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Global Precision Medicine Software Market Analysis and Forecast 2027- including drivers, constraints, intimidation, challenges, opportunities, and…

Global Precision Medicine Software Market presents insights into the present and upcoming industry trends, enabling the readers to identify the products and services, hence driving the enlargement and effectiveness. The research report provides a comprehensive breakdown of all the major factors impacting the market on a global and regional scale, including drivers, constraints, intimidation, challenges, opportunities, and industry-specific trends. Further, the report cites global certainties and endorsements along with downstream and upstream analysis of leading players.

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Major Players:

Abbott Laboratories(US)Syapse, Inc. (US)Roper Technologies(US)Sunquest Information Systems Inc. (US)Pfizer, Inc., Merck & Co., Inc.(US)N-of-One, Inc. (US)NantHealth, Inc. (US)LifeOmic Health, LLC (US)Fabric Genomics (US)Allscripts(US)GlaxoSmithKline plc(UK)Gene42, Inc. (Canada)Foundation Medicine, Inc. (US)Koninklijke Philips N.V. (Netherlands)PierianDx, Inc. (US)Translational Software, Inc. (US)Flatiron Health, Inc. (US)IBM Watson Group (US)Sanofi S.A.(France)Tempus Labs, Inc. (US)AstraZeneca plc(US)2bPrecise LLC (Israel)Qiagen(Germany)SOPHiA GENETICS SA (Switzerland)Human Longevity, Inc. (US)

Global Precision Medicine Software Market research reports enlargement rates and the market value based on market dynamics, growth factors. Complete knowledge is based on the newest innovation in business, opportunities, and trends. In addition to SWOT examination by key suppliers, the report contains an all-inclusive market analysis and major players landscape.

The regional segmentation covers:

Segmentation by Type:

Cloud-basedOn-premise

Segmentation by Application:

Healthcare providersResearch centers & Government institutesPharmaceutical & Biotechnology companiesOther end users

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Report Objectives

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Table of Content:

The Global Precision Medicine Software Market

Chapter 1: Precision Medicine Software Market Overview, Drivers, Restraints and Opportunities

Chapter 2: Precision Medicine Software Market Competition by Manufacturers

Chapter 3: Precision Medicine Software Production by Regions

Chapter 4: Production, By Types, Market share by Types

Chapter 5: Consumption, By Applications

Chapter 6: Comprehensive profiling and analysis of Manufacturers

Chapter 7: Manufacturing cost analysis

Chapter 8: Industrial Chain, Sourcing Strategy and Downstream Buyers

Chapter 9: Marketing Strategy Analysis, Distributors/Traders

Chapter 10: Precision Medicine Software Market Effect Factors Analysis

Chapter 11: Precision Medicine Software Market Forecast

Chapter 12: Conclusion of Precision Medicine Software Market

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Mifepristone Increases Lifespan in Flies and Worms…Can It Improve Longevity in Humans? – MedicalResearch.com

MedicalResearch.com Interview with:

John Gerard TowerProfessor of biological sciencesUniversity of Southern California

MedicalResearch.com: What is the background for this study?

Response: Mifepristone is a synthetic steroid drug that is used in humans for birth control and as a treatment for Cushings disease, and is currently in clinical trials as an anti-cancer treatment.

We have previously shown that mifepristone dramatically increases the life span of mated female Drosophila flies.

MedicalResearch.com: What are the main findings?

Response: In the present study, we find that mifepristone increases fly life span by altering genes and metabolic pathways that are shared with humans, including interactions with the microbiome.

In addition, we find that mifepristone increases the life span of mated C. elegans worms.

MedicalResearch.com: What should readers take away from your report?

Response: It is striking how conserved the regulation of life span appears to be across species. The metabolism associated with a long, healthy life in humans is similar to the metabolism associated with a long, healthy life in flies, and this is promoted by mifepristone. The finding that mifepristone can increase life span in species as different as fly and worm suggests the possibility that mifepristone might also be able to increase life span in humans.

MedicalResearch.com: What recommendations do you have for future research as a result of this work?

Response: It will be important to identify the exact molecular target of mifepristone in the fly, as this remains unknown, and identifying this target may be useful for designing further anti-aging interventions. It may also be of interest to design human clinical trials to test for possible life span effects of mifepristone.

Nothing to disclose.

Citation:

John Tower, Sean P Curran, Daniel E L Promislow, Jie Shen, Mina Abdelmesieh, Shinwoo Lee, Palak Patel, Jimmy Wu, Tianyi Wang, Jonah Vroegop, Ina Wang, Yang Fan, Lu Wang, Chia-An Yen, Devon V Doherty, Gary N Landis.Metabolic Signatures of Life Span Regulated by Mating, Sex Peptide and Mifepristone/RU486 in Female Drosophila melanogaster.The Journals of Gerontology: Series A, 2020; DOI:10.1093/gerona/glaa164

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The information on MedicalResearch.com is provided for educational purposes only, and is in no way intended to diagnose, cure, or treat any medical or other condition. Always seek the advice of your physician or other qualified health and ask your doctor any questions you may have regarding a medical condition. In addition to all other limitations and disclaimers in this agreement, service provider and its third party providers disclaim any liability or loss in connection with the content provided on this website.

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Umbrine Fatima, MD, FACP, CPHIMS, an Internist with My Health 360 – York Pedia

Get to know Internist Dr. Umbrine Fatima, who serves patients in Clarence, New York.

(YorkPedia Editorial):- New York City, Jul 10, 2020 (Issuewire.com)Recognized as a reputable, board-certified internist, Dr. Fatima strives to help patients live their best and achieve their individual health and wellness goals. She is the owner & operator of My Health 360, a membership-based premier concierge internal medicine practice which also offers medical esthetic procedures in Clarence, New York.

