Page 19«..10..18192021..3040..»

Philippe Starck Is Living the Future – Mansion Global

Its difficult to describe Philippe Starck in a few wordsor even a few sentences. The French designer, whos known globally for his work in interior, exterior, product, furniture, industrial, and architectural design, has designed everything from low-energy wooden prefabricated houses (known as P.A.T.H., or Prefabricated Accessible Technological Homes), to yachts and hotels, to the residences of the French president.

Hes also responsible for one of the worlds most iconic pieces of furniturethe ghost chair.

Mr. Starck, 71, has coined the phrase democratic design, describing it as something that provides quality pieces at accessible prices.

More: Aspen Brokerage Founder Says Its Core Area is Expanding

And early this year, he announced his newest furniture collection, Oh, It Rains!, in collaboration with B&B Italia Outdoor, a company that focuses on functional furniture. The sofas and armchairs in the collection include a mechanical joint that allows the backrest to recline, as well as to fold over the cushions in order to protect the furniture in case of rain. The pieces are made of water-repellant proprietary textiles.

Outside of furniture and home design, Mr. Starck also had a brief stint as art director for the Virgin Galactic spaceport, is a winemaker (with his own Champagne with Maison Louis Roederer), makes perfume under the label STARCK Paris (interestingly, his mother operated a parfumerie when he was a child), and creates ultraflexible eyeglasses in collaboration with Luxottica, a project that combines design with biomechanics.

We caught up with Mr. Starck to discuss his passions, his inspirations, and what he felt was missing from outdoor furniture.

From Penta: Worldwise: Chef Nina Comptons Favorite Things

Mansion Global: Who are some of your inspirations in the design world?

Philippe Starck: I have no admiration for designers, architects, or artists. I love scientists. My heroes are Ptolemy, Einstein, Archimedes, et cetera. They are among the ones who change the world.

What does democratic design mean to you now? Has that changed throughout the years?

Im not really proud of what I do because design is useless. It can help improve lives, but it does not save lives. However, Im proud of my battle to democratize design: increasing quality, yet lowering prices in order to make design affordable for the wider public. Now that this battle is won, I can continue with democratic ecology and democratic architecture. I started with P.A.T.H., highly technological and high-quality prefabricated houses, to save energy, time, money, and guarantee longevity at the right price. Recently, I worked on the next commercial International Space Station in collaboration with Axiom to develop commercial space tourism. Im very happy to take part in this project because companies like Axiom are focusing on space research and are searching for solutions in order to democratize space.

How did the project with B&B Italia come about? What was your design inspiration for that collaboration?

I always say that to make beautiful children, parents have to be in love. Its the same with projects; to make beautiful projects, you have to share the same values with your partner. I always thought there was something wrong with outdoor furniture collections. When you are in a beautiful hotel, enjoying the swimming pool, and suddenly someone says: Oh, it rains! and hundreds of waiters start panicking, picking up all the pillows and cushions, there is something not quite right. So I wanted to create a solution. I worked on a whole range of options that allow you to intervene in a few simple steps when it starts to rain. For example, by simply folding the backrest forward, you can cover the upholstery like a protective flap, and as soon as the sun comes back, simply unfold and youre ready. This is the most elegant design made with high technology, high quality, and high intelligence.

More: Barrier-Breaking Architect Says Its Time for More Women in the Field

What will the furniture of the future look like?

Design is a simple tool that has been created to improve the ugly obligations of our daily life. There is no future for design, as we are now entering the era of bionism [the art of taking inspiration from the body to create technologies better suited to the human being, according to Mr. Starck] and dematerialization. In the coming years, all the useless things around us will disappear, they will become integrated directly into the walls, to the body. The next designer will be our coach, our dietician.

Youve also launched perfume. How do you get inspired to come up with scents? And what interests you about being in that business?

STARCK Paris is not a design project. It is a personal project, coming from my brain, from my heart. ...With my wife, Jasmine, we spent years discovering the works of almost all existing master perfumers,

carrying out blind tests. And eventually we recognized Daphn Bugey, Annick Mnardo, and Dominique Ropion as part of my sentimental tribe. People who share a vision and creative intelligence. We invented a new diagonal language in order to translate my vision, my mental space, actually turning my words into chemicals and perfumes. I am passionate about perfume because it is so powerful, abstractlike a vehicle, a weapon. With a nanodrop of scent, that is less than a milligram of liquid, you can create your own universe, your own territory.

Whats next for you?

To continue to direct my creation and my production toward immateriality, toward the minimum while giving the maximum. My Starck Biotech Paris glasses are a good example. We continue to explore biotechnology, while working on dematerialization and bionism by proposing new, innovative solutions. ... stay tuned.

This story first appearedin Mansion Global magazine, published on March 14th, 2020.

Click to Read More Luxury Real Estate Professionals Share Their Insights

Read the original:
Philippe Starck Is Living the Future - Mansion Global

Recommendation and review posted by Alexandra Lee Anderson

Read the Rest...

