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Boost your health with a step counter – Blaine Northern Light

By Beth Sanborn

Its summer in Whatcom County. That generally means pleasant weather, usually not too hot or rainy, and longer daylight hours. Add in the coronavirus pandemic and many people are getting their daily exercise outdoors, often with walking or running. Using a fitness tracker to monitor activity levels is popular, often with a goal of taking 10,000 steps each day.

For some people, that goal of 10,000 steps is motivating and helps them be physically active. But for others, especially if they arent reaching their goal, its discouraging, reduces motivation and may lead to less physical activity.

Have you wondered how scientists came to recommend 10,000 steps per day as a fitness goal? Well, the truth is, the idea has little to no scientific research behind it. In 2019, Harvard Medical School researcher I-Min Lee looked into the history of the 10,000 steps a day goal and discovered that it most likely originated in the 60s when a Japanese company marketed a pedometer called Manpo-kei, which in Japanese means 10,000 steps meter. Most likely the name was chosen because the Japanese character for 10,000 looks a little like a man walking. Ads for the step counter said, Lets all walk 10,000 steps a day. This idea has persisted through the decades.

While theres nothing wrong with that goal, it may not be necessary for achieving health and longevity. Multiple researchers have concluded that while 10,000 steps is a good goal, there is nothing magical about that number and even 7,000-8,000 steps can improve health and longevity. (The average American adult takes about 3,000-5,000 steps a day.) Or, looking at exercise goals another way, as the Centers for Disease Control and Prevention has done, aim for at least 30 minutes of moderate exercise five days a week (which correlates to 7,000-8,000 steps a day).

The human body was designed for movement and physical activity is important for good health. Physical activity like walking can help control blood pressure, blood sugar and cholesterol levels. It can also stimulate creative thinking and is associated with living longer and healthier.

So if using a step counter or fitness tracker motivates you to exercise and you reach 10,000 steps a day (or more), thats great. But dont be discouraged if you dont reach that number. Make it your goal to be physically active above the level of your normal daily activity and enjoy the beauty of summer in the Pacific Northwest.

Beth Sanborn is a licensed nutritionist who lives in Birch Bay and holds a masters degree in public health nutrition.

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Boston is among Americas top fittest cities, new study says; ranked as most likely to bike or walk to work – MassLive.com

Boston is among the top 10 fittest cities in America, according to a new study by the American College of Sports Medicine and the Anthem foundation.

The study, released in the American Fitness Index, used 33 health behaviors, chronic diseases, and community infrastructure indicators to rank 100 cities.

Cities with the highest scores are considered to have strong community fitness, a concept analogous to individuals having strong personal fitness, the city states. Cities that rank near the top of the Fitness Index have more strengths and resources that support healthy living and fewer challenges that hinder it.

Boston came in at number 10, cracking the top 10 list for the first time, according to WCVB. Arlington, Virginia was named the fittest city in the country for the third time in a row.

With the health care costs of physical inactivity exceeding $117 billion yearly, increasing physical activity has never been more important to the nations health and economic outcomes, the study states.

Boston residents were the most likely to bike or walk to work and was only one of two cities to have all residents living within a 10-minute walk to a park, the study states.

Massachusetts was also recently named the best state for health care in the United States, according to WalletHub.

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Silicon Valley, the start-up incarnation 4/5. Palmer Luckey, the geek who needed to make sure the army supremacy of the West – Pledge Times

Gone is the poster of Uncle Sam pointing the finger at you with that We need you injunction. The US military has long relied on video games to recruit. Americas Army, a shooting game developed to restore the reputation of the institution and attract young recruits, is also in its fourth version. And if, at the origin, the joysticks were inspired by the controls of military planes or helicopters, now it is the combat drones which are piloted with game console controllers. Palmer Luckey is the result of this strange mixture. He is now the head of a $ 2 billion start-up that has the avowed aim of leading the United States and the West to technological supremacy in the war of the future.

Ten years ago, Palmer, a teenager with a passion for war games and Hawaiian shirts, was thinking in the basement of his preschool in California on how to make his favorite hobby more immersive. He imagines the Oculus Rift, a virtual reality headset suitable for gaming. If he is not the most sociable of teenagers, he is part of a very large online network of very conservative white gamers, who are fighting against the irruption of women and any form of progressive idea in the video game industry. In 2012, he launched his idea on Kickstarter, a crowdfunding platform, and thus raised $ 2.5 million. Two years later, Facebook bought Oculus for 2 billion, including 1.6 in Facebook shares. Palmers fortune is made.

