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Category : Human Longevity

Purdue taking part in life-long study of dogs health and aging – WTHR

WEST LAFAYETTE, Ind. (WTHR) Researchers are looking for America's oldest dog.

They don't want to teach him new tricks, but they are hoping he could teach them a few things.

And your dog could be part of their life-long scientific study that's looking to learn from pets nationwide.

More than 40 scientists and researchers from across the United States including one from Purdue University are looking for dogs to participate the national study of the general health and wellness of dogs.

The Dog Aging Project will be looking at dogs of all breeds and mixes from across the nation. This is the first major longitudinal study involving dogs, and it's scheduled to last at least 10 years.

We are going to look at a lot of different aspects of dogs lives that affect their health and longevity, says Audrey Ruple, a veterinary epidemiologist at Purdue.

Dogs are good models for humans, she says. They have similar genetics, share our environment, and they also have similar diseases and health issues. We will be asking, How do dogs age healthfully? in order to help better understand how we can age healthfully, too.

Dogs of all age ranges, breeds and sizes are eligible to participate in the study. Owners go online to register their dogs, then create a personal profile to track health, home life, diet, environment and lifestyle.

Dogs will need to make regular veterinarian visits every year. If a dog is assigned to a specific group, the owners may get a kit for their veterinarian to collect blood, urine or other samples during the annual visit.

Participation is voluntary and there is no cost to participate.

Its important to get dogs from all parts of the U.S. because of the different environmental factors present, Ruple said. And were trying to find the oldest dog in America, as well.

All dogs registered will be eligible to participate in various studies. The group conducted a soft launch with 4,500 dogs registered earlier this fall. Recently, the researchers reached 75,000 dogs for the study.

Our study population just keeps growing and growing and growing, Ruple said.

Researchers hope to find out more details on how genetics, demographics and environmental factors such as chemical exposures and noise pollution impact health and longevity.

Ruple says one goal of the study is to not just improve the health and longevity of dogs, but also extend those findings to improve human health. By studying aging in dogs, we hope to learn how to better match human health span to life span so that we can all live longer, healthier lives, Ruple said.

Funding for the Dog Aging Project comes from the National Institute of Aging, a part of the National Institutes of Health, as well as from private donations.

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Purdue taking part in life-long study of dogs health and aging - WTHR

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Cycling Without Age Gives Seniors Access to Biking in Cities Around the Globe – Next City

When Ole Kassow was three, his father was diagnosed with MS. We couldnt do the same things that other fathers and sons, we couldnt fish or play soccer, Kassow recalls. But he was really good at putting a positive spin on many things. We invented imaginary superhero glasses wed just turn our thumbs and fingers into little glasses and wed go around and Id pull him in his wheelchair with my bike. In many ways, thats where the seed for Cycling Without Age, a non-profit that uses tri-shaw bikes to take seniors living in care facilities out for rides in cities across the world, was first planted.

What started with Kassow in Copenhagen in August of 2012 has since blossomed into a global network of more than 1,643 Cycling Without Age chapters in 42 countries, including over 300 chapters and counting in the U.S. With my dad, I saw what it does to a person when you lose mobility, Kassow says, noting that many people lose friends when theyre no longer able to engage in the activities they once loved.

After seeing an elderly man sitting on a bench one August day, Kassow got to thinking how much mobility and access to community he could provide to seniors through something as simple as a bike ride. I was dedicated to seeing this man back on a bike. I hired this old tri-shaw and showed up at a care home and began taking elders out for rides, Kassow says. It wasnt exactly cycling: The seniors dont pedal or steer, as those tasks are left up to a volunteer. But the riders get all of the adventure, freedom, and wind in their hair that a traditional bike ride provides.

Kassow quickly saw a slew of unanticipated benefits as well. Seniors who were described as loners who had all but given up on talking suddenly became chatty with everyone from the staff member accompanying them to their bike driver once again as the world became exciting again from their three-wheeled perch. I think what it does is that it allows people to get access to relationships again, Kassow says, musing on the fact that there isnt anything in the [UNs] human rights charter about relationships, even though I just read a book by Susan Pinker that talked about the important role social relationships play in longevity and happiness.

Kassow has since come to see relationships as something of a human right that his organization works to restore through bike rides, an idea that the city of Copenhagen was eager to support. The city funded Kassows first five bikes, a boon because the tri-shaw bikes essentially pedicabs where the seat is in front of the cyclist, rather than behind the organization relies on can cost $7,000 $10,000. In April of 2013, Kassow hosted a joint ride where everyone, regardless of age or mobility, was invited. Over 100 people showed up. It was a cold, clear, frosty day and it was fantastic, he recalls. A lot of people who came said that they wanted to join as volunteers. From there it was a matter of experimenting to figure out how it was going to work.

Largely through word of mouth, the program spread to different care homes across Copenhagen and eventually to different cities as well. Kassow eventually developed a train the trainers methodology so that each new chapter would be able to support the development of other chapters without requiring Kassows direct involvement.

In late 2014 Kassow was invited to give a TED Talk in Copenhagen. Thats when the Cycling Without Age really began to spread, leading to something like 10 new chapters popping up over the course of just a few months. This was also when Kassow left his consulting business to focus on Cycling Without Age full time.

Chapters, like Kalynn McLains in Meridian, Idaho, are still popping up today.

What started as an adventure in testing out electric bikes with her mother in law in October 2017 ended with the duo stumbling across a chapter kickoff in nearby Eagle, Idaho. The Eagle chapter didnt take off, despite having already acquiring a tri-shaw. The woman eventually donated it to McLain. It kind of fell into my lap. I hadnt intended to start a chapter, but I couldnt say no, she says.

With the hardest part acquiring the tri-shaw behind her, McLain set out to establish her chapter by filing with the state and getting logistics like an insurance policy in order. In April of this year McLain began offering rides in partnership with a local assisted living facility.