Dr. Ronnie S. Stangler: What Does Madonna Know About Her Genes That You Don’t? Genomics and Its Impact on Families of Wealth | Horizons: Family Office…

Ronnie S. Stangler, M.D., physician and psychiatrist, is Founder of Genome Advisory, based in New York City. Uniquely positioned at the intersection of health, wealth and science, Genome Advisory consults with individuals, global families and their advisors, using the DNA science of genomics to enhance strategic plans regarding health, risk and legacy.

Dr. Stangler served for over a decade as Chief Medical Officer to an international family office in London, Liechtenstein and Switzerland.

She is Clinical Professor of the Department of Psychiatry and Behavioral Sciences at the University of Washington, and contributed as Advisor to the Department of Genetics, Personal Genetics Education Project, Harvard Medical School.

When Madonna performs, she reportedly engages a sterilization team to sweep, mop and wipe every surface of her dressing room, so that no trace of her DNA is left for surreptitious analysis, cloning or experimentation. Hacking portends the specter of a black market which will trade in valuable genetic information about prominent individuals and families. Is Madonna paranoid? Or smart? You decide...


The DNA science of genomics is now a critical part of strategic planning regarding health, risk and legacy for wealthy individuals, global families and their advisors.

Every living organism is made up of cells. Each cell contains a set of genes encoded with DNA which provides comprehensive instructions that constitute the master blueprint for our lives. In conjunction with environment and lifestyle, our genes are responsible for determining fundamentals of who we are: our appearance; traits; how we survive and prosper; how we age; how we decline.

Genes are our universal inheritance and legacy. They have been so since the onset of humankind. Historically they have been an invisible presence. Until now.

We have entered the Age of the Genome, an extraordinary era of transformative biotechnology. Today, we can not only fully see our genes - an essential building block of our humanity - but we can read them like the words of a book. And now we can edit, enhance and create genes, as well.


Genetics is the study of heredity and individual genes. Many of us first learned about genetics in high-school biology as we contemplated Mendels pea plant experiments of the 1860s.

Genomics is the study of an organisms complete set of genes, called the genome, the entirety of its DNA. The genome can be analyzed through a process called whole genome sequencing (WGS).

The first human genome was sequenced in 2003. This fifteen year project cost over $3B. Today, we can analyze the human genome for less than $1,000 within weeks. Personal motivations for WGS currently include: accessing health information, often providing actionable insights; understanding disease risk; knowing what one will pass on to ones children; and receiving information about response to particular medications (pharmacogenomics).


While DNA and genes are now very much a part of public consciousness, propelled mostly by widespread adoption of direct-to-consumer (DTC) genotyping products (e.g. 23andMe,, etc.), few understand the specifics of what these products offer.

The technology underlying direct-to-consumer genetic analyses is genotyping, which provides a limited picture of less than one percent of ones genes, preselected by individual companies on the basis of known associations with specific traits and diseases.

Alternatively, whole genome sequencing provides a literal snapshot of the entirety of ones genes. Some have compared the difference between genotyping and WGS to the difference between a tricycle and a race car.


The wealthy represent a population with the same concerns about health and genes as all others. However, factors in their environment generate unique concerns. The very terms family enterprise, family office and family legacy convey their requisite focus on all that is family. And genes permeate all aspects of family.

Traditionally the wealthy have focused on financial well-being, preservation and growth of capital. New knowledge of family genes will progressively influence all aspects of health, physical and emotional well-being; reproduction and family relationships; as well as the most traditional domains of family advising and operation of family enterprise. And the wealthy are already amongst the earliest adopters of cutting-edge DNA science.

Genomic information is already being used to inform best decisions around health, risk and legacy. Thus, knowledge of genomics and its impact on wealthy families is now part of an essential toolkit for the family advisory. Preeminent families have already embraced planning of genomics strategy.


Genomics has moved from an abstract quantitative entry in investment portfolios to a vital living tool for creating healthier, longer, disease-free lives.

How can we consider succession without considering genes??Heredity is succession. It is the succession of genes. How will succession planning be affected by knowledge of health futures of family members?

How can we consider trusts without considering genes??As we learn more about health risks, there are profound financial and social implications. If a family member has significant likelihood of imminent disease, appropriate planning is critical. What family resources should be allocated to access new mitigating interventions? Early gene- editing therapies are extremely costly, and no matter how wealthy a family, resources are finite.

How can we consider estate planning without considering genes??Radical longevity and the genetic means to achieve it will alter financial requirements. New financial instruments must be developed to accommodate increased lifespan.

How can we consider fiduciary responsibility without considering genes??Trustees and advisors will be challenged by new medical information that is difficult to interpret. Deciding how to utilize this information creates unprecedented ethical dilemmas. Families must align on an ethical framework to guide such decisions.

How can we consider governance without considering genes??Governance must reflect a common family vision with the understanding that genetics is not a solo sport. Every biologically related family member is literally tied to every other by the life thread of shared DNA.

How can we consider next-gen without considering genes??Next-gen have access to rapidly evolving radical reproductive technologies. They must also navigate new relationships with parents who may be physically and mentally vital well into their nineties and beyond. Parents may wish to continue their tenure within the family enterprise. This will create new frictions. Parents may also choose to create genetically enhanced new children, perhaps younger by an entire generation than their older siblings.


Family offices are as unique as the families they serve. Genomics strategy must be developed to support families as they navigate the complex field of genomics and engage with the science directly.

