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askST@NLB podcast looks at new ways of working – The Straits Times

With most workplaces shut to stem the spread of Covid-19 during the circuit breaker period, the importance of flexible work arrangements and the use of technology to facilitate remote working came under the spotlight like never before.

Now, as Singapore has entered phase two of reopening its economy, working from home continues to remain the default for most employees.

In the third episode of the askST@NLB podcast series, The Straits Times' manpower correspondent Joanna Seow, along with Singapore Human Resources Institute president Low Peck Kem and Singapore National Employers Federation executive director Sim Gim Guan, considered these new ways of working, as well as the sustainability of the current workforce.

"It took us a crisis to get us going in the direction (of greater digitalisation)," said Ms Seow, adding that this could bring about "transformation in essential service sectors like healthcare, cleaning and public transport". Jobs in these sectors will soon become less labour intensive, owing to telemedicine, robots and autonomous vehicles.

Mr Sim said companies should transform the way they do business. "They will need to upskill and reskill their workers, so that they can take on new jobs or new ways of doing their job," he added.

Aside from acquiring skills in information and communication technology, employees should equip themselves with relevant "analytical, conceptual and evaluative skills", along with interpersonal skills that could help improve their employability, said Mr Sim.

By leveraging technology and redesigning work processes, Singapore will be able to focus on productivity and reduce its reliance on both foreign and local manpower. This is pertinent since the citizen working-age population is expected to shrink from around this year.

To address this, Singapore should "tap older workers, as well as those who are economically inactive", explained Mr Sim. This is where flexible work arrangements will prove crucial.

Many older workers tend to favour part-time work. Those who are economically inactive mainly comprise female workers who have exited the workforce for family and caregiving reasons. Hence, having flexi-work arrangements and schemes like the Professional Conversion Programme could ease them back into the workforce.

Ms Low introduced the idea of "productive longevity" - that living longer entails having people "work longer to ensure (their) retirement adequacy".

"When more services can be delivered digitally or virtually, biases like age, looks, nationality and geographical location get diminished, so people in their 60s or 70s who want to remain active and productive can continue to do so," she said.

The fourth episode of the askST@NLB podcast series, slated for July 3, will feature Straits Times senior food correspondent Wong Ah Yoke and hotelier-restaurateur Loh Lik Peng.

It is titled: The new normal in restaurant dining. The episode will examine how the Covid-19 pandemic has transformed the food and beverage landscape in Singapore.

Readers can send in their questions for the speakers by 6pm on June 28 at str.sg/JPXG.

In the meantime, in order to ensure that flexible work arrangements remain sustainable, especially working from home, a relationship of trust has to be established between the supervisor and the employee. Ms Low stressed that supervisors should seek to understand the challenges of older employees "and provide them with the assurance that (they) will walk the journey with them to have them accustomed to the new way of work".

The 25-minute podcast, which is part of a collaboration between ST and the National Library Board, was released yesterday and is available for free on Spotify, Apple Podcasts, Google Podcasts, the ST Facebook page, radio station Money FM 89.3 and at str.sg/JWfR.

The talks were previously held at the Central Public Library in Victoria Street but they have now become a podcast series recorded remotely in the light of safe distancing measures to guard against Covid-19.

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askST@NLB podcast looks at new ways of working - The Straits Times

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By Transforming a ‘Stroad,’ Denver Can Move Forward on a Safer, More Inclusive Transportation System – Streetsblog Denver

(Safety-focused Lincoln Street redesign: Dedicated bus lane, traffic-calming lane reduction, bollards, and pedestrian improvements create the conditions for a people-focused multimodal thoroughfare.)

Amanda Roberts is a neighborhood advocate working towards a multimodal future for kids growing up in Denver. Follow her on Twitter @AmandaMtn.

Like many rapidly growing cities across the United States, Denver wrestles with its car-prioritized legacy of interstate building and exit expansions through its increasingly traffic-snarled communities. Just off the Lincoln/Broadway exit today, the dangerous, multilane urban arterial roadway we know as Lincoln Street whisks cars as quickly as possible from I-25 into downtown. Not surprisingly, drivers take full advantage. They speedand they crashplacing Lincoln in the High Injury Network.

Fortunately, Denver has adopted a Vision Zero Action Plan and has started to build out multimodal networks to address its growing traffic crash rate, dedicating bus lanes along downtown and adjacent streets such as Broadway. However, there is one last piece of the puzzle in this transit-oriented area that needs a safety-centric touch: that unique, urban, and mostly residential segment from I-25 to Speer, considered Baker on the west side and Washington Park West on the east side.

Today, its a car-centric stroadan unproductive, unsafe hybrid of a street and a road, on the brink of decline in some areas. But, with a few improvements to the Corridor to increase access and safety for those walking, cycling and taking transit, it can be transformed into a community-first place worth arriving at.

A walk down Lincoln today reveals just how much the street prioritizes cars over people. Drivers regularly travel at speeds well above the posted speed limit of 30mphtypically in the range of 40-50mph, and higher at night. Holding a conversation with another person with street noise at 75-80 decibels is a challenge. Vibrations from fast-moving heavy vehicles such as buses can be felt in adjacent structures, particularly where tree lawns were removed and the distance from doorways to speeding vehicles is minimal. While attempting to access grocery stores, shops, bus stops and light rail, or simply taking a stroll down the street, pedestrians are dodging cars, even in crosswalks. Cyclists have taken to riding on the sidewalks to stay safe.

