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How low T increase risk of severe COVID-19 in men – The Southern Maryland Chronicle

Research recently conducted connects diminished blood concentrations of testosterone in men with more severe presentations of COVID-19.

This data completely debunks popularly brandished myths and presumptions suggesting that higher testosterone levels explained why men stood at greater risk of developing severer cases of the illness than their female counterparts.

That said, as the pandemic has progressed, data put forth by healthcare providers has concluded that men seem to develop worse cases than women.

One initial theory supporting the hypothesis that hormonal differences seen in the genders might make men more vulnerable to the pathogens most serious impacts. Researchers continued to suggest that testosterone correlates with aggressive behavior, as mens bodies contain much more testosterone than women. Early speculation centered around such factoids being the reason men seemed to fare worse.

However, newer findings might suggest that, in actuality, the opposite is true. That said, this research didnt provide any data unequivocally linking low T levels to serious cases of the COVID-19. Researchers emphasize that such outcomes could be related to other underlying factors.

That said, these same medical professionals strongly caution the efficacy and safety of clinical trials of drugs used to lower testosterone or heighten estrogen levels as therapeutic protocols for men diagnosed with COVID-19.

In a fresh study Association of Circulating Sex Hormones With Inflammation and Disease Severity in Patients With COVID-19, doctor Abhinav Diwan, who also serves as a professor of medicine at Saint Louiss Washington University School of Medicine, said that the pandemic has created a prevailing belief amongst medical community members that testosterone fuels COVIDs fire.

The physician continued that the reality is quite the opposite. On average, men who possessed diminished systemic concentrations of testosterone upon entering the hospital actually had a higher risk of developing severe COVID-related manifestations or even death than men with higher internal levels of the hormone.

Moreover, researchers found that, if men with already low testosterone levels experienced further systemic declines, their risk for significant complications rose even greater.

Study overseers examined the blood samples of 90 men and 62 women who visited the Barnes-Jewish Hospital presenting with confirmed cases. Of the 143 patients ultimately admitted, researchers again sampled their blood after 3, 7, 14, and 28 days. In addition to testosterone, researchers measured systemic levels of several other notable hormones.

Examiners found that, in women, no appreciable links between hormonal levels and disease severity could be found. Amongst men, no other substances but testosterone revealed any notable findings.

Blood concentrations of testosterone are considered low if the numbers fall below 250 nanograms per deciliter. At admission, men with serious COVID-19 presentations averaged readings of 53 nanograms per deciliter. However, men with milder cases averaged 153 nanograms per deciliter.

Moreover, the results produced by the sickest subjects continued to decline as time progressed. By their third day in the hospital, readings dropped to an average of 19 nanograms per deciliter.

Researchers emphasize that other factors are known to induce more severe illness. Such as high blood pressure, diabetes, older age, and obesity are also connected to low testosterone.

Also, they discovered that men with low T who were not terribly ill at first were more likely to require placement in intensive care or intubation in the immediate days that followed.

Such data, inspired endocrinologist and study author, Dr. Sandeep Dhindsa to confidently opine that lower T levels seemed to be a significant predicting factor in which patients would grow significantly ill.

Additionally, this team of researchers is examining if these findings might suggest links between reproductive hormones and post-Covid cardiovascular concerns. Diwan, who is a cardiologist by trade, opined that when symptoms lingered on for months after initial infection, such issues could arise.

The doctor also stated that men stricken with severe cases or lingering manifestations might benefit from testosterone therapy. For some time, this therapeutic protocol has been employed as a treatment for men coping with low T levels and experiencing the physical and emotional symptoms of said occurrence.

The study was conducted in collaboration with Washington Universitys biorepository and the academic institutions Institute of Clinical and Translational Sciences.

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Longevity and Anti-Senescence Therapy Market 2021 Size, Status and Global Outlook Acorda Therapeutics, Calico Life Sciences, Human Longevity Inc.,…

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First AMR Preparedness Index finds UK, US top charts amid first world failures to address antimicrobial resistance threat – Homeland Preparedness News


A new report from the Global Coalition on Aging (GCOA) and the Infectious Diseases Society of America (IDSA), a first of its kind known as the AMR Preparedness Index, provides an evaluation and roadmap for the 11 largest global economies and their efforts to tackle rising cases of antimicrobial resistance.

While recognition of the threat has risen, according to the organizations, there has been a broad failure to match public promises and actual actions to avert a crisis. The U.K. and the United States have fared best along with Brazil, Canada, China, France, Germany, India, Italy, Japan, and South Korea. Case studies were presented from Australia, Kenya, Russia, Saudi Arabia, and Sweden as well.