Once I started working with them, other facilities started asking about it. What I ended up doing was working through the parks and rec department to be able to ride in parks and on pathways around the city, she says. McLain and her stable of volunteers now meet seniors shuttled from their facilities at parks where the rides take place. They get outdoors and it gets them talking to people of different generations and telling their stories, she says.

Currently its McLains handful of volunteers who give most of the rides while she hangs back.

Across the 109 rides that the Meridian chapter gave this season, McLain is most pleased by the seniors who come back time and time again, especially largely nonverbal residents from memory care facilities who have burst into words on their ride.

I had one ride, McLain says, where the staff was asking the resident if she was enjoying the ride and she suddenly said, Yes! Im loving it! The staff member turned to me and was like, Did you hear that?! It was the first time that resident had spoken in some time, all inspired by the ride Cycling Without Age was able to provide.

Cinnamon Janzer is a freelance journalist based in Minneapolis. Her work has appeared National Geographic, U.S. News & World Report,, and more. She holds an MA in Social Design, with a specialization in intervention design, from the Maryland Institute College of Art and a BA in Cultural Anthropology and Fine Art from the University of Minnesota, Twin Cities.

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Cycling Without Age Gives Seniors Access to Biking in Cities Around the Globe - Next City

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Longevity And Anti-Senescence Therapy Market 2018 Overview, Consumption, Supply, Demand & Insights – Downey Magazine

The global longevity and anti-senescence therapies market should grow from $329.8 million in 2018 to $644.4 million by 2023 with a compound annual growth rate (CAGR) of 14.3% during 2018-2023.

Report Scope:

The scope of this report is broad and covers various therapies currently under trials in the global longevity and anti-senescence therapy market. The market estimation has been performed with consideration for revenue generation in the forecast years 2018-2023 after the expected availability of products in the market by 2023. The global longevity and anti-senescence therapy market has been segmented by the following therapies: Senolytic drug therapy, Gene therapy, Immunotherapy and Other therapies which includes stem cell-based therapies, etc.

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Revenue forecasts from 2028 to 2023 are given for each therapy and application, with estimated values derived from the expected revenue generation in the first year of launch.

The report also includes a discussion of the major players performing research or the potential players across each regional longevity and anti-senescence therapy market. Further, it explains the major drivers and regional dynamics of the global longevity and anti-senescence therapy market and current trends within the industry.

The report concludes with a special focus on the vendor landscape and includes detailed profiles of the major vendors and potential entrants in the global longevity and anti-senescence therapy market.

Report Includes:

71 data tables and 40 additional tables An overview of the global longevity and anti-senescence therapy market Analyses of global market trends, with data from 2017 and 2018, and projections of compound annual growth rates (CAGRs) through 2023 Country specific data and analysis for the United States, Canada, Japan, China, India, U.K., France, Germany, Spain, Australia, Middle East and Africa Detailed description of various anti-senescence therapies, such as senolytic drug therapy, gene therapy, immunotherapy and other stem cell therapies, and their influence in slowing down aging or reverse aging process Coverage of various therapeutic drugs, devices and technologies and information on compounds used for the development of anti-ageing therapeutics A look at the clinical trials and expected launch of anti-senescence products Detailed profiles of the market leading companies and potential entrants in the global longevity and anti-senescence therapy market, including AgeX Therapeutics, CohBar Inc., PowerVision Inc., T.A. Sciences and Unity Biotechnology

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Global longevity and anti-senescence therapy market deals in the adoption of different therapies and treatment options used to extend human longevity and lifespan. Human longevity is typically used to describe the length of an individuals lifetime and is sometimes used as a synonym for life expectancy in the demography. Anti-senescence is the process by which cells stop dividing irreversibly and enter a stage of permanent growth arrest, eliminating cell death. Anti-senescence therapy is used in the treatment of senescence induced through unrepaired DNA damage or other cellular stresses.

Global longevity and anti-senescence market will witness rapid growth over the forecast period (2018-2023) owing to an increasing emphasis on Stem Cell Research and an increasing demand for cell-based assays in research and development.

An increasing geriatric population across the globe and a rising awareness of antiaging products among generation Y and later generations are the major factors expected to promote the growth of global longevity and anti-senescence market. Factors such as a surging level of disposable income and increasing advancements in anti-senescence technologies are also providing traction to the global longevity and anti-senescence market growth over the forecast period (2018-2023).

According to the National Institutes of Health (NIH), the total geriatric population across the globe in 2016 was over REDACTED. By 2022, the global geriatric population (65 years and above) is anticipated to reach over REDACTED. An increasing geriatric population across the globe will generate huge growth prospectus to the market.

Senolytics, placenta stem cells and blood transfusions are some of the hot technologies picking up pace in the longevity and anti-anti-senescence market. Companies and start-ups across the globe such as Unity Biotechnology, Human Longevity Inc., Calico Life Sciences, Acorda Therapeutics, etc. are working extensively in this field for the extension of human longevity by focusing on study of genomics, microbiome, bioinformatics and stem cell therapies, etc. These factors are poised to drive market growth over the forecast period.

Global longevity and anti-senescence market is projected to rise at a CAGR of REDACTED during the forecast period of 2018 through 2023. In 2023, total revenues are expected to reach REDACTED, registering REDACTED in growth from REDACTED in 2018.

The report provides analysis based on each market segment including therapies and application. The therapies segment is further sub-segmented into Senolytic drug therapy, Gene therapy, Immunotherapy and Others. Senolytic drug therapy held the largest market revenue share of REDACTED in 2017. By 2023, total revenue from senolytic drug therapy is expected to reach REDACTED. Gene therapy segment is estimated to rise at the highest CAGR of REDACTED till 2023. The fastest growth of the gene therapy segment is due to the Large investments in genomics. For Instance; The National Human Genome Research Institute (U.S.) had a budget grant of REDACTED for REDACTED research projects in 2015, thus increasing funding to REDACTED for approximately REDACTED projects in 2016.

