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Folded, frozen, and faster: JUST Egg is now more convenient, and cheaper, to enjoy – FoodNavigator-USA.com

The folded version of the JUST Egg comes frozen and can be prepared in a few ways: toaster oven, skillet, or for the time-strapped, the standard toaster where the company suggests selecting the bagel setting for about 6.5 minutes.

"The genesis of it really was, how do we figure out a little bit of a faster way for people to enjoy it?We got really excited about this idea of folding and what that means from a texture perspective. It feels more like as if you made an omelette and put it in a biscuit," Tetrick told FoodNavigator-USA.

2019 was the first full year JUST Egg was in retail and the results surpassed both the company's and Tetrick's internal goals for the product.

"Last year we managed to get into most of the major retailers, most of them in the egg set and have managed to become the No. 1 liquid egg," said Tetrick who added that the company has sold the equivalent of 20 million eggs in its first year.

What was even more encouraging, and unexpected, was that the majority of consumers buying JUST Egg are not vegan or vegetarian, and 20% to 22% are buying the product not just as an egg replacement, but as their main source of protein, said Tetrick.

"We didnt expect that was going to happen.Even saying it out loud, you have a hard time wrapping your brain around it."

Tetrick noted that the new folded egg is a different, fluffier version than the patty plant-based egg product JUST Egg supplies to the foodservice channel.

The product will begin rolling out in April in the freezer section of Whole Foods Markets; select Albertsons Safeway stores; Gelsons Markets in Southern California; Stop & Shop in the Northeast, Kings Food Markets in the New York metro area and Giant Martin's in the Mid-Atlantic, with more to come.In all, it will be sold in approximately 5,000 stores at launch and will be available for restaurants and other foodservice destinations from major distributors.

"There are millions of shoppers going to the frozen set who have probably never heard of us, probably never heard of JUST Egg, and now theyll be able to see it," said Tetrick.

Retail frozen food alone is a $57bn business annually, with the category growing in both dollar and units in 2018, according to the American Frozen Food Institute and Food Marketing Institute.

The folded egg, which was developed with breakfast sandwiches in mind, has potentially much broader, all-day appeal with consumers, says the firm. According to arecent survey, conducted by the company of nearly 1,000 consumers, 50% would use the fold-over egg replacement as a general sandwich ingredient and 40% would add it to other dishes such as salads or fried rice, underscoring its appeal as a convenient protein source.

As a frozen product, the JUST Egg contains the same base ingredients (i.e. mung bean protein) but is free-from the preservatives of the liquid egg product, noted Tetrick. At retail, the products will be placed either next to traditional frozen breakfast sandwiches or in the plant-based protein alternatives section.

"It will next It will be good for us, because you can hypothesize about which set works best," Tetrick said. With the company's liquid JUST Egg product, the products perform better when placed next to conventional eggs than when put next to chilled alternative proteins.

"People are not just looking at this as a way to replace an egg, thats an element of it, but theres a big percentage of people that are looking at this as clean, healthy, sustainable protein,"he noted.

Opening up its own dedicatedproduction facility in Western Minnesota at the end of last year, means that JUST Egg can start reducing costs and make the products accessible to all, not just high-income shoppers.

"Our objective ultimately is to be the most cost effective protein source human beings consume, not just the most cost efficient egg source," Tetrick said. The average cost of an egg, globally, is about USD$0.08. Through efficient production and ingredient sourcing of the mung bean, JUST Egg has been able to reduce its cost to just over USD$0.20/egg, while still more than double the cost, it is much more cost effective than when the company first launched seven and a half years ago, said Tetrick.

According to the company, it has cut its cost of the final JUST Egg product to $4.99 SRP a bottle, down from $7.99. Its folded egg product is also $4.99 SRP, with four folded eggs to a box.

"Its not just the taste and texture, we need to hammer on this cost piece so that the folks that I grew up with in Birmingham, Alabama, can not just afford, but easily afford," added Tetrick.