Increasing resistance to life-saving antimicrobials, together with our broken innovation pipeline, threatens to erode the very foundation of modern medicine and, with it, erase one of the principal achievements of the 20th century the miracle of human longevity, Michael Hodin, CEO of the GCOA, said. As the United Nations (UN) and World Health Organization (WHO) Decade of Healthy Ageing brings greater attention and energy to our remarkable demographic achievement and the COVID-19 experience make clear the compounded risk to older adults from infectious disease, we must fully acknowledge the threat that AMR poses to the very prospect of healthy and active aging. Without true action to effectively address AMR, tens of millions of lives both young and old will be cut short, and so many others will be diminished as a result of care foregone over concerns about now untreatable infection.

It is estimated that 700,000 people die each year from drug-resistant infections, and those figures are expected to grow as the problem worsens. Resistance is increasing to existing drugs, increasing the risk of even routine medical care.

If unaddressed, the continued rise of AMR is expected to lead to as many as 10 million deaths per year, disability and lower quality of life for millions more, and $100 trillion in lost GDP by 2050, the organizations said in a statement.

Countries were ranked based on seven categories. The results led the GCOA and IDSA to recommend several means of bolstering government action, as well, including:

The COVID-19 pandemic has made painfully clear to all the far-reaching impact of untreatable infectious diseases across societies and economies, Dr. Barbara Alexander, IDSA president, said. As we enter the next stage of the pandemic and with global momentum for AMR action building among G7 countries in the UK with the launch of the subscription pilot, and most recently, with the reintroduction of the PASTEUR Act in the US Congress the 2021 AMR Preparedness Index comes at a pivotal moment. We are pleased to partner with the Global Coalition on Aging to create this vital tool that will help governments around the world reinforce their words with actions.

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What if marmosets lived on the Moon? – The Economist

Jul 3rd 2021


Editors note: This year What If?, our annual collection of scenarios, considers the future of health. Each of these stories is ction, but grounded in historical fact, current speculation and real science. They do not present a unied narrative but are set in dierent possible futures

THEY CAN, at times, look somewhat sinister, their faces oddly small for their heads, their white ear tufts jutting out almost aggressively. Their ability to throw themselves at people across seemingly unfeasible distances can be unsettling, and their buzzing and shrieking takes a lot of getting used to, as does their smell. But the members of the Caird collective will not hear a word spoken against the marmosets with whom they share their spaces at the Moons South Pole. As they sit in their insulated caves hoovering moondust out of the animals tails, few of the Cairders can imagine their life on the rim of Shackleton crater without themand none wants to. The marmosets of the Moon are the first and best example of what has turned out to be a fundamental fact of space flight: that the further humans get from Earth, the more they benefit from the companionship of other Earthly animals.

The marmosets were originally brought to the Moon as unwilling participants in a vital research project. Marmosets are lighteven under Earth gravityand reasonably easy to care for, but they have placentas much more like those of humans than any other animal their size, and reasonably short gestation periods. That made them ideal for looking at a fundamental question: can humans have healthy pregnancies in the low gravity of the Moon, where things weigh only one-sixth what they do on Earth?

In the 2020s and 2030s, the years of what the novelist Wil McCarthy called the Rich Mans Sky, questions of obstetrics and gynaecology received remarkably little attention. For many, the idea of staying in space long enough for such things to matter made little sensespace stations in Earth orbit and bases on the Moon were places for fixed-length work contracts and research sojourns, or for tourism. Babies were no more of an issue than they were in isolated 20th-century Antarctic research outposts.

There were, as it happens, a few babies born in Antarctica even back then, when its ice cover was all but intact. The Argentine and Chilean governments both saw the creation of natives on the continent as a way to establish sovereignty and arranged births to that end. But there was no reason to think that Antarctica was inimical to pregnancy and infancy. The long-term health effects of low gravity and microgravitywhich for those in orbit include brittle bones, muscle wasting and eye diseasewere something else. Adults could counter some of these effects with treadmills and tension cords. But as the title of an early paper on the subject succinctly put it, The fetus cannot exercise like an astronaut.

Even those, like Elon Musk, who talked of permanent settlements on Mars spent little time working on the question. It was left to a small team of scientists in the Japanese modules of the Artemis base founded in 2029 by America and its allies to explore the question experimentally with the help of marmosets, gene-splicing technology, intra-uterine monitoring devices and a giant centrifuge.

They had some success. Like human fetuses, marmoset fetuses spend most of their gestation with a density equal to that of the amniotic fluid around them, a neutral buoyancy that leaves them indifferent to local gravity; only relatively late on do differences due to gravity start to crop up. After a few years of trial and error, and some dainty gene-editing to rebalance the rate at which bones grow when not stressed through use, the researchers developed a regime involving hormone treatments for the mothers and regular late-pregnancy sessions in their custom-made room-sized centrifuge, known as the marmo-go-round. This reliably produced pups with strong-enough bones and muscles and little by way of deformity, though their tails were impressively long even by marmoset standards.

