Page 11234..1020..»

Category : Nanomedicine

Nanomedicine Market 2019 Industry Outlook, Comprehensive Insights, Growth and Forecast 2025 – Med News Ledger

The Nanomedicine research report is a valuable source of data for business strategists. It provides the Nanomedicine overview with growth analysis and historical and futuristic cost revenue demand and supply data. The research analysis provides an elaborative description of the value chain and distributor analysis.

Request Sample Copy of This Report: @https://99marketresearch.com/global-nanomedicine-market-size-status-and-forecast-2019-2025/102924/#Free-Sample-Report

The Nanomedicine market study provides comprehensive data that enhance the understanding, scope and application of this report.

The report provides a basic overview of the industry including definitions and classifications. The Nanomedicine analysis is provided for the international markets including development trends, competitive landscape analysis, and key regions development status.

Prominent players of Nanomedicine market:

Product Type Coverage (Market Size & Forecast, Major Company of Product Type etc):

Application Coverage (Market Size & Forecast, Different Demand Market by Region, Main Consumer Profile etc.):

Development policies and plans are discussed as well as manufacturing processes and cost structures are also analyzed. This report also states import/export consumption, supply and demand Figures, cost, price, revenue and gross margins.

This report studies the Nanomedicine status and outlook of Global and major regions, from angles of players, countries, product types and end industries; this report analyses the top players in global market, and splits the Nanomedicine By product type and applications/end industries.

Read Detailed Index of full Research Study at @ https://99marketresearch.com/global-nanomedicine-market-size-status-and-forecast-2019-2025/102924/

To comprehend 2018-2026 Nanomedicine dynamics in the world mainly, the worldwide 2018-2026 Nanomedicine is analyzed across major global regions. Nanomedicine Also provides customized specific regional and country-level reports for the following areas.

North America: United States, Canada, and Mexico.

South & Central America: Argentina, Chile, and Brazil.

Middle East & Africa: Saudi Arabia, UAE, etc

The study objectives of this report are:

To study and forecast the market size of Nanomedicine

To analyze the global key players, SWOT analysis, value and global market share for top players.

To define, describe and forecast the market by type, end-use and region.

To analyses and compare the market status and forecast among global major regions.

To analyses the global key regions market potential and advantage, opportunity and challenge, restraints and risks.

To identify significant trends and factors driving or inhibiting market growth.

TOC-

Check here for the discount@https://99marketresearch.com/global-nanomedicine-market-size-status-and-forecast-2019-2025/102924/#Buying-Enquiry

Customization of the Report:This report can be customized to meet the clients requirements. Please connect with our sales team (sales@99marketresearch.com), who will ensure that you get a report that suits your needs.

See original here:
Nanomedicine Market 2019 Industry Outlook, Comprehensive Insights, Growth and Forecast 2025 - Med News Ledger

Recommendation and review posted by Alexandra Lee Anderson

Global Nanomedicine Market Forecast (2019-2024) Report: By Regions, Type and Application with Sales and Revenue Analysis – Editorials 360

Market share of global Nanomedicine industry is dominate by companies like Combimatrix, Ablynx, Abraxis Bioscience, Celgene, Mallinckrodt, Arrowhead Research, GE Healthcare, Merck, Pfizer, Nanosphere, Epeius Biotechnologies, Cytimmune Sciences, Nanospectra Biosciences and others which are profiled in this report as well in terms of Sales, Price, Revenue, Gross Margin and Market Share (2017-2018).

Access Report Details at: https://www.themarketreports.com/report/global-nanomedicine-market-by-manufacturers-countries-type-and-application-forecast

Market Segment by Regions, regional analysis covers:

Market Segment by Type, covers:

Market Segment by Applications, can be divided into

Purchase this premium research report at: https://www.themarketreports.com/report/buy-now/1490823

With the help of 15 chapters spread over 100 pages this report describe Nanomedicine Introduction, product scope, market overview, market opportunities, market risk, and market driving force. Later it provide top manufacturers sales, revenue, and price of Nanomedicine, in 2017 and 2018 followed by regional and country wise analysis of sales, revenue and market share. Added to above, the important forecasting information by regions, type and application, with sales and revenue from 2019 to 2024 is provided in this research report. At last information about Nanomedicine sales channel, distributors, traders, dealers, and research findings completes the global Nanomedicine market research report.

