natural areas of nature. By partaking in ecotourism and helping to conserve parts of nature and wildlife, you have the opportunity to witness magnificent, once in a lifetime nature scenes up close and personal.

In efforts to push a safer, more eco-friendly mode of tourism, here are some of the benefits of seeing unique, and oftentimes threatened, natural environments through ecotourism.


One of the great perks of taking an ecotourism-focused adventure is that you are exposed to new, less popular aspects of nature. Although traveling to incredibly popular sight-seeing destinations and visiting highly-visible attractions or monuments is exciting, there is so much else to see and explore.

Through ecotourism, you have the chance to see some of the most unique environments and view nature closer than ever. These types of excursions are much more exciting than viewing animals at your local zoo.

You may be able to see wildlife up close and within their wild, natural habitat, which isnt something you are able to experience every day. Ecotourism takes you along vast seascapes, wildlife habitats, and more, to view nature through an environmentally low-impact medium. With that being said, not only do you get to see nature from a new lens, but you also help to conserve many of the animals and habitats that are threatened or unprotected.

One example of ecotourism that aims to expose travelers to an abundance of magic is by experiencing bioluminescence. During the warmer months on the east coast of the U.S., there are many opportunities to see majestic sea life. On the shores of Florida, bioluminescent sea life lights up the dark water, exposing you to a once in a lifetime view of a glowing ocean.

Bioluminescence is a chemical process that permits living sea life to create light within their bodies. When the water is obstructed through wave creation or splashing from humans, the seawater begins to glow bright neon blue. This type of interactive experience exposes you to a side of nature that you may not otherwise get to witness.

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As you partake in ecotourism excursions, you can also receive an abundance of information educating you on topics pertaining to that areas wildlife and natural environments. For instance, you will see nature as it currently stands, as well as learn vital information on how to properly interact with wildlife and preserve these ecosystems.

Observing animals within a zoo environment does not always provide accurate insight into an animals daily life. Much of the animal culture within zoos are artificial. For instance, arctic penguin exhibits are usually not in climate-controlled areas where you can see them play on glaciers. Although zoos do a heap of good by protecting endangered animals, many animals endure stress from not being in the wild or having ample social interactions with other members of their species.

This takes away from witnessing authentic animal behavior within nature. By partaking in ecotourism, you can view animals that havent been displaced and also gather greater insight on how various species have become endangered, as well as how you can help.

As you travel, there is nothing like witnessing animals within their own wild environments where they are fully immersed in their own culture. Through these eco-tourism excursions, you are invited to submerge yourself within an animals environment and experience a small part of their daily lives.


By interacting with a natural environment through an ecotourism lens, you have the opportunity to leave it better than you found it. As a viewer and wildlife lover, ecotourism provides you with an outlet to minimize the negative impacts of tourism on these natural environments and protect what is left.

For example, you can transition from merely observing to positively interacting with these environments through participatory cleanup.

Alongside the provided education about how to conserve these environments, participatory cleanup is a great way to interact with nature on a personal level, all while ensuring that this environment and its wildlife can thrive. This can be demonstrated by cleaning up trash off the beaches and out of the ocean in efforts to prevent wildlife from dying as a result of human impact.

This acts as a way to protect species who oftentimes cannot differentiate between what is food and what is a plastic straw. By witnessing the impacts of humans on the environment while being in a proper wildlife setting, you can gather a comprehensive perspective and push to protect these habitats with proper knowledge and understanding.

Through exposure and education, we can work to protect wildlife spaces and ensure a better future for wildlife and their respective environments.

Human impact plays a large role in the longevity of the lifespans of wild animals and with your help, you can decrease the negative impacts and allow for a higher quality of life for these animals. As you begin to plan your next excursion, perhaps consider these benefits to ecotourism and push to protect the wildlife of that area. Take this opportunity to educate yourself, and your loved ones, on the many ways that animal harm can be prevented and how we can best conserve these natural areas.

Josh Myers is the owner of Florida Adventurer, a bioluminescence kayaking company. Josh is extremely passionate about ecotourism and the wildlife he interacts with on a daily basis. In order to further educate tourists around ecotourism, Josh ensures that each individual on his tours understands why and how to protect the indigenous animals that they encounter and how to conserve the natural area where he operates.