Unfortunately, in 2038 that research was interrupted by the geopolitical meltdown of the wolf-and-wimp war and then by the 26 months of the Great Grounding. With all powered flight within or through the Earths atmosphere prohibited, the various Moon bases seemed doomed even after they agreed to pool their resources to create what became known as the Polynational James Caird Collective. With all the groups biotech know-how turned to increasing food production and nutrient recycling, the marmosets were at first ignored and then freed to roam within the bases. Their effect on morale was instantaneous and profound.

The importance of companion animals to the mental health of people engaged in a homeless lifestyle was well documented in pre-war societies. It has been suggested that the effect of the marmosets on the Caird collective was similar; cut off from Earth, the humans were more homeless than any group of people had ever been before. Caring for, playing with and grooming marmosets also became a basis for bonding between humans, many of whom had not known each other before the Grounding, and some of whose countries had been adversaries in the war. By the time the mysterious entity responsible for the Great Grounding finally abandoned its control of the Earths air-traffic-control and missile-defence systems, allowing traffic with the Moon to resume, the marmosets had become an indispensable part of the settlers new identity and society. Few believe that a lack of companion animals was, in itself, the reason that the Mars base failed during the Grounding. But it surely did not help.

The bond between the Moons larger and smaller primates persisted even as the rigours of separation came to an end. Almost all Cairders still dislike spending any significant time deprived of marmoset company. They cuddle them and relish their low-gravity acrobatics. In a joking way that seems, at some level, not to be a joke, they treat the abnormally long tails of the Moon-born marmosets as a sign of providence, holding the tail-fur to be particularly good at picking up moondust. The dust, which can cause lung disease, infiltrates their habitats despite all the airlock precautions; its suppression is a constant battle. Whether hoovering it out of tails which accumulate it in the manner of a feather duster is in fact more effective than the settlements electrostatic air-filtration systems is open to question. But it is clearly more therapeutic. And the marmosets enjoy the attention.

The oldest Earth-born marmoset, New Mrs Chippy (who is, despite his name, male) enjoys an honorary seat on the collectives council. He has now reached the age of 31 with no obvious signs of ageing other than a pelt almost as white as his ear tufts. This is seen as a good omen for human longevity among those Cairders who refuse to countenance a return to Earth. In Japan, by contrast, laboratory marmosets rarely make it past their 21st birthday.

The most salient biological, as opposed to sociological, novelty among Moon-born marmosets is a very high prevalence of adolescent-onset blindness. The constellation of eyesight problems known as Spaceflight Associated Neuro-ocular Syndrome (SANS) has been studied since early this century. In adult humans SANS normally develops only during long stays in the microgravity conditions of space stations; it is rare and mild among humans on the Moon. But in marmosets born in low gravity it develops swiftly and severely at the onset of puberty and leads to almost complete loss of vision.

There is as yet no agreed explanation for this pathology. Some researchers believe it is not in fact gravity-related but the result of an off-target effect of the gene editing which realigned the calcium pathways used in bone growth, but it is hard to square this with the similarity to SANS as experienced by genotypical adult humans. Others think its onset could be avoided if newborn pups were required to spend more, or all, of their time in the simulated Earth-normal gravity of the centrifuge. But it has proved hard to test this hypothesis. Infants that have spent any time at all in lunar gravity are greatly distressed by the rigours of the centrifuge and will not suckle when put into it. And Cairders are unanimous in their opposition to anything that causes marmosets distress.

The blind marmosets are not badly off. Their sibling groups and human companions provide what little practical support they need. And they are happier than sighted marmosets to travel in the pouches which many Cairders have incorporated into the suits they use for working on the lunar surface. Sighted marmosets are clearly disturbed by the harsh monochrome landscape, even when emotionally supported with the amplified sound of their companions heartbeat.

Sudden-onset SANS leaves the question of whether human children can be born and raised on the Moon unanswered. It is sometimes suggested that a blind woman happy with the idea of a child who might also be blind could choose to join the collective and explore the issue. But bringing a child to term would require a centrifuge capable of holding a grown human, rather than a 250-gram marmoset. There is no appetite among Cairders for devoting resources to such a project, and their juche ethic of self-sufficiency will not let them accept funding for such experiments from Earth. Thus how well humans may eventually be able to breed on alien worlds remains unknown, even today.

That they will take animal companions with them, though, now seems certain. And some of those companions will surely have shocking-white ear tufts, odd little faces and very long tails.