(North-facing Lincoln Street today, just off the I-25 exit ramp. Though this is a transit-rich area, walking is dangerous since buffer zones to protect pedestrians have been removed to ensure interstate traffic is whisked quickly downtown.)

While the problems of Lincolns dangerous design are numerous and complex, the solutions are already laid out in city plans: Blueprint Denver and Denver Moves: Transit. By reclassifying streets, Blueprint Denver communicates a key distinction between Lincoln and its one-way couplet partner, Broadway. While Broadway maintains its commercial thoroughfare status as a Main Street Arterial, Lincoln Street is reclassified as a Residential Arterial. This new classification takes into account the adjacent land use, and implies that Lincolns street design be similar to parallel north-south Residential Arterials in the area, Logan and Downing. Both of these streets are considered thoroughfares like Lincoln, yet they have two general purpose travel lanes instead of three, two-way traffic flow, and traffic calming elements such as medians and buffer zones with tree lawns and/or parking.

Lincoln Street, however, is unique: as part of the Lincoln/Broadway Corridor, it is also considered a High Capacity Transit Corridor by Denver Moves Transit. This means its a candidate for Bus Rapid Transit or rail, each of which require full bus or rail stop amenities. Fortunately, implementing the goals of each of these documents is straightforward and in line with the Citys goals for Complete Streets Design, which are the citys new guiding principles for the citys public right of way, detailing how we allocate space to transportation, utilities and other public infrastructure. Lincoln Streets general travel lanes can be pared down from three to two, to bring it inline with its new street classification. To meet the citys transit goals for the street, another lane can be dedicated for bus service. And the final lanewhich was removed in the past to move cars and currently is a multi-purpose, difficult-to-manage flex lane that splits bus hours with car parkingcan be permanently transformed into a transit-friendly, easy-to-manage buffer zone.

(Red Carpet Lincoln: Dedicated Offset Bus Lane to provide adequate space for shelters, a buffer zone for a variety of parking types, mixed with in-street tree planters, bollards to limit curb-jumping from crashes, and an asphalt overlay to ensure the longevity of the red paint.)

To get larger numbers of people out of their cars and sustain our urban transit system long-term, we need to go a step further by designing it for human beings. Ill leave this with some questions for consideration. Would you rather:

To address transportation pollution impacts and rising traffic deaths head-on, we need to make the entire experience of transit something that large numbers of people can safely and comfortably opt into. That means we need to invest in repairing the urban spaces that have been cut away in the past to move cars, and redesign our public streetscapes for people so they will choose healthier, safer modes.

The time to do this is now by replacing travel lanes with lower cost tactical transit lanes. Only when we take that step forward will we see a safe, sustainable future for moving people in, out, and around Denver.

Streetsblog Denver informs the movement for sustainable transportation and a livable city. Give $5 per month.

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Nanobiotix Receives Feedback From US FDA to Advance Phase III Head and Neck Cancer Study Design and CMC Development Plan for NDA – Business Wire

PARIS & CAMBRIDGE, Mass.--(BUSINESS WIRE)--Regulatory News:

With our recent Fast Track designation for NBTXR3 in this patient population, acceptance of the design of our pivotal phase III trial and agreement on our CMC plan, Nanobiotix is well positioned to deliver on our promise of serving the unmet needs of head and neck cancer patients. Our head and neck cancer pathway is our top priority and these developments represent critical milestones that will allow us to administer and supply our trial. We look forward to taking the necessary steps to initiate NANORAY-312 and evaluate the potential of NBTXR3 to improve treatment outcomes for patients around the world. Laurent Levy, CEO of Nanobiotix.

NANOBIOTIX (Euronext : NANO ISIN : FR0011341205 the Company) (Paris:NANO), a clinical-stage nanomedicine company pioneering new approaches to the treatment of cancer, today announced that the FDA has provided necessary feedback regarding the design of NANORAY-312, the Companys pivotal phase III global registration trial in head and neck cancer. The FDA also agreed to the NBTXR3 chemistry, manufacturing, and controls (CMC) Development Plan to support the phase III trial and a future New Drug Application (NDA) for the product.

NANORAY-312: A Phase III Study of NBTXR3 Activated by Investigators Choice of Radiotherapy Alone or Radiotherapy in Combination with Cetuximab for Platinum-based Chemotherapy-ineligible Elderly Patients with Locally Advanced Head and Neck Squamous Cell Carcinoma.

NANORAY-312 will be a phase III investigators choice, dual-arm, randomized (1:1) global registration trial including elderly head and neck cancer patients who are ineligible for platinum-based chemotherapy.

Patients in the control arm will receive radiation therapy with or without cetuximab (investigators choice), and patients in the treatment arm will receive NBTXR3 activated by radiation therapy with or without cetuximab (investigators choice).