Ask your report related queries at: https://www.themarketreports.com/report/ask-your-query/1490823

View original post here:
Global Nanomedicine Market Forecast (2019-2024) Report: By Regions, Type and Application with Sales and Revenue Analysis - Editorials 360

Recommendation and review posted by Alexandra Lee Anderson

Robust Growth Of The Nanomedicine Market Predicted Over The Forecast Period 2013 – 2019 – Hitz Dairies

Newest Learn about at the International Nanomedicine Market

The lately printed record via Transparency Market Analysis at the world Nanomedicine marketplace provides resourceful insights referring to the long run possibilities of the Nanomedicine marketplace. The underlying developments, enlargement alternatives, impeding elements, and evident marketplace drivers are totally studied within the introduced record.

As in keeping with the record, the worldwide Nanomedicine marketplace is projected to develop at a CAGR of ~XX% and exceed the worth of ~US$ against the tip of 2029. Additionally, an in-intensity research of the micro and macro-financial elements which are expected to steer the trajectory of the Nanomedicine marketplace all through the forecast length (2019-2029) is integrated within the record.

Experiences are to be had at discounted charges! Be offering expires quickly!

Request For Bargain On This Document @ https://www.transparencymarketresearch.co/sample/sample.php?flag=D&rep_id=1753

Important Insights Associated with the Nanomedicine Market within the Document:

Nanomedicine Market Segments

A radical analysis of the long run possibilities of the Nanomedicine marketplace throughout more than a few areas is tracked within the record.

segmentation, and demanding situations out there were mentioned at duration within the analysis record.

Review of the Cloud Computing Market in Healthcare Trade

As in keeping with the analysis record, the worldwide marketplace for cloud computing within the healthcare business used to be valued at US$1.82 bn in 2011 and is projected to succeed in a worth of US$6.79 bn via the tip of 2018. The marketplace is projected to sign up a exceptional 21.30% CAGR between 2012 and 2018.

The safety of get entry to and knowledge integrity and several other different advantages presented via cloud computing are estimated to inspire the expansion of the marketplace in the following couple of years. Alternatively, information leakage considerations, information integration and consistency, and knowledge relocation are one of the key elements estimated to restrain the expansion of the worldwide cloud computing marketplace within the healthcare business in the following couple of years.

At the moment, the instrument-as-a-provider phase leads the worldwide cloud computing marketplace within the healthcare business. However, the platform-as-a-provider phase is estimated to witness considerable enlargement within the coming years. Moreover, at the foundation of finish use, the non-scientific knowledge techniques marketplace is projected to guide the worldwide marketplace within the close to long run.

A number of the key geographical segments, North The usa is estimated develop at a swift tempo and account for an enormous proportion within the world marketplace for cloud computing within the healthcare business in the following couple of years. The top enlargement of this area may also be attributed to the presence of numerous biopharmaceutical gamers. As well as, the emerging focal point on analysis and construction actions is anticipated to give a contribution widely against the expansion of the marketplace.

Firms Discussed within the Analysis Document

The world marketplace for cloud computing within the healthcare business is very fragmented in nature as no key gamers grasp greater than a proportion of 10% out there at this time. CareCloud, ClearDATA Networks, Oracle Company, Microsoft, Agfa Healthcare, IBM Company, and Merge Healthcare are one of the key gamers running within the world cloud computing marketplace within the healthcare business.

Key Segments of the International Cloud Computing marketplace in Healthcare Trade

International Cloud Computing marketplace in Healthcare Trade, via provider fashions

International Cloud Computing marketplace in Healthcare Trade, via pricing fashions

International Cloud Computing marketplace in Healthcare Trade, via finish customers

International Cloud Computing marketplace in Healthcare Trade, via Geography

This record provides you with get entry to to decisive information equivalent to:

Key highlights of this record

Request Pattern Document @ https://www.transparencymarketresearch.co/sample/sample.php?flag=B&rep_id=1753

Essential queries associated with the Nanomedicine marketplace addressed within the record:

Why Make a selection TMR?