Patients suffering from diabetes, high cholesterol, high blood pressure, arthritis, hormone imbalance, chronic pain, obesity, or other chronic conditions can turn to My Health 360 for premium care. A firm believer in taking a holistic approach to care, Dr. Fatima focuses on each patient as an individual instead of just treating their medical condition(s). She uses personalized, alternative, and lifestyle strategies were needed to enhance ones quality of life.

From health to wellness, the doctor and her team of skilled professionals offer the following services: aesthetics, concierge care, cosmeceuticals, deprescribing, genomic testing, hair products and treatments, iCARI Data Wallet, pain management, and weight management.

Aesthetics: Helping patients to look and feel rejuvenated using simple, minimally invasive solutions, Dr. Fatima and her expert esthetic team offer botox, fillers, herbal facial serums, hair loss treatments, and nonsurgical face-lifts. They strive to help each patient achieve desired effects, including tighter, lifted skin; younger looking skin; better facial symmetry; restored facial volume; and fewer skin creases and folds.

Concierge care: My Health 360 Concierge Care offers an old-fashioned direct patient-physician relationship with premium medical care at an affordable membership fee of $1,500 per person per year, which entitles members up to four medical visits per year, including some lab tests. House visits, if deemed medically necessary, may be available for an additional cost.

Cosmeceuticals: Cosmeceuticals are cosmetic products and treatments with therapeutic properties that improve the look and health of ones skin well after their application. With a holistic and integrative approach to care, Dr. Fatima combines traditional medical treatments with alternative therapies to improve overall health and wellness. Utilizing cosmeceuticals, the goal is to help each patient meet their esthetic goals, while also caring for the underlying cause of their individual beauty concerns.

Deprescribing: Dr. Fatima and her colleagues offer deprescribing strategies to optimize medication regimens or reduce the number of medications patients take in favor of healthy lifestyle changes. They will review a patients symptoms, medical history, medication list, and advise on possible interactions and adverse effects one may be experiencing with recommendations to deprescribe if needed. The goal of deprescribing is to maintain or improve quality of life.

Genomic testing: From a simple cheek swab, Dr. Fatima and her experienced team access copious amounts of genomic data (DNA makeup, biochemistry, metabolism, and more) and analyze broad or specific areas of concern. They deliver personalized, actionable information, providing patients with evidence-based roadmaps for effective dietary and lifestyle interventions based on their unique genetic and biochemical needs.

Pain management: Chronic pain management at My Health 360 involves treatments that ease long-lasting pain without addictive opioids or invasive surgery. Dr. Fatima reviews each patients symptoms and medical history completes an exam and may use blood or imaging tests to diagnose the cause of their pain and develop personalized chronic pain treatments with a goal to restore quality of life naturally.

Weight management: Weight management at My Health 360 is a medically supervised program with proven success that helps patients achieve or maintain a desirable weight and lower their risk of chronic diseases. Alongside her team, Dr. Fatima uses sophisticated methods, including genomics-guided lifestyle modifications, to guide treatment decisions which may be based on hormone levels, food cravings, nutrient utilization, metabolism, thyroid function, biochemistry, and other genetic factors. By doing so, she develops personalized diets and exercises plans to get patients on track with a healthy lifestyle.

With over two decades of experience in her field, Dr. Fatima earned her medical degree from DOW University of Health Sciences in Pakistan. Upon relocating to the United States, she completed her residency in internal medicine at NewYork-Presbyterian Queens.

Following her education, she became board-certified in internal medicine by the American Board of Internal Medicine (ABIM). The ABIM is a physician-led, non-profit, independent evaluation organization driven by doctors who want to achieve higher standards for better care in a rapidly changing world.

A physician informaticist with an extensive background in health informatics and data analytics consulting, Dr. Fatima is the President and Founder of Health Information Technology Consultants, Inc. She combines her clinical and informatics experience to help healthcare organizations implement technologies that balance best security practices and efficient clinical workflows with a focus on patient safety while minimizing physician burnout. To date, she has successfully led many health information technology projects to support business needs of healthcare organizations throughout North America.

Licensed to practice medicine in New York and Florida, Dr. Fatima is also the Medical Director of Capacity for Development of Mentally Disabled Adults through SASINC.org. She is a Fellow of the American College of Physicians (FACP) and a Certified Professional in Healthcare Information and Management Systems (CPHIMS).

Internal medicine is the medical specialty dealing with the prevention, diagnosis, and treatment of adult diseases. Physicians specializing in internal medicine are called internists. They manage and prevent common and complex diseases by providing comprehensive care and promoting overall well-being.

In addition to English, Dr. Fatima speaks Urdu and Hindi.

Learn More about Dr. Umbrine Fatima:

Through her findatopdoc profile, https://www.findatopdoc.com/doctor/81722926 or through My Health 360, https://myhealth360.net/pages/about-us

About FindaTopDoc.com

FindaTopDoc is a digital health information company that helps connect patients with local physicians and specialists who accept your insurance. Our goal is to help guide you on your journey towards optimal health by providing you with the know-how to make informed decisions for you and your family.

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Where to Buy Healthy and Nutritious Detox Drinks Online – MYANMORE Yangon

Are you in your practice of cleansing your body and boosting your energy with healthy food and drinks? Well, detox juice can be a good daily ritual for your health. Detox drinks are known to cleanse your digestive system, your liver and your body and they can enrich a healthy lifestyle.

So, here are four places where you can buy detox juice online for delivery in Yangon.

1RAW Juice

Established in 2016, Raw Juice is one of the most popular places to get healthy detox juice in Yangon. Made from 100% organic fruits and vegetables, RAW sources them from a local market and all of RAW Juice are cold-pressed. RAW has got several different plans for different needs such as Intense Plan, Confidence Dinner Plan, etc. You can order the juices one day in advance and enjoy healthy and tasty RAW juices. Along with its cold-pressed juices, RAW has launched its new healthy GREENS menu with healthy salad bowls and meals.