The trial is expected to recruit approximately 500 patients. A futility analysis is expected 18 months after the first patient in the trial is randomized, and the interim analysis for progression-free survival (PFS) superiority is expected at 24-30 months. The final analysis will report on PFS and overall survival. Quality of Life will also be measured as a key secondary outcome. In the event of favorable data from the interim analysis, the FDA has advised that NBTXR3 could potentially qualify for accelerated approval.

In support of the phase III trial and a future NBTXR3 New Drug Application (NDA), Nanobiotix met with the FDA in a Type B end-of-phase I meeting on October 16, 2019. Following additional correspondence with the FDA, including written responses to the FDAs recommendations, the Company received written FDA guidance on April 3, 2020. The Company expects to commence NANORAY-312 after making protocol refinements and securing the requisite financing to fund the trial.

Agreement to CMC Development Plan

The FDAs written response regarding the CMC Development Plan does not raise any safety concerns for continued clinical development of NBTXR3, and the FDA agreed to the updated CMC Plan for NBTXR3 during an ongoing phase III clinical trial.

***

About NBTXR3NBTXR3 is a first-in-class product designed to destroy tumors through physical cell death when activated by radiotherapy. NBTXR3 has a high degree of biocompatibility, requires one single administration before the first radiotherapy treatment session, and has the ability to fit into current worldwide standards of radiation care. The physical mode of action of NBTXR3 makes it applicable across solid tumors.

NBTXR3 is actively being evaluated in clinical trials worldwide as a potential treatment in various cancer indications. The Company is prioritizing the development of NBTXR3 in the United States and the EU for the treatment of patients with locally advanced head and neck cancers ineligible for chemotherapy.

Nanobiotix is also running an Immuno-Oncology development program, evaluating NBTXR3 activated by radiotherapy as a primer of immune response in combination with checkpoint inhibitors. The Company has launched a phase I clinical trial of NBTXR3 activated by radiotherapy in combination with anti-PD-1 checkpoint inhibitors in patients with locoregional recurrent (LRR) or recurrent and metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) amenable to re-irradiation or with lung or liver metastasis (mets) from any primary cancer eligible for anti-PD-1 therapy.

Other ongoing NBTXR3 trials are treating patients with liver cancers (hepatocellular carcinoma and liver metastasis), locally advanced or unresectable rectal cancer in combination with chemotherapy, head and neck cancer in combination with concurrent chemotherapy, and pancreatic cancer. The Company has a broad, comprehensive clinical research collaboration with The University of Texas MD Anderson Cancer Center (initially expected to support nine new clinical trials in the United States) to evaluate NBTXR3 across several cancer types.

About NANOBIOTIX: http://www.nanobiotix.com Incorporated in 2003, Nanobiotix is a leading, clinical-stage nanomedicine company pioneering new approaches to significantly change patient outcomes by bringing nanophysics to the heart of the cell.

The Nanobiotix philosophy is rooted in designing pioneering, physical-based approaches to bring highly effective and generalized solutions to address unmet medical needs and challenges.

Nanobiotixs first-in-class, proprietary lead technology, NBTXR3, aims to expand radiotherapy benefits for millions of cancer patients. Nanobiotixs Immuno-Oncology program has the potential to bring a new dimension to cancer immunotherapies.

Nanobiotix is listed on the regulated market of Euronext in Paris (Euronext: NANO / ISIN: FR0011341205; Bloomberg: NANO: FP). The Companys headquarters are in Paris, France, with a US affiliate in Cambridge, MA, and European affiliates in France, Spain and Germany.

Disclaimer

This press release contains certain forward-looking statements concerning Nanobiotix and its business, including its prospects and product candidate development. Such forward-looking statements are based on assumptions that Nanobiotix considers to be reasonable. However, there can be no assurance that the estimates contained in such forward-looking statements will be verified, which estimates are subject to numerous risks including the risks set forth in the universal registration document of Nanobiotix registered with the French Financial Markets Authority (Autorit des Marchs Financiers) under number R.20-010 on May 12, 2020 (a copy of which is available on http://www.nanobiotix.com) and to the development of economic conditions, financial markets and the markets in which Nanobiotix operates. The forward-looking statements contained in this press release are also subject to risks not yet known to Nanobiotix or not currently considered material by Nanobiotix. The occurrence of all or part of such risks could cause actual results, financial conditions, performance or achievements of Nanobiotix to be materially different from such forward-looking statements.

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Disordered proteins follow diverse transition paths as they fold and bind to a partner – Science Magazine

Shedding light on disordered proteins

Disordered proteins often fold as they bind to a partner protein. There could be many different molecular trajectories between the unbound proteins and the bound complex. Most methods to measure transition paths rely on monitoring a single distance, making it difficult to resolve complex pathways. Kim and Chung used fast three-color single-molecule Foster resonance energy transfer (FRET) to simultaneously probe distance changes between the two ends of an unfolded protein and between each end and a probe on the partner protein. They show that binding can be initiated by diverse conformations and that the molecules are held together by non-native interactions as the disordered protein folds. This allows the association to be diffusion limited because most collisions lead to binding.