RequestTOC For ThisDocument @ https://www.transparencymarketresearch.co/sample/sample.php?flag=T&rep_id=1753

Read more:
Robust Growth Of The Nanomedicine Market Predicted Over The Forecast Period 2013 - 2019 - Hitz Dairies

Recommendation and review posted by Alexandra Lee Anderson

Yuehe Lin named to National Academy of Inventors – WSU News

Yuehe Lin

Yuehe Lin, professor in the School of Mechanical and Materials Engineering, has been named a fellow of the National Academy of Inventors (NAI).

He was cited for his highly prolific spirit of innovation in creating or facilitating inventions that have made a tangible impact on the quality of life, economic development, and welfare of society, according to the selection committee. Lin is one of 168 NAI Fellows for 2019, which is the highest professional distinction accorded solely to academic inventors. The program includes more than 1,000 fellows from 250 universities around the world that hold more than 41,500 U.S. patents.

Dr Lin has made significant research contributions with real-world impact in the fields of energy and health, said Mary Rezac, dean of WSUs Voiland College of Engineering and Architecture. His hugely varied work from finding possible new ways to treat cancer to innovations in water splitting for a future hydrogen economy and development of a better catalyst for fuel cells often comes down to simple solutions that can provide real change and improvements in peoples lives.

With WSU since 2013, Lin, who also holds a joint appointment at Pacific Northwest National Laboratory, conducts research in nanotechnology, particularly development of small-scale devices, materials and analytical systems for biomedical diagnosis, drug delivery and energy and environmental applications.

He has more than 500 peer-reviewed publications, which have been cited more than 50,500 times, according to Google Scholar. He has an h-index, a measure of a scientists productivity and impact, of 112. He has been named among the worlds most highly cited researchers every year from 2014 to 2019 by the Web of Science Group.

He has received funding from the National Institutes of Health, U.S. Centers for Disease Control and Prevention and U.S. Departments of Energy and Defense. He holds more than 20 patents, some of which have been licensed to industrial partners for commercialization.

Lin is a fellow of the American Association for the Advancement of Science, Royal Society of Chemistry and American Institute of Medical and Biological Engineering as well as a member of the Washington State Academy of Sciences. He serves as editor or editorial board member for approximately 20 international journals, including Advance Materials Technologies; Analytica Chimica Acta; Biosensors and Bioelectronics; Electroanalysis; International Journal of Nanomedicine; Research; Journal of Nanoscience and Nanotechnology; and Sensors and Actuators B.

Lin will join the induction ceremony for fellows on April 10 as part of the annual Conference of the National Academy of Inventors in Phoenix, AZ.

Go here to read the rest:
Yuehe Lin named to National Academy of Inventors - WSU News

Recommendation and review posted by Alexandra Lee Anderson

Nanomedicine Market Analysis Global Opportunities, Revenue, Demand and Geographical Forecast To 2024 – The Connection

Nanomedicine Market 2019 report contains a focused socio-economic, political, and environmental analysis of the factors affecting the Nanomedicine industry. The report contains an analysis of the technologies involved in production, application and much more.

The report also carries in-depth case studies on the various countries which are actively involved in the Nanomedicine production. An analysis of the technical barriers, other issues, cost effectiveness affecting the Nanomedicine Market. Determining the opportunities, future of the Nanomedicine and its restraints becomes a lot easier with this report.

Request for Sample Copy of Nanomedicine Market Report athttps://www.pioneerreports.com/request-sample/46784

Details of Table of Content of Nanomedicine Market Report are as follows:

Chapter One Introduction of Nanomedicine Industry1.1 Brief Introduction of Nanomedicine1.2 Development of Nanomedicine Industry1.3 Status of Nanomedicine Industry

Chapter Two Manufacturing Technology of Nanomedicine2.1 Development of Nanomedicine Manufacturing Technology2.2 Analysis of Nanomedicine Manufacturing Technology2.3 Trends of Nanomedicine Manufacturing Technology