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Patience to Pay Off in Japan for a Loyal Aide – Bloomberg

Yoshihide Suga is patient. The longest-serving chief cabinet secretary in Japanese history, hes been a loyal aide in Prime Minister Shinzo Abes government, managing his public messaging and smoothing over internal quarrels.

Eight years on, hes widely expectedto take over from Abe, who is stepping down for health reasons, with the ruling party picking a new leader on Monday.

Abes time in office provided a period of stability after years of leadership turnover, including his own previous, and brief, premiership in 2006-2007.

The son of farmers, Suga worked his way up through the party machinery, honing his negotiating tactics. Hes played an instrumental role in Abenomics, the premiers marquee economic policy.

As such, Suga is unlikely to substantially change direction. Hes being touted as a continuity candidate who will hew to Abes policies.

On some issues he may push less hard. Abe comes from a family of politicians, including his paternal grandfather and father. His maternal grandfather was prime minister. His hopes of rewriting Japans pacifist constitution were deeply personal. For Suga less so.

But he would still have to manage relationships with the U.S., China, Russia and South Korea. On foreign policy hes largely untested. There are tensions with Beijing and Seoul, especially over Japans wartime past. Suga would need to engage with whoever wins the U.S. election, including on trade.

And its unclear if, at 71, hes seen as a bridging premier, or someone with longevity. With the economy struggling under the pandemic, and structural problems with an aging society and dwindling labor force, Japan can ill-afford a return to leadership uncertainty.

Abegestures atSuga during a news conference in Tokyo on May 4.

Photographer: Eugene Hoshiko/AP

Click herefor Bloombergs most compelling political images from the past week. Tell us how were doing or what were missing

China pitch, 2.0 | President Donald Trump is reviving his 2016 campaign playbook on attacking China, but running as the incumbent means defending a record of limited success in rewriting the economic relationship with Beijing. As Jenny Leonard reports, much of what the Trump team has laid out sounds like campaign promises made four years ago.

Campaign 2020

There are 53 days until the election. Heres the latest on the race for control of the White House and Congress.

Trump and his Democratic rival, Joe Biden, will signal today that their paths to the White House run through Pennsylvania, as both commemorate the anniversary of the Sept. 11 attacks near the town of Shanksville, where one of the hijacked planes crashed in 2001.

Other developments:

Sign up to receive daily election updates as a direct mobile notification on Twitter. Simply click on this link and like the tweet.

Talks fray | The British government rebuffed a European Union request to scrap a plan to re-write their divorce accord after the bloc gave a three-week ultimatum to do so and threatened legal action. The dispute risks jeopardizing efforts to secure a trade deal by Dec. 31 if theres no agreement by then it will trigger tariffs and snarl commerce with extra paperwork at the border.

High stakes | India and China pledged to de-escalate tensions along their disputed Himalayan border after their foreign ministers met yesterdayfor the first time since May, when the stand-off began. The nations have been increasing troop strength along the 3,488-kilometer Line of Actual Control for months and this week the first shots were fired since 1975 an indication multiple rounds of talks have done little to lower the temperature.

Election strategy | With opposition leader Alexey Navalny hit by a near-fatal poisoning, President Vladimir Putin faces a key test of support in Russian regional elections starting today. The three-day ballot, a prelude to 2021 parliamentary elections, is also a showcase for a smart voting campaign promoted by Navalny before he fell ill. It encourages voters in individual areas to back the politician most likely to defeat the ruling United Russia partys candidate.

Corruption probe | Lawmakers in Peru will vote today on whether to start impeachment proceedings against President Martin Vizcarra after the release of tapes of him discussing a minor graft case. Prosecutors are investigating allegations that a singer used contacts in the presidential palace to obtain contracts worth about $50,000, despite lacking experience.

Less than a week after Serbia agreed to move its embassy in Israel to Jerusalem by July as part of a deal with Kosovo brokered by Trump, the Balkan nations president has cast doubts on the plan.

French President Emmanuel Macron is meeting his government today to plan how to curb a surge in coronavirus infections almost 10,000 new cases yesterday without harming a fragile economic rebound.