Human and behavioral perspectives cannot be ignored. Genomic information will have an impact on family dynamics; family identity; and the psyches of individuals who learn about new health risks, vulnerabilities and opportunities for enhancement.

Wealthy families are already formalizing family genomics chartersto guide ethical decision making, now and through the future.

Genes are rarely absolute destiny. Our environment and life experiences profoundly alter the expression of genes. Will knowledge of genes spur us to better life choices? Change is challenging. Family members require high-touch support to alter behavior in positive ways.

There is dire need, as well, for trustees and advisors to understand the complex nature of systems of wealth and to integrate rapidly evolving biological considerations through processes when appropriate and beneficial to do so. Trustees and advisors will help determine how decisions are made; where sensitive data is saved; who has the right to access such data and when; and how resources will be allocated.

Families of wealth have the financial means to direct education and funding of medical initiatives of unique concern, as well as the potential to fund more generative, legacy and aspirational projects.

For example, when Sergei Brin, Co-Founder of Google, learned about his genetic vulnerability to Parkinsons Disease, he radically altered his philanthropic strategy to support basic science research in the field. After changing the way the world searches for information on the web, he has now revolutionized how scientists approach Parkinsons Disease.

Genomics will inevitably become an essential component of the family philanthropy portfolio in highly personal ways.


Risk mitigation is a core responsibility in management of UHNW families and wealth. Direct- to-consumer genetic testing products present risks that must be contained immediately.

In December 2019, the United States Pentagon provided strong caution about the use of consumer genetic products by the military (Pentagon Warns Military Personnel Against At-Home DNA Tests, The New York Times, 24 December 2019).

Legal professionals have spoken out as well: Collecting [genetic] data could have unintended consequences. It can be lost to hackers, spies, others who might steal it... or exposed in government investigations through subpoenas... So people planning to plaster their deepest internal and family secrets into private company databases should consider the risks that the private DNA mills dont want you to think about. (The Shell Game Played with Your DNA, or 23 and Screwing Me, The National Law Review, 23 January 2020).

These groups represent a mere handful of increasingly concerned entities who detail gross compromise of privacy, security and accuracy. And Madonna saw it coming!

As a predominantly unregulated industry, DTC genetic testing entities often provide misleading information based on pseudoscience, making undeliverable promises. At times they offer false and dangerous reassurance about lack of medical vulnerability. For example, 23andMe only tests for three variants of BRCA genes responsible for breast and ovarian cancer, although more than 1,000 BRCA variants are known to increase cancer risk. 90% of participants who carry a BRCA mutation would be missed by todays 23andMe test.

Families of wealth, who require safety, security and privacy at all costs, must reject these at-home testing products entirely. The infotainment they provide is not an acceptable trade-off for the risks they impose, especially compromised safety.

By contrast, the whole genome sequencing industry is strictly regulated, governed by law and operates with the highest evidence-based technical medical standards and protection requirements for those whom they serve. Whole genome sequencing presents a far superior alternative for families of wealth.

Sequencing itself is but the first step of a life-long genomics journey. Once you have been sequenced, interpretation of your raw genomic data is a dynamic process, constantly evolving. New and increasingly complex insights will become available at exponential speed. Professional guidance is an absolute requirement to optimize translation and enhance health.

Imagine the following scenario:

A highly educated, vital, healthy 35 year-old family member is appointed CEO of the core global family enterprise. He dies at his desk from an unanticipated cardiac event on the second day of his tenure.

Consider the profound emotional and social impact of such an event on his family, the family office and the larger family organization. And consider the economic risk of not anticipating such an event, especially as this silent medical condition might have been understood using currently available DNA medical science through whole genome sequencing (Predicting Sudden Cardiac Death, The Harvard Gazette, 16 November 2019).


Families of wealth, family offices and family enterprise will ultimately be enriched by the gifts of genomics. This disruptive, deeply intimate human science bodes an extraordinary future with elimination of malignant disease, enhanced well- being and healthy longevity.

With new knowledge and agency comes new fiduciary responsibility to protect the lives of those we serve. We must all wrestle with its challenges, especially its ethics. Arming families with a working knowledge of genomics and a formal blueprint for its ethical application allows them to shape their most powerful legacy and future.

See the original post:
Dr. Ronnie S. Stangler: What Does Madonna Know About Her Genes That You Don't? Genomics and Its Impact on Families of Wealth | Horizons: Family Office...

Recommendation and review posted by Alexandra Lee Anderson

Read the Rest...

Cars We Remember: The Rebel Machine by AMC and a rare 1971 Matador Go Machine – The Providence Journal

Q: I enjoy the nostalgia articles in my hometown newspaper The Gainesville Sun. The recent Cars We Remember section was really fun to read, and I enjoyed the AMC history of high performance. One AMC car you didn't mention was the 1970 Rebel Machine, and I'm wondering your thoughts on the Rebel Machine by AMC? How many were ever made and is it a worthy collector car?

Shawn S., Gainesville, Florida.

A: Shawn, I'm happy to tell you about the 1970 Rebel Machine and also a very rare 1971 AMC muscle car, too.