Science, this issue p. 1253

Transition paths of macromolecular conformational changes such as protein folding are predicted to be heterogeneous. However, experimental characterization of the diversity of transition paths is extremely challenging because it requires measuring more than one distance during individual transitions. In this work, we used fast three-color single-molecule Frster resonance energy transfer spectroscopy to obtain the distribution of binding transition paths of a disordered protein. About half of the transitions follow a path involving strong non-native electrostatic interactions, resulting in a transition time of 300 to 800 microseconds. The remaining half follow more diverse paths characterized by weaker electrostatic interactions and more than 10 times shorter transition path times. The chain flexibility and non-native interactions make diverse binding pathways possible, allowing disordered proteins to bind faster than folded proteins.

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Case Medical Awarded Patent for Multi Enzymatic Solution for Cleaning Medical Devices and Food Industry Utensils and Surfaces Exposed to Brain Wasting…

Patent is a significant step toward commercializing cleaning products to effectively inactivate and degrade prions

Case Medical today announced that it was awarded U.S. patent number 10,699,513 B2, by the U.S. Patent and Trademark office for "compositions and methods for handling potential prion contamination." The patent is a significant step for the company toward commercializing cleaning products that will enable prion contaminated devices and surfaces to be processed without resorting to the extraordinary methods required today.

Prions are a type of protein that can cause unfolding in normal prion proteins most commonly found in the brain, but also in the spine, eye, spleen, and lymphoid tissues. Prion diseases are described by the CDC as "a family of rare progressive neurodegenerative disorders that affect both humans and animals. They are distinguished by long incubation periods, characteristic spongiform changes associated with neuronal loss, and a failure to induce inflammatory response." The CDC also indicates that "the abnormal folding of the prion proteins leads to brain damage... Prion diseases are usually rapidly progressive and always fatal."

Prions are transmitted by eating of meat infected with prions, but also in healthcare settings from blood transfusions and from medical devices, especially from surgical instruments, even from apparently cleaned devices, having residual prion contamination.

"The challenge with prions is that they are almost impossible to detect before a fatal occurrence of the disease and they are also extremely hard to remove from contaminated devices and surfaces," said Marcia Frieze, CEO of Case Medical. "The logical solution would be to make prion decontamination a standard part of medical device processing but the current options are extremely time consuming and so harsh that they significantly reduce the useful life of the devices themselves."

Currently, prion contaminated materials are either incinerated or pre-treated with sodium hypochlorite, sterilization, oxidizing agents, peracetic acid, or pre-treatment at temperatures above 100C for extended periods of time. These methods and materials are environmentally unfriendly and excessively corrosive to the materials being cleaned. The cleaning solution patented by Case Medical uses a multi enzymatic formulation to achieve a safer, more thorough result and requires much less time and effort, suggesting a feasible process for healthcare settings and the food processing industry.

In brief, Case Medicals formulation uses specific enzymes combined with a surfactant. The enzymes effectively digest or inactivate prions rendering them ineffective and the surfactant lowers the level of friction to allow easy rinsing. The process is easy, biodegradable, and environmentally preferred.

"While prion diseases are currently rare and a much bigger issue in Europe than in the U.S., the coronavirus pandemic has hopefully taught us the value of being prepared," said Frieze. "We still have many regulatory steps before we can fully commercialize this product and process, but we are continuing to work as fast as we can."

Testing and validation were performed in conjunction with the U.S. Geological Service (USGS) through their National Wildlife Health Center at the Class III prion lab in Madison, Wisc.

About Case Medical

Case Medical is a FDA registered, ISO certified manufacturer of validated, sustainable, and cost effective products for instrument processing. Our reusable sterilization containers and instrument chemistries meet the highest standards for patient safety and environmental preference. Case Medical was an inaugural recipient of the U.S. EPA Safer Choice Partner of the Year award. Visit http://www.casemed.com for more information.

View source version on businesswire.com: https://www.businesswire.com/news/home/20200616005865/en/

Contacts

Lisa Forsell, Director of MarketingPhone: 201-313-1999 x302Email: lforsell@casemed.com Web: http://www.casemed.com

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Morgan Stanley’s CEO Said He Is ‘Committed’ to Diversity. A Lawsuit Filed by the Firm’s Former Diversity Head Alleges Otherwise. – Institutional…

Earlier this month, Morgan Stanleys chief executive officer James Gorman shared a planon LinkedInto improve diversity at the bank.It included promotions for certain Black employees, the creation of an Institute of Inclusion and a $5 million donation to the NAACP.

On Tuesday, less than two weeks later, the firms former diversity head, Marilyn Booker, filed a lawsuit against Morgan Stanley alleging racial discrimination. The suit was filed on behalf of herself and her former Black female colleagues in the U.S. District Court in the Eastern District of New York.

Booker is suing Morgan Stanley, her former supervisor Barry Krouk, and Gorman for alleged discrimination and retaliation in violation of the Civil Rights Act of 1866, alleged discrimination and retaliation in violation of the New York State Human Rights Law, and alleged violations of both the Equal Pay Act and the New York Equal Pay Law. Booker has also filed an Equal Employment Opportunity Commission complaint, according to her lawsuit.

We strongly reject the allegations made in this claim and intend to vigorously defend ourselves in the appropriate forum, a Morgan Stanley spokesperson said. We are steadfast in our commitment to improve the diversity of our employees and have made steady progress while recognizing that we have further progress to make. We will continue to advance our high priority efforts to achieve a more diverse and inclusive firm.