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Longevity And Anti-Senescence Therapy Market 2018 Overview, Consumption, Supply, Demand & Insights - Downey Magazine

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The L Word: Nobody Rocks a Power Suit and Cufflinks Like Jennifer Beals – IndieWire

Shane may be the resident heartthrob of The L Word, but no character more embodies Showtimes Los Angeles-set lesbian melodrama than Bette Porter. Accomplished, stubborn, magnetic, and self-destructive, Bette instantly became the archetypical 21st century power dyke. She fills out a Jil Sander power suit as confidently as she tops her pregnant wife; casually drops names of the myriad women artists in her private collection; and now added to her resume for the shows next iteration, The L Word: Generation Q runs a savvy mayoral campaign. (She is also, unofficially, the obvious avatar for the shows creator Ilene Chaiken.)

Of course, there would be no Bette Porter without Jennifer Beals. A luminous and deeply intelligent actor, Beals naturalism, humor, and deeply felt performance grounded the original series, spearheading its ascension beyond mere sexy soap opera, and cementing its place as the most influential piece of lesbian culture of the 21st century.

The role has defined the last decade of Beals career much in the way her breakout role in 1983s Flashdance shaped her early work. In between, she had notable roles in independent films such as Alexandre Rockwells In the Soup, Nanni Morettis Caro Diario, Rockwells segment of Four Rooms, Carl Franklins Devil in a Blue Dress, and Whit Stillmans The Last Days of Disco. Like countless actresses before her, she never reached the movie star heights that Flashdance could have incited.

Nevertheless, she stuck it out. Her incredible longevity in Hollywood speaks not just to a deep and abiding love of the craft, but a tenacity and iron will not unlike her character Bettes.

Jennifer Beals


Its kind of crazy, Beals told IndieWire in a recent phone interview. I was thinking about it the other day, and its like I just wouldnt stop. You cant make me stop. Im just going to keep going.

To what does she attribute such longevity?

Persistence. Really persistent. I guess I am blindly stubborn sometimes, she said. Its like a Marine, where you just put one foot in front of the other to get up the mountain. Or a monkand its only recently that Ive started to look up the mountain top and go, Hey, let me maybe predetermine where I would like to go.'

The realization led her to spearhead the return of The L Word, shepherding The L Word: Generation Q to the air. As an executive producer on the new series, (along with fellow returning cast members Leisha Hailey and Katherine Moennig), Beals suggested plot points, brought on new showrunner Marja-Lewis Ryan, reviewed cuts, and advised on casting the new generation. Rounding out the trifecta of the shows most popular characters, Hailey and Moennig also reprise their roles as Alice and Shane, respectively.

Honestly, it was such a surreal moment being back on the set with Kate [Moennig] and Leisha [Hailey], Beals said. We all shared an office and checked in with each other all the time. [It] was so much fun getting to work with them as executive producers. I always knew they were amazing actors, but theyre also brilliant human beings and they have a brilliant sense of story and music. It was very, very exciting to be working with them in that new capacity.

The reunion was just as fun for the actresses as it is sure to be for the viewers.

Jennifer Beals, Leisha Hailey and Katherine Moennig


Whenever we had scenes together, which was every episode, wed go to Kates house and rehearse and then wed all have dinner together. So its like family dinner every Sunday night.

Returning the role she left behind over 10 years ago was also a surreal experience. But there was one thing that helped Beals lock right back into character as Bette. (Its a feeling many fans have probably experienced themselves.)

Re-exploring the character in those early wardrobe fittings, we were trying to think how much does the style change in 10 years? And nothing was working, nothing was working, Beals recalled. And I said Can I just have a power suit and my cufflinks? I just really need to go back to that. And as soon as I literally put the cufflink in the hole, I just went Ah, yes, yes. Okay. I completely remember this. This is waking up my DNA and this makes sense now.'

Ten years may have passed, but the real question is has Bette, who nearly torpedoed her marriage with an affair with a carpenter, learned from her past mistakes?

Oh, no, apparently not, Beals laughed. I just thought to myself Okay, here we go again.'

The first episode of The L Word: Generation Q premieres on Showtime on Sunday, December 8.

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The L Word: Nobody Rocks a Power Suit and Cufflinks Like Jennifer Beals - IndieWire

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Gail Fisher’s ‘Dog Tracks’: Spoiling you dog with extra food could cut short its life – The Union Leader

HERE IT IS just a few days after Thanksgiving, and Im probably not alone in thinking about the poundage I usually put on (then struggle to lose) in just one extremely treat-filled month. There is no doubt from the many studies on this topic about the relationship between weight and longevity in humans. While there are no studies of longevity in dogs that Im aware of, its likely the same relationship exists.

Longevity in dogs is a problem or rather lack of longevity. The American Veterinary Medical Association claims dogs are living longer. Longer than what? A hundred years ago, sanitation and medical improvements saved infants and the young from early death, greatly affecting human longevity. The claim that dogs are living longer might be related to the reduction and elimination of diseases that kill puppies. At the other end of the spectrum, the sad fact is that dogs do not live as long as they used to.

When I was a child, dogs often lived well into their teens. My next-door-neighbors dog, an Irish setter, was the same age as I. She died when I was a freshman in college. We were both 17. They also had a cocker spaniel that lived to be 20!

Nearly 50 years ago, I interviewed for a job at a Newfoundland kennel with more than 40 dogs, many that were 18 to 20 years old. They fully expected their dogs to live well into their mid-to late teens. Now, a mere 45 years later, a Newfie that lives to be 10 is old hardly an increase in longevity.

While genetics plays a role in longevity, there is a profound message for dog owners in this simple statement: Thin creatures live longer than fat ones.

Could it be that our pets reduced longevity is in part because we feed them too much? There is a lot we dont know about why so few dogs live into their late teens, but certainly one factor could well be excess weight even just a few too many pounds. A 50-pound dog that is just 10 pounds overweight is carrying 20% more weight than its frame and organs are designed for. This is considered to be obesity in humans, but in dogs its considered show weight or proof that we love and spoil our dogs usually said with an apologetic shrug.