As I mentioned in the Cars We Remember special edition, by the time AMC released its pony and muscle car lineup during the latter part of the 1960s the company was way behind the performance youth movement that began in earnest with the 1964 GTO. And even though Chevy, Ford and Chrysler produced some really hot full-size muscle cars in 1961-1963 like the Chevy 409, Ford 390-406-427 and the MOPAR 413-426, American Motors was not in the performance ballgame at all.

To make things worse when it came to AMC completely missing this very profitable muscle car boom, the stuffed shirts at the board meetings decided to release newspaper advertisements that emphasized the only "race" AMC was interested in was the "human race." So, even though the baby boomer generation was clearly into excitement and muscle cars in a big way, AMC was not.

After finally relenting, AMCs mid-size performance started in 1967, when the good-looking Rebel SST hit the showroom floors. As a precursor to the Rebel Machine, the SST featured a 343-inch V8 with 280 horsepower and some interesting high-performance options like Carter 4-barrel carb, bigger camshaft, and even an optional 4:44 rear end gear. Still, a 343-V8 with just 280 horsepower was no match against the competition, like an Olds 442, Chevelle SS396 or a Ford Fairlane GT. It just didn't cut it.

But to answer your Rebel Machine question, immediately following AMC's compact size SC/Rambler American in 1969, which happened to be the hottest AMC ever to hit the roads and just 1,512 were ever built, AMC then decided to release the Rebel Machine in 1970. The Rebel Machine rode on a 114-inch wheelbase and was more in line with the Plymouth Roadrunner size of muscle car than the compact style SC/Rambler. The first 1,000 were painted red, white and blue, while the others could be ordered in any solid color.

Under the hood sat a 390-inch, 340-horse engine mated to the great shifting Borg Warner T-10 four-speed with a factory Hurst shifter. The suspension was beefed up with stiffer AMC station wagon springs in the rear, resulting in a nice "funny car style" rake. However, the raised rear resulted in some wheel hop under full acceleration with street tires at the drags. The car would run in the 14-second range at 90 mph, which was good back then for a street muscle car.

Other "The Machine" notables were a ram air type hood operated by vacuum with an integrated 8,000 RPM tachometer. In my opinion, the Rebel SST and the Rebel Machine were the best-looking AMC's of all, hands down.

As for longevity, the Rebel Machine was produced only one year, 1970, at a base price of $3,450. Thus, it is a very rare collector car and only 2,326 were ever built. Concerning pricing, a 390 Rebel Machine in excellent original or fully restored condition today will fetch an easy $50,000 and up according to NADA pricing. Even an average condition Machine needing some TLC should go in the $20,000 range, making it a desirable collector car.

Now for that other AMC performance car I mention above, which may well be the rarest AMC muscle car ever built.

Following AMC dropping the Rebel Machine from its lineup, a real sleeper popped up for just a bit of time in 1971 when less than 60 1971 AMC Matador two-door hardtops were delivered with AMC's "The Machine Go Package" option. The Go Package added either a 360-V8 at 290 horses or the preferred 401-inch V8 with 330-horsepower. The Borg Warner T-10 was again part of the package, along with dual exhaust, heavy duty suspension, 15-inch Goodyear Polyglas raised letter tires and a 3.90 rear end gear. As rare as this Rambler is, I've never seen one in person but it may well be the best of the mid-size muscle cars from AMC. By mid-1971, the option disappeared.

If you ever see a 1971 Matador with the 401 The Machine Go Package (valued at a top price of near $50,000) you are in the minority as very few survived the crusher. Thanks for your question.

Greg Zyla writes weekly for More Content Now and GateHouse Media. Contact him at

Read more here:
Cars We Remember: The Rebel Machine by AMC and a rare 1971 Matador Go Machine - The Providence Journal

Recommendation and review posted by Alexandra Lee Anderson

Read the Rest...

How to Fight Coronavirus With Folding@home and a Gaming PC – How-To Geek


Want to help in the battle against the novel coronavirus? You can put your PCs graphics processor to work with Folding@home. Youll join an army of computers running calculations to help scientists understand the virus.

Folding@home is a distributed computing project thats been around since the year 2000. Its named after protein folding. If you install the software and join a project, it will run in the background and use spare graphics processing (GPU) power to run calculations. Your PC will be one of the hundreds of thousands of PCs running these calculations, all working together.

The software has previously been used to help find cures to cancer, Parkinsons, Huntingtons, influenza, and many other diseases. Now, Folding@home is helping scientists understand the structure of the SARS-CoV-2 virus that causes COVID-19. As Folding@home director Greg Bowman explains, a better understanding of the virus could aid in the development of life-saving drugs.

In other words, you can put your PCs GPU to work crunching numbers that will help scientists better understand and fight the novel coronavirus.You can read specifics about how Folding@home is simulating the dynamics of COVID-19 proteins to hunt for new therapeutic opportunities on the projects website.

This work is GPU-dependent and requires NVIDIA or AMD graphics hardware. It will work best on computers with powerful graphics hardware.

To put your PC to work battling coronavirus, download the Folding@home installer and run it to install the software. Its available for Windows, Mac, and Linux. Well show how it works on Windows here.

Once youve installed the Folding@home software, youll be taken to the page, where you can control the software on your PC. You can choose to fold anonymously or set up an identity.