Chapter Three Analysis of Global Key Manufacturers3.1 Company A3.1.1 Company Profile3.1.2 Product Information3.1.3 2014-2019 Production Information3.1.4 Contact Information3.2 Company B3.2.1 Company Profile3.2.2 Product Information3.2.3 2014-2019 Production Information3.2.4 Contact Information3.3 Company C3.2.1 Company Profile3.3.2 Product Information3.3.3 2014-2019 Production Information3.3.4 Contact Information3.4 Company D3.4.1 Company Profile3.4.2 Product Information3.4.3 2014-2019 Production Information3.4.4 Contact Information&

Look into Table of Content of Nanomedicine Market Report at https://www.pioneerreports.com/TOC/46784

Regions Covered in Nanomedicine Market are:-

Chapter Four 2014-2019 Global and Southeast Asia Market of Nanomedicine4.1 2014-2019 Global Capacity, Production and Production Value of Nanomedicine Industry4.2 2014-2019 Global Cost and Profit of Nanomedicine Industry4.3 Market Comparison of Global and Southeast Asia Nanomedicine Industry4.4 2014-2019 Global and Southeast Asia Supply and Consumption of Nanomedicine4.5 2014-2019 Southeast Asia Import and Export of Nanomedicine

Chapter Five Market Status of Nanomedicine Industry5.1 Market Competition of Nanomedicine Industry by Company5.2 Market Competition of Nanomedicine Industry by Country (USA, EU, Japan, Southeast Asia etc.)5.3 Market Analysis of Nanomedicine Consumption by Application/Type

Chapter Six 2019-2024 Market Forecast of Global and Southeast Asia Nanomedicine Industry6.1 2019-2024 Global and Southeast Asia Capacity, Production, and Production Value of Nanomedicine6.2 2019-2024 Nanomedicine Industry Cost and Profit Estimation6.3 2019-2024 Global and Southeast Asia Market Share of Nanomedicine6.4 2019-2024 Global and Southeast Asia Supply and Consumption of Nanomedicine6.5 2019-2024 Southeast Asia Import and Export of Nanomedicine

Chapter Seven Analysis of Nanomedicine Industry Chain7.1 Industry Chain Structure7.2 Upstream Raw Materials7.3 Downstream Industry

Chapter Eight Global and Southeast Asia Economic Impact on Nanomedicine Industry8.1 Global and Southeast Asia Macroeconomic Environment Analysis8.1.1 Global Macroeconomic Analysis8.1.2 Southeast Asia Macroeconomic Analysis8.2 Global and Southeast Asia Macroeconomic Environment Development Trend8.2.1 Global Macroeconomic Outlook8.2.2 Southeast Asia Macroeconomic Outlook8.3 Effects to Nanomedicine Industry

Chapter Nine Market Dynamics of Nanomedicine Industry9.1 Nanomedicine Industry News9.2 Nanomedicine Industry Development Challenges9.3 Nanomedicine Industry Development Opportunities

Chapter Ten Proposals for New Project10.1 Market Entry Strategies10.2 Countermeasures of Economic Impact10.3 Marketing Channels10.4 Feasibility Studies of New Project Investment

Chapter Eleven Research Conclusions of Global and Southeast Asia Nanomedicine Industry

Key market insights include:

1. The analysis of Nanomedicine market provides market size and growth rate for the forecast period 2019-2024.

2. It offers comprehensive insights into current industry trends, trend forecast, and growth drivers about the Nanomedicine market.

3. The report provides the latest analysis of market share, growth drivers, challenges, and investment opportunities.

4. It offers a complete overview of market segments and the regional outlook of Nanomedicine market.

5. The report offers a detailed overview of the vendor landscape, competitive analysis, and key market strategies to gain competitive advantage.

In this study, the years considered to estimate the market size of Nanomedicine Market are as follows:-

Single User Licence Price: USD 3900

No Of Pages in Nanomedicine Market Report: 136

Purchase of Nanomedicine Market Report at:https://www.pioneerreports.com/checkout/46784

Continued here:
Nanomedicine Market Analysis Global Opportunities, Revenue, Demand and Geographical Forecast To 2024 - The Connection

Recommendation and review posted by Alexandra Lee Anderson

Automation increases productivity in materials science by 384 times, say researchers – Robotics and Automation News

An automated method of conducting materials science research can increase productivity by 384 times when compared to a human, according to researchers.

The robot-plus-software system also makes it easier for people who are not expert researchers or scientists to create new materials.