If by spoiling our dogs were shortening their lives, wouldnt it be better to be tough (read kind) and cut out fattening snacks? Consider the greyhound, a large, sleek hound with a life expectancy many years beyond large, heavier hounds. Bloodhounds, a similar size, but much heavier dog, live to 10 or 11, while a greyhound often lives to 14 or 15. Greyhounds are one of the only show dogs for whom show weight is not overweight. You can see the ribs of a healthy greyhound, while it is often hard to even feel the ribs on many pet dogs.

I firmly believe that one of the reasons my English mastiffs lived to 13 or 14 (years beyond the life expectancy of the breed) was in part because I keep my dogs thin anathema for many mastiff people. For many giant breed owners, bigger is better. Theyll proudly exclaim, My Mastiff weighed 250 pounds! He might have died at the age of 6 and could barely walk because he was grossly overweight, but, by golly, he was huge!

Veterinarians we talk to almost universally agree that most pet dogs are too fat. In many cases, they have given up fighting that battle. Despite recommendations that the dog needs to lose weight, many owners seem to have a hard time cutting back on their dogs food and seem to believe theyre punishing their dog if they provide low-fat snacks. Youre not! Youre being kinder to your dog.

So in this holiday season, consider not sharing your turkey skin and leftover gravy with your dog. Or if you do, cut back on your dogs food that day. Your dog wont hate you for it, and you might well have him around a few extra months or years.

Gail Fisher, author of The Thinking Dog and a dog behavior consultant, runs All Dogs Gym & Inn in Manchester. To suggest a topic for this column, which appears every other Sunday, email or write c/o All Dogs Gym, 505 Sheffield Road, Manchester, NH 03103. Past columns are on her website.

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Gail Fisher's 'Dog Tracks': Spoiling you dog with extra food could cut short its life - The Union Leader

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Three reasons women live longer than men – Firstpost

Worldwide, there are now 31 people over the age of 110. Of these, 30 are women.

Sounds odd?

According to the Morbidity-Mortality Paradox or Health Paradox, despite higher rates of disability and poorer health than men, women experience greater longevity in modern human societies.

Representational image. Image source: Getty Images.

What is the reason behind this? Is it a woman's immune system, luck or magical powers?

None of the above. Here are three science-backed reasons why women outlive men:

One of the factors that affect longevity in men is that they are more likely to be seen with a cigarette hanging out of their mouths - according to the World Health Organization (WHO), 40% of men are smokers compared to 9% of women. Also, fewer women tend to abuse alcohol compared to men.

Scientists confirm that these habits make men more prone to chronic obstructive pulmonary disease (COPD), lung cancer, coronary heart disease, digestive problems, and liver disease.

Studies have also shown that compared to women, men are at a higher risk of developing diabetes and its complications like diabetic nephropathy and diabetic foot.

Also read:World COPD Day 2019: Why this lung disease is still under-diagnosed in India

Scientists have shown that testosterone may stimulate the prostate gland and increase the risk of prostate cancer. Also, studies have shown that testosterone improves reproductive function earlier in life but shortens the lifespan in the long run (antagonistic pleiotropy effect).

Other than maintaining female sexual organs, estrogen helps in blood clotting, increases the level of good cholesterol and maintains gastrointestinal tract.

Estrogen also has antioxidant properties and helps delay the decrease of skin collagen in women as they grow older.

Scientists believe that because of estrogens protective effect, premenopausal women are less likely to have coronary heart disease than men and women who have hit menopause.

Some scientists believe that girls are more robust, stronger and healthier, than boys from birth itself.

Joy Lawn, director of the Centre for Maternal, Reproductive, and Child Health at the London School of Hygiene and Tropical Medicine, has said that whenever a newborn boy comes into the neonatal unit, statistically, he is more likely to die compared to a girl.

The extra X chromosome in the female DNA is somehow said to be responsible for this.

Human DNA is made up of at least two sex chromosomes that decide the gender. Females have XX, whereas males have XY.

Recently, research was done on two sets of mice: one with natural male-female mouse biology (XX and XY) and the other set with XX chromosomes paired with testes and XY chromosomes paired with ovaries. A senior author of the study and neurologist, Dena Dubal, found that mice with two X-chromosomes outlived all the mice but the ones with testes and XX chromosome also turned out to live longer. This longevity effect was observed after 21 months, as it is considered to be the end of a normal mouse's lifespan.

The researchers concluded that the second X and its genetic expression has a protective effect that increases survival.

Health articles in Firstpost are written by, Indias first and biggest resource for verified medical information. At myUpchar, researchers and journalists work with doctors to bring you information on all things health. For more information, please read our article onEstrogen.

Updated Date: Dec 02, 2019 15:39:41 IST

Tags : Live Longer, Longer Life, Longer Lifespan, Longevity, Men Age, NewsTracker, Why Women Live Longer, Women Live Longer

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Three reasons women live longer than men - Firstpost

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Increasing Longevity by Decreasing Oxidization – Nanalyze

Somewhere in a coffee shop in America, some green-haired millennial is typing away feverishly on their brand new Macbook Air, broadcasting to their Twitter followers about how evil capitalism is. As they pour a dab of pasture-grazed New Zealand cows milk into their freshly roasted cup of Guatemalan organic free-trade coffee, they lament their woes to the world. Whycant society give me more? Why cant I enjoy success without hard work? On the other side of the globe, some hard workers in New Zealand are pulling off some prettymajor feats to put that delicious milk on the table.

It all starts at LIC, a New Zealand cooperative whose core business is dairy genetics. (Theyre responsible for inseminating 80% of New Zealands national dairy herd.) Next to LICs headquarters in Hamilton sit the prized bulls whove sired tens of thousands of calves. When the time comes, the bull is loaded into a custom tractor-trailer and taken to a building thats been there for decades. (The bull is transported this way so it doesnt stub its toe while walking over and consequently produce less sperm.) The bull is led up to an attractive cow who stands waiting while a human handler watches and waits. Once the bull convinces the cow that hes not just another player interested in a one-night stand, he mountsher, and this is where all the fun begins.