Booker, who was fired from the firm in December, had worked at Morgan Stanley for 26 years, according to her complaint.

She spent about 16 years as the firms global head of diversity before allegedly being shuffled around through different departments. In 2010, she was moved to the office of development, which was eliminated in 2011. That year, she was selected to lead the firms urban markets group, overseeing minority financial advisors.

Booker alleged in the lawsuit that her salary was essentially held flat in that role as the firm slashed its budget for the program year after year.

According to Bookers complaint, she tried to create a plan to internally address the firms racial biases in 2019. Her plan, called Project Genesis was created with the goal of addressing Morgan Stanleys Black employees constant feelings of isolation and lack of support.

This included addressing their alleged inability to join financial advisory teams and barriers to partnering with white financial advisors on new business opportunities, including unfair commission splits and exclusion from new client meetings. According to the lawsuit, less than one percent of the firms financial advisors are Black.

Krouk, her supervisor, allegedly helped Booker identify analysts and executives who could help Booker on the project last year.

However, Krouk allegedly later told Booker not to tell her colleagues about the project, and allegedly stalled when she asked to present the project to senior management.

A meeting Booker allegedly expected to cover the project was scheduled in December 2019. During it, though, Booker was fired from the firm, the complaint said.

Despite her longevity, loyalty and stellar performance record, Morgan Stanley offered no explanation for her expulsion other than to vaguely say that her position which is one that primarily helps Black people and people of color gain financial literacy and acumen had to be eliminated, the lawsuit said.

[II Deep Dive: The Story Behind Shundrawn Thomass Open Letter to Asset Management]

Gormans plan to improve diversity at the firm, shared on June 4, includes the creation of a similar initiative: the Institute of Inclusion. This group will set up policies and metrics to track diversity and will oversee mentoring, development, and promotion of the firms diverse employees. The announcement said that Morgan Stanley will set aside $25 million for the initiative.

This is the second discrimination lawsuit filed against Morgan Stanley this year. In late April, a female former financial advisor at the firm alleged in a lawsuit that she missed out on pay and was harassed by co-workers because she is a woman,Institutional Investorssister publicationRIA Intelreported at the time.

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Morgan Stanley's CEO Said He Is 'Committed' to Diversity. A Lawsuit Filed by the Firm's Former Diversity Head Alleges Otherwise. - Institutional...

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When It Comes To Device And Website Security, Automation Is More Important Than Ever – Forbes

CEO ofSectigo, driving innovation in digital identity and cybersecurity for today's enterprises, including automation, IoT and DevOps.

Getty

The world faces an unprecedented global health crisis. As governments race to protect the health and well-being of their citizens, businesses must find innovative ways to serve clients and customers. Although countless employees in a wide range of industries have been asked to work remotely to prevent further spread of the new coronavirus, these businesses must continue producing. For many, this represents a unique opportunity to improve and modernize their practices.

Much-needed changes that organizations have been meaning to get to will now become paramount. Manual management of an environment by group participation works when the group is together in a common area, but when the group is dispersed, the tasks become exponentially riskier and more challenging. That means the need for automation is now. Businesses that embrace automation will realize its full benefits, while laggards will suffer from risk and inefficiency in our increasingly complex business world.

Automation has become essential to countless business processes, from manufacturing to fielding customer service calls. But many areas of business are still ripe for automation, particularly in IT. In the new work-from-home reality, IT departments must enable secure remote access for dispersed workforces. Automating important website security processes enables IT personnel to focus on other business-critical tasks while preventing costly lapses in protection. Automation solutions are usable by employees with limited technical skills. Manual processes, in contrast, often are built by experts who provide little by way of documentation or training materials. Should these experts become nonessential, the business would suddenly be at great risk.

Workforce Disruptions Can Generate Security Lapses

Digital certificates are a critical aspect of website and device security, and we have already seen an earlier example of how a workforce disruption can affect them. The U.S. federal government shutdown of 2018-19 furloughed hundreds of thousands of government employees, including IT personnel who were unable to conduct routine operations such as issuing and renewing expiring certificates. As a result, many government services and websites went offline during the 35-day shutdown, including more than130 online services and applications in a single week. Affected websites ranged from the U.S. Court of Appeals to NASAs rocket testing website.

Manual certificate maintenance requires careful management. For instance, browsers will only trust a website certificate for a certain term length (at present two years, but soon dropping to one). That means more certificates will require renewal, or browsers will no longer trust the site. If IT departments are unable to track upcoming certificate expirations for timely renewal, they risk their sites being flagged as untrustworthy and critical systems going offline. In fact, many high-visibility service outages for major digital systems stem from certificate management errors. December 2018sday-long service outagefor 32 million O2 customers is a perfect example.

Todays global workforce disruption dwarfs the 2018 government shutdown in scale and longevity. The biggest shake-up so far stems from shutting down office locations in favor of employees homes, introducing a new set of needs and risks and catching many IT departments off guard. As time goes on, this new norm will take a further toll on businesses as workforces struggle with adversity in many forms:

These factors combine to place extreme risk on any human-intensive process in the enterprise, especially one as intolerant of delay or error as certificate renewal.