Full contents of this What If?Freedom to tinker, October 2029: What if biohackers injected themselves with mRNA?The other epidemic, June 2025: What if America tackled its opioid crisis?A tale of two cities, June 2041: What if a deadly heat wave hit India?You are what you eat, January 2035: What if everyones nutrition was personalised?iHealthy, September 2028: What if smartphones become personal health assistants?Mrs Chippys benediction, February 2055: What if marmosets lived on the Moon?*Novel treatments, August 2050: What if dementia was preventable and treatable?Rage against the machine, December 2036: What if an AI wins the Nobel prize for medicine?Germ of an idea: What if germ theory had caught on sooner?

This article appeared in the What If? section of the print edition under the headline "Mrs Chippys benediction"

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What if marmosets lived on the Moon? - The Economist

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Quote Of The Week: Zach Bush MD On World Microbiome Day – Longevity LIVE – Longevity LIVE

Zach Bush MD, is an internationally recognized educator and thought leader on the microbiome as it relates to health, disease, and food systems. Celebrating World Microbiome Day on 27th June 2021, he explained why theres no better time to pay tribute to the microbiome.

As human beings, our neurologic capacity begins with our connection to the microbiome Zach Bush MD

In his latest weekly newsletter, Bush said, It is, in its entirety, vital to life and the reason why we are here today. Without the microbiome, life on Earth would not exist.

At its most basic definition, micro means small, and biome means living creatures essentially all of the living microbes on and inside the human body. Today, we know human cells are not at the foundation of the human microbiome, but rather its the fungi and bacteria that are. It is estimated that we have 50 to 70 trillion human cells, which pale in comparison to the 1.4 quadrillion bacteria and 10 quadrillion fungi inside our bodies.

He explained further that as we learn more about the microbiome and our human biology, its clear that this diverse non-human micro ecosystem is what makes life possible. Its what fuels our development, immunity, and nutrition, enabling our production of energy, micronutrients, and regenerative pathways. Within every organ system throughout our whole body, its this unique niche of bacteria, fungi, and yeast that nurture our human cells.

Get out! Kick off the shoes, walk in a garden, on a forest path, a beach, a meadow, or a mountain top. Zach Bush, MD

World Microbiome Day was celebrated on the 27th June. You can read more about it here: #microbiome4life

Zach Bush MD is a physician specializing in internal medicine, endocrinology and hospice care. He is an internationally recognized educator and thought leader on the microbiome as it relates to health, disease, and food systems. Dr Zach founded *Seraphic Group and the nonprofit Farmers Footprint to develop root-cause solutions for human and ecological health. His passion for education reaches across many disciplines, including topics such as the role of soil and water ecosystems in human genomics, immunity, and gut/brain health. His education has highlighted the need for a radical departure from chemical farming and pharmacy, and his ongoing efforts are providing a path for consumers, farmers, and mega-industries to work together for a healthy future for people and planet.

Quote Of The Week: Zach Bush MD On World Microbiome Day - Longevity LIVE - Longevity LIVE

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Where Is the Endgame in Chess Experts’ Visual Memory Abilities? – University of Texas at Dallas

Chess experts are known for their remarkable ability to recall configurations of chess pieces on a board. For decades, neurological experts have investigated how this memory functions and whether it can be applied to information beyond the gameboard.

To further probe this topic, researchers from The University of Texas at Dallas Center for Vital Longevity (CVL) turned to the UTDallas chess team. Since the chess programs inception in 1996, 24 Grandmasters and International Masters have played for the UTDallas team, which has competed in the Presidents Cup known as the Final Four of College Chess in 17 of the last 21 seasons.

Dr. Chandramallika Basak

The researchers tested 14 chess team members, along with 15 chess novices, on rapid-fire processing of visuospatial information in working memory.

Their findings, published June 14 in Memory and Cognition, help pinpoint the strengths and limitations of the subjects recall framework and how that framework can be applied to human cognition in general.

Prior studies have shown that chess experts advantage in visual memory is limited to chess pieces on chess boards, said corresponding author Dr. Chandramallika Basak, associate professor of psychology in the School of Behavioral and Brain Sciences. We wanted to see whether the expertise generalizes beyond chess pieces to unfamiliar, new stimuli, and where does this expertise break down for immediate memory.

Chess masters visual short-term memory for arrangements that can occur in chess has been of particular interest to cognitive scientists, said Basak, director of the Lifespan Neuroscience and Cognition Laboratory.

Its almost like chess experts have snapshots of these positions they demonstrate remarkable visuospatial working memory, given that the information is presented for less than half a second, she said. But is it driven by the visual aspects or spatial aspects of what they saw? Or a combination of both?

Evan T. Smith, a UTDallas cognition and neuroscience doctoral student, is the papers lead author. He described the difference between working and long-term memory as analogous to the gap between whats on top of your desk and whats filed away in a cabinet.

Evan T. Smith

The existing theory is that chess players have so thoroughly memorized and categorized board configurations that their long-term memory for this information functions like working memory, he said.

The researchers collaborated with Jim Stallings, director of the UTDallas chess program, to bring test subjects on board from the team.