Pop quiz, readers (no cheating!). Which Disney live-action remake is under pressure for filming in a sensitive region? Send your answer to

And finally ... The newest Covid-19 vaccine candidate to start human testing is the first where volunteers wont get a painful injection. Instead, theyll receive a spray through the nose. The Chinese-made vaccine joins about 35 other candidates currently in human testing, as the global race to be first with an effective weapon against the deadly pathogen intensifies. Some scientists hope a vaccine that gets sprayed through the nose may have a better chance of stopping the spread of the virus through respiratory tracts.

A woman receives an H1N1 flu nasal spray vaccination in December 2009 in San Francisco.

Photographer: Justin Sullivan/Getty Images North America

With assistance by Karl Maier, Kathleen Hunter, Anthony Halpin, and Isabel Reynolds

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Patience to Pay Off in Japan for a Loyal Aide - Bloomberg

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Nutrition and the Wisdom of Ethnic Cuisine: A Japanese Doctor’s Perspective –

When it comes to healthy eating, one size does not fit all. Japanese cooking, with its emphasis on rice, fish, and vegetables, may not be the best diet for everyone, but it is marvelously suited to the physiology of the Japanese, writes physician and writer Okuda Masako.

The popularity of Japanese cuisine has soared in recent decades, and one reason is undoubtedly its healthful image. The average lifespan of the Japanese people climbed rapidly after World War II. By around 1980, Japan had the highest life expectancy of any country in the world, and it still ranks near the top. (The worlds oldest living person is also a Japanese woman.) Amid a slew of investigations into the secrets of Japanese longevity, attention quickly centered on the benefits of washoku, traditional Japanese cooking.

My research and experience have taught me that the optimal diet depends on a variety of hereditary and environmental factors. But there is no denying that washoku has contributed to the health and longevity of the Japanese people. Let us begin by examining how.

In terms of health and long life, the biggest physiological factor the Japanese have going for them is a low risk of atherosclerosis. Atherosclerosis occurs when fats and other substances build up along the walls of arteries, restricting or even blocking blood flow. In the brain, such a blockage is known as a cerebral infarction (stroke); in the heart, it is called a myocardial infarction (heart attack). The incidence of myocardial infarction in Japan is among the lowest in the world.

Scientists believe that both genetics and diet play a role in protecting Japanese arteries. One factor is a high level of good cholesterol, or HDL (high-density lipoproteins), in the blood. In a 2008 study, Japanese HDL levels were found to be roughly 10% higher than those of white Americans on average. Another reason is that fish is a big part of the traditional Japanese diet, and fish contains EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid), two polyunsaturated fatty acids that help prevent hardening of the arteries. Since ancient times, the Japanese have been eating oily fish like mackerel, sardines, yellowtail tuna, and eel, which are abundant off the coast of Japan and are rich in EPA and DHA. In a 2015 study, the average concentration of DHA in Japanese maternal milk was determined to be up to six times that found in Western countries and about twice that found in China.

A second major contributor to Japanese health is the gut microbiota, the many and varied microorganisms living in the intestinal tract. A 2016 analysis of the intestinal microbiota of subjects from 12 countries found that the Japanese had the highest counts of beneficial bifidobacteria. (Interestingly, the gut microbiome of the Chinese subjects was closer to that of the Western subjects studied.) This can probably be attributed to the high fiber content of the traditional Japanese diet, with its emphasis on grains and vegetables. Dietary fiber provides a good nutritional environment for beneficial microbes and helps cleanse the gut of the harmful substances that unhealthy bacteria produce. Since it takes a generation or more to permanently alter the gut microbiota, todays Japanese probably owe their intestinal health to the dietary habits of their parents and grandparents.

All of this might lead one to the conclusion that eating washoku will automatically make one healthier. Unfortunately, it is not quite so simple. In general, the traditional diets that developed in various parts of the world were optimally adapted to the local environment and the needs of the native population. The physiology of the native population, in return, adapted to the diet.

There are obvious physical differences between Japanese people and Westerners. But the differences go beyond hair texture and eye color. There are also disparities in musculature, body fat, and body temperature, as well as various factors that affect digestion and metabolism of alcohol: hormone and enzyme secretion, the shape of the stomach, the composition of the gut flora, and so forth. Race is not just skin-deep.

The Japanese stomach is adapted to consumption of grain.