A Rutgers-led team of engineers has developed an automated way to produce polymers, making it much easier to create advanced materials aimed at improving human health.

The team says this innovation is a critical step in pushing the limits for researchers who want to explore large libraries of polymers, including plastics and fibers, for chemical and biological applications such as drugs and regenerative medicine through tissue engineering.

While a human researcher may be able to make a few polymers a day, the new automated system featuring custom software and a liquid-handling robot can create up to 384 different polymers at once, a huge increase over current methods.

Synthetic polymers are widely used in advanced materials with special properties, and their continued development is crucial to new technologies, according to a study in the journal Advanced Intelligent Systems. Such technologies include diagnostics, medical devices, electronics, sensors, robots and lighting.

Senior author Adam J. Gormley, an assistant professor in the Department of Biomedical Engineering in the School of Engineering at Rutgers UniversityNew Brunswick, says: Typically, researchers synthesize polymers in highly controlled environments, limiting the development of large libraries of complex materials.

By automating polymer synthesis and using a robotic platform, it is now possible to rapidly create a multitude of unique materials.

Robotics has automated many ways to make materials as well as discover and develop drugs.

But synthesizing polymers remains challenging because most chemical reactions are extremely sensitive to oxygen and cant be done without removing it during production.

The Gormley labs open-air robotics platform carries out polymer synthesis reactions that tolerate oxygen.

The group developed custom software that allows a liquid handling robot to interpret polymer designs made on a computer and carry out every step of the chemical reaction.

One benefit is that the new automated system makes it easier for non-experts to create polymers.

The lead author is Matthew Tamasi, a Rutgers doctoral student. Co-authors include doctoral student Shashank Kosuri and undergraduate student Jason DiStefano.

A researcher at the Australian Centre for Nanomedicine and Centre for Advanced Macromolecular Design contributed to the study, which was funded by the New Jersey Health Foundation.

You might also like

Visit link:
Automation increases productivity in materials science by 384 times, say researchers - Robotics and Automation News

Recommendation and review posted by Alexandra Lee Anderson

Electroplating method makes conductive nanostraws for injecting into and sampling from cells – Chemical & Engineering News

Credit: ACS Appl. Mater. Interfaces

An array of platinum nanostraws can be used to deliver molecules to cells or sample their contents.

Hollow nanosized needles, or nanostraws, are a promising tool for opening up tiny, temporary holes in cell membranes to deliver molecules or sample a cells contents. Nanostraws could also deliver gene editors into cells for immunotherapy, cutting the need to use costly viruses for the job. But making nanostraws requires expensive manufacturing equipment in a clean room facility, and using nanostraws often requires applying a high voltage in order to open up the cell membrane. Now, researchers have developed a more affordable fabrication approach that can be done in an ordinary lab. Whats more, the new nanostraws are conductive, thus lowering the amount of voltage needed to levels less likely to damage cells (ACS Appl. Mater. Interfaces 2019, DOI: 10.1021/acsami.9b15619).

Researchers made earlier iterations of nanostraws with atomic layer deposition (ALD), which grows thin films of materials such as metal oxides one layer of atoms at a time. In their new approach, Xi Xie of Sun Yat-Sen University and colleagues replaced ALD with electroplating, a simple process which uses an electrical potential to deposit ions in a solution onto a surface.

Sign up for C&EN's must-read weekly newsletter

They first sputtered a thin layer of gold on the bottom surface of a polycarbonate template containing an array of pores in order to make a conductive base layer. Then they electroplated platinum, gold, or the conductive polymer poly(3,4-ethylenedioxythiophene)three common materials used in electrophysiology studiesfrom the top. The materials lined the pores of the template, creating the hollow nanostraws. The team then used mechanical polishing and oxygen plasma etching to remove the polycarbonate template, revealing an array of vertical nanostraws, each a few hundred nanometers in diameter. According to Xie, their method can work with templates of various pore sizes or pore densities, or with other plating materials.

Ciro Chiappini, a nanomedicine researcher at Kings College London, says this study is a needed and significant step toward developing affordable nanostraws.

Using a representative platinum nanostraw array, Xie and colleagues demonstrated that they could deliver a fluorescent dye into cultured human cells and extract intracellular materials to examine how the levels of an enzyme changed over time.