Not enjoying himself in Zuckerbergs firm, where he cannot express his alt-right ideas too openly, he leaves and sets up a new business, co-financed with Peter Thiel, who also likes Donald Trump a lot and the Lord of the Rings. Thiel had launched Palantir, The all-seeing eye in the novel by Tolkien, a data management company working for intelligence. He helps Luckey to create Anduril, the name of the heros sword which means Protector of the West the West would be fairer in this case.

I created Anduril because Im afraid that the United States will lose its supremacy, explained Palmer, still in Hawaiian shirt, at the Lisbon Web Summit in 2018. The big industrialists are good at making fighter planes, but not are not looking for autonomous weapons, soldier enhancement through transhumanism or military artificial intelligence. The young man then describes his vision of the war of the future. I think the soldiers will soon be omniscient superheroes () I dont think they will directly carry weapons. Each soldier will have an augmented reality headset through which he will have a general and precise view of the battlefield and through which he will control his weapons. Yes, it essentially describes a video game.

Anduril, who has at 1 er July raised 200 million dollars again, landed real contracts with the Pentagon for its flagship product, Lattice (trellis in French). The idea is to cover a territory with sensors: a military base, critical infrastructures, borders An artificial intelligence models the terrain in real time and identifies any intrusion. With a virtual reality headset, a human can almost verify the intrusion with their own eyes. He erected a virtual wall that stretches across the Mexican border and made it possible to arrest dozens of migrants, which Luckey is very proud of. It has just added to Lattice the Interceptor, a combat drone capable of intercepting in the area to be protected another drone in mid-flight, operating completely autonomously. An equally autonomous tank would be in preparation in the hangars of Anduril in Silicon Valley. If we want to define the rules of this war of tomorrow, we must be the first, assures Luckey. We were able to impose rules on nuclear weapons, because we were the best. Technological supremacy is a prerequisite for ethics.

-

Tomorrow Travis Kalanick, Uber.

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Global Healthcare Nanotechnology (Nanomedicine) Industry Outlook 2020-2027 with Profiles of 46 Players Including Abbott Labs, Celgene Corp, GE…

DUBLIN, Aug. 5, 2020 /PRNewswire/ -- The "Healthcare Nanotechnology (Nanomedicine) - Global Market Trajectory & Analytics" report has been added to ResearchAndMarkets.com's offering.

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The publisher brings years of research experience to this 9th edition of the report. The 190-page report presents concise insights into how the pandemic has impacted production and the buy side for 2020 and 2021. A short-term phased recovery by key geography is also addressed.

Global Healthcare Nanotechnology (Nanomedicine) Market to Reach $475.2 Billion by 2027

Amid the COVID-19 crisis, the global market for Healthcare Nanotechnology (Nanomedicine) estimated at US$183.9 Billion in the year 2020, is projected to reach a revised size of US$475.2 Billion by 2027, growing at a CAGR of 14.5% over the analysis period 2020-2027.

Therapeutics, one of the segments analyzed in the report, is projected to record a 14.1% CAGR and reach US$369.5 Billion by the end of the analysis period. After an early analysis of the business implications of the pandemic and its induced economic crisis, growth in the Regenerative medicine segment is readjusted to a revised 15.7% CAGR for the next 7-year period.

The U.S. Market is Estimated at $54.3 Billion, While China is Forecast to Grow at 14% CAGR

The Healthcare Nanotechnology (Nanomedicine) market in the U.S. is estimated at US$54.3 Billion in the year 2020. China, the world's second largest economy, is forecast to reach a projected market size of US$82.8 Billion by the year 2027 trailing a CAGR of 14% over the analysis period 2020 to 2027.

Among the other noteworthy geographic markets are Japan and Canada, each forecast to grow at 12.8% and 12.5% respectively over the 2020-2027 period. Within Europe, Germany is forecast to grow at approximately 10.7% CAGR.

In-vitro diagnostics Segment to Record 16.3% CAGR

In the global In-vitro diagnostics segment, USA, Canada, Japan, China and Europe will drive the 16.1% CAGR estimated for this segment. These regional markets accounting for a combined market size of US$5.7 Billion in the year 2020 will reach a projected size of US$16.2 Billion by the close of the analysis period.