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High Focus on Product Innovation & Development to Assist the Growth of the Folding Cartons Market between and . 2017 2025 Dagoretti News -…

The market report envelopes an all-in information of the global Folding Cartons market and the nature of the market growth over the foreseeable period. The report provides a comprehensive elaboration of the positives and negatives of the global Folding Cartons market with DROT and Porters Five Forces analysis. With SWOT analysis, the report offers detailed insights about different players operating within the Folding Cartons market. In addition, the analysts of the report have served the qualitative and quantitative scrutinizing of different micro- and macro-economic factors influencing the global Folding Cartons market.

The Folding Cartons market report examines the consumption patter of each segment and the factors affecting the pattern. In addition, the report focuses on the production footprint of each segment in various industries and regions across the globe.

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The Folding Cartons market report helps the readers grasp the changing trend in the industry supply chain, manufacturing techniques and expenses, and current scenario of the end uses in the global Folding Cartons market.

All the players running in the global Folding Cartons market are elaborated thoroughly in the Folding Cartons market report on the basis of proprietary technologies, distribution channels, industrial penetration, manufacturing processes, and revenue. In addition, the report examines R&D developments, legal policies, and strategies defining the competitiveness of the Folding Cartons market players.

segmentation to vendor landscape, the report offers a detailed study of critical aspects of the market. Buyers of the report are expected to receive a comprehensive guideline that could lead them to their peak success when operating in the market.

Global Ethanol Market: Dynamics

The world ethanol market is prophesied to be strong against tough conditions that could paralyze its growth. Despite challenging production economics due to low oil prices, ramping up of opponents against the RFS, and uncertainty because of regulatory indecision, the market survived pretty well in 2015. The year showcased the resolve and strength of the ethanol sector. Producers were able to ride out the storm with the help of the indispensable value of ethanol as a low-cost, clean octane booster and thriving export demand. In the U.S., millions of metric tons of high-protein animal feed and billions of gallons of high-octane renewable fuel were produced in ethanol bio-refineries of several states.

Global Ethanol Market: Segmentation

The international ethanol market is forecasted to be classified according to two classes, viz. type of feedstock and end use. As per the classification by feedstock, the market could see a segmentation into coarse grain-based, sugarcane-based, and wheat-based ethanol. Although there could be different markets for ethanol in terms of feedstock type, one is expected to garner a larger share in the coming years. The analysts foresee the market to be dominated by coarse grain-based ethanol, which represented a 53.0% share in 2017.

On the basis of end-use segmentation, the international ethanol market is predicted to be segregated into fuel, industrial solvents, beverages, and cosmetics.

Regionally, North America could set the tone for a staggering growth in the international ethanol market while collecting a revenue of US$48.3 bn by the end of 2022. Another attractive region for the market is prognosticated to be Europe. However, there could be other geographies such as Japan showcasing a slower growth in the near future. Asia Pacific except Japan (APEJ) and the Middle East and Africa (MEA) drew a greater revenue than Japan in 2017.

Global Ethanol Market: Competition

The competition in the worldwide ethanol market is elaborately explained in the publication while profiling key players such as Archer-Daniels-Midland Company, Cargill, Incorporated, Solvay Group, Mitsubishi Chemical Corporation, Pacific Ethanol, Inc., Green Plains, Inc., The Andersons, Inc., Valero Energy Corporation, POET, LLC, and Flint Hill Resources LP.

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Vegetarianism: Know the different types of vegetarian diets – Times Now

Vegetarianism: Know the different types of vegetarian diets  |  Photo Credit: Getty Images

New Delhi: Vegetarianism is becoming a rage and a statement of health and fitness in India. Perhaps, a lot of celebrities in the West are turning to East and opting for vegetarianism. Basically, a vegetarian diet majorly includes pulses, cereals, nuts, seeds, vegetables and fruits. In this article, lets talk about the various aspects of vegetarian diets.