Tel: 09 785 061 066Facebook: RAW Juice

2Jungle Detox

Jungle Detox offers a detox program that includes packages for Beginner Level, Advanced Level, Expert Level and Dinner Plan. The packages include detox juices made with a good mix of fruits, vegetables, seeds and nuts for beginner level, more vegetables, less fructose and less calories for advanced level, packed with a lot of superfoods for expert level and 3 nutrient packed detox juices plus a booster shot for dinner plan. Give it a try for a better and healthier lifestyle with Jungle Detoxs nutritious and organic detox juices.

Tel: 09 770 333 309Facebook: Jungle Detox

3Body Detox

Body Detox offers one-day detox plan, which includes six 500 ml bottles for the whole day. You may need to drink it according to the labeled bottle liver detox, colon detox, kidney detox, Vitamin C Booster, etc. They also have three-day detox plan, either. Give them a call for your order and build a healthier lifestyle with its healthy detox juices.

Tel: 09 512 1159Facebook: Body Detox

4IVY Diet & Detox

IVY offers detox drinks by planning different programs for different customers including 1-day Program, 3-day Program, Special Program and Breakfast or Dinner Plan. Each plan has its own benefit for customers with different needs. For instance, 1-day Program which includes six 500 ml bottles is dedicated to those who want to cleanse their bodies, who need healthy lifestyle without losing weight, who are required to eat essential fruits and vegetables, etc. The price is also very affordable, with delicious-looking juices which will create a healthier lifestyle for you.

Tel: 09 793 850 520Facebook: IVY Diet & Detox

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Growth of Global Testosterone Replacement Therapy Market in Global Industry: Overview, Size and Share 2020-2029 – Cole of Duty

KandJ market research added a new market research report on 2014-2029 Global Global Testosterone Replacement Therapy Market by Player, Region, Type, Application and Sales Channel in the database of market research collaterals consisting of overall market scenario with prevalent and future growth prospects, among other growth strategies used by key players to stay ahead of the market.

Report Overview

It is our aim to provide our readers with report for Global Testosterone Replacement Therapy market, which examines the industry during the period 2014 2029. One goal is to present deeper insight into this line of business in this document. The first part of the report focuses on providing the industry definition for the product or service under focus in the Global Testosterone Replacement Therapy market report. Next, the document will study the factors responsible for hindering and enhancing growth in the industry. After covering various areas of interest in the industry, the report aims to provide how the Global Testosterone Replacement Therapy market will grow during the forecast period.

The Global Testosterone Replacement Therapy market report between the years 2020-2029 will highlight the current value of the industry. At the same time, there is also an estimate of how much this line of business will be worth at the end of the forecast period. As it is our goal to maintain high levels of accuracy at all times, we will take a look at the CAGR of the Global Testosterone Replacement Therapy market. We make sure that all the information available in this report has excellent levels of readability. One way we achieve this target is by Global Testosterone Replacement Therapy market segmentation. Going through the report for 2020 -2029 will bring our readers up-to-date regarding this industry.

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COVID-19 can affect the global market in 3 ways: by directly affecting the production and demand, by creating supply chain and market disturbance, and by its financial impact on enterprises and financial markets.

While examining the information from this document, one thing becomes clear, the elements which contribute to increase in demand for the product or service. At the same time, there will be a focus on what drives the popularity of these types of products or services. This report is for those who want to learn about Global Testosterone Replacement Therapy market, along with its forecast for 2020-2029. Information regarding market revenue, competitive partners, and key players will also be available.

Segmentation

As discussed earlier, there is segmentation in the Global Testosterone Replacement Therapy market report, to improve the accuracy and make it easier to collect data. The categories which are the dividing factors in the industry are distribution channels, application, and product or service type. With this level of segmentation, it becomes easier to analyze and understand the Global Testosterone Replacement Therapy market. At the same time, there is emphasis on which type of consumers become the customers in this industry. When it comes to distribution channels, the Global Testosterone Replacement Therapy market report looks at the different techniques of circulation of the product or service.

Market Analysis By Key Companies

Market Analysis By Type

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Market Analysis By Applications

Market Analysis By Regions

Latest Industry News

From this Global Testosterone Replacement Therapy market report, the reader will also get to learn about the latest developments in the industry. The reason is that these products or services have the potential to disrupt this line of business. If there is information about company acquisitions or mergers, this information will also be available in this portion of the Global Testosterone Replacement Therapy market report.Additionally, recent trends, mergers and acquisitions, region-wise growth analysis along with challenges that are affecting the growth of the market are also stated in the report.

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TSET awards Healthy Living Program Grant to Gateway to Prevention and Recovery – Shawnee News Star

Vicky O. Misa|The Shawnee News-Star

The Board of Directors for the Oklahoma Tobacco Settlement Endowment Trust (TSET) selected Gateway to Prevention and Recovery in Shawnee as a grantee for the next round of the TSET Healthy Living Program during their quarterly board meeting in May. The award in the first year of the grant is up to $220,000.

The grant initiative will utilize county and municipal health data, along with community feedback to customize a data-driven plan to tackle the barriers associated with healthy eating, physical activity and tobacco use in high risk areas within the funded county. The approach involves collaboration with leaders and key stakeholders at the local level.

The coronavirus pandemic has shown that prevention is more important than ever for public health, said TSET Board of Directors Chair Bruce Benjamin, Ph.D. Those with underlying conditions like diabetes, high blood pressure, or heart of lung disease are more likely to experience serious complications and death from the coronavirus.

At Gateway, we believe that local people solve local problems and people help support what they create, said TSET Healthy Living Consultant Holly Gordon. The Healthy Living Program allows community partners, organizations, and Gateway staff to work together to reduce the number of preventable deaths in Oklahomans.