Dr. Basaks study varies from other chess studies done with youngsters, Stallings said. This study goes directly to chess expertise and working memory. I look forward to sharing the results with the chess community.

The control group included UTDallas students of similar age and education level to the chess players who had never formally learned how to play chess.

In each test, participants saw a two-dimensional chessboard with a number of pieces displayed for three-tenths of a second. After a one-second pause, they saw a second chessboard and had to decide if there had been a change.

The tests were conducted with standard chess pieces and with novel, unfamiliar symbols. Basak said that this switch helped to determine if the chess players memory abilities were domain specific to chess or domain general to a wider range of objects.

One series of tests asks about changes in location; the second asks if the objects the pieces themselves have changed, Basak said. A third test incorporates changes in location or changes in object, or both, or no change at all. Finally, the grid of the board is removed.

The researchers found that while both chess experts and novices performed better with chess stimuli than with the unfamiliar symbols, the experts, for the most part, outperformed the control group for both chess stimuli and for the new objects particularly when detecting positional changes.

Section A of this figure from the Memory and Cognition article shows how each trial works: An initial configuration appears for three-tenths of a second, followed by a one-second pause. The three different trial types then could change an objects identity, location, or both. Section B shows the chess stimuli and novel stimuli used. Section C shows a trial with the grid removed.

When changing the identity of the objects, however, but not location, the chess players advantage was limited to the chess pieces. They performed no better than the control group at remembering when the identity of the novel symbols changed.

You would expect that this advantage that chess players have is related to a familiarity with the chess pieces or the chess players expectation of what they are about to see, Basak said. But results from our study say otherwise. It seems like the chess players can rapidly process a chessboard-like layout in a very holistic manner, like the brain does with faces. The next step in our research may be to do a functional MRI study to see if the face-processing regions of the brain are also used for chess.

The experiments also were split into tests using fewer than four pieces which is within the normal limits of an average persons focus of attention and five to eight pieces. With the larger number of pieces, long-term memory should come into play. The chess experts performed better than the controls in the tests with more pieces.

We observed an eight-item working-memory capacity for chess experts, Basak said. We assume that ties back to the idea that chess players are viewing the board and the set of positions as a single object, as they would recognize a face.

The grid-versus-no-grid portion of the study something that Basak said has not been examined before produced some of the more striking results.

The grid is the linchpin that supports the scaffolding of this memory structure, Smith said.

Basak added: Any expertise-related advantage disappeared in the absence of the chessboard display. It appears to be essential, acting as a road map, a familiar framework to aid the memory.

Collectively, the results indicate that visuospatial memory advantages associated with chess expertise extend beyond chess stimuli in certain circumstances, particularly to position changes with between five to eight items. But the grid appears to be necessary for experts to leverage these advantages.

We cannot generalize our findings beyond what we tested, so we cannot claim, based on our data, that chess experts will be better at studying for school, Basak said. But their advantage does go beyond chess pieces, provided the grid remains. We believe this indicates that experts are automatically encoding spatial-relational information.

Other contributors to the research were Dr. Daniel Krawczyk, UT Dallas professor of psychology, holder of the Debbie and Jim Francis Chair in Behavioral and Brain Sciences, deputy director of the Center for BrainHealth and associate professor of psychiatry at UT Southwestern Medical Center; and Dr. James Bartlett, a distinguished scholar in cognitive neuroscience and cognitive psychology and a longtime UTDallas faculty member who played a key role in the beginning of the project. Bartlett died in 2019.

Jim Bartlett played a big role in designing the experiments and in bringing Jim Stallings and the chess team on board, Basak said. He was a mentor, friend and valued collaborator, and we dedicate this publication in honor of his memory.

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Nagy: The president and the tsar –

TIBOR NAGY| Lubbock Avalanche-Journal

Churchill had some brilliant quotes, but his most famous one about Russia a riddle wrapped in a mystery inside an enigma. -- is wrong. Russias self-identified role in the world hasnt been a mystery since Napoleons wars, maybe even earlier: to protect its heartland by extending its control and influence as far as possible in every direction, and to perpetuate the privileges of its ruling class thru all possible means.

Through expansion under a succession of Tsars and Commissars the Russian landmass now covers 11 time zones and exerts influence much farther. While Russias vastness and bitter winters consistently defeated a series of enemies who had no problems overrunning the rest of Europe, its leaders have been less consistent in their capabilities. But its current tsar, President Vladimir Putin, is also one of its ablest understanding fully how to maximize Russias weakened global position. With the end of the Soviet Union in 1991, Russia lost about 25% of its territory, and as recently as 2009 was characterized as Burkina Faso with nuclear arms (meaning its economy relied on the export of natural resources).