China will remain among the fastest growing in this cluster of regional markets. Led by countries such as Australia, India, and South Korea, the market in Asia-Pacific is forecast to reach US$56.9 Billion by the year 2027.

Competitors identified in this market include, among others:

Total Companies Profiled: 46

For more information about this report visit https://www.researchandmarkets.com/r/44bvip

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NeoGenomics Slumps in Q2 but Readies for Second-Half Rebound – The Motley Fool

The coronavirus pandemic hit the business pretty hard, but NeoGenomics (NASDAQ:NEO) had been preparing investors for months. Properly setting expectations turned out to be a great move.

Shares of NeoGenomics reached all-time highs shortly after the company announced second-quarter 2020 operating results. The financial metrics weren't pretty, and there's lingering uncertainty about the course of the coronavirus pandemic and its effects on the business, but investors are largely confident in the long-term strategy.

Can the growth stock maintain its expensive valuation?

Image source: Getty Images.

NeoGenomics is an oncology reference lab operating two business segments: clinical services and pharma services. The former collects patient samples from doctors, performs the test(s) selected by customers from a comprehensive menu, and returns the data. The latter helps biopharmaceutical companies to identify biomarkers for drug development, access oncology-specific datasets from pathologists, and develop and validate companion diagnostics.

When first-quarter 2020 operating results were announced, management prepared investors for a sour showing in the second quarter. The coronavirus pandemic was expected to impact clinical trials, which would hurt both business segments. However, NeoGenomics announced it wouldn't furlough employees and would continue investing in the business.

For the second quarter of 2020, total revenue slipped 14% compared to the year-ago period -- a sharp contrast to the double-digit growth investors have grown accustomed to in recent years. Gross profit sank due to lower revenue per test and higher costs, leaving investors with a relatively weak first-half showing for the business.

Metric

First Half 2020

First Half 2019

Change (YoY)

Clinical services

$166.9 million

$175.2 million

(5%)

Pharma services

$26.1 million

$22.1 million

18%

Total revenue

$193.0 million

$197.3 million

(2%)

Gross profit

$74.4 million

$96.1 million

(22%)

Operating income

($24.2 million)

$7.0 million

N/A

Net income

($13.8 million)

($0.4 million)

N/A

Operating cash flow

($5.0 million)

$1.4 million

N/A

Data source: SEC filing. YoY = year over year.

Pharma services revenue was the only bright spot, although the increase was entirely explained by the recent acquisition of assets from Human Longevity.

Despite the tough operating environment, management didn't flinch. On the second-quarter 2020 earnings conference call, CEO Douglas VanOort laid out a six-part business update comprising strategy and investments. Two developments in particular stood out.

NeoGenomics has converted a portion of its lab space to run up to 10,000 SARS-CoV-2 diagnostic tests per day, which could increase in the future. The business has also made a $25 million investment in a liquid biopsy start-up called Inivata. The equity investment gives the oncology reference lab the exclusive option to acquire Inivata.

More important, the investment provides NeoGenomics the option to commercialize the company's InvisionFirst-Lung liquid biopsy test. The diagnostic tests 37 relevant genes to drive care decisions for non-small cell lung cancer (NSCLC), is covered by Medicare and multiple private insurance payers, and is one of only two next-generation sequencing (NGS) tests with specific Medicare coverage.

NeoGenomics ended June with $331 million in cash, which is more than enough to weather a prolonged downturn. Management acknowledged the uncertainty of the coronavirus pandemic, but has already begun to see signs of a rebound.

In April, test volumes were down 30% compared to the year-ago period. By June, test volumes were back in line with the prior-year period, although they were about 15% below pre-pandemic expectations for 2020. Volumes had not recovered to pre-pandemic expectations through July.

But management remains confident in the long-term plan. NeoGenomics is well-positioned for a strong recovery if and when the market permits. The business doesn't need an exceptional recovery -- a "V-shaped" recovery, if you will -- to climb back to profitability or growth. What's more, it could take advantage of the economic effects of the pandemic to acquire smaller peers that might be struggling.

That said, shares of NeoGenomics are certainly expensive. Is that the price to pay for profitable growth in an uncertain world? Perhaps, but investors might be better off waiting for a pullback, as the current valuation (as with many stocks right now) appears unsustainable in the near-term.

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How to live longer: Diet shown to burn fat, improve heart health and to boost longevity – Express

In ones quest to find solutions to help live a long and disease-free life, numerous theories and suggestions have been declared. Intermittent fasting has gained much notoriety over the pastyear,and according to leading healthexperts, this type of eatingcould be the answer to helping you boost your life longevity. How?