The TSET Healthy Living Program prioritizes work in communities where health risk factors tobacco use, poor nutrition and sedentary lifestyle -- are among the highest. At their May meeting, the TSET Board awarded nearly $7 million to 35 organizations that will serve 37 counties through the program. The new grant cycle begins July 1 and is renewable annually.

This initiative builds on years of success through multiple community-based programs funded by TSET, said Julie Bisbee, TSET executive director. It takes a comprehensive approach to partner with organizations that have a demonstrated ability to tackle high-impact interventions to help change health behaviors in our state.

TSET recognizes that local people are best at solving problems at the municipal level.

For a complete list of the grantees, visit tset.ok.gov.

The Oklahoma Tobacco Settlement Endowment Trust (TSET) serves as a partner and bridge builder for organizations working toward shaping a healthier future for all Oklahomans. Investing $45 million in prevention and research in Oklahoma each year, TSET has been a driving force in the decade-long decline in tobacco use in the state. TSET provides leadership at the intersections of health by working across Oklahoma, by cultivating innovative and life-changing research, and by working across public and private sectors to develop, support, implement and evaluate creative strategies to take advantage of emerging opportunities to improve the public's health. To learn more, visit http://www.tset.ok.gov.

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Scientists Say You Can Cancel the Noise but Keep Your Window Open – The New York Times

Car alarms, jackhammers, a drunken argument and the rumble of the No. 7 train passing overhead. It is the glorious urban symphony that pours into a typical New York City apartment building day and night.

Sure, closing the window can help, but there goes your natural ventilation.

What if there were technology to cancel the offending clamor, like a pair of giant noise-canceling headphones for your apartment?

Researchers in Singapore have developed an apparatus that can be placed in a window to reduce incoming sound by 10 decibels. The system was created by a team of scientists, including Masaharu Nishimura, who came up with the basic concept, and Bhan Lam, a researcher at Nanyang Technological University in Singapore.

I grew up in Singapore, Dr. Lam said in a Zoom interview from his apartment there. Its a small city with a lot of noise, so I have some motivation to solve this problem.

Their results were published on Thursday in Scientific Reports. The prototype is not yet the most practical device in real world conditions, but it points the way toward the development of technologies that may help ease the strain of noisy city living.

Borrowing from the same technological principles used in noise-canceling headphones, the team expanded the concept to fit an entire room by placing 24 small speakers in a window. The speakers emit sound waves that correspond to the incoming racket and neutralize it or, at least some of it.

The system is based on the frequency of the sound waves and, for now, the optimal range is between 300 and 1,000 hertz.

In Singapore, a city near the Equator where temperatures are often high, overlapping transportation systems and the desire for natural ventilation in modern high-rise apartment towers can pose a healthy-living conundrum.

Dr. Lam explained that in places like Singapore, we want to keep the windows open as much as possible to reduce the use of carbon-intensive air-conditioners and to prevent buildup of stale air that can pose health risks for some people.

But with windows open, the constant din from city traffic, trains, jets passing overhead and construction equipment can rattle apartments. The Anti-Noise Control Window, as it is called, is the sonic equivalent of shutting a window.

With any sound, the best way to reduce it is at the source, like a guns silencer. So the researchers treated the window aperture itself as the noise source, because most noise enters a room that way.

The system uses a microphone outside the window to detect the repeating sound waves of the offending noise source, which is registered by a computer controller. That in turn deciphers the proper wave frequency needed to neutralize the sound, which is transmitted to the array of speakers on the inside of the window frame.

The speakers then emit the proper anti waves, which cancel out the incoming waves, and there you have it: near blissful silence.

If you sit in the room, you get that same feeling like when you flick on the switch of noise-canceling earphones, Dr. Lam said, splaying his hands to denote the calming effect.

The system is best at attenuating the audible blasts from the types of steady noise sources found within the optimal frequency range.

Unfortunately, human voices do not fit within most of that range. One of the next hurdles will be to find a way to silence loud conversations from across the way.

Another limitation is that the system is not good at neutralizing sporadic noises, like firecrackers, car horns or the occasional earsplitting crash of metal storefront shutters the kinds of noises that drive many New Yorkers to slam their windows shut.

One reason for the limitation on frequency is the size of the speakers. To cancel out lower frequencies would require larger bass speakers. But those would interfere with ventilation and your ability to see through the window.

Its a trade-off, and one solution might be installing larger windows, or discovering a way to make it work with smaller speakers.

As it is, the 24 speakers, each about 2 inches in diameter, are a bit of an aesthetic hindrance.

One complaint that we get is that its ugly, Dr. Lam said.

But if it can neutralize the sound of the jet taking off from Runway 13 at LaGuardia, that is (soft) music to the ears.

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Canadian health care isnt immune to racism, experts say. Heres why – Global News

Police in Ontario shot 62-year-old Ejaz Choudry in his home. In New Brunswick, they shot Chantel Moore in her home and Rodney Levi at a friends barbecue. Prior to that, Regis Korchinski-Paquet fell from her balcony in Toronto while police were in her apartment. All four have died in the last six weeks; police called not because they committed crimes, but to check on their well-being.

Amid national and international reckonings over racism and police brutality, there have been widespread calls to use mental health practitioners not cops in moments of crisis. But while mental health is just one aspect of overall health (albeit a very important one), Canadian health care is not immune to the systemic racism impacting the countrys police forces.

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Experts say thats evident in a myriad of ways, from the coronavirus pandemics disproportionate impact on Indigenous people and Black people to other, non-COVID-19 headlines.

In Alberta, the minister of health recently ordered an independent investigation into the health authoritys handling of a noose taped to an operating room at the Grande Prairie Hospital in 2016. In B.C., the province is looking into allegations that some staff have been engaging in a racist game of whats-the-blood-alcohol-level of the (primarily) Indigenous patients who come to them seeking care.