Collecting a jump Source: Livestock Improvement Corporation (LIC)

The human handler then needs to manipulate the bull with a device that collects the prized semen or a jump as its called in dairy lexicon. Once collected, some of the semen is frozen and shipped to various parts of the world. Its where life starts, and its a fitting place for a longevity company to start as well.

Founded in 2015, Hamilton, New Zealand startup Synthase Biotech has taken in$3.36 millionin funding and contributions to develop a platform technology that seems to have limitless promise. The technology behind the company came about as somewhat of an accident while researchers were looking for an alternative to latex when the Japanese were constraining supply. In an Arizona desert exists a shrub that contains latex that also contains an enzyme that prevents the latex from oxidizing. (Oxidization ishow a substance reacts to oxygen, and in some instances its not good like rust.) Its this plant enzyme that may, eventually, be used to increase longevity in humans.

Turns out that humans dont react well to prolonged exposure to oxygen over time. While oxygen is what you need to live, its also what can ultimately take you out in the end.Youve probably all heard of antioxidants which can prevent oxidative damage to cells and tissues by scavenging unconstrained radicals. Its damage that arises from unconstrained free radicals that can eventually be fatal. Synthase Biotech hasan enzyme that it calls Aloxsyn which has extraordinary specificity and rates of reaction against toxic lipid peroxides. In other words, this enzyme can be used to halt and even repair much of the damage that aspects of oxidization can do to mammalian cells, andthe company has developed a way to produce the enzymeusinga fermentation process.

We sat down to talk with Dr. Andrew West of Synthase Biotech, which has IP protection around the use of this enzyme, Aloxsyn, in their first product applications for frozen bull semen and cattle embryos.

Given how much work happens in Hamilton around frozen bull semen, it was a likely place to start. If a cow isnt fertile, its not producing milk. Consequently, you want to maximize cow fertility in order to maximize milk production. Keeping a cow that doesnt produce milk is uneconomic and produces unnecessary greenhouse emissions from its belching, or whatever it is theyre supposed to be doing thats wrecking the planet.

Ideally, fresh semen works best for artificial insemination, but there are many use cases where frozen semen is needed.You may need to transport the semen long distances, or you may want to preserve some semen from a prized bull to be used next year. When using frozen semen instead of fresh semen, fertility rates can drop as you might expect. However, when adding some Aloxsyn to the mix, you can get a better outcome. Thats based on a major trial that Synthase Biotech recently conducted.

If youre talking cattle, the final customer is always the farmer. Thats who Aloxsyn is helping. But its just one of many potential applications for this technology.

Synthases proprietary bioactive, Aloxsyn, may have a positive impact anywhere inflammationcan be found. Dr. West believes that the number of potential applications for the companys enzyme are very large. One application Synthase is looking at is storage of blood platelets, which will require some trial testing, but which represents a huge potential market. Then, there are more sperm applications.

Once a bull has a jump, that sperm dies almost immediately if it doesnt end up inside the cow where it belongs. Whilst working on frozen sperm, it looks like Aloxsyn also extendsthelife of fresh cattle sperm by five days. (LIC scientistsshowed us a proprietary solution theyre using that increases the life of cattle sperm by three days.) Why stop at cattle sperm? Fertility of pigs and horses could also be of interest as well, not to mention human fertility.

Source: Synthase Biotech

All of these fertility applications are higher margin, but there are also lower margin applications that can be considered such as increasing the shelf life of food. With around 30% of food waste in developed markets attributed to food spoilage, its another way that we may be able to help feed all the billions of mouths coming online. (Seems like a fitting application considering that theyre about increasing human fertility.) In order to address high-volume applications like this, production would need to be scaled and costs would need to be driven down. It all requires investment and partnerships with interested parties who want to collaborate.

No longevity companyis without some grand visions of what the future might hold. In some preliminary experiments, a rats heart was stopped from beating for 30 minutes and then blood applied with the enzyme. The rat heart recovered 100% of its function. A rat with a severe stroke could fully recover if Aloxsyn was applied within 45 minutes of that stroke. The implication here is an interesting one. Perhaps lipid peroxides in all thatbacked up blood behind the clot serve to damage the brain when the clot is overcome, and Aloxsyn cleans up those toxins? Its a promising example of what the future might hold, and if you have about $100,000 to pony up, Dr. West says Synthase Biotech will work to create a mouse that produces its own Aloxsyn, a mouse that just might live longer. Its a drop in the bucket forthe many billionairesout thereseeking the fountain of youth. For New Zealand investors, however, that sort of work is pretty risky.

The New Zealand Herald published a pretty comprehensive articleon Synthase Biotech last year which contains some relevant information about the state of biotech in New Zealand. Its dismal. Investorsdont look favorably on life sciences companies and that could be because the New Zealand stock exchange isnt of a size that would support them. (The entire New Zealand stock exchange has a market cap of just $142 billion. To put that number in perspective, Johnson & Johnson is over twice that size with a market cap of $363 billion.)

On the other hand, Australia is much more accepting towards biotechs with about 200 listings on the ASX. Synthase is not pursuing an ASX listing, but if the company moves into development of a human drug based on Aloxsyn, it will need millions of dollars for clinical trials. Significant investments over time will allow Synthase to add a range of human applications to complement its livestock ones. After a few years of selling animal products, their manufacturing operation will have all the kinks sorted out, andthats half the battle before embarking on some human trials.

The more we know about the world, the more we realize how little we know. Thats obvious when you consider how some of the worlds greatest inventions penicillin, X-rays, the microwave, LSD were all discovered by accident. The Peter Thiel types out there who are willing to sink large sums into theburgeoning longevity industrymight find the capital requirements for companies like Synthase Biotech to be more economical. According to a talk by Finistere Ventures a few years back, agtech valuations in the United Statesare half of fintech valuations, while New Zealand agtech valuations are half of that. If the fountain of youth exists inThe Land of the Long White Cloud, its likely to be selling at bargain-basement prices.