A review of past animal and human studies in The New England Journal of Medicine recommend adopting a way of eating known as intermittent fasting which can help reduce blood pressure, aid in weight loss and improve longevity.

Alternating between fasting and eating can help to improve cellular health.

Professor Mark Mattson from John Hopkins University said the way of eating can help to trigger a metabolic switch.

In metabolic switching, cells use up their fuel stores and convert fat to energy this in turns helps fat to switch from fat-storing to fat-saving and has many health benefits.

The way of eating involves daily-time restricted feeding.

This narrows the time of eating to six to eight hours per day which is also known as 5:2 intermittent fasting, in which people limit themselves to one moderate-sized meal two days each week.

Findings on intermittent fasting range in the diets effectiveness, but some studies in animals and humans have linked the practice to longer lives, healthier hearts and improved cognition.

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When finding benefits of the diet, looking at different countries who adopt this way of eating as a norm often helps.

Residents of Okinawa are known for their extreme longevity and low-calorie, nutrient-rich diet.

Their way of eating has been suggested to help contribute to their long-life spans, low number of obesity and reduced risk of diseases.

Professor Mattson says studies have shown that this switch improves blood sugar regulation, increases resistance to stress and suppresses inflammation.

The professor notes that four studies in both animals and people found intermittent fasting also helped to decrease blood pressure, blood lipid levels and resting heart rates.

Preliminary studies suggest that intermittent fasting could benefit brain health too.

A clinical trial at the University of Toronto found that 220 healthy adults who maintained a calorie restricted diet for two years showed signs of improved memory in a battery of cognitive tests.

Professor Mattson added: Patients should be advised that feeling hungry and irritable is common initially and usually passes after two weeks to a month as the body and brain become accustomed to the new habit.

Mattson suggests a gradual acclimation to fasting rather than going cold turkey will help with this.

Mattsonalsohopes this study will give better insight to physicians, who can pass that guidance on to their patients.

For an added benefit, eating a Mediterranean diet during the eating phasecouldnot only boost longevity but improve heart health too.

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Covid-19 Impact On Cellular Reprogramming Tools Market 2020: Global Industry Overview By Top Key Players Analysis And Growth Factors Up To 2026 |…

Global Cellular Reprogramming Tools Market report offers in-depth insights, revenue details, and other vital information regarding the global Cellular Reprogramming Tools market, and the various trends, drivers, restraints, opportunities, and threats in the target market till 2026. The report offers insightful and detailed information regarding the various key players operating in the market, their financials, supply chain trends, technological innovations, key developments, apart from future strategies, acquisitions & mergers, and market footprint. Global Cellular Reprogramming Tools market report has been segmented on the basis of type, application, and region.

SDMR has recently published a report, on Global Cellular Reprogramming Tools Market Insights, Forecast to 2025. The market research report is a brilliant, complete, and much-needed resource for Cellular Reprogramming Tools . The research report speak about the potential development openings that exist in the worldwide market. The report is broken down on the basis of research procedures procured from historical and forecast information. The global Cellular Reprogramming Tools market is relied upon to develop generously and flourish as far as volume and incentive during the gauge time frame. The report will give a knowledge about the development openings and controls that will build the market. Pursuers can increase important perception about the eventual fate of the market.

Final Cellular Reprogramming Tools Report will add the analysis of the impact of COVID-19 on this Market.

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Top Key Keyplayers Covered In This Report: Celgene, Cynata, Advanced Cell Technology, BIOTIME, Osiris Therapeutics, Human Longevity, FUJIFILM Holdings, STEMCELL Technologies, Mesoblast, Astellas Pharma, EVOTEC, Japan Tissue Engineering

The prime objective of this report is to help the user understand the market in terms of its definition, segmentation, market potential, influential trends, and the challenges that the market is facing with 10 major regions and 30 major countries. Deep researches and analysis were done during the preparation of the report. The readers will find this report very helpful in understanding the market in depth. The data and the information regarding the market are taken from reliable sources such as websites, annual reports of the companies, journals, and others and were checked and validated by the industry experts. The facts and data are represented in the report using diagrams, graphs, pie charts, and other pictorial representations. This enhances the visual representation and also helps in understanding the facts much better.

The Global Cellular Reprogramming Tools Market is estimated to reach xxx million USD in 2020 and projected to grow at the CAGR of xx% during the 2021-2026. The report analyses the global Cellular Reprogramming Tools market, the market size and growth, as well as the major market participants.