But where defunding the police is an option, defunding health care is decidedly not. Nor, says Dr. Suzanne Shoush, does adding more Black, Indigenous and other racialized health-care providers solve the problem on its own you have to change the system.

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Like policing, health cares racism problem is systemic, says Shoush, who is a Black Indigenous doctor of Sudanese and Coast Salish heritage and the Indigenous health faculty lead for the University of Torontos family and community medicine department. Much like policing, she says, tackling it will require facing up to some uncomfortable truths.

It really all has to do with the blindness of privilege. People who have privilege are really, really blind to the fact privilege plays a role in where they are today.

Start with thesocial determinants of health: key factors that contribute to how healthy you, as an individual, are, as well as the group of people living around you.

Some you can control (to a degree), others you cannot: income and social status, employment and working conditions, education and literacy, childhood experiences, physical environments, access to health services, biology and genetic endowment, gender, culture, race and racism, and historical trauma.

These factors merge together, making Indigenous people amongthe highest-risk groups for diabetes and complications from diabetes, over-represented in HIV infection cases, tuberculosis cases and sexually transmitted infections, with a stroke rate nearly twice as high as non-Indigenous Canadians and a suicide rate among First Nations youth five to seven times higher than their non-Indigenous peers.

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For Black people in Canada, the data is harder to come by (a factor experts sayserves to worsen Black health). Buta research review from the Wellesley Institute, a non-profit that seeks to improve health equity in the Greater Toronto Area, indicates Black peoples health is harmed in part because they live in a racist environment. Much like Indigenous people, any racism experienced during their interactions with the system impacts their access to future care.

Furthermore, statistics compiled by the Black Health Alliance reveal that Black people make up 18 per cent of Canadians living in poverty even though they only represent less than three per cent of the total population. In Ontario, the risk of psychosis for people of Caribbean, East African and West African origin is 60 per cent higher than for others. And the likelihood that breast cancer kills Black women is 43 per cent higher than for white women.

Epidemiologist Nancy Kriegerboils it down to six pathways through which racism harms a persons health, including economic and social deprivation, socially inflicted trauma, inadequate or degrading medical care, and ecosystem degradation and alienation from the land the latter a recurring theme in reports like theRoyal Commission on Aboriginal Peoples, the Truth and Reconciliation Commission and theNational Inquiry into Missing and Murdered Indigenous Women and Girls.

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When you are displaced, you are not healthy, says Shoush, who recently wrote about how Canada was founded without the consent of Indigenous and Black people.

When we have a society that reflects and was founded in a non-consensual relationship, its very displacing, and this is why we see huge disparities in wellness, in health, chronic disease, life expectancy, child poverty.

Where some Indigenous people in Toronto will not consider going to the doctor, they might consider chatting with Cheryllee Bourgeois. They see her, after all, with her three children out in the community, at a powwow, at Thursday night socials at the Native Centre.

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Bourgeois is an exemption Mtis midwife working with Seventh Generation Midwives Toronto, as well as a professor in Ryerson Universitys midwifery education program. She became the citys first exemption midwife in 2018, following in the well-trodden footsteps of exemption midwives in Six Nations in southern Ontario.

Working under the exemption allows registered midwives (Bourgeois was one for more than a decade) to provide a broader scope of care to their clients to do Pap tests, address sexual and reproductive health and provide other health care not confined to pregnancy and the first six weeks of a babys life.

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The job itself is a tacit reminder of systemic racism in health care and recognition that increasing Indigenous access to health care involves community accountability and acknowledging Canadian history.

The health-care system was a very critical, key piece of the whole colonial history of the subjugation of Indigenous people, Bourgeois says.

There were such things as Indian hospitals where you were provided substandard care and where you were not allowed to go to the mainstream hospital.

Even now, it doesnt matter if Indigenous people give birth in rural, remote or urban settings in Canada, she says, their outcomes remain the same.

So that leads to something deeper, which is this very pervasive and strong systemic racism that exists within the system, affecting health outcomes, she says. In other words, its good to look at improving access, but if thats the sole focus of change then it doesnt actually solve the problem.

But Bourgeois patients grow by word of mouth, so-and-so telling their aunt or brother or cousin or friend youll be treated well there.

When the first wave of the coronavirus pandemic struck Canada this spring, Bourgeois and Shoush started Call Auntie, an information hotline for Indigenous people to ask their COVID-19 questions. In only a few short months, its morphed into something more.

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Its a form of accountability, Bourgeois says health-care workers can call ahead to certain testing centres to let them know an Indigenous person is incoming, a warm referral. Some people also ask about how to apply for the Canada Emergency Response Benefitor how they can get food delivered to their house because they have a compromised immune system.

Sometimes, Bourgeois says, people just want to talk through their concerns with a supportive listener. It isnt always about COVID-19. People call to say theyre living on the street Black people and Indigenous people are over-represented in Torontos homeless population and theyre scared of going to a shelter, so what can they do?

Its low stakes, Bourgeois says, because nothing they ask will get them put on a list of trouble clients.

They want to keep the line going after the pandemic.

For the Indigenous community, there is literally I dont want to say zero but really, theres zero trust in the health-care system that theyre actually going to be able to give them what they need, Bourgeois says.

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In pain? Labelled as drug seeking. Having a trauma response to something? Youre non-compliant. Treated badly so you dont go to your next appointment? Youre kicked out of care.

Its about so much more than extra funding, she says, because the current funding models dont take into account that need for community accountability the need for health-care providers like Bourgeois, who deliver babies, give people birth control shots, answer the questions people are scared to ask and then bring their children to Thursday night socials.

When health care your whole life has basically worked against you, youre going to do everything in your power to avoid it, she says.

Youre really not going to do anything if you dont change the system If you actually want to see a change in outcomes or a change in people engaging, you need to build trust.