The conductivity of the new nanostraws allowed the researchers to open tiny pores in the cell membrane by applying a voltage of only 35 V, a safer range for cells compared with 1020 V needed when using nonconductive nanostraws.

These straws could make cellular treatments such as CAR-T therapy faster, safer, and cheaper, says Nicholas A. Melosh, a materials scientist at Stanford University who has done nanostraw research. Typical immunotherapy delivers therapy to a patients immune cells using viruses, which is costly and carries the risk of dangerous immune responses once the cells are put back into the patient, he says. Nanostraws could potentially deliver the necessary therapies to cells without the need for viruses.

Continue reading here:
Electroplating method makes conductive nanostraws for injecting into and sampling from cells - Chemical & Engineering News

Recommendation and review posted by Alexandra Lee Anderson

Protein-Protected Metal Nanoclusters That Behave Like Natural Enzymes – Advanced Science News

Share

Share

Email

Metal nanoclusters, made up of several to one hundred metal atoms (e.g., Au, Ag, Cu, Pt), are a novel class of intermediate between metal atoms and nanoparticles. As their size (<2 nm) borders on the Fermi wavelength of electrons, metal nanoclusters possess strong photoluminescence in comparison with large metal nanoparticles (>2 nm). This, combined with tunable fluorescence emissions, high photostability, good quantum yields and facile synthesis, make them excellent fluorescent labels for biomedical applications.

However, the reduction of metal ions in liquid solution during synthesis usually causes large nanoparticles rather than small metal nanocluster formation because of their tendency to aggregate. In light of this, proteins whose thiol, amino, and carboxyl groups have a strong affinity for metal atoms are typically used to stabilize metal nanoclusters to protect them from aggregationthese proctected clusters are commonly called protein-protected metal nanoclusters.

Protein-protected metal nanoclusters have excellent biocompatibility and have received considerable attention as a luminescent probe in a number of fields such as biosensing, bioimaging, and imaging-guided therapy. However, apart from unique optical properties, protein-protected metal nanoclusters also possess interesting biological properties such as enzyme-like activity similar to that of natural enzymes; until recently, this has been an overlooked quality that is starting to shine in basic research and practical applications.

Nanozymes is a new termed used to refer to nanomaterials with intrinsic enzyme-like activity. Since professor Yan and coworkers first discovered that nanoparticleswhich are traditionally assumed to be inertpossessed intrinsic enzyme-like activity, a substantial amount of work has focused on further developing and harnessing the advantageous properties of nanozymes, which include high catalytic ability, high stability, and low cost. Nowadays, more than 540 kinds of nanomaterials, which possess intrinsic enzymatic activity, have been reported from 350 laboratories in 30 countries and have been used in biological analysis, environmental treatment, as antibacterial agents, cancer therapy, and antioxidation therapy.

In a recent study published in WIREs Nanomedicine and Nanobiotechnology, Professor Xiyun Yan and Kelong Fan explore the newly developing field of biologically active protein-protected metal nanoclusters, namely those that possess peroxidase, oxidase, and catalase activities, and are consequently used for biological analysis and environmental treatment.

An intriguing example of this is bovine serum albumin-protected gold (Au) nanoclusters, which exhibit peroxidase enzymatic activity to catalyze the oxidation of colored organic substrates, which is currently carried out using natural peroxidases. This method showed an advantage over the natural peroxidase-based methods because bovine serum albumin-protected Au nanoclusters exhibited higher robustness and retained enzymatic activity over a wide range of pH and temperatures. In another example, lysozyme-protected platinum (Pt) nanoclusters exhibit oxidase enzymatic activity which has been applied to the oxidative degradation of pollutants, such as methylene blue in lake water.

The proteins themselves not only provide protection and stabilization during synthesis, but can also provide a myriad of other functions to the nanoclusters. Proteins have been shown to enable in vivo applications because of their enhanced biocompatibility. In fact, a protease-responsive sensor for in vivo disease monitoring was designed by utilizing the peroxidase activity of peptide-protected Au nanoclusters and their ultra-small size dependent tumor accumulation and renal clearance properties.