Segmentation by Product:

Adult Stem CellsHuman Embryonic Stem CellsInduced Pluripotent Stem CellsOther

Segmentation by Application:

Drug DevelopmentRegenerative MedicineToxicity TestAcademic ResearchOther

Global Cellular Reprogramming Tools Market: Competitive RivalryThe segmentation is used to decide the target market into smaller sections or segments like product type, application, and geographical regions to optimize marketing strategies, advertising techniques, and global as well as regional sales efforts of Global Cellular Reprogramming Tools Market. Common characteristics are being considered for segmentation such as global market share, common interests, global demand and access control unit supply. Moreover, the report compares the production value and growth rate of the Global Cellular Reprogramming Tools market across different geographies.While segmentation has been provided to list down various facets of the Cellular Reprogramming Tools market, analysis methods such as S.T.E.E.P.L.E., S.W.O.T., Regression analysis, etc. have been utilized to study the underlying factors of the market. Summarization of various aspects consisted of the report has also been encompassed.

Scope of the Report: The all-encompassing research weighs up on various aspects including but not limited to important industry definition, product applications, and product types. The pro-active approach towards analysis of investment feasibility, significant return on investment, supply chain management, import and export status, consumption volume and end-use offers more value to the overall statistics on the Cellular Reprogramming Tools Market. All factors that help business owners identify the next leg for growth are presented through self-explanatory resources such as charts, tables, and graphic images.

Key Questions Answered: What is the size and CAGR of the global Cellular Reprogramming Tools Market? Which are the leading segments of the global Cellular Reprogramming Tools Market? What are the key driving factors of the most profitable regional market? What is the nature of competition in the global Cellular Reprogramming Tools Market? How will the global Home Appliance market advance in the coming years? What are the main strategies adopted in the global Cellular Reprogramming Tools Market?

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Table of ContentsReport Overview: It includes major players of the global Cellular Reprogramming Tools Market covered in the research study, research scope, and Market segments by type, market segments by application, years considered for the research study, and objectives of the report.

Global Growth Trends: This section focuses on industry trends where market drivers and top market trends are shed light upon. It also provides growth rates of key producers operating in the global Cellular Reprogramming Tools Market. Furthermore, it offers production and capacity analysis where marketing pricing trends, capacity, production, and production value of the global Cellular Reprogramming Tools Market are discussed.

Market Share by Manufacturers: Here, the report provides details about revenue by manufacturers, production and capacity by manufacturers, price by manufacturers, expansion plans, mergers and acquisitions, and products, market entry dates, distribution, and market areas of key manufacturers.

Market Size by Type: This section concentrates on product type segments where production value market share, price, and production market share by product type are discussed.

Market Size by Application: Besides an overview of the global Cellular Reprogramming Tools Market by application, it gives a study on the consumption in the global Cellular Reprogramming Tools Market by application.

Production by Region: Here, the production value growth rate, production growth rate, import and export, and key players of each regional market are provided.

Consumption by Region: This section provides information on the consumption in each regional market studied in the report. The consumption is discussed on the basis of country, application, and product type.

Company Profiles: Almost all leading players of the global Cellular Reprogramming Tools Market are profiled in this section. The analysts have provided information about their recent developments in the global Cellular Reprogramming Tools Market, products, revenue, production, business, and company.

Market Forecast by Production: The production and production value forecasts included in this section are for the global Cellular Reprogramming Tools Market as well as for key regional markets.

Market Forecast by Consumption: The consumption and consumption value forecasts included in this section are for the global Cellular Reprogramming Tools Market as well as for key regional markets.

Value Chain and Sales Analysis: It deeply analyzes customers, distributors, sales channels, and value chain of the global Cellular Reprogramming Tools Market.

Key Findings: This section gives a quick look at important findings of the research study.

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Six Thoughts to Deal with Your COVID-19 Anxiety – Longevity LIVE

It is a frightening time for everyone. Countries, cities, schools, and businesses are shutting down due to the COVID-19 pandemic. Some of us live in areas that have been greatly affected by this dangerous disease. Others are preparing for the worst. All of us are watching the news so that we can figure out what to do next.

For most people, the uncertainty surrounding this disease is the most difficult thing to handle. We dont know how worse it will get in the future and what that means to our loved ones and careers. This makes us vulnerable to anxiety and depression. As we face this unique crisis, there are certain things you can do to manage your fears and anxiety.