But while Putin may be holding a pair of tens, hes playing them like a full house. Added to his mastery of history and geopolitics is his expertise in human behavior gleaned from decades of KGB tradecraft which makes him doubly dangerous as an adversary. He has a near perfect record of opportunistic timing on when/how to strike with calculated impunity: seizing Crimea, saving Assad in Syria, sending combat volunteers into eastern Ukraine, manipulating Western Europe to embrace his Nordstream II natural gas pipeline, winking at cybercriminals who inflict major damage on U.S. infrastructure and morale, and poisoning political opponents when he cant simply arrest and torture them.

But for once, going into a summit with a Russian leader, the U.S. side was represented by a president who himself has long political experience and doesnt suffer from naivete or geopolitical ignorance. The U.S. track record in these meetings has been poor: e.g. Roosevelt giving away Eastern Europe to Stalin and Kennedy coming off so weak to Khrushchev that the Soviets were emboldened to move nuclear missiles to Cuba. (Reagan being an exception who more than held his own against Gorbachev.) There will be thousands of words written analyzing the Biden/Putin Summit, but they matter little. What counts is what measure Putin took away from their meeting because that will determine how Putin will play his pair of tens during Bidens presidency.

Putin will stay as he has - searching for and exploiting whatever weaknesses he detects in the US leadership or the western alliance. He will use every geopolitical weapon he believes he can get away with, pursue the Big Lie as effectively as any Soviet leader ever did, neutralize his opponents with whatever means work, and continue to allow his cronies to amass immense wealth at the expense of his people. Russia is neither a mystery, riddle nor enigma. Russia will simply continue its centuries-long policy of opportunistically and brutally assuring its place in the world and the longevity of its ruling class.

Ambassador Tibor Nagy was most recently Assistant Secretary of State for Africa after serving as Texas Techs Vice Provost for International Affairs and a 30-year career as a US Diplomat.

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Anti-Aging Medicine Market Trends Analysis Report By Product, Competitive Landscape And Growth Forecast 2021-2027 The Manomet Current – The Manomet…

Anti-Aging Medicine Market report highly exhibit on current market analysis scenario, upcoming as well as future opportunities, revenue growth, pricing and profitability.

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Note: Report Covers the Detailed Pre and Post COVID-19 Impact Analysis on Anti-Aging Medicine Market

Anti-Aging Medicine Market Forecast:

Following the pandemic, the market is estimated to rebound from 2021 to 2027 during the forecast period; the Anti-Aging Medicine market is expected to grow at an impressive CAGR of XX %. The market size for three different scenarios will be included in the global forecast: pessimistic, most likely, and optimistic. The case study will aid stakeholders and market participants in budgeting and planning market investment for the short- to medium-term strategy period.

EFFECT OF COVID-19 on Anti-Aging Medicine Market

Covid-19 has influenced every organization and impacted the market dynamics, competition, and global supply chains. The revenues have gone down in 2020 drastically and may resume an uptrend gradually form 2021. The year, 2021 is probably going to be superior to 2020 for the Anti-Aging Medicine market players as the greater part of the organizations have continued their activities and the interest is getting re-established for them.

Some Major 10+ Key players in the Anti-Aging Medicine market:

This research report provides company profiles of top 10+ companies that are active in the market. Alongside, we can also provide you a study on companies that fall within your arena of peers. A specialized study of such companies can offer your deep insights to deal with competition prevailing in the market and gain maximum possible profits from the market.



LG Life Science

Merz Pharma




Haohai Bio

Daewoong Pharmaceutical


Suneva Medical

SciVision Biotech

Anti-Aging Medicine Market Research Report by Application, by Type, by End-Use Industry, by Region Global Forecast to 2027 Cumulative Impact of COVID-19:

Sneak peek (Segmentation) into the Report:

Research report reviews Anti-Aging Medicine Market Report volume in recent years. The report also emphasizes the major restraints and drivers determining the growth of the market. Reports also highlight market factors like latest trends and opportunities. The report provides a detailed analysis of current and future market trends to identify the investment opportunities. Also the restraining factors coupled with the challenges being faced by the market players are included within the Anti-Aging Medicine market report.

By Segments

By Type,

Dermal Fillers

Botulinum Toxin


By Application,

Hospital Pharmacies

Retail Pharmacies


Drug Stores

This report provides market intelligence most comprehensively. The report structure has been kept such that it offers maximum business value. It provides critical insights into the market dynamics and will enable strategic decision-making for the existing market players as well as those willing to enter the market.

Geographical Analysis:

The expansion of the Anti-Aging Medicine market is largely due to enlarged adoption of Industry. Among further regions, North America is expected to be the determined profitable region in the world. Furthermore, the Anti-Aging Medicine market is increasing due to growing awareness of technology in the countries, such as India and China, of Asia-Pacific region.