The sensor was developed using peptides which are the substrates/targets of disease related proteases as protective ligands to synthesis the Au nanoclusters nanozymes, which were then conjugated to a carrier. After reaching the site of disease, the sensor was disassembled in response to the dysregulated protease and the liberated Au nanoclusters were filtered through the kidneys and into urine to produce a rapid and sensitive colorimetric readout of diseases state. By employing different enzymatic substrate as protective ligands for Au nanoclusters, this modular approach could enable the rapid detection of a diverse range of diseases with dysregulated protease activities such as cancer, inflammation, and thrombosis.

These findings have extended the horizon of protein-protected metal nanoclusters properties as well as their application in various fields, says Kelong Fan. Furthermore, in the field of nanozymes, protein-protected metal nanoclusters have emerged as an outstanding new addition. Due to their ultra-small size (<2 nm), they usually have higher catalytic activity, more suitable size for in vivo application, better biocompatibility and photoluminescence in comparison with large size nanozymes. We think that ultra-small nanozymes based on protein-protected MNCs are on the verge of attracting great interest across various disciplines and will stimulate research in the fields of nanotechnology and biology.

Despite the advantages and advancedprogress in the development of protein-protected metal nanoclusters asultra-small nanozymes, there are still some challenges that need to be addressedin future work.

First, most researchers still only rely on bovine serum albumin as both the reducing agent and stabilizer. Since we know that protein-protected metal nanoclusters may retain the bioactivity of the protein ligand, it is necessary to explore methods for synthesizing other new protein-protected metal nanoclusters, which will widen the diagnostic and therapeutic applications of protein-protected metal nanoclusters nanozymes.

Second, there are six types of catalytic reactions in nature: oxidoreductases, transferases, hydrolases, isomerases, ligases, and lyases. Thus far, although many protein-protected metal nanoclusters have demonstrated enzyme activities they all are oxidoreductase-like activities such as peroxidase, oxidase, and catalase. Therefore, there is a ample room to develop other types of nanozymes based on protein-protected metal nanoclusters. In this regard, more understanding of the structures and catalytic mechanisms of protein-protected metal nanoclusters is required in addition to the deeper understanding on natural enzymes themselves.

Third, a considerable number of reports have suggested that ultra-small nanozymes based on protein-protected metal nanoclusters are promising tools for biological analysis. However, little is known about the therapeutic function of these ultra-small clusters in vivo despite their advantages of suitable size and good biocompatibility. It is well known that peroxidase, oxidase, and catalase are main enzymes in biological systems involved in the maintenance of redox homeostasis. Thus, more attention should be paid to the usage of these ultra-small nanozymes based on protein-protected metal nanoclusters as bio-catalysts in various human diseases involved in redox dysregulation such as cancer, inflammation, cardiovascular diseases. It is also possible to employ the products of redox nanozymes to treat other diseases, for example, use the toxic hydroxyl radicals produced by peroxidase nanozymes to treat bacterial infection.

Overall, there is still much room for future research and application of ultra-small nanozymes based on protein-protected metal nanoclusters. It is expected that the enzyme-like activity of protein-protected metal nanoclusters will certainly attract broader interests across various disciplines and stimulate research in the fields of nanotechnology and biology, making these emerging ultra-small nanozymes become novel multifunctional nanomaterials for a number of biomedical applications.

Kindly contributed by the authors.

View original post here:
Protein-Protected Metal Nanoclusters That Behave Like Natural Enzymes - Advanced Science News

Recommendation and review posted by Alexandra Lee Anderson

Innovative Report on Nanomedicine Market with Focusing on Eminent Players- Nanosphere Inc.,Pfizer Inc.,Combimatrix Corp – Finance Daily Tribune

Global Nanomedicine Market research report from Crystal Market Research covers overview defines characteristics, size and growth, segmentation, regional breakdowns, competitive landscape, market share, trends and strategies for the Nanomedicine industry.The size section gives the revenues, covering both the historic data of the Nanomedicine market and forecasting the future. Drivers and restraints are studied with respect to external factors influencing the growth of the market.