Its important to remember that equitable access is not the same as equitable outcomes, says Kwame McKenzie, CEO of the Wellesley Institute, but he thinks people spend a lot of time thinking about the former rather than the latter.

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Whatd he like people to think about is: if everybody gets the same service, is the outcome the same? And is giving everybody the same service a reasonable thing to do?

Take something simple like treating high blood pressure, McKenzie says. One size does not fit all because the commonly used drugs do not work well for people of Caribbean and African origin. In other words, he says, equal access might be the same drug for everyone but it wont translate into equal outcomes.

Outcomes can be not as good because the intervention is the wrong intervention and you need a completely different intervention for different groups, he says.

You need a system that interacts with the social determinants of health because both your risk of illness and chance of getting better are very linked to who you are, how you live, what your income is.

More than a decade before health-care workers in British Columbia allegedly made a game out of guessing the blood alcohol levels of (predominantly) Indigenous people seeking care, Brian Sinclair wasignored to death in a Winnipeg ER in September 2008 presumed to be another drunken Indian rather than a 45-year-old with a severe bladder infection.

Sinclair was not ill but simply sleeping or intoxicated. This assumption, made and remade over and over in the 34 hours while Sinclair sickened and died in a hospital ER, is a striking and painful example of one of the structures of indifference that cost Brian Sinclair his life, as it has cost the lives of other Indigenous people in Canadian cities, wrote Mary Jane Logan McCallum and Adele Perry in their book Structures of Indifference: An Indigenous life and death in a Canadian City.

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It isnt that people dont recognize when things are problematic, Shoush says they do, and that realization isnt new. She thinks here of the Jane Elliott clip thats been circulating on social media.

In it, Elliott, a diversity educator, asks a room full of white people in the 1960s to please stand if theyd like to be treated the way Black people are treated. Nobody stands. She asks again. Nobody stands.

Then, she tells the room, That says very plainly that you know whats happening, you know you dont want it for you. I want to know why youre so willing to accept it or to allow it to happen for others.

Decades later, Shoush says more people are starting to understand how the structure of systems be it child apprehension, policing, incarceration or health care impacts individual outcomes, but more is needed.

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We understand that there are deep, deep injustices in our culture, in our society, but we always say that they should somehow pull themselves up, we should pull ourselves up by the bootstraps, not realizing that some people have been resourced from birth, she says.

That myth of individualism has to be shattered across every aspect of our society.

with files from The Canadian Press

The Call Auntie information hotline for Indigenous people is open daily from 4 to 9 p.m. at 437-703-8703. All messages left after hours will be responded to.

2020 Global News, a division of Corus Entertainment Inc.

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Canadian health care isnt immune to racism, experts say. Heres why - Global News

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Prayers Answered – The Herald

Story by Leann BurkePhotos by Marlena Sloss

Early afternoon sunlight shone through the stained glass windows of the new St. Mary Catholic Church building in Ireland as Pat Gress led his mother, the late Rita Gress, through the building she helped plan for and prayed about for decades.

As the pair entered the nave that late May day, Rita looked to the high altar a combination of the high altar and two side altars from the now closed St. Patrick Catholic Church in Corning and teared up.

Duane Gress takes his mother, Rita, on a tour led by his brother, Pat, not pictured, of the new St. Mary Catholic Church in Ireland on May 17. Rita was part of the original long-term planning committee for the new church and Pat was the construction manager. She had leukemia and was able to visit the new church weeks before she died.

Its just fantastic, she said of the whole church. I just cant believe it.

Im glad you like it, Pat said. You were instrumental in getting this thing going.

Pat managed construction on behalf of the church.

The congregation at St. Mary began discussing the possibility of building a new church about 40 years ago. The old building located at 2829 N. 500 W opened in 1905, and at that time, about 45 families attended the church. Today, the church is home to about 1,000 families, many of whom have been members for generations. The Gress family, for example, has been part of the congregation for about a century, and Rita was part of the early discussions about expanding.

When the first long-range planning committee formed in the 1970s, Rita joined and advocated for the construction of a new church building. Ultimately, the committee chose to expand the 1905 building and to begin saving for the construction of a new church down the line.

Then, in the early 2000s, discussion about building a new church picked up again. Rita eagerly took a role on that iteration of the long-range planning committee, as did her son-in-law, Steve Buechler. Steve attended Holy Family Catholic Church in Jasper before he married Ritas daughter, Margaret, and began attending St. Mary.

The 15-person committee spent hours talking to parishioners about what style they wanted the church to have traditional, country Catholic was the consensus and researching architects and designs. Part of their research included a structural study of the 1905 building, which revealed some issues that would have made the cost of remodeling that building about the same as building a new one. That, coupled with the knowledge that a remodel would mean losing that traditional, country look, led the committee to pursue building a new church.

We took a very serious approach, Steve said. We knew we were planning for the next 100 years of our parish.

The new church began to become a reality in 2017 when the parish launched the Building Our Future capital campaign to raise the $6 million needed for the project. As of March, the campaign had raised about $5.6 million.

Construction crews work on the pillars on the top of the new St. Mary Catholic Church in Ireland on Jan. 16. The new church was designed to look as similar as possible to the old church, seen in the background.

According to guidelines from the Catholic Diocese of Evansville, the campaign needed $4.8 million 80% of the total cost to break ground. That threshold was met by 2018, and construction crews broke ground that year. At last, the decades of research and planning were turning into something tangible.

St. Mary parishioners dedicated so many years to planning for their new church that when Evansvilles bishop, Joseph Siegel, dedicated the new building on June 28, he joked in his homily that the parishioners had been dreaming of their new church almost as long as the biblical Jews of Jesus time spent building the temple from which Jesus expelled merchants in the second chapter of The Gospel of John. According to the story which was the Gospel reading for the dedication Mass that biblical temple took 46 years to build.