Automation can eliminate expiration-based outages, cut mistakes and free up IT professionals time for other projects. It does not require in-depth institutional knowledge, and administrators can easily configure and operate automated systems.

Getting Started With Certificate Automation

Thinking of embarking on a certificate automation project? You may already have started. Microsoft CA is Microsofts built-in certificate management system, and it enables automatic management of certificates within Windows environments. For those using Windows in any capacity, it is a valuable first step into automation. Of course, few organizations operate exclusively in Windows, which means Microsoft CA is best used in conjunction with other services capable of managing certificates for all operating systems and use cases.

When adding a new system, it is wise to conduct an inventory of existing certificates. An automated certificate discovery tool can do this for you. In addition to identifying production certificates before they expire and create a crisis, you also can ensure all certificates are following mandated security practices and meeting appropriate compliance requirements.

Make sure you find a solution that provides interoperability with your critical systems those you use today and those youre likely to expand to in the future. To ensure interoperability, look for these capabilities:

Adjusting To The Present Is Also Planning For The Future

With IT teams still working to adjust to the new normal, they are discovering that now is the perfect time to automate essential business practices. Many organizations expect newly automated processes and more flexible work-from-home policies to remain in placewell after the current crisis, so ensuring that they are prepared to face the IT and security challenges that go along with our new reality anywhere, anytime is of paramount importance.

Forbes Technology Council is an invitation-only community for world-class CIOs, CTOs and technology executives. Do I qualify?

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When It Comes To Device And Website Security, Automation Is More Important Than Ever - Forbes

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dr-simon-whitesman-on-why-mindfulness-is-medicine – Longevity LIVE

Gisele Wertheim Aymes speaks to Dr. Simon Whitesman (MBChB) about why mindfulness is medicine. Dr. Whitesman is a practitioner of medical psychotherapy at Christiaan Barnard Memorial Hospital in Cape Town and chairman of the Institute of Mindfulness.

A: I always wanted to be a doctor. However, when I became one, the experience was nothing that I had imagined. There was a strong missing element. Then a colleague suggested I start meditating. I had heard of TM, so I went and did TM training. This helped me become very disciplined, and it made a relatively quick and deep impact on my physical well-being. I had suffered from tension headaches and now found relief. And it was this that started my scientific interest in meditation.

When I read Quantum Healing by Deepak Chopra, I experienced an epiphany. It was like walking into a room I had been in and recognizing everything.

It resonated with me. This idea that raising consciousness is the basis for all healing like a key fitting into a lock.

And from there I began an exploration of this insight. I have walked many paths as a psychotherapist. From mind-body connection and Buddhist contemplative therapies to more contemporary approaches to mindfulness. This is where I have really found more meaning now in a more contemporary approach to mindfulness.

A: I discovered it was about my own healing a parallel process while wanting to find expression as a clinician and a doctor. And then recognizing a symmetry on the inside that was compelling for me, in terms of my own path and personal growth.

Then, through Jon Kabat-Zinns work, I was exposed to mindfulness, which is not the same as TM.

Jon Kabat-Zinn is an American professor emeritus of medicine, and creator of the Stress Reduction Clinic and the Center for Mindfulness in Medicine, Health Care and Society at the University of Massachusetts Medical School, in the US. Kabat-Zinn was a student of Zen Buddhist teachers such as Philip Kapleau, Thich Nhat Hanh and Seung Sahn, and a founding member of the Cambridge Zen Center. His practice of yoga and studies with Buddhist teachers led him to integrate their teachings with scientific findings. He teaches mindfulness, which he says can help people cope with stress, anxiety, pain, and illness. The stress-reduction program created by Kabat-Zinn, mindfulness-based stress reduction (MBSR), is offered by medical centers, hospitals, and health-maintenance organizations.

A: The original roots of mindfulness are part of a set of teachings from Buddha 2 500 years ago. Buddha was a human who woke up to who he was and developed a way of teaching others to help them wake up. Central to this path was mindfulness. There were obviously many other aspects, but mindfulness was central.

Kabat-Zinn understood that there are so many people who could benefit from mindfulness, but who were not necessarily interested in Buddhist teachings. He developed mindfulness around keeping the essential qualities of Buddhism, but without the beliefs. You could say it is Buddhism without the belief. Its a contemporary re-contextualization of ancient wisdom and tradition. This meant that if you were a Catholic priest, you could benefit from mindfulness; it didnt conflict with your own set of beliefs. This was a subtle, but very important shift.

A: Mindfulness enables you to be more compassionate, more present, less reactive. Its meditation made more accessible.

Kabat-Zinn first offered it in a contemporary tertiary teaching hospital in Worcester, Massachusetts. He saw it could be a benefit for so many those suffering from chronic pain syndrome, the people who fall through the cracks. He told colleagues to send them to him. Kabat-Zinn taught these patients how to turn inward, to find a new way of being in pain. From there, his work expanded into other chronic disorders.

Medicine doesnt want to go there. I saw that, but for me, there is a desire to bring it back to my life. For me, it is not so much about mindfulness, but more heartfulness.

A: I went to the US and started training in that approach. While I had learned the TM technique, Jon Kabat-Zinn helped to orientate me to what meditation truly is.