By Region:

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Anti-Aging Medicine Market Trends Analysis Report By Product, Competitive Landscape And Growth Forecast 2021-2027 The Manomet Current - The Manomet...

Recommendation and review posted by Alexandra Lee Anderson

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Discontinuing Metformin: The Crowdsourced View – Medscape

Recently I posed a question about a patient, drawn from my own practice: Is It the Right Time to Deprescribe This Frail Patient's Metformin?

My patient was an 81-year-old woman with type 2 diabetes of 20 years' duration, chronic kidney disease, obesity, and mild dementia. Her family hoped to reduce the number of medications she was taking, one of which was metformin. I decided that we could accept a less stringent A1c goal, so I discontinued her metformin and monitored her glycemic control.

Thank you for the lively discussion and strong ideas regarding the care of this patient. In a case without a clear correct response to the options (continue metformin, discontinue metformin, reduce the dose, or switch to an SGLT2 inhibitor), readers' opinions were decidedly split on the best course of action.

The most common solution was a compromise: Continue metformin, but with the once-daily, extended-release form. This would reduce her pill count and the burden on the patient and her family for medication adherence. Some evidence suggests that this intervention can be effective. In a meta-analysis of 51 studies, there was a gradual reduction in medication use with each additional daily dose. The difference in medication use comparing once-daily and twice-daily regimens was -6.7%. This result was statistically significant but not highly impactful clinically. However, there was a 13.1% difference favoring once-daily dosing vs twice-daily dosing in terms of overall regimen adherence.

Another lesson I take from the advice to reduce her dosing frequency is to think outside the managed care formulary. Our managed care plans for Medicaid and Medicare do not cover extended-release metformin, so I did not even consider this option.

A couple of readers mentioned another possible reason to continue metformin for this patient: as a potential anti-aging medication. There is evidence that metformin has activity on the 5'-AMP-activated protein kinase pathway, where it can help reduce inflammation and cellular stress. Metformin supplementation in middle-aged mice was associated with a 5.8% increase in lifespan. The UK Prospective Diabetes Study found a cardiovascular benefit associated with long-term metformin use among adults with diabetes, but meta-analyses have failed to find a benefit associated with cancer for metformin. Overall, there is not enough current evidence to recommend metformin as an anti-aging medicine, but two trials are underway evaluating the effects of metformin among adults without diabetes.

Finally, it is worth considering the point of deprescribing. Patients should not feel abandoned or that they are not worthy of certain treatments. The values and preferences of patients and their supporters are highly important in the decision to discontinue chronic medications. But it is the clinician's duty to bear these things in mind:

Polypharmacy is common among older adults, and it is associated with a higher risk for gait decline and falls. This is true even after adjusting for confounding by indication.

There are many chronic medications which are unproven among older adults. More research is necessary in this area, particularly as the population as a whole ages.

There was more than one correct answer to this clinical scenario. However, a dogmatic approach that is not patient- (and family-) centered can do more than damage the relationship between clinician and patient. It can result in more loss to follow-up, less preventive care, and higher rates of morbidity and mortality.

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Discontinuing Metformin: The Crowdsourced View - Medscape

Recommendation and review posted by Alexandra Lee Anderson

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The Recovery Room: News beyond the pandemic June 25 – Medical News Today

The coronavirus pandemic has dominated the headlines and our daily lives for more than a year. Medical News Today has covered this fast-moving, complex story with live updates on the latest news, interviews with experts, and an ongoing investigation into the deep racial disparities that COVID-19 has helped unmask.

However, this has not stopped us from publishing hundreds of fascinating stories on a myriad of other topics.

This week, we begin with news of whats exciting researchers working on dementia. We spoke to six experts who discuss the latest work to improve the quality of life of people with the condition, find new targets for treatment, and monitor the risk of dementia in former sports players.

We also offer the latest in our Medical Myths series, this time tackling 11 common misconceptions about migraine, and coverage of a study revealing the hazards of wearing fashionably pointy footwear in Medieval England.

Next, we delve into how the biology of naked mole rats allows them to resist aging and cancer and live for decades. Its all in their genes, of course. Next up is an examination of the multifaceted role of omega-3 fatty acids in cancer and depression. Finally, we close out the week by exploring the benefits of going for a walk after eating its good news for those who make the effort.

We highlight this research below, along with several other recent stories that you may have missed amid all the COVID-19 fervor.

How far are we from finding effective treatments for dementia? MNT quizzed six experts about the research they find most exciting and shared their responses as part of a Special Feature.

One fertile area of research is how we might improve quality of life for people with dementia. Maintaining familiar routines, sensations, and personal possessions appears to be important. We also report on the recent discovery that decreased blood flow to the brain can precede cognitive decline by years and could actually cause dementia. This spurred research into the precise role of blood supply in neurodegenerative diseases, and the reason why a failing memory may be one of the earliest signs of dementia.