If you set up an identity, you can track your work and earn points. You can even join a team with other people and compete to see who can earn the most pointsjust a bit of friendly competition.

However, you dont need to set up an identityyou can just select Fold as Anonymous and click Start Folding to begin.

To ensure youre helping with COVID-19 research, ensure Any disease is selected under the I support research fighting box. This is the default option. With it enabled, Folding@home will prioritize work related to the novel coronavirus.

Work may not be available immediately, and your client may work on other diseases like Alzheimers, cancer, Huntingtons, or Parkinsons while waiting for COVID-19 jobs. Leave it running in the background, and it will automatically start any available work.

The Folding@home software will remain running in the backgroundeven when you have the web page closed. It will automatically use any spare resources and get out of the way when youre using your GPU for other purposes, like playing a PC game.

Look for the Folding@home icon in your computers notification area (system tray) to find options, pause it, or quit the software and prevent it from running.

If you decide you no longer want to participate, head to the Uninstall or change a program list in Windows and uninstall the FAHClient program.

Even NVIDIA has called for gamers to install Folding@home and donate any spare computing power they might have. Computers all over the world are joining the fight.

For more information, take a look at thisFAQ about the SARS-CoV-2 projects in Folding@home. Youll also find updates on Folding@homes news page.

Excerpt from:
How to Fight Coronavirus With Folding@home and a Gaming PC - How-To Geek

Recommendation and review posted by Alexandra Lee Anderson

Read the Rest...

Join Team Hackaday To Crunch COVID-19 Through Folding@Home – Hackaday

Donate your extra computer cycles to combat COVID-19. The Folding@Home project uses computers from all over the world connected through the Internet to simulate protein folding. The point is to generate the data necessary to discover treatments that can have an impact on how this virus affects humanity. The software models protein folding in a search for pharmaceutical treatments that will weaken the virus ability to attack the human immune system. Think of this like mining for bitcoin but instead were mining for a treatment to Coronavirus.

Initially developed at Standford University and released in the year 2000, this isnt the first time Hackaday has advocated for Folding@Home. The Team Hackaday folding group was started by readers back in 2005 and that team number is still active, so lets pile on and work our way up the rankings. At the time of writing, were ranked 267 in the world, can we get back up to number 30 like we were in 2008? To use the comparison to bitcoin once again, this is like a mining pool except what we end up with is a show of goodwill, something I think we can all use right about now.

You can get set up in five minutes. The software package is just a few megabytes and configuration is minimal:

Thats about it, just open FAHControl and the software will connect to the Folding at Home servers and request a Work Unit (WU) part of the protein folding math puzzle currently being solved. Once it has a WU the software will solve that unit and upload the result. Rinse and repeat and youre a worker bee in a super-computer thats distributed throughout the world.

The F@H project is seeing a surge of new computers on the network. Because of this you may run into a situation where no new WUs are getting downloaded. I experienced this on Wednesday morning and believe its simply caused by the buffer of work running out and needing to be replenished. The nice thing is you dont need to do anything, so just let your instance run and itll get to work when more is available.

The software does allow you to use your GPU for much more efficient calculations, but that setup may be non-trivial and beyond the scope of this article. I suggest you just get the client up and running and then look to configure GPU as a later step.

Are you making a difference? Yes! But of course metrics tell this message the best. You can see the team summary above. This statistics page includes a user summary showing 21 active users right now, including the hackaday_wrencher instance I added when working on this article which is just beginning to score points.

This group has over 1600 members right now but most are inactive. Can we reactivate those? Can we double that number? Grab those gaming rigs and let the electrons flow. Folding@Home has made a huge impact on research over the last twenty years and now more than ever we can build on that groundwork by joining in to fight this global pandemic.

See original here:
Join Team Hackaday To Crunch COVID-19 Through Folding@Home - Hackaday

Recommendation and review posted by Alexandra Lee Anderson

Read the Rest...

Researchers turn to PC gamers for help with COVID-19 –

Share this article

PC gamers are being asked to donate their unused computational power to help researchers better understand the novel coronavirus (COVID-19).

Folding@home is a distributed computing project for disease research which uses idle resources to simulate protein folding.

By downloading Folding@home, PC gamers can help researchers develop treatments for COVID-19, which has so far killed over 8,000 people and caused global disruption.

"The data you help us generate will be quickly and openly disseminated as part of an open science collaboration of multiple laboratories around the world, giving researchers new tools that may unlock new opportunities for developing lifesaving drugs," said Folding@home director Greg Bowman in a post detailing the project.

Early projects are geared around understanding how the virus interacts with human host cells, and developing new antibodies to disrupt it.

Folding@home intends to make the data readily available to researchers and the public.

"While we will rapidly release the simulation data sets for others to use or analyse, we aim to look for alternative conformations and hidden pockets within the most promising drug targets, which can only be seen in simulation and not in static X-ray structures," said Folding@home computational chemist John Chodera.

"We hope that these structures -- once validated by emerging compound screening data -- could help direct the virtual screening campaigns or the targeting of new pockets for which atomistic structures were not yet available."

See original here:
Researchers turn to PC gamers for help with COVID-19 -

Recommendation and review posted by Alexandra Lee Anderson

Read the Rest...