The authors of the Nanomedicine report shed light on lucrative business prospects, prominent trends, regulatory situations, and price scenarios of the global Nanomedicine market. Importantly, the report gives a detailed analysis of macroeconomic and microeconomics factors impacting the growth of the global Nanomedicine market. It is divided into various sections and chapters to help with easy understanding of each and every aspect of the global Nanomedicine market.

Click Here To Access The Sample Report @https://www.crystalmarketresearch.com/report-sample/HC122205

Continue

Check Exclusive Discount on this report @https://www.crystalmarketresearch.com/check-discount/HC122205

To get this report at a profitable rate @ https://www.crystalmarketresearch.com/send-an-enquiry/HC122205

Contacts Us:

Sherry | APAC Marketing Division: Level 23-1, Premier Suite

Mont Kiara, 50480 Kuala Lumpur

Malaysia

E-mail: sales@crystalmarketresearch.com

See the article here:
Innovative Report on Nanomedicine Market with Focusing on Eminent Players- Nanosphere Inc.,Pfizer Inc.,Combimatrix Corp - Finance Daily Tribune

Recommendation and review posted by Alexandra Lee Anderson

Design and Synthesis of Gold-Gadolinium-Core-Shell Nanoparticles as Co | IJN – Dove Medical Press

Fatima Aouidat,1 Sarah Boumati,2 Memona Khan,1 Frederik Tielens,3 Bich-Thuy Doan,2 Jolanda Spadavecchia1

1CNRS, UMR 7244, CSPBAT, Laboratory of Chemistry, Structures and Properties of Biomaterials And Therapeutic Agents University Paris 13, Sorbonne Paris Cit, Bobigny, France; 2UTCBS Chimie ParisTech University Paris Descartes - CNRS UMR 8258 INSERM U1022 Equipe Synthesis, Electrochemistry, Imaging and Analytical Systems for Diagnostics SEISAD, Paris, France; 3General Chemistry (ALGC), Vrije University of Brussel (Free University Brussels-VUB), Brussel, Belgium

Correspondence: Jolanda Spadavecchia Email jolanda.spadavecchia@univ-paris13.fr

Introduction: The development of biopolymers for the synthesis of Gd(III) nanoparticles, as therapeutics, could play a key role in nanomedicine. Biocompatible polymers are not only used for complex monovalent biomolecules, but also for the realization of multivalent active targeting materials as diagnostic and/or therapeutic hybrid nanoparticles. In this article, it was reported for the first time, a novel synthesis of Gd(III)biopolymerAu(III) complex, acting as a key ingredient of core-shell gold nanoparticles (Gd(@AuNPs).Material and methods: The physical and chemical evaluation was carried out by spectroscopic analytical techniques (Raman spectroscopy, UV-visible and TEM). The theoretical characterization by DFT (density functional theory) analysis was carried out under specific conditions to investigate the interaction between the Au and the Gd precursors, during the first nucleation step. Magnetic features with relaxivity measurements at 7T were also performed as well as cytotoxicity studies on hepatocyte cell lines for biocompatibility studies. The in vivo detailed dynamic biodistribution studies in mice to characterize the potential applications for biology as MRI contrast agents were then achieved.Results: Physicalchemical evaluation confirms the successful design and reaction supposed. Viabilities of TIB-75 (hepatocytes) cells were evaluated using Alamar blue cytotoxic tests with increasing concentrations of nanoparticles. In vivo biodistribution studies were then accomplished to assess the kinetic behavior of the nanoparticles in mice and characterize their stealthiness property after intravenous injection.Conclusion: We demonstrated that Gd@AuNPs have some advantages to display hepatocytes in the liver. Particularly, these nanoconjugates give a good cellular uptake of several quantities of Gd@NPs into cells, while preserving a T1 contrast inside cells that provide a robust in vivo detection using T1-weighted MR images. These results will strengthen the role of gadolinium as complex to gold in order to tune Gd(@AuNPs) as an innovative diagnostic agent in the field of nanomedicine.

Keywords: Gd-gold complex, theoretical study, MRI, relaxivity, biodistribution

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License.By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Read more:
Design and Synthesis of Gold-Gadolinium-Core-Shell Nanoparticles as Co | IJN - Dove Medical Press

Recommendation and review posted by Alexandra Lee Anderson


Page 11234..1020..»