Figure 1 illustrates the stomach shapes typically found in Japanese people on the one hand and people of Westerners extraction on the other. The differences are the result of disparities in the traditional diet.

The Japanese have long relied on rice and other grains as their dietary staple. Grains are a good source of energy, but whole grains in particular take time to digest because of their high fiber content. The Japanese stomach is vertically elongated so as to store, mix, and break down such food before it continues on into the intestines. The intestines, in turn, are rich in the kinds of bacteria that help digest and extract nutrition from starchy foods.

By contrast, the traditional European diet, with its emphasis on meat and dairy products, is considerably higher in protein and fat. Since protein and fat are digested primarily in the intestines, the food needs to move more rapidly from the stomach to the gut. The digestive system evolved to deal with these demands. For example, a large quantity of stomach acid is produced so that the stomach can process the food quickly; comparatively thicker stomach muscles then push it smoothly into the intestines.Plenty of enzymes and other fluids are secreted to aid the digestion of fat and protein inside the intestines.

It has long been known that the ability of adults to digest milk varies by ethnicity and region. The bodys capacity to digest the lactose in milk hinges on continued production of the enzyme lactase. The map in figure 2 shows the global distribution of lactose-intolerant adults in various parts of the world, with higher concentrations indicated by darker shades. While most people in the British Isles and Scandinavia digest milk easily, close to 90% of adults in Southeast Asia and East Asia (including Japan) have trouble with it.

Darker shades indicate regions with higher rates of adult lactose intolerance.

Such differences in physiology can translate into serious health problems when people adopt different diets and lifestyles. One example involves vitamin D, which is essential to bone health, among other things. Vitamin D is produced inside the body when the skin is exposed to the suns ultraviolet rays, but it can also be obtained from dietary sources like oily fish. It has been suggested that Africans, who evolved in a part of the world where year-round UV exposure is high, may be less well equipped to absorb vitamin D from dietary sources, and this may be why African Americans tend to have relatively low vitamin-D levels. Some experts have warned that African Americans need to adjust their diets to avoid health problems resulting from vitamin D insufficiency. The optimum diet for any person depends on genetic makeup, as well as lifestyle and environment.

Genetics also influences the way our bodies accumulate fat. One characteristic of the Japanese constitution is the tendency to accumulate visceral adipose tissue, or fat inside the abdominal cavity, as opposed to the subcutaneous fat that collects under the skin. Unfortunately, visceral fat is the more worrisome kind.

Cross-sections showing the distribution of abdominal fat in representative Japanese (left) and Westerners (right) subjects.

This is a fairly recent phenomenon, mind you. In earlier times, obesity was relatively rare in Japan, and the incidence of chronic diseases associated with visceral fatincluding type 2 diabetes, along with other diseases like breast cancer and colon cancerwas correspondingly low. That began to change in the 1960s to 1980s, as the Japanese diet became increasingly westernized, leading to higher fat consumption and lower intake of fiber. And with more people doing deskwork and leading sedentary lifestyles, lack of exercise contributed to the rise of obesity and the accumulation of visceral fat. The result has been a significant increase in disease, raising concerns for the future.

Extensive studies have revealed that a traditional Japanese dietlow in meat and dairy products, high in soybeans and fish, and high in fiber from grains, vegetables, and seaweedis tied to very low accumulation of visceral fat. In other words, washoku is ideally suited to the physiological traits of the Japanese people, protecting them from their innate tendency to accumulate visceral fat. Without knowing the science, our forebears managed to develop, preserve, and pass down a dietary culture perfectly adapted to our own metabolism.

Washoku has other health benefits as well. Soybeans, green and yellow vegetables, and small fish eaten whole all help to build strong bones. Lifelong consumption of soy foods also contributes to the relativelylow incidence in Japan of diabetes, breast cancer, and colon cancer, all ailments linked closely to visceral fat levels, as compared with the West

One notable weakness of the Japanese diet as it has developed in the past two or three centuries is the overwhelming preference for polished rice. For the health-conscious, I would recommend brown rice, which has seven times the dietary fiber of white rice and contains substances that help the body burn visceral fat.