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How Bitcoin points to the future of decentralized protest – Decrypt

Protests throughout the world, in Hong Kong, Chile, France, the Middle East and elsewhere, are embracing the principles and products of cryptocurrencyin many cases without even knowing it.

Todays movements are made up of hundreds and thousands of protestors, groups of disparate individuals aligned around values and causes. The decentralized networks theyve adoptedreliant on technology rather than leaderscould ensure their longevity. It could also permanently alter the geopolitical landscape.

In the same way, blockchain, the technology that underpins Bitcoin and other cryptocurrencies, is reliant on decentralized networks.

But just how closely aligned are these leaderless movements with the similarly decentralized blockchain and cryptocurrencies? And what impact are they having on the adoption of decentralized principlesand, ultimately, on the price and perception of crypto?

The Internet provides a backbone for 21st century rebellion, but is also its weakest link.

The Swiss Army Knife for modern day protesters is the smartphone; a communications tool thats also a camera, GPS and more besides. The killer app is private, encrypted social media and messaging apps such as Telegram, with its secret chat function.

These tools enable protestors to evade surveillance; form anonymous groups; post video footage; agree how and where to rally, and request additional supplies.

But, earlier this month, Iranian authorities showed how they can be defused.

Mass demonstrations against petrol rises, the result of US sanctions, turned violent but were quickly diffused when Iran pulled the plug on Internet connectivity for over 90% of the country.

Its not an easy thing to do. But regimes around the world, including those in Russia, have been busy retrofitting traditional private and decentralized networks with cooperation agreements, technical implants, or a combination of both, to give themselves more power over Internet access.

In both Russia and Iran, Telegram has been banned by authorities since last year. But Russian dissidents have managed to find ways around the ban, often using VPNsVirtual Private Networkswhich route an Internet connection through a different country. Telegram founder Pavel Durov has also proved adept at moving the companys servers to stay one step ahead of authorities.

Decentralized applications, dapps, are also becoming increasingly popular. Messaging apps Bridgefy and FireChat both work by creating a mesh network of users mobile phones offline, via Bluetooth. Messages are relayed from phone to phone until they reach their destination.

But the technology is still nascent and not practical in confrontational situations, say protestors. And its especially difficult for Iranians to access foreign servers and infrastructure because many companies ban them for fear of US sanctions.

One of the main attractions (and criticisms) of Bitcoin is that it can be used indiscriminately by anyone from protestors to terrorists to sanctioned regimes. Everyone from the Iranian regime, which has mined bitcoin to dodge sanctions, to Ukrainian protestors, who held up signs with QR codes during 2014s Maidan Square uprising in a bid to raise funds, has taken advantage of its censorship resistance.

Fundraising techniques are becoming increasingly sophisticated to evade detection; the armed wing of Palestinian group Hamas reportedly uses a fresh digital wallet for each transaction. But for donations, even cryptocurrency is fallible. Payment processor BitPay was accused of blocking crypto donations to the Hong Kong Free Press for several weeks last October.

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Of course, being associated with funding for terrorist groups, and other violent organisations, doesnt do the image of cryptocurrencies any favours.

Nevertheless, Bitcoin proponents such as Morgan Creek Digital co-founder Anthony Pompliano, believe that the non-seizability of Bitcoin becomes ever more attractive in moments of geopolitical crisis.

Data for OTC (Over-the-counter) crypto trades from LocalBitcoins suggests that, during the early months of the Hong Kong protests, peer-to-peer trading increased. A further spike appears to coincide with the protests escalation, at the end of last month.

Libertarians point to events in troubled countries such as Chile, which is seeing widespread protests over long-standing economic injustice. ATMs reportedly ran out of cash there earlier this month. They argue that when people experience such measures, theyre more likely to sell local currency for bitcoin to escape the uncertainty surrounding the legacy markets. Essentially, it's a tool of freedom for people under tyranny and that's significant, Bitcoin advocate Jimmy Song told Decrypt back in September.

Song has been working with the non-profit Human Rights Foundation to teach activists how Bitcoin might be useful to them. Its a significant part of what Bitcoin is supposed to be. Its becoming a much bigger part of the human rights movement all around the world, he said.

But while enthusiasts might be quick to suggest that Bitcoin is acting as a safe haven for funds, or a protest tool in Hong Kong, analysts warn that reliance on a single source is unwise.

Hong Kong's 2014 Umbrella Movement shaped the form of today's protest. IMAGE: Flickr

LocalBitcoins volumes are one indicator but they're hardly reflective of the full BTC market in any given region, Mati Greenspan, founder of the Quantum Economics newsletter, told Decrypt.

He said that investment funds and analysts are tracking protest movements and political instability as bellwethers of crypto price, but emphasized that economic stability remains the most important factor.

In countries where the local currency sees massive devaluation the propensity to hold bitcoin is much higher, he said. Correlations between buying activity and inflation in Venezuela, or political events in Argentina are more likely, he believes.

But thats assuming funds are accessible. In Lebanon, five weeks of anti-government protests were fuelled by anger at corruption, and bank accounts were frozen. Protestors there reported that digital assets are rarely useful as currency, since citizens were cut off from global exchange platforms.

Leaderless rebellion is not new, despite recent headlines. In the 1980s, during the last phase of the anti-apartheid struggle, black Africans evaded martial law by organizing in a cell-like structure. A major factor in the movements eventual success was the effective coordination of economic boycotts against white businesses by these so-called cells.

Similarly, in the ongoing Hong Kong protests, members of the protest movement made an early decision to eschew centralized leadership. The fact that all the leaders of the unsuccessful 2014 Umbrella movement protest were convictedand received sentences ranging from two to 16 monthsis still fresh in citizens minds.

But decentralized protest is mushrooming even in areas of the world where penalties for rebellion are far less severe. The Occupy movement over wealth inequality, which started with Occupy Wall Street, went viral in 2011, after thousands of protestors pitched tents in the heart of New York City.