Lacto-vegetarians: A vegetarian diet that includes vegetables as well as daily products like milk.

Ovo-vegetarian: A vegetarian diet that includes eggs but no milk products

Lacto-ovo vegetarian: Here, milk and eggs can be consumed along with a vegetarian diet.

Jain vegetarian: Practiced by the followers of Jain culture and philosophy, this is a lacto vegetarian diet with no roots and tubers like onion, garlic, potato, colocasia, etc.

Raw vegetarian: No cooked foods

Pesco-vegetarian: A vegetarian diet plan that includes fish.

Some possible reasons for adapting vegetarianism include:

It has been seen that vegetarians have a lower BMI, blood pressure and serum cholesterol. This has been attributed to the fibrer-rich foods like fruits, vegetables, legumes they eat. These foods are also a rich source of antioxidants as compared to non-vegetarian foods.

It is important to know the pros and cons of any diet that one wishes to follow. Consult an expert before starting any diet as a well-planned diet can help keep deficiencies away!

(Disclaimer: The author, Parul Patni, Nutritionist, is a guest contributer and a part of our medical expert panel. Views expressed are personal)

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Vegetarianism: Know the different types of vegetarian diets - Times Now

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The average adult will try this shocking number of diets in their lifetime – Ladders

As of 2018, the weightloss market is worth an estimated $70 billion. This staggering figure is staffed by the 45 million people that take up at least one new diet per year.

When everything is taken into account the average adult will try about 126 different diets in their lifetime.

This data comes courtesy of a new survey conducted by One Poll and commissioned by Love Fresh Berries.

The three most popular reasons the respondents picked up an emergency diet are as follows: wanting to be more satisfied when looking in the mirror(24%), preparing for holidays or a vacation where a lot of food will be served (21%) and getting ready for a big event (18%.)

A lack of consensus regarding long-term application kept the vast majority of the 2,000 participating respondents from seeing a diet through to their goal weight. Fifty-two percent of the study pool said that they didnt really know what made one regimen more sustainable over another.

An additional 20% admitted that they have no idea where to find reliable nutrition guidelines. In fact, the respondents were so perplexed by diet science 33% thought that it was actually healthier to eat fewer fruits.

In their defense, nutrition standards are infamously inconsistent,especially as it pertains to fad diets. Sadly this is by design. As previouslyreported by Ladders, theJournal of Public Policy and Marketingidentified four commercial tactics used by name brand companies to capitalize on emergency trend diets i.e underscoring things like low fat to belie the impression that a product is healthy even though there are a myriad of products that are low in fat and high in other things that do not contribute to optimal health.

There are plenty of trendy diets that offer substantive benefits but only if you adopt them with the long-view in mind.

Just about 50% of the participants looked to Google when in the market for a new crash diet,27% would consult a medical professional,15% rely on a combination of social media and self-help books and the remaining kept an eye out for whatever their favorite celebrity was doing it.These routes led to the Keto diet the most often, followed by intermittent fasting.

Irrespective of the method of discovery most dropped their diet plan afterjust six days.

Despite this average 16% said that they were so desperate to lose weight quickly they would drink12glasses of lemon juice every day if it meant they would. Some said instead of lemon juice they would use baby food and one in 20 said that they would eat a tapeworm to slim down.

The reasons for dropping diets were varied. For some, the side effects associated with the early stages of emergency diets, namely fatigue (21%), weakness (29%), and headaches (26%), were just too much to bear.

Others enjoyed food too much.Chocolate, bread, andpastawere the top three most difficult foods to cut.

January tends to be the month when people embark on fad diets as a quick fix. However, we know that it isnt a sustainable or even healthy approach, explained Love Fresh Berries chairman Nick Marston in a statement. Instead, nutritionists advise that we follow evidence-based nutritional advice and look for a well-balanced diet that does not cut out any food groups. Incorporating lots of fruit and vegetables is important, including berries as they have many important nutritional benefits.