What are you going to do when you finish meditation? When you finish meditating, can you make the next moment valuable, engaged, connected, awake, with a quality of curiosity, interested in your own experience? Its valuable to meditate, but the application is deeper than sitting and closing your eyes. Dedicate time to understanding your own mind. Its a willingness to explore and be interested in your own experience.

You dedicate time to silence, to understand your own mind better. Then I also need to get up and go to the world, be present in the world. Its always available to us. Awareness isnt going anywhere. Awareness is now, attending to each and every moment of our lives. Then life becomes meditation.

If you do take time to be with yourself, understand your relationship between body and mind, then life becomes a meditation. Its a radical shift in understanding, broadly and universally applicable. . Mindfulness isnt about thought; its prior to thought. Train yourself to be aware of the thought prior to its occurring.

A: Yes, agreed. We get lost in thinking. We lose a wider presence with our body. Most of us are lost in thinking the revered space between our left and right ear. And we lose our consciousness of Earth and others. You have to start with mindfulness of the body, then mindfulness of thoughts. And it becomes a trainable skill, an actual physiological skill transforming our own awareness. Not randomly, but in service of the greater good, to reduce our own suffering, then the suffering of others. In order to experience a more meaningful existence and live life, we have to train our minds.

When you train for the Two Oceans, you train your body extensively. You cant run a marathon if you havent trained physically. People think the mind is easier. Its not. Youre asking people to open up and be uncomfortable. Gym is not comfortable; gym can be hard. Its the same as training for consciousness. It isnt easy, but it is simple.

Mindfulness is about focusing on the present, not worrying about yesterday or tomorrow.

A cartoon shows two Buddhist monks sitting side by side. Theyre deep in meditation when the younger one opens an eye and gives the older, wiser one a questioning look.

Nothing happens next. This is it, the older one responds.

I treat mindfulness daily in my practice, and I teach an eight-week program on mindfulness. We are training professionals in mindfulness at the Faculty of Medicine at Stellenbosch University. Its much broader than doctors. We train the trainers through the Faculty of Medicine and Health Sciences. This is the only university in South Africa that offers this course. I also contribute towards IMEISA, a non-profit around mindfulness, to create more awareness and debunk myths around mindfulness.

Everyone can benefit from mindfulness. However, the only way you will know the benefit is if you practice. It will be in your own experience. However, for me, I saw my own changes: reduced reactivity and stronger connection with myself and others, as well as everything around me. Its the human condition to be lost in thought. We cant connect if were not present. Something happens when we dont make our mind the enemy. Be more engaged in the moment. Its not an idea; its a truth.

This is how mindfulness can heal trauma. Read more.

Apart from his role as a practitioner of medical psychotherapy at Christiaan Barnard Memorial Hospital in Cape Town, Dr Simon Whitesman is the co-ordinator of the post-graduate certificate training in Mindfulness-Based Interventions at Stellenbosch Universitys Faculty of Medicine and Health Sciences. Hes also director and chairperson of the Institute for Mindfulness South Africa (IMISA), and co-director of the first Mindfulness-Based Stress Reduction (MBSR) program in South Africa. He received certification as a teacher in MBSR from the University of Massachusetts Center for Mindfulness, and in psychoanalytic psychotherapy from the South African Institute for Psychotherapy.

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Why Strange New Worlds is the show Star Trek and the world needs right now – GamesRadar+

Whats in a name? When it comes to Star Trek TV shows, a title says a hell of a lot. The opening credits of The Next Generation were enough to tell us it was Trek for, well, a new generation; Voyager implied a crew on a long journey; Picard instantly made it clear that the mission was a man. Prequel series Enterprise tried to make a statement by removing Star Trek from its name entirely though it did wind up reinstating it for season three when the producers realised their mediocre efforts at subterfuge were fooling nobody.

The recently announced Star Trek: Strange New Worlds has arguably the most evocative title of the lot. Lifted from James T. Kirks original five-year mission statement yknow, the one about seeking out new life and new civilisations it conjures the spirit of adventure, that back-to-basics formula of an intrepid crew boldly going to unexplored regions of the galaxy. It has the potential to be the purest distillation of the original Star Trek ethos since The Next Generation last beamed off screens in 1994, and could just be just what the franchise and planet Earth needs in these unusual times.

Strange New Worlds certainly seems to be the show the Star Trek faithful want, with fan power a driving force in the series green light. Audiences were so taken with Captain Christopher Pike, Science Officer Spock and First Officer Number One when the USS Enterprise warped into Star Trek: Discovery last year that theyve been given the command codes to their own spin-off. Think Angel, Frasier or ahem Joey, but in the 23rd century.

When we said we heard the fans outpouring of love for Pike, Number One and Spock when they boardedStar Trek: Discoverylast season, we meant it, executive producer and Treks TV commander-in-chief Alex Kurtzman toldStarTrek.com. These iconic characters have a deep history in Star Trek canon, yet so much of their stories have yet to be told. The Enterprise, its crew and its fans are in for an extraordinary journey to new frontiers in the Star Trek universe.