In recent years, science has made considerable progress in identifying genetic differences among ethnic groups. In 2016, a Japanese team of researchers released the first Japanese reference genome panel (JRG v1), a whole-genome assembly representing the genes of a typical healthy Japanese. Comparison with the human reference genome has revealed millions of single-nucleotide differences, many of which doubtless reflect significant differences in nutrition physiology. We need to abandon the one-size-fits-all approach to nutrition and consider what diet works best for each ethnic group.

Nowadays, the Japanese people are able to enjoy delicious cooking from every part of the world. That is a splendid thing, as long as we keep in mind that washoku is the bedrock of our much-admired health and longevity.

(Originally written in Japanese. Banner photo: Dairy and meat products figure heavily in the Western diet, while the traditional Japanese diet has much to offer in the area of human health. Pixta.)

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A Russian-born startup based in Singapore uses AI to penetrate the mysteries of human longevity – bne IntelliNews

Can artificial intelligence and machine learning help mankind address diseases related to ageing, and delay mortality? Gero, a Singaporean company with Russian roots, believes so. To address this biological and technological challenge, Gero has teamed up with the National University of Singapore, conducting experiments involving aged animals, reports East-West Digital News (EWDN).

These works demonstrated mortality delay (life-extension) and functional improvements after a single experimental treatment, says Gero.

Gero believes this new drug could enable patients to recover after a stroke and help cancer patients in their fight against accelerated ageing resulting from chemotherapy. Geros platform is also used to develop drugs in other areas including potential therapies for Covid-19.

Commenting on Gero, Dr. Nir Barzilai said that their research provides answers to the most important practical questions and translates the received knowledge into medical technologies to combat ageing. A professor of medicine and genetics, Dr. Nir Barzilai is director and leading aging researcher at the Einstein-Institute for Aging Research in New York City.

The company has just secured $2.2mn from an investor pool led by Belarusian fund Bulba Ventures. Gero previously raised more than $5mn, including through an undisclosed seed round in May last year, which also involved Bulba.

8 years of R&D Founded in Russia in 2012, Gero initially pursued a larger goal developing a computational technology to facilitate the discovery of small drug molecules.

We identified a series of drug candidates in-house and via partnerships, company founder Peter Fedichev told East-West Digital News.

For example, Fedichevs team identified a small molecule inhibitor of novel HIV targets as well as inhibitors for proteinprotein interactions TLR4 antagonist.

The company created a spinoff dedicated to metabolic reprogramming of neurons in excitotoxicity conditions. Another project to be announced later this year was developed with a leading US university, said Fedichev.

During these years, Gero also studied ways to use AI/ML approaches to tackle ageing.

This field became the exclusive focus of the startup in 2015. Gero gained access to large biobanks, aiming to develop next-gen modeling platforms for anti-aging targets and aging biomarkers identification.

We discovered and tested multiple life-extending interventions based on the predictive capacities of our platform, said Fedichev.

While the most promising therapeutic modalities in this field are currently under development, experiments with mice were prerequisites for future clinical trials. Such experiments were first conducted in France, then at the National University of Singapore at a much larger scale.

A single shot provides the systemic rejuvenation and mortality delay (life- extension), which is a definitive milestone for drug discovery AI, Fedichev told EWDN.

In 2019, the team published a research paper in Nature Research Journal about the application of machine learning techniques to big omics data as a means to discover anti-aging drugs. This became one of the most popular papers in the field of cell and molecular biology, notes Fedichev.

Asias anti-ageing appeal Why didnt Gero pursue its development from Russia? Fedichev points several reasons for moving to Singapore three years ago: First, this is a great place for doing business, and some of our investors were familiar with the jurisdiction. Second, we started a critically-important collaboration with the National University of Singapore. Finally, says Fedichev, it appears that the Singaporean government is ahead of the curve when it comes to ageing. It is very aggressive in tackling the related [health and wellness] challenges. The Singaporean authorities fund cutting-edge projects in this field, and contemplate innovative clinical trial strategies. Thus, Singapore is asserting itself at the forefront of ageing science and biotech developments, believes Fedichev. Asia is going to be hit hard by a silver tsunami, he notes, with 250mn senior citizens by 2025 in China only.

In 2016, researchers from Oxford Economics and AARP estimated the volume of the annual US longevity market alone at $7.1 trillion. They forecast that by 2032 this figure will almost double to $13.5 trillion.

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