Sticking to a diet plan doesnt exclusively come down to self-control. Research has shown that those who establish goals that go beyond cosmetics not only commit to their diets longer theyre also more forgiving of themselves when they breach them. This mindset is also helpful when finding transitioning to a regimen more aligned with your specific objectives.

Make a plan, consider a contingency and accept that lapses are inevitable.

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What’s the difference between a vegan and an ethical vegan? – Lexology

Casamitjana v The League Against Cruel Sports ET3331129/2018

Facts

Mr Casamitjana was an ethical vegan so he followed a vegan diet and opposed the use of animals for any purpose. His former employer, The League Against Cruel Sports, was an animal welfare charity that campaigned against sports such as hunting and coursing. Mr Casamitjana was employed as a researcher. He concluded that his employer's pension funds were invested unethically and took steps to ensure his contributions were invested in an ethical fund. He suspected his colleagues were unaware of the nature of the investments and would be similarly offended. He therefore sent a number of emails to colleagues. He was dismissed for gross misconduct, as he had given financial advice to colleagues in breach of an express and repeated instruction not to do so. He brought claims for indirect discrimination, direct discrimination, harassment and victimisation by reference to his belief in ethical veganism. In order to succeed, Mr Casamitjana had to convince the employment tribunal that his ethical veganism was a protected characteristic under the Equality Act 2010. A preliminary hearing was held to consider this issue.

Decision

The employment tribunal judge held that ethical veganism constituted a philosophical belief and was therefore protected by the Equality Act. The judge applied the test set out in Grainger v Nicholson and decided that the belief was genuinely held, it was a belief as to a weighty and substantial aspect of human life and behaviour, it attained a certain level of cogency, seriousness, cohesion and importance, it was worthy of respect in a democratic society, it was not incompatible with human dignity and it did not conflict with the fundamental rights of others.

This decision has attracted a huge amount of interest but its implications are limited because it is not binding and Mr Casamitjana is a very committed vegan; other vegans would have to prove their belief qualified for the same protection, which is unlikely to happen in the case of those who are health vegans rather than ethical vegans. There is a merits hearing next month to decide whether Mr Casamitjana was dismissed because of his veganism.

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Vegans are brave and they have a point – Spectator.co.uk

It was a clear and icy night at home in Derbyshire last week. I love these times and, before bed, stepped outside to stand on the lawn in the moonless pitch-black and take it in. All at once the dark was pierced with an awful scream. I was not greatly alarmed the rural night is full of strange noises but stood there, puzzling out what it might be.

The scream, almost human, was repeated, and its provenance seemed to be moving from one side to the other of the field adjacent to ours. Could it be a fox? Vixens do make some blood-curdling cries during the mating season but does that start as early as January? Or might it be a foxs victim a hare or rabbit, perhaps, fighting back as the poor creature was carried off or even an owls prey? Might it be the call of some kind of night-bird? But this was a call Id never heard from anything with feathers.

I felt curious, but only mildly so. Whatever creature was calling, this was nature calling. Alone in the dark I was standing in, not outside, nature, and in nature another animal screaming but posing no threat to me was not a matter for alarm. Animals kill each other, usually for food.

But it made me think about veganism. Ive been thinking about veganism a lot recently. Were told this month is -Veganuary, and more people than I can remember are toying with the idea, if only temporarily, of not eating meat. From time to time Ive done so myself. My lodger in the London flat is a serious vegan and I respect him very much for it. Though we carnivores may grumble about veggies and vegans and think them awkward, the fact remains that its a carnivores world, things are organised to suit meateaters, and people who go against that have to put up with endless inconvenience. They are brave.

They also have a point. I cannot pass a lorry full of pigs being carried to the slaughter without wincing. I switched off a radio discussion of slaughterhouses last week, unable to listen. We try (dont we, most of us?) not to think about the millions of animals being killed each week for our tables; and things we try not to think about are so often things were not confident we could justify.