It is important to stay informed of whats happening around. This allows you to follow safety precautions as reported by health experts. However, other people are taking advantage of the opportunity to spread the wrong information. Its important to choose what you watch and listen to carefully.

Remember, your mind will always project what you feed it regularly. Here are a few tips:

At the moment, there are so many things that are not in your control. They include the length of the pandemic, how people behave, and what will happen to our loved ones. Although its difficult to accept, most of us react by searching for answers on the web and thinking of the different scenarios that might play out.

Focusing on things that are not in your control will not get you anywhere. Theyll leave you feeling anxious, drained, and overwhelmed. Whenever you catch yourself getting caught up in fear and anxiety, shift your focus immediately to the things you can control. There are a lot of things you can do to minimize the risk of catching the virus or spreading it to your loved ones. They include:

Apart from these guidelines, you can also:

Research studies have shown that the majority of people with coronavirus, especially young healthy people dont show any symptoms but can spread the virus. Thats why it is important to follow the guidelines by practicing social distancing.

But human beings are social creatures. We all crave to connectwith others. Isolation can make us feel anxious. And this affects our physical health negatively. This is why its important to stay connected with our loved ones as much as possible. You can:

You need to eat healthy foods, meditate, read books, and get plenty of sleep. If you have a backyard, consider getting some sun and exercising regularly.

You need to be kind to yourself. Dont be too hard on yourself. Take some time off from work to relax and communicate or play with your loved ones.

Find new ways of exercising. Staying indoors all day can make you anxious and stressed. Come up with new ways to stay active in and out of the house. You should consider cycling, walking, or hiking. You can also look for exercise classes online if you dont want to go outside.

Avoid self-medicating when you are dealing with anxiety and depression. Now is not the time to abuse drugs.

Right now, its easy to get caught up in our struggles and fears. However, you should keep in mind that other people are facing harder times than you. You can focus on helping and supporting communities in need. Doing kind acts for others will not only help you regain control over your life but also add a sense of meaning and purpose to life.

More than 80 percent of people in the US consider themselves religious or spiritual. Spiritualityhas been linked to happiness and wellbeing because it gives us a sense of meaning and purpose. One of the best ways to protect yourself against anxiety is to have this sense of meaning and purpose.

Whenever you are feeling anxious, say a short prayer or meditate for a few minutes. You can also come up with a list of fun activities that you can do whenever you start feeling anxious.

Fear about the coronavirus disease can take a toll on you, especially if you have underlying mental issues. We shall persevere. You are not alone. By using these tips, youll have the power to smile and help others calm down.

https://www.who.int/https://www.marieclaire.com/health-fitness/a28280412/spiritual-ideas/https://health.clevelandclinic.org/jow-to-stay-connected-to-loved-ones-despite-social-distancing/

Leon Collier is a blogger at essay writing service UKfrom Edinburgh, who loves to write about everything: pop-culture, history, travel, self-development, education, marketing. When not writing, you can find him behind a book or playing tabletop games with his friends. Follow him on Twitter @LeonCollier12.

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The latest book in the ‘Avatar: The Last Airbender’ universe gives us one of its most compelling relationships – Business Insider Australia

Its the summer of Avatar: The Last Airbender. With the beloved series available on Netflix and its sequel series,The Legend of Korra, on its way there in August, the franchise is more readily available to fans than its been in years. Now, the franchises revitalized fandom has a new book, too.

F.C. Yees The Shadow of Kyoshi is the second instalment of a prequel series about one of the most fabled Avatars of all time. Building off of 2019s The Rise of Kyoshi, the series follows Kyoshi, an Avatar known in the main series for her strength, longevity, and uncompromising judgment, during the nascent stages of her Avatarhood. In turn, it serves to humanize one of the Avatar franchises most legendary characters.

Kyoshis beginnings werent particularly auspicious. The Avatar is an individual tasked with mastering all four elements and their bending disciplines, learning how to mainpulate and fight using water, earth, fire, and air. In turn, theyre tasked with bringing balance to the world, mitigating both human and spiritual conflict in the four nations: The Earth Kingdom, the Fire Nation, the Water Tribes, and the Air Nomads. Each Avatar faces a unique set of challenges in carrying out this mission.