Most recently, Extinction Rebellion (XR), a global, non-violent protest movement sparked by the lack of government action over climate change, mobilized hundreds of thousands to take part in civil disobedience.

Decentralized organization gives you a great deal of autonomy, which I think appeals to people who become involved in protests and activism because they tend to be protesting against authority figures and rigid hierarchical structures anyway, Steve Tooze, a local organizer for XR, told Decrypt.

He believes that, like himself, many of those joining the movement have a minimal history of activism. I think people are desperatein our current climate of growing authoritarianismto feel empowered, and able to have agency of their own, and I think XR gives that to them, he said.

Tooze praised the fluid and transparent nature of the movement, which seeks to adhere to a detailed constitution, empowering anybody to act so long as they agree to its core principles, But he admitted that the process of reaching consensus on which actions to pursue could be time consuming and frustrating.

But the biggest challenge facing XR, he contends, is the authorities determined persecution of figures perceived to be XR leaders. Roger Hallam, one of the movements founders, is seen as something of a driving force behind it. Last week, he was accused of anti-Semitism for comments he made about the Holocaust, and disowned by the German faction of the group.

Earlier this year, XR members also disowned a controversial plan he was involved in, to fly drones and disrupt holiday flights at Heathrow, the UKs busiest airport. The consensus was that it crossed the line of non-violent protest.

But other controversial actions have gone ahead. During one rush-hour protest at Londons Canning Town, protestors attempting to stop trains were dragged down from their roofs by angry commuters.

Tooze said that the Canning Town action was massively controversial, but that, like other major actions, it was subject to extensive debate beforehand. He emphasized that, in 99.9% of cases, there were no problems, but explained that if a group of people decide theyre going to carry out an action, if there are three of you, and you adhere to the principles, you can act in the name of XR.

XRs decision-making structures, the connection between loose groups of rebels, and ways to make communications more effective, are all under review, said Tooze. The movement is currently processing an extensive survey among its membership, which will inform the future choices it makes.

Its very difficult for mass movements to prevent unwelcome or unhelpful actions or words by minorities among the memberswords or actions which can then be used by enemies to judge or condemn the whole movement, Carne Ross, author of The Leaderless Revolution: How Ordinary People Will Take Power and Change Politics in the 21st Century, told Decrypt.

The only recourse is to emphasize, to the press, that the minority do not represent the majority, even if its inevitable that those who use violence or provocative words will get more attention, he said.

He added that it was legitimate, in his opinion, to exclude and publicly condemn those who endanger the movement by negative actions or words. A former British diplomat turned anarchist, Ross contends that successful and long-standing examples of leaderless rebellion do exist, and can provide a template for the future.

As an example, he points to the forums that take the place of leadership in Rojava, a region in Northern Syria which revolted against the regime in 2012 and achieved de-facto autonomy as a result. He contends that, thanks to modern communications and social media, such movements can scale with unprecedented speed and range to a massive extentthats what is so exciting about them.

Technology, he said, means you dont need a leader to disseminate strategy, which can spread horizontally. And, while authorities can turn off the Internet, its not a viable long-term strategy.

By their nature, communication systems like WhatsApp are decentralized, said Ross. That characteristic of decentralization gives the network its powerboth as a tool to disseminate information and tactics widely, but also to protect users against the targeting of leaders.

He also believes that, should a revolution develop into a new and more democratic way of doing things, a new way of government, then a role for cryptocurrencies should be anticipated.

But not everyone agrees. In his book The Square and the Tower: Networks and Power, from the Freemasons to Facebook, historian Niall Ferguson, warns that a Libertarian utopiaof free, equal and interconnected netizensis a romantic ideal, not borne out by the past experience of history.

Vast, new networks have been made possible but, like the networks of the past, they are hierarchical in structure, with small numbers of super-connected hubs towering over the mass of sparsely connected nodes, writes Ferguson.

The powers that lend leaderless protest its force (such as decentralized networks on the Internet) can just as easily be co-opted by the less benign forces they seek to overthrow, he suggests.

So advocates of decentralization through blockchain should keep an eye on how decentralized protestand the authorities' response to itis evolving.

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How Bitcoin points to the future of decentralized protest - Decrypt

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Pollution woes add to our ongoing survival struggle – Tehelka

Smog enveloping the capital city. New Delhi caught in that smog, human beings affected, breathless and restless. Choking and crying out, as smog tightens its hold on our throats and chestskilling us in that slow steady way.

Inhalers and masks the urgent need of the day, as citizens go coughing amidst cries trying to survive in this faade-ridden scenario where even encounters are turning out to be fake. Harnessing of that tiny little mosquito or any of the strays loitering around seemingly impossible by all possible might under the state machinery, so in utter frustration they hound and pound the two-legged human being ,who is anyway dying a painfully slow death in these developed times!

And as I walked around, gasping in the midst of this haze, I came across several freshly opened medical outlets equipped with surgical dens. Nah, not to be confused with surgical strikes, though not too certain of the near killing sessions well-inside in the operation theatres. Outside the hospital wards and operation theatres, the dying and even the undying discussing death and the human destruction in these developed times.

Though this smouldering smog can be called as one of those levellers but even here money coming to the rescue of those well-equipped with sagging-pockets. For them holds out an array of air purifiers and conditioners and all those get- away destinations How many amongst us can actually flee?

Wrapped in nostalgia, wondering rather aloud: werent we better off in those good old days when developing or under-developed we were with fewer wants.Just two square meals and that once in a while dining out sessions seemed to take care of everyday wants.

The skies up there looked blue .The flowers bloomed. The human face looked carefree and hassle freethe human form was still intact and those cravings for emotional anchorages were not to be confused with surcharged sexual releases. Those were the good old days when we actually lived and lived quite happily! Not like today where even the basic traces of survival are turning out to be an ongoing struggle for survival.

I am more than shocked when rulers of the day continue to talk of growth, development, longevity, and whatever else they can package in their package of lies. In fact, contrary to their claims, today, in these so called developed times we are more prone to deaths and decay.