People who take pleasure in confronting vegetarians with whataboutery (What about your shoes? That violin music you bought though its played on a catgut? And thats a leather armchair you just sat in, ha ha etc) infuriate me. Trying to make the best the enemy of the good often masks our own guilt, and I dare say that in the days of slavery, abolitionists were taunted for using sugar that had been grown in slave plantations.

So my instincts towards veganism are sympathetic. I know and understand the case against using animals for our own gratification; I understand, too, how the logic carries you onward to complete veganism, and I dont question that logic.

But as I stood there in the dark hearing another creature scream last week, it was a contrary thought that troubled me. A thought, no more. I wouldnt dignify it with the word argument, in some ways it was more of a feeling, but it was a strong feeling. Isnt using animals bound up with needing them, and bound up with them (cows, sheep, horses) needing us? Isnt mutual need, however red in tooth and claw, something that binds us into nature, makes us humans a kind of animal, living with animals as animals live with us? Might it be an important corrective against the arrogance that goes with believing we are masters of the universe, a race of gods looking down on the world and the natural order in it but not in the complete sense part of it?

One reason I dare not call this an argument or theory is that our whole evolution as a species seems to point towards that destination. We have so mechanised and specialised and compartmentalised food production that some city people have never even seen a cow face to face, and very few people, urban or rural, have ever visited a slaughterhouse. Maybe thats what civilisation, what we call human progress, means. Long gone are the days when every family could keep and slaughter their own pig.

Yet if thats where were going, perhaps we should say so: acknowledge it to ourselves. It will be a world in which nature is no longer something were part of, but something we control. The world will be our garden. The wild will be what we have decided to designate as the wild. There will be humans, and there will be national parks. Will we still want domestic animals at all, when we have no use for them? Maybe we could keep a few in a zoo, or in farmexperience places you could visit.

Shall we let the animals we include in our master-plan hunt and eat each other? Maybe, and we could watch. Or maybe we could require the carnivores among them to eat meat-like proteins manufactured or grown without the infliction of suffering on any other animal. And gradually over the centuries ahead we could turn our world into a planet where we decided these matters.

The irony (as it seems to me) is that vegans and vegetarians have played an early and important and a very creditable part in the movement to abolish or limit old-fashioned zoos and animal-inclusive circuses: and I approve of much in that mission. Yet the same thinking may lead in the end towards the establishment of the biggest and most ambitious zoo in all creation. The zoo will be the natural world, and we shall be the zookeepers.

I turned away from those screams in the dark and returned to the warm. The itch to discover, and perhaps intervene and correct or rescue, had left me.

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Clene Nanomedicine Announces First Patient Dosed in the RESCUE-ALS Clinical Trial for the Treatment of Amyotrophic Lateral Sclerosis (ALS) with Lead…

SALT LAKE CITY, Jan. 21, 2020 /PRNewswire/ --Clene Nanomedicine, Inc., a clinical-stage biopharmaceutical company, today announcedits Australian subsidiary had completed enrollment and dosing of the first participant in the Phase 2 RESCUE-ALS study with its lead nanocatalytic therapy, CNM-Au8, for the treatment of Amyotrophic Lateral Sclerosis (ALS). The RESCUE-ALS study is substantially funded by FightMND.

"The objective of the randomized, double-blind RESCUE-ALS study is to demonstrate that improvements in brain bioenergetic cellular support in early symptomatic ALS patients treated with CNM-Au8 will help preserve motor neurons survival and function. The primary endpoint is the mean change in the average difference between active treatment and placebo from baseline through week 36 for the Motor Unit Number Index (MUNIX) score, which quantitatively reflects the loss of motor neurons in ALSthe primary cause of clinical progression in ALS," said Robert Glanzman, MD, FAAN, Clene's Chief Medical Officer.

"We are excited to advance CNM-Au8 clinically into this Phase 2 study for ALS patients," said Rob Etherington, President and CEO of Clene. "As neurodegenerative diseases such as ALS have very few treatment options, this study will prove whether CNM-Au8 may be an effective disease-modifying treatment for people with ALS."