Join PC Gamer’s Folding@home team and help research a cure for Covid-19 – PC Gamer

A couple of weeks ago we learned about a new game called Foldit, developed by researchers at the University of Washington, that could help with the development of a treatment for the Covid-19 coronavirus. Essentially, players solve puzzles by folding protein chains into new shapes that change the function of the protein, with points awarded based on the effectiveness of the solution. Researchers can then experiment on those folded proteins in order to determine their usefulness in the real world.

If that game doesn't appeal to you, but you happen to be sitting beside an expensive, powerful PC that's not really doing anything, why not let it handle the task for you?

In Foldit you have to work for a spot on that leaderboard, but through Folding@home, you can put your PC to work. Folding@home is a distributed computing project founded by Stanford University in 2000 that uses idle PCs around the world for medical research, including the coronavirus pandemic.

The way it works, essentially, is that protein data is broken up into work units, which are then downloaded automatically by the Folding software. Your PC crunches away on it until the work unit is complete, at which point the result is uploaded to the server. A new work unit is downloaded, and the process starts again. As a weak but thematically appropriate analogy, it's a bit like Team Fortress 2, except extraordinarily slow, it's nothing but bots, and the whole world is playing in the same match.

You can fold by yourself (and bravo for doing your bit) but these things are always more fun when you're part of a teamsuch as the PC Gamer Folding@home Team. The setup instructions might look a little intimidating but it's actually quite simple, and once you're rolling it's entirely automated, although you can tweak various settings, like how much processing power to dedicate and whether or not you want it to work while you're using your PC.

If you do run into problems or have any questions with Folding@home, or just feel like chatting, the PC Gamer forum thread linked above can help out. The Folding website is struggling a little bit right now, but once it's squared away you'll be able to following along with the team's progress here.

We're maintaining a roundup of esports competitions and other gaming events that have been impacted by the coronavirus outbreak that you can keep up with here.For more information on the Covid-19 coronavirus, visit the Centers for Disease Control for updates in North America, the European Centre for Disease Prevention and Control, or the World Health Organization.

This is what it looks like when proteins fold.

See the original post here:
Join PC Gamer's Folding@home team and help research a cure for Covid-19 - PC Gamer

Recommendation and review posted by Alexandra Lee Anderson

Read the Rest...

Why AI might be the most effective weapon we have to fight COVID-19 – The Next Web

If not the most deadly, the novel coronavirus (COVID-19) is one of the most contagious diseases to have hit our green planet in the past decades. In little over three months since the virus was first spotted in mainland China, it has spread to more than 90 countries, infected more than 185,000 people, and taken more than 3,500 lives.

As governments and health organizations scramble to contain the spread of coronavirus, they need all the help they can get, including from artificial intelligence. Though current AI technologies arefar from replicating human intelligence, they are proving to be very helpful in tracking the outbreak, diagnosing patients, disinfecting areas, and speeding up the process of finding a cure for COVID-19.

Data science and machine learning might be two of the most effective weapons we have in the fight against the coronavirus outbreak.

Just before the turn of the year, BlueDot, an artificial intelligence platform that tracks infectious diseases around the world, flagged a cluster of unusual pneumonia cases happening around a market in Wuhan, China. Nine days later, the World Health Organization (WHO)released a statementdeclaring the discovery of a novel coronavirus in a hospitalized person with pneumonia in Wuhan.

BlueDot usesnatural language processingandmachine learning algorithmsto peruse information from hundreds of sources for early signs of infectious epidemics. The AI looks at statements from health organizations, commercial flights, livestock health reports, climate data from satellites, and news reports. With so much data being generated on coronavirus every day, the AI algorithms can help home in on the bits that can provide pertinent information on the spread of the virus. It can also find important correlations between data points, such as the movement patterns of the people who are living in the areas most affected by the virus.

The company also employs dozens of experts who specialize in a range of disciplines including geographic information systems, spatial analytics, data visualization, computer sciences, as well as medical experts in clinical infectious diseases, travel and tropical medicine, and public health. The experts review the information that has been flagged by the AI and send out reports on their findings.

Combined with the assistance of human experts, BlueDots AI can not only predict the start of an epidemic, but also forecast how it will spread. In the case of COVID-19, the AI successfully identified the cities where the virus would be transferred to after it surfaced in Wuhan. Machine learning algorithms studying travel patterns were able to predict where the people who had contracted coronavirus were likely to travel.

Coronavirus (COVID-19) (Image source:NIAID)

You have probably seen the COVID-19 screenings at border crossings and airports. Health officers use thermometer guns and visually check travelers for signs of fever, coughing, and breathing difficulties.

Now,computer vision algorithmscan perform the same at large scale. An AI system developed by Chinese tech giant Baidu uses cameras equipped with computer vision and infrared sensors to predict peoples temperatures in public areas. The system can screen up to 200 people per minute and detect their temperature within a range of 0.5 degrees Celsius. The AI flags anyone who has a temperature above 37.3 degrees. The technology is now in use in Beijings Qinghe Railway Station.