Learn more about the latest dementia research.

June is National Migraine and Headache Awareness Month, so this weeks edition of Medical Myths tackles some misconceptions about migraine.

How serious are migraine headaches or episodes? Are they simply a kind of headache? Do special migraine diets help? What about supplements? Does caffeine cause migraine? We tackled each question in turn with the help of three experts. We also look at how prevalent the condition is in the United States and worldwide.

Though there is no cure for migraine yet, research into the condition is ongoing, and new treatment options, including smartphone apps, are emerging.

Learn more about migraine.

This week, we reported on a claim that a penchant for pointy shoes among the well-heeled of Medieval England may have spurred an increase in bunions.

Archaeologists at the University of Cambridge in the United Kingdom examined skeletons dating from the Middle Ages. They found evidence that bunions were significantly more common in the 14th15th centuries than in the 11th13th centuries. They were also more prevalent in affluent areas.

For more on this fascinating insight into life in Medieval England, and the health problems affecting the most affluent and privileged people of the time, jump to the article via the link below.

Learn more.

Naked mole rats are of great interest to scientists, as they live for over 30 years and are apparently immune to aging. Very few, if any, of these rodents have been found to have cancer, while theyre also highly resistant to some types of pain. They can also survive for up to 18 minutes without oxygen, making them extraordinarily resilient little creatures. As such, researchers are working hard to unravel the secrets of their anti-aging abilities.

A recent study, covered by MNT this week, focuses on the adaptations that protect the genome in naked mole rats. It appears that they are not only able to correct mutations in their DNA, they also benefit from an extra copy of a gene that protects their DNA from damage in the first place.

Learn more about naked mole rats.

One of our most popular articles this week reported on a study revealing how the brains of people with Alzheimers disease may contain metal contaminants. Researchers were surprised to discover highly reactive particles of elemental iron and copper in postmortem brain samples. Furthermore, these metals appeared to be stabilized within the beta-amyloid plaques, a hallmark of the disease.

Before this discovery, scientists had only identified these elemental metals in microorganisms, viruses, and plants. Their presence in human brains could ultimately lead to new treatments that target metals and also aid diagnosis. Click the link below to learn more about how researchers were able to detect metal particles and rule out contamination of their samples.

Learn more.

Can consuming certain foods or nutrients reduce the risk of developing cancer? One growing area of cancer treatment research is the therapeutic potential of dietary interventions.

Previous studies in mice suggest that omega-3 fatty acids may be effective as an antitumor treatment. Now, new research has identified a possible mechanism that explains this. It appears that omega-3 fatty acids encourage tumor cell death via a process called ferroptosis, but this was not seen with other fatty acids.

This finding supports the case for targeted dietary intervention with omega-3s, though more research is now needed to determine whether the same effect applies to humans.

Learn more.

We stay with omega-3s in our next article, this time exploring their role in depression. Researchers in the United Kingdom have discovered that high doses of these fatty acids may help relieve symptoms of this condition. Their anti-inflammatory effect appears to decrease the rate of cell death in a region of the brain called the hippocampus.

This may partly explain the observation that people who eat a diet rich in fish and seafood have a lower risk of depression, as such foods are high in omega-3 fatty acids.

Learn more.

Another of this weeks articles examined the effect of everyday stress on depression. The brains of people without this condition are better at adapting to elevated stress, and this can be observed in changes to the medial prefrontal cortex. An inability to accommodate in this way may lead to depression.

To discover how these brain changes were identified, the studys limitations, and how its findings might apply to treating depression, click below.

Learn more.

This week, our editors published this important article on the consequences of gender bias in medicine, focusing on misdiagnosis, delays in treatment, and how it may risk avoidable deaths.

With examples including chronic pain, bleeding disorders, autoimmune conditions, mental health, COVID-19, and heart disease, we look at the causes of gender bias, its roots in sexism, and what can be done to counter its pernicious effect on people of all genders. Its clear that gender bias in diagnosis, medical research, and treatment causes harm and needs to be eliminated from medicine.

Learn more.

Finally, this week, we look at an activity enjoyed by millions after a meal. Walking has many benefits, but does going for a post-dinner stroll have any downsides? We look at the evidence and conclude that on the whole, it is a healthy activity, but you may want to wait a little while after a substantial meal.

To discover all the mental and physical benefits of heading out after tucking in, follow the link below.

Learn more.

We hope this weeks Recovery Room has provided a taste of the stories that MNT covers. We will be back with a new selection next week.

We publish hundreds of new stories and features every month. Here are some upcoming articles that may pique our readers interest:

Continue reading here:
The Recovery Room: News beyond the pandemic June 25 - Medical News Today

Recommendation and review posted by Alexandra Lee Anderson

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