In The Rise of Kyoshi, everyone (including Kyoshi) believes that another Earth Kingdom boy, Yun, is the next Avatar. Living, working, and training at the estate of Jianzhu, a powerful Earth Kingdom politician, Kyoshi and Yun are friends. A violent encounter reveals their mistaken identities, cementing Kyoshi as the next Avatar and setting her on a path towards revenge.

The Shadow of Kyoshi is haunted by the specter of that encounter, while still maintaining the first novels wry sense of humour and adventure. After accepting a summons from the Fire Lord himself (with, of course, the promise of reuniting with her lover and Firebending master Rangi), Kyoshi finds herself trapped in a foreign political snare while simultaneously grappling with a new threat from the spirit world. Given that shes spent the better part of her Avatarhood hunting down corrupt bandits and detaching herself from the politics of her own nation, the situation leaves Kyoshi out of her depth.

The weighty, political conflict is just as thrilling as the action sequences peppered throughout the novel. Garden parties are just as fraught with tension as intense battles; strained clan relations have the potential to cause more trouble than physical threats. It also leaves ample room for granular worldbuilding, including new details about previous Avatars, like the oft-maligned Kuruk and the venerated Yangchen, as well as tidbits of information about geography, political history, and language that wasnt touched upon in the animated series.

Yees prose is also just as visceral as Avatars renowned animation sequences. Regarding The Rise of Kyoshi, the author told Polygon in 2019 that he looks for moments that were more easy to capture in a novel format, in particular where the action suddenly turns on a dime rather than attempting to capture every beat of a single action scene. Those intense, pivotal moments are what make The Shadow of Kyoshi a harrowing read, bringing an emotional resonance and vibrancy that cuts through the page.

A new cast of auxiliary companions and antagonists keep things lively, each imbued with their own complexities and mystery that prevent them from becoming just side characters to the larger conflict. Kyoshis Airbender companion, Jinpa, and his sky bison Yingyong, are particularly fun additions to the story, in addition to a cast of Fire Nation nobles that drive the political arc of the novel.

Rangi and Kyoshis relationship is the most compelling. With the realisation of feelings and getting together out of the way in the first novel, The Shadow of Kyoshi gives the two women plenty of space to be tender, bicker, fight, and reconcile over the course of the book. Thats part of what makes their relationship feel so different from other romantic entanglements in the Avatar universe: the franchise has never shied away from love stories, but both The Last Airbender and The Legend of Korra end with romantic resolution rather than grapple with the relationships after the fact (although their central romances are continued in spin-off comics).

The fact that Kyoshi and Rangi have the most fully fleshed-out queer love story in the Avatar canon shouldnt go unmarked either. A Legend of Korra spin-off comic revealed in 2017 that Kyoshi was bisexual, and its a promise that Yee made good on in The Rise of Kyoshi, telling Polygon at the time that it felt important to not strip away Kyoshis queerness and do her relationships justice. In The Shadow of Kyoshi, Yee explores the complexities of Kyoshi and Rangis relationship and the ways that it affects their judgment, particularly in times of crisis with nuance and empathy. Their relationship is foundational to Kyoshis ascendance, and legacy, as the Avatar. In many ways, Rangi serves as her emotional and moral centre.

The Shadow of Kyoshi is a rewarding read for both dedicated Avatar fans and newcomers alike. Ultimately, it exceeds the task of fleshing out Kyoshis origin story, delivering a compelling character-driven narrative that bears just as much emotional heft as any other entry into the franchise.

The Shadow of Kyoshi is now available for purchase and debuted at number two on the New York Times Young Adult Hardcover Bestseller List.

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The latest book in the 'Avatar: The Last Airbender' universe gives us one of its most compelling relationships - Business Insider Australia

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UB study finds testosterone therapy can lead to remission in men with Type 2 diabetes – UB Now: News and views for UB faculty and staff – University…

The findings from a recent study by a UB researcher and others could prove to be a game-changer for men with Type 2 diabetes.

The single-site study, conducted over 11 years in Bremerhaven, Germany, found that testosterone therapy reversed Type 2 diabetes in one-third of the study participants.

The occurrence of this syndrome is common, and with appropriate testosterone replacement, obesity insulin resistance and diabetes may be reversible, says Paresh Dandona, SUNY Distinguished Professor in the Department of Medicine in the Jacobs School of Medicine and Biomedical Sciences at UB. He co-authored the study, titled Remission of type 2 diabetes following long-term treatment with injectable testosterone undecanoate in patients with hypogonadism and type 2 diabetes: 11-year data from a real-world registry study.