Alibaba, another Chinese tech giant, has developed an AI system that candetect coronavirus in chest CT scans. According to the researchers who developed the system, the AI has a 96-percent accuracy. The AI was trained on data from 5,000 coronavirus cases and can perform the test in 20 seconds as opposed to the 15 minutes it takes a human expert to diagnose patients. It can also tell the difference between coronavirus and ordinary viral pneumonia. The algorithm can give a boost to the medical centers that are already under a lot of pressure to screen patients for COVID-19 infection. The system is reportedly being adopted in 100 hospitals in China.

A separate AI developed by researchers from Renmin Hospital of Wuhan University, Wuhan EndoAngel Medical Technology Company, and the China University of Geosciences purportedly shows 95-percent accuracy on detecting COVID-19 in chest CT scans. The system is adeep learning algorithmtrained on 45,000 anonymized CT scans. According to a preprint paperpublished on medRxiv, the AIs performance is comparable to expert radiologists.

One of the main ways to prevent the spread of the novel coronavirus is to reduce contact between infected patients and people who have not contracted the virus. To this end, several companies and organizations have engaged in efforts to automate some of the procedures that previously required health workers and medical staff to interact with patients.

Chinese firms are using drones and robots to perform contactless delivery and to spray disinfectants in public areas to minimize the risk of cross-infection. Other robots are checking people for fever and other COVID-19 symptoms and dispensing free hand sanitizer foam and gel.

Inside hospitals, robots are delivering food and medicine to patients and disinfecting their rooms to obviate the need for the presence of nurses. Other robots are busy cooking rice without human supervision, reducing the number of staff required to run the facility.

In Seattle, doctors used a robot to communicate with and treat patients remotely to minimize exposure of medical staff to infected people.

At the end of the day, the war on the novel coronavirus is not over until we develop a vaccine that can immunize everyone against the virus. But developing new drugs and medicine is a very lengthy and costly process. It can cost more than a billion dollars and take up to 12 years. Thats the kind of timeframe we dont have as the virus continues to spread at an accelerating pace.

Fortunately, AI can help speed up the process. DeepMind, the AI research lab acquired by Google in 2014, recently declared that it has used deep learning to find new information about the structure of proteins associated with COVID-19. This is a process that could have taken many more months.

Understanding protein structures can provide important clues to the coronavirus vaccine formula. DeepMind is one of several organizations who are engaged in the race to unlock the coronavirus vaccine. It has leveraged the result of decades of machine learning progress as well as research on protein folding.

Its important to note that our structure prediction system is still in development and we cant be certain of the accuracy of the structures we are providing, although we are confident that the system is more accurate than our earlier CASP13 system, DeepMinds researchers wroteon the AI labs website. We confirmed that our system provided an accurate prediction for the experimentally determined SARS-CoV-2 spike protein structure shared in the Protein Data Bank, and this gave us confidence that our model predictions on other proteins may be useful.

Although its too early to tell whether were headed in the right direction, the efforts are commendable. Every day saved in finding the coronavirus vaccine can save hundredsor thousandsof lives.

This story is republished fromTechTalks, the blog that explores how technology is solving problems and creating new ones. Like them onFacebookhere and follow them down here:

Published March 21, 2020 17:00 UTC

Here is the original post:
Why AI might be the most effective weapon we have to fight COVID-19 - The Next Web

Recommendation and review posted by Alexandra Lee Anderson

Read the Rest...

How you can help find a drug to stop coronavirus by not using your computer – News 5 Cleveland

If you're reading this on a computer really, if you own a working computer you can help to find a potential treatment for coronavirus.

Folding@Home, a project that uses the collective computing power of thousands of computers around the world to simulate protein dynamics, is tackling SARS-COV-2, the novel coronavirus that causes COVID-19.

By downloading the Folding@Home software and letting it run simulations when your computer is idle, like when youre asleep and totally not scrolling through some quality quarantmemes on phone, youre helping scientists in the Bowman Lab at the University of Washington in St. Louis understand how the coronavirus proteins work, and how to design therapeutics to stop them.

Its similar to the long-running project SETI@Home, which is unfortunately ending the volunteer program this month. It uses distributed computing to analyze radio telescope data in the Search for Extraterrestrial Intelligence, and, by the way, if youre listening, we could use some help here.

By donating your spare computational power to Folding@Home, youll be a part of one of the worlds fastest computing systems, running at a speed of about 98.7 petaFLOPS, according to recent statistics from the site. Thats 10 to the 15th power FLOPS. A 98,000 teraFLOPS. The Titan Supercomputer cranks out a measly 20 petaFLOPS.

Folding@Home recently simulated a protein from Ebola virus that was considered undruggable, and after performing experiments confirming that prediction, theyre now on the hunt for drugs to bind to this newly discovered site.

Learn more about the project here.

Read more:
How you can help find a drug to stop coronavirus by not using your computer - News 5 Cleveland

Recommendation and review posted by Alexandra Lee Anderson

Read the Rest...

Thousands of These Computers Were Mining Cryptocurrency. Now Theyre Working on Coronavirus Research – Yahoo Money

CoreWeave, the largest U.S. miner on the Ethereum blockchain, is redirecting the processing power of 6,000 specialized computer chips toward research to find a therapy for the coronavirus.