Those frontiers arent entirely new, of course. Pike, Spock and Number One pre-date even Kirk himself, having headed up the Enterprise crew in the original Star Trek pilot. Filmed in 1965, their sole appearance in "The Cage" didnt make the grade with network executives and didnt air until decades later though the pilot did become canon via flashbacks in Original Series two-parter "The Menagerie". The suits had seen enough to give Star Trek creator Gene Roddenberry an unlikely second chance, but by the time the series left Spacedock in 1966, only Spock was still serving on the Enterprise bridge.

With barely an hour of screentime to play with, original Pike Jeffrey Hunter never really got the chance to make his mark. Indeed, despite his matinee idol good looks, Hunters Pike is too dry and strait-laced to convince as the lead of an action TV show there are few signs hed ever have become a pop culture icon of Kirk-shaped proportions.

Yet in just one season on board Discovery, Anson Mount turned Pike into one of Starfleets most memorable commanding officers, a man whose boy scout decency never got in the way of his innate charisma. The contrast with evil Mirror Universe CO Gabriel Lorca couldnt have been starker this Pike is so honourable that he takes painful visions of his tragic future on the chin for the greater good yet he instantly made the captains chair his own.

When Discovery blasted off to the distant future in the season two finale, established continuity ensured that Pike had to stay behind. So Strange New Worlds provides a welcome excuse to keep him and Spock and Number One on TV. Thats good news because Mount, Ethan Peck (as Spock) and Rebecca Romijn (as Number One a comparative blank slate at this point) have already done enough to suggest they have good enough on-screen chemistry to carry a show. Handled wisely the trio could even echo the iconic Kirk/Spock/McCoy axis that was the engine room of the Original Series.

If either Discovery or Picard were your introduction to the Star Trek universe, youll be wondering what executive producer Akiva Goldsman was on about when he told Variety, Were going to try to harken back to some classical Trek values, to be optimistic, and to be more episodic.

In Trek terms, however, the recent heavily serialised, morally ambiguous shows are the anomaly, as much products of the present day as the half-century-old franchise that spawned them. In this era of peak TV dominated by shades-of-grey antiheroes and complex moral choices Roddenberrys idealistic vision of the future had come to feel unfashionable, an anachronism of old-school network TV. But now that Trek has proved it can escape its roots, theres no reason it shouldnt go back why be apologetic about being part of one of the greatest pop culture franchises of all time?

Standalone stories of the week are part of Star Treks DNA. Beaming to a new planet, sorting out a few problems, going home and forgetting all about it that's been part of the mix since day one. But as with Doctor Who, the ability to be a new show every week, telling a different story in a different location with a new cast of supporting players, has always been key to Treks longevity. There are plenty of strange new worlds still to explore, and a hell of a lot of debates to have about the pro and cons of violating the Prime Directive. Who wants to let The Orville have all the fun?

Besides, theres no reason Spocks old adage about infinite diversity in infinite combinations shouldnt also apply to Star Trek TV shows. With Kurtzman having already told the Hollywood Reporter that, the intention is to have something Star Trek on the air all the time,Discovery, Picard and Strange New Worlds will be joined on screen by animated comedy Lower Decks and spy drama Section 31. That means even more Trek shows running simultaneously than we had in the glory days of the 90s and if theyre all going to survive, they need to be distinct.

(Image credit: Netflix)

... we have Star Trek: Discovery season 3 to look forward to. Click that link to find our everything we know about S3.

The powers-that-be (kind of) realised that in the 90s and early 00s Deep Space Nines space station setting was a big departure from The Next Generations starship adventures, while Voyagers lost in the Delta Quadrant set-up (theoretically) shook things up again. But DS9 aside those shows were often hamstrung by a What would Roddenberry do? approach that kept ongoing storylines and conflict between the ships crew at a bare minimum. Even Enterprise, set a century before the Original Series, struggled to break free from the franchises long-standing conventions. At least now there should be the freedom to have five shows all carving their unique course in the Star Trek universe. All Trek but all different.

Now that Discovery and Picard have pulled the franchise into the 21st century, the course is cleared for Strange New Worlds to celebrate Star Treks past, the modern-day franchises hymn to positivity. The depressing state of planet Earth right now doesnt mean that every TV show has to be a joyful celebration of life; therell always be room for complex drama exploring the dark side of the human condition. But the optimistic ideals of the future Trek was built on a world of tolerance, listening to other points of view, and working together towards a common goal are all messages we could use right now. If Star Trek cant work in that space unashamedly, then what on earth is it for?

Want more Trek coverage? Here's our guide to the Star Trek timeline

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Animal Stem Cell Therapy Market What Factors will drive the Animal Stem Cell Therapy Market in Upcoming Years and How it is Going to Impact on Global…

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To a producer, can control the total production cost through worldwide procurement, localization procurement and concentrative purchase, more purchasing focuses on fewer suppliers to large-scale purchase, to large-scale and high efficiency. Now the logistics and information is well-developed, beneficial to worldwide procurement, localization procurement and concentrative purchase. In future, more manufacturers will attach importance to the raw materials purchasing, with strategic sourcing.

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Animal Stem Cell Therapy Market What Factors will drive the Animal Stem Cell Therapy Market in Upcoming Years and How it is Going to Impact on Global...

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