The years of hard work and planning paid off, however. The final designs for the new church yielded a traditional country church that looks much like the old building, but will fit 700 per mass, with room for additional folding chairs if need be, rather than the 380 the 1905 building housed. It also includes several features the parishioners wanted, including an additional parking lot, a space inside the church building for offices, a cry/bridal room, a covered entrance and a narthex, a large open area before the nave where parishioners can gather before and after church services.

The builders did an amazing job of bringing our vision into reality, Steve said.

The wish list also included refurbishing the original nine stained-glass windows from the 1904 church for use in the new building, and the commissioning of 11 new windows. For that, the parish called on Mominee Studios of Evansville. The original windows were made according to the American Opalescent style following the technique developed by John La Farge, an artist at the forefront of the American Arts and Crafts Movement of the late 1800s, according to the Smithsonian American Art Museum.

When [St. Mary Church] was built in 1904, all the churches were using [that style], said Jules Mominee, owner of Mominee Studios.

To restore the nine old windows, Jules and members of his team spent most of a day carefully removing the century-old, intricately decorated windows some of which consisted of three glass panels and loading them into a truck for transport to the studio in Evansville. There, the team refurbished the windows to make them vibrant again.

Mominee Studios employee Nick Morgan assembles the St. Scholastica stained glass window in Evansville on Oct. 17. Mominee Studios worked on 26 windows for the new church, including designing and building 9 new windows. From the beginning of the design process to the installation of the final window, Mominee Studios spent two years on the project.

The artists also built the 11 new windows at the studio, following techniques almost identical to those used by La Farge in the late 1800s. If a single artist worked on one window from start to finish, Jules said, the process would take two months, but his team of six artists can complete a single window in two weeks, and they always work on groups of windows at the same time to make a project move along quickly.

Like the stained-glass windows, the high altar, too, took a long time to prepare for its place in the new church. Jim Buechlein, owner of Buechleins Kwik Strip & Custom Furniture & Design in Jasper, oversaw the removal of the three altars from St. Patrick in Corning three years ago and refurbished them into the ornate, gothic-style altar that is now the focal point in St. Marys nave.

It was no small task, but Jim who attends Precious Blood Catholic Church in Jasper and has built custom pieces for several local churches, including Precious Blood and St. Ferdinand was confident he could create a beautiful piece for the new church.

The process included sanding down and refinishing the altars before combining the three separate altars into a single high altar. The latter meant rebuilding some of the pieces before painting the entire structure white with milk paint, which is an architectural paint made from the milk protein casein mixed with lime, clay and earth pigments. Its a type of paint common to historic pieces.

All finished, Jim estimates the altar is worth about $1 million. He and his team installed the altar in late May.

It was like a sigh of relief, he said. It felt good to see it sitting in the church.

Jim Buechlein, left, of Buechlein's Kwik Strip & Custom Furniture & Design, hands a piece of the altar to Sam Wagner of Wagner Brothers Construction while they assemble the altar at the new St. Mary Catholic Church in Ireland on May 15. The altar was re-designed from three separate altars from a St. Patrick Parish Church in Corning that closed down.

Tom Wagner and a team of workers helped Jim install the altar. A lifelong member of St. Mary, Tom was excited to see the new church coming together and to be part of it.

It was time, Tom said of building a new church. Its going to be a lot better.

After about two years of construction, the new church building opened to parishioners on Sunday, June 28, with the Rite of Dedication led by Bishop Siegel. The pews filled with mask-clad parishioners who spread throughout the pews to socially distance and eagerly waited to anoint the halls of their new house of worship. Several local priests also attended to celebrate the event with St. Marys Father Joseph Effie Erbacher and the parish.

The dedication kicked off with the handing over of the building when representatives of the architect and general contractor presented plans for the building to Bishop Siegel. Then, Fr. Erbacher opened the doors to the nave, beginning the processional to the altar.

Enter the gates of the Lord with thanksgiving, his courts with songs of praise, Bishop Siegel said as Fr. Erbacher opened the doors.

In addition to the celebration of the eucharist, the dedication Mass also included several steps to consecrate the building and prepare it to house decades of worship. As soon as the bishop reached the altar, he performed the blessing and sprinkling of water where he blessed water before sprinkling it over the parishioners and the walls of the church. During the anointing of the altar and the walls of the church with sacred Chrism a consecrated oil used in certain sacraments the bishop spread Chrism over the Altar of Sacrifice before he and Fr. Erbacher anointed the walls of the church with the oil as well.

Pat participated in the anointing of the altar as one of two parishioners who wiped down the altar after it was anointed.

Im extremely happy to have been part of it. I almost teared up a few times, he said. Seeing people in there and knowing it is the first of hundreds of years of worshippers is an amazing feeling.

The bishop also blessed the altar with incense while deacons carried braziers with incense through the aisles to bless the parishioners and walls as well, and the candles surrounding the altar and throughout the church were lit ceremonially.

Bishop Joseph Siegel spreads holy water on The Altar of Sacrifice during the new St. Mary Catholic Church dedication in Ireland on June 28.

Toward the end of the dedication, Fr. Erbacher addressed his congregation.

It has been three years of faith, dedication and love, and I thank you all very much, he said.

Missing from the pews during the dedication was Rita. Despite the decades of prayer and intentional action she dedicated to making the new church a reality, she was not meant to attend Mass in the new building. She passed away a few weeks prior to the dedication. Her funeral Mass held June 29 was the first Mass Fr. Erbacher led in the new church.

Cindy Gress, Rita Gress' daughter-in-law, touches Rita's casket after speaking during her funeral Mass at the new St. Mary Catholic Church in Ireland on June 29.

The Gress family chose to wait to hold her funeral Mass until after the dedication because of how much the church meant to her and how active shed been in bringing the new building to fruition. In the last days of her life, the idea of having her funeral in the new building brought her peace, said her daughter, Carla Allbright of Mitchell.