These graphics processing units (GPUs) will be pointed toward Stanford Universitys Folding@home, a long-standing research effort that unveiled a project on Feb. 27 specifically to boost coronavirus research by way of a unique approach to developing pharmaceutical drugs: connecting thousands of computers from around the world to form a distributed supercomputer for disease research.

CoreWeave co-founder and Chief Technology Officer (CTO) Brian Venturo said the project has at least a shot at finding a drug for the virus. As such, CoreWeave has responded by doubling the power of the entire network with its GPUs, which are designed to handle repetitive calculations.

Related: State Power After Coronavirus, Feat. Peter McCormack

See also: Bitcoiners Are Biohacking a DIY Coronavirus Vaccine

According to Venturo, those 6,000 GPUs made up about 0.2 percent of Ethereums total hashrate, earning roughly 28 ETH per day, worth about $3,600 at press time.

There is no cure for the coronavirus just yet (though various groups are working on vaccines and research to combat the disease, including IBMs supercomputer). Venturo noted that Folding@home has been used to contribute to breakthroughs in the creation of other important drugs.

Their research had profound impacts on the development of front-line HIV defense drugs, and we are hoping our [computing power] will aid in the fight against coronavirus, Venturo said.

Related: SkyWeaver Didnt Plan for a Captive Audience of Millions but It Sure Helps

The coronavirus is taking a toll across the world. Italy and Spain are on lockdown. Conferences, stores and restaurants are closing to stem the spread of the disease; by stoking fears, its slamming the financial markets in the process.

When the idea of using GPUs for coronavirus research was mentioned to CoreWeave, the team didnt think twice.

They had a test system up and running within minutes, Venturo said. Since then, the project quickly snowballed. CoreWeave has been contributing over half of the overall computing power going into the coronavirus wing of Folding@home.

The idea of should we do this? was never really brought up, it kind of just happened. We were all enthusiastic that we might be able to help, Venturo added.

Folding@home is a decentralized project in the same vein as Bitcoin. Instead of one research firm alone using a massive computer to do research, Folding@home uses the computing power of anyone who wants to participate from around the world even if its just a single laptop with a little unused computing power to spare.

See also: Bitcoiners in Europe Reflect on Economic Shocks as Coronavirus Spreads

In this case, the computing power is used to find helpful information relating to the coronavirus. Much like in bitcoin mining, one user might detect a solution to the problem at hand, distributing this information to the rest of the group.

Their protein simulations attempt to find potential pockets where existing [U.S. federal agency Food and Drug Administration (FDA)] approved drugs or other known compounds could help inhibit or treat the virus, Venturo said.

Viruses have proteins that they use to suppress our immune systems and reproduce themselves. To help tackle coronavirus, we want to understand how these viral proteins work and how we can design therapeutics to stop them, a Folding@home blog post explains.

Simulating these proteins and then looking at them from different angles helps scientists to understand them better, with the potential of finding an antidote. Computers accelerate this process by shuffling through the variations very quickly.

Our specialty is in using computer simulations to understand proteins moving parts. Watching how the atoms in a protein move relative to one another is important because it captures valuable information that is inaccessible by any other means, the post reads.

Folding@home could use even more power. Venturo urges other GPU miners to join the cause.

Even without these calls for participation, though, miners of other cryptocurrencies are already independently taking action. founder Johann Tanzer put out a call to action to Tezos bakers (that blockchains equivalent of miners) last week, promising to send the leading contributor to Folding@home a modest 15 XTZ, worth roughly $20 at press time.

Story continues

The initiative blew up, to Tanzers surprise. Though they might not be contributing as much power as CoreWeave, 20 groups of Tezos miners are now contributing a slice of their hashing power to the cause. Tanzers pot has swelled to roughly $600 as Tezos users caught wind of the effort and donated.

But thats not to say all miners can participate. While GPUs are flexible, application-specific integrated circuits (ASICs), a type of chip designed specifically for mining, arent, according to Venturo. Though ASICs are more powerful than GPUs, theyre really only made for one thing: To mine cryptocurrency. This is one advantage Venturo thinks Ethereum has over Bitcoin, since GPU mining still works on the former, whereas the latter is now dominated by ASICs.

See also: Israeli Bitcoiners See Surveillance as Unavoidable During Coronavirus Crisis

This is one of the great things about the Ethereum mining ecosystem, its basically the largest GPU compute resource on the planet. We were able to redeploy our hardware to help fight a global pandemic in minutes, Venturo said. (However, its worth noting that Ethereum has seen ASICs enter the fray. Not to mention, ether miners might soon go extinct when a pivotal upgrade makes its way into the network.)

ASICs are useless for the Folding@Home effort, but if bitcoin miners have old GPUs lying around from the early days that they could contribute, too.

Even if other miners join up, though, its still a long shot that the effort will lead to a helpful drug.

After discussing with some industry experts [] we believe the chance of success in utilizing the work done on Folding@Home to deliver a drug to market to be in the 2-5% range, Venturo said.

Continued here:
Thousands of These Computers Were Mining Cryptocurrency. Now Theyre Working on Coronavirus Research - Yahoo Money

Recommendation and review posted by Alexandra Lee Anderson

Read the Rest...

Page 19«..10..18192021..3040..»