The prospective, registry-based study was published in June in the online journal Diabetes, Obesity and Metabolism. Dandona also presented the data at the Annual Mohan Diabetes Foundation Symposium in Chennai, India, on July 25, where he was given the organizations Lifetime Achievement Award.

Type 2 diabetes, also known as Type 2 diabetes mellitus, results from a combination of insulin resistance and insufficient production of insulin, causing high blood sugar. The condition is common, with more than 3 million new cases per year in the United States. Reduced testosterone concentrations are found in 33% of men with Type 2 diabetes.

The discovery of this syndrome of hypogonadism in Type 2 diabetes was made by Dandonas group at UB in 2004. This group then extended the prevalence of this syndrome to include 25% of non-diabetic obese men in 2010. Thus, diabetes and obesity became the main cause of male hypogonadism. The group went on to demonstrate that such patients have additional insulin resistance that reverses with testosterone treatment in 2016.

Testosterone deficiency, which is also called male hypogonadism, contributes to reduced response of insulin to glucose, increased insulin resistance and eventually the onset of Type 2 diabetes.

The objective of the researchers study was to determine if men with Type 2 diabetes who also exhibit hypogonadism, when treated with testosterone in addition to their regular diabetes treatment, would demonstrate improved glycemic control and insulin sensitivity, and possibly eventually experience remission of Type 2 diabetes.

The investigators observed 356 men in a single urology practice clinic over 11 years. All patients received standard diabetes treatment, which included mandatory educational courses and materials. In addition, 178 men with a mean age of 62 years received 1,000 milligrams of subcutaneously injected, slow-release testosterone every 12 weeks after an initial six-week interval. The 178 subjects, mean age 64 years, who opted out of the testosterone therapy served as the control group.

The researchers took numerous measurements, including height, weight, waist circumference, blood pressure, hemoglobin, fasting glucose, HbA1c (the average amount of glucose in blood over a six- or 12-week period), insulin, heart rate, lipids, highly sensitive C-reactive protein and total testosterone, among others. They also assessed quality of life using the Aging Males Symptoms scale. Erectile function was also assessed, using the International Index of Erectile Function. Assessment of these clinical metrics was performed at least twice a year, and data over 11 years were analyzed.

The results showed that the men treated with testosterone had significant progressive and sustained reductions in their body weight, fasting glucose, HbA1c and fasting insulin over the treatment period, the authors wrote. In the control group, fasting glucose, HbA1c and fasting insulin increased.

One-third (34.3%) of men treated with testosterone saw remission of their diabetes; almost half (46.6%) achieved normal glucose regulation with antidiabetic treatment and a vast majority (83.1%) reached their target level of HbA1c.

Patients in the control group saw no remission of diabetes or reduction in glucose or HbA1c levels.

In addition, there were fewer deaths, myocardial infarctions, strokes and diabetic complications in the group treated with testosterone.

The research indicates that long-term treatment with testosterone is potentially a novel additional therapy for men with Type 2 diabetes and hypogonadism, the authors wrote.

The clinical significance of these results is further enhanced by the fact that one-third of men with Type 2 diabetes have hypogonadism. Hence, physicians encounter men with hypogonadism and diabetes very frequently. It is remarkable that while Type 2 diabetes mellitus leads to hypogonadism, treatment of hypogonadism results in remission of diabetes itself, the authors wrote.

Going forward, prospective randomized controlled trials are needed to confirm the data. One such trial is currently in progress.

Dandona is one of the worlds leading experts in the treatment of diabetes and vascular disease. He is also the ex-chief of endocrinology at UB and founder of the Diabetes and Endocrinology Center of Western New York, which is sponsored by the Jacobs School and Kaleida Heath. He sees patients at UBMD Internal Medicine.

Dandonas co-authors on the study include Karim Sultan Haider and Ahmad Haider, urologists in Bremerhaven, Germany; Farid Saad, a consultant to Medical Affairs Andrology at Bayer AG in Berlin; Gheorghe Doros from the Department of Epidemiology and Biostatistics at the Boston University School of Public Health; Markolf Hanefeld from GWT-TU Dresden GmbH and Medizinische Klinik, Universittsklinikum Carl Gustav Carus, in Dresden; Sandeep Dhindsa from the Division of Endocrinology, Diabetes and Metabolism at Saint Louis University; and Abdulmaged Traish from the Department of Urology at the Boston University School of Medicine.

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