Although Pat and the rest of his family had hoped Rita would live to see the new church building open, Rita didnt expect to herself, and she seemed at peace with that knowledge. As her tour of the nearly completed church came to an end that day in May, she looked around the nave with tears of joy in her eyes and a smile on her face.

When its all finished, she said, Ill see it from heaven.

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Prayers Answered - The Herald

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Protein Folding and Evolution: Information, Function and …

The structure/function link for proteins has for a long time served as a convenient paradigm. Increasing evidence suggests however that the order/disorder landscape in proteins is far more complex than hitherto imagined, and is an ongoing product of an exquisitely tuned evolutionary process. Furthermore, the field has been dominated by a restricted mindset resulting in neglected areas and unconventional concepts on the periphery of the main topic that we feel deserve to be addressed. Following on from the introduction of the concept of structural capacity and its inextricable origins in ribosome evolution, we wish to illustrate how transitions involving order/disorder rearrangements are involved not only in the selection of new folds and thus functions, but also play a role in the unavoidably associated increase in dysfunction and disease. The underlying theme will be the emergence of the role of information transfer between the genetic code repository and protein structure/function.

The number of potential protein folds and hence structures is immense. It is a sobering fact that the number of known folds is infinitesimally small compared to those potentially available. Current techniques, strongly influenced by main-stream structural biology approaches such as X-ray crystallography have described few of the protein structures that potentially could exist. The concept of evolutionary selection as an ongoing process, and the acceptance that proteins are dynamic structures lead to a reorganization of how the protein structure/function paradigm is viewed. The immense impact of molecular modelling, powered not only by huge computational capacities but also by machine learning and AI (Artificial Intelligence) algorithms is revolutionizing the whole field.Our aim therefore, is to collate a series of original articles that address the relationship between protein structure and function from both an evolutionary and dynamic point of view. We aim to create a platform for launching new models based on original, innovative ideas or experimental approaches. The final goal is thus to seek and exploit hitherto unexplored facets of protein structure/function with the practical aim of facilitating protein engineering and expanding our knowledge of the origins and direction of life processes, with important impact on health issues.

Within the broad scope of protein evolution, we are seeking contributions on the following topics although this list is neither exhaustive nor exclusive:

The evolution of protein folds and function;The role of order disorder transitions in protein evolution;The consequences of ribosomal evolution;Information theory, protein structure/function and evolution;Evolution, protein folding and disease;The inevitable link between evolved function and disease;The evolution of information transfer: from the genetic code to protein structure;Moonlighting proteins: disorder and order in multi-functional proteins;Protein Engineering and design: how to harness disorder?

Articles may be either data based novel observations, innovative technologies which grant new insights into protein dynamics or theoretical approaches that provide new testable models. We will be particularly attentive to fringe ideas independent of how unconventional they may be and welcome contributions from young unestablished scientists.

Dr. Ashley Buckle is founder of the structural biology and protein engineering company PTNG Consulting, and holds patents in the field. All other Topic Editors declare no competing interests.

Keywords:protein evolution, protein folding, protein engineering, intrinsically disordered proteins, protein folding evolution and disease

Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

The structure/function link for proteins has for a long time served as a convenient paradigm. Increasing evidence suggests however that the order/disorder landscape in proteins is far more complex than hitherto imagined, and is an ongoing product of an exquisitely tuned evolutionary process. Furthermore, the field has been dominated by a restricted mindset resulting in neglected areas and unconventional concepts on the periphery of the main topic that we feel deserve to be addressed. Following on from the introduction of the concept of structural capacity and its inextricable origins in ribosome evolution, we wish to illustrate how transitions involving order/disorder rearrangements are involved not only in the selection of new folds and thus functions, but also play a role in the unavoidably associated increase in dysfunction and disease. The underlying theme will be the emergence of the role of information transfer between the genetic code repository and protein structure/function.

The number of potential protein folds and hence structures is immense. It is a sobering fact that the number of known folds is infinitesimally small compared to those potentially available. Current techniques, strongly influenced by main-stream structural biology approaches such as X-ray crystallography have described few of the protein structures that potentially could exist. The concept of evolutionary selection as an ongoing process, and the acceptance that proteins are dynamic structures lead to a reorganization of how the protein structure/function paradigm is viewed. The immense impact of molecular modelling, powered not only by huge computational capacities but also by machine learning and AI (Artificial Intelligence) algorithms is revolutionizing the whole field.Our aim therefore, is to collate a series of original articles that address the relationship between protein structure and function from both an evolutionary and dynamic point of view. We aim to create a platform for launching new models based on original, innovative ideas or experimental approaches. The final goal is thus to seek and exploit hitherto unexplored facets of protein structure/function with the practical aim of facilitating protein engineering and expanding our knowledge of the origins and direction of life processes, with important impact on health issues.

Within the broad scope of protein evolution, we are seeking contributions on the following topics although this list is neither exhaustive nor exclusive:

The evolution of protein folds and function;The role of order disorder transitions in protein evolution;The consequences of ribosomal evolution;Information theory, protein structure/function and evolution;Evolution, protein folding and disease;The inevitable link between evolved function and disease;The evolution of information transfer: from the genetic code to protein structure;Moonlighting proteins: disorder and order in multi-functional proteins;Protein Engineering and design: how to harness disorder?

Articles may be either data based novel observations, innovative technologies which grant new insights into protein dynamics or theoretical approaches that provide new testable models. We will be particularly attentive to fringe ideas independent of how unconventional they may be and welcome contributions from young unestablished scientists.

Dr. Ashley Buckle is founder of the structural biology and protein engineering company PTNG Consulting, and holds patents in the field. All other Topic Editors declare no competing interests.

Keywords:protein evolution, protein folding, protein engineering, intrinsically disordered proteins, protein folding evolution and disease

Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Protein Folding and Evolution: Information, Function and ...

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