The environmental pollution is killing our very organs. Not to overlook the noise pollution hitting the very heart. And the limbs cannot be left spared with strays around. In fact, in these recent months wherever I have travelled local residents have cried out, detailing the havoc caused by monkeys and dogs on the prowl. Blatantly attacking pedestrians and intruding into homes and fields yet there is nobody out there to harness their moves. Shouldnt the municipal authorities step in? Shield the human being from these deadly attacks. In fact, though we talk of dengue and viral fevers but little focus on rabies. Why? Whats become of us to be overlooking these deadly animal bites and attacks.Today who cares whether our flesh is ripped through and we die a painful death!


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Pollution woes add to our ongoing survival struggle - Tehelka

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Turkey is a leading NATO member. Its time this commitment was recognised, not criticised View – Euronews

This week is the 70th anniversary of NATO, and it will be marked by a gathering of the Alliances leaders in London. The anniversary follows both President Emmanuel Macrons recent comments about the Alliance suffering from a brain death and the legacy of last years summit, during which tensions were high and questions swirled about NATOs longevity and utility.

This time around, Turkey is a topic of discussion in the lead-up, with some pointing to actions weve taken to protect our national security like our recent operation in northern Syria as evidence of our rejection of the Alliance. This analysis, however, is wrong-headed and a misinterpretation of the facts of our situation.

Turkey continues to exhibit its commitment to NATO in the most meaningful ways a country can. As one of its earliest members, we have the second largest armed forces in the Alliance, and with roughly 1.9% of our GDP going to NATO, we are one of its top contributors and have committed to raising this to the target 2% by 2024. Our troops have participated in NATO missions, operations and exercises around the world from the Korean War to the Balkans to Afghanistan - and play pivotal roles in humanitarian missions.

We observe a world around us with new challenges and shared security threats, and in that world, Turkey firmly believes that NATO is tremendously relevant and should be bolstered, ensuring it can function effectively and in a spirit of genuine alliance.

Our particular geography surrounded by Syria, Iraq, Iran, and Russia has for decades placed us at the forefront of the Alliance, first during the Cold War and now as the only wall stopping terror groups along our borders from traveling to Europe. This geography and all the realities it portends has made us acutely aware of the risks that exist in our world. There always will be threats state and non-state and while the form and tactics will change over years and decades, we will never be done with the job of securing ourselves. We can choose to be vulnerable, or we can choose to be well-protected. The fact is that we have been and will be safer when like-minded nations are allied, that NATO has made us all safer.

Crucially, we believe NATO will be decisive in the worlds ability to destroy terrorism in all its manifestations; united militaries and security apparatuses with a collective commitment to its defeat. This commitment, however, must be thorough or risks the entire project being thrown into question. And while our NATO allies have fought terrorists with determination in many parts of the globe, in one case, they have shirked their duty.

For years, Turkey called on its allies to help clear a corridor run by a terrorist group along our border that posed a serious threat to our national security and regional stability. The activities of this group, the YPG - the Syrian wing of the PKK, an internationally-designated terror group that has killed 40,000 of our citizens - included ushering ISIS prisoners toward Turkey and digging tunnels into Turkish soil to smuggle explosives to commit their heinous acts of terror. We repeatedly proposed establishing a safe zone with our NATO partners and we agreed on plans together with the US that werent followed through on. Action was needed and although we sought a collective approach, ultimately, we were left going it alone.

Most of our allies refused to help us identify and pursue a solution to the very real security crisis we faced with the YPG, leaving us on our own to put up a defense and then condemned us for doing just that.

This reaction is all the more galling because it follows Turkeys track record of approaching security and counter terrorism with the utmost seriousness and professionalism and a high level of coordination with our NATO allies. For years now in Syria, Turkey has led the Coalition military effort against ISIS by air and ground, with our army as the only NATO military to have fought hand-to-hand combat with ISIS in northern Syria.

We also provide resources, including Incirlik Air Base, a critical staging ground for Coalition counter terrorism operations in the region. Our NATO community knows us; theyve planned with us, been on-the-ground with us on combat missions the world over, and we share intelligence and coordinate counter terrorism efforts every day. This alliance, in its best form, would be working with us, finding ways to solve Turkeys serious security concerns together, and standing with us.

On our own, Turkey has taken every precaution to prevent civilian casualties and damage to infrastructure, including historic and cultural sites. We are avoiding impacting on the fragile humanitarian situation in Syria. Turkey, after all, has shouldered more burden than any other outside nation for the ongoing war and human suffering in Syria. We have hosted 4 million Syrian refugees equal to the population of Los Angeles hundreds of thousands of whom, incidentally, are Kurds who fled the tyranny of YGP terror group. Turkey has spent $40 billion (36 billion) on refugees education, healthcare and housing. We more than most understand the consequences of more destruction and have cause to pursue a peaceful, stable future for our neighbour.

Since launching the operation, we have twice reached agreements to pause hostilities, only to see them quickly violated by YPG terrorists. Meanwhile, we are working in northern Syria to restore basic services for the local population; repairing and equipping hospitals, water networks and the power grid. Turkeys fight is not against the Kurds, our previous actions have exhibited this without equivocation.

Anyone paying attention knows that our fight is against terrorists on our borders and in our region, and that we seek a secure, democratic Syria on our doorstep. This is well in line with NATOs priorities and international law.

Alas, Turkey will not throw the baby out with bathwater, so to speak. So, we continue our full-throated commitment to NATO, and we continue to back up that commitment financially and with the efforts of our brave troops. We also expect in the years ahead that the Alliance will adapt into an even stronger, healthier union one that serves true to its mission and principles, ensuring the safety and security of each ally.

NATO is a resilient and agile organisation that has shown it can evolve to changing times and the demands they bring. In the meantime, we are here, we are allied.


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Turkey is a leading NATO member. Its time this commitment was recognised, not criticised View - Euronews

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