"We are very excited to partner with Clene on the Phase 2 study in ALS, RESCUE-ALS," said Professor Steve Vucic, Director of Neurophysiology, Department of Neurology, at Sydney Medical School, Westmead Hospital. "CNM-Au8 offers an innovative approach of potentially treating neurodegenerative diseases, such as ALS, for which there are no effective treatments at present. We are hopeful that CNM-Au8 will be an effective therapy in the future and this trial will go a long way in addressing this question."

About RESCUE-ALS

RESCUE-ALS is Phase 2 multi-center randomized, double-blind, parallel group, placebo-controlled study examining the efficacy, safety, pharmacokinetics, and pharmacodynamics of CNM-Au8 in participants who are newly symptomatic ALS (within 24-months of screening or 12-months from diagnosis) and with a clinically probable or possible or definite ALS diagnosis. Enrolled subjects will be randomized 1:1 to receive either active treatment with CNM-Au8 30 mg or placebo in addition to their current standard of care. Participants will receive their randomized oral treatment daily over 36 consecutive weeks during the Treatment Period. The treatment is taken by mouth once daily first thing every morning. The objective of this study is to assess bioenergetic catalysis with CNM-Au8 to slow disease progression in patients with ALS.

About CNM-Au8

CNM-Au8 is a concentrated, aqueous suspension of clean-surfaced faceted nanocrystalline gold (Au) that acts catalytically to support important intracellular biological reactions. CNM-Au8 consists solely of gold atoms organized into faceted, geometrical crystals held in suspension in sodium bicarbonate buffered, pharmaceutical grade water. CNM-Au8 has demonstrated safety in Phase 1 studies in healthy volunteersand both remyelination and neuroprotection effects in multiple preclinical models. Preclinical data presented at scientific congresses demonstrated that treatment with CNM-Au8 in neuronal cultures improved survival of neurons, protected neurite networks, decreased intracellular levels of reactive oxygen species, and improved mitochondrial capacity in response to cellular stress, induced by multiple disease-relevant neurotoxins. Oral treatment with CNM-Au8 improved functional behaviors in a rodent models of ALS, multiple sclerosis, and Parkinson's disease versus vehicle (placebo). CNM-Au8 has received regulatory approval to proceed to clinical studies for the treatment of remyelination failure in patients with multiple sclerosis and neuroprotection in patients with amyotrophic lateral sclerosis(ALS) and Parkinson's disease.

About Amyotrophic Lateral Sclerosis (ALS)

ALS is a universally fatal neurodegenerative disorder that results in loss of motor neurons in the cerebral cortex, brain stem, and spinal cord. ALS, also known as Lou Gehrig's disease, leads to the death of the neurons controlling voluntary muscles resulting in weakness, muscle atrophy, and progressive paralysis. ALS affects more than 15,000 patients in the United States and is the most prevalent adult-onset progressive motor neuron disease.

About Clene

Clene Nanomedicine, Inc. is a privately-held, clinical-stage biopharmaceutical company, focused on the development of unique therapeutics for neurodegenerative diseases. Clene has innovated a novel nanotechnology drug platform for the development of a new class of orally-administered neurotherapeutic drugs. Founded in 2013, the company is based in Salt Lake City, Utah with R&D and manufacturing operations located in North East, Maryland. For more information, please visit http://www.clene.com.

About FightMND

FightMND is a not-for-profit registered charity, founded in 2014. It was established to raise the awareness of Motor Neurone Disease (MND) in Australia, to increase funding for research to find an effective treatment and cure and to provide care equipment for MND patients. We have a clear objective to a have a world free from MND.

FightMND is Australia's largest independent MND foundation focused on funding large- scale, collaborative research and clinical trials. The generous donations contributed by everyday Australians, right across the country, has enabled FightMND to raise and commit millions to cure and care initiatives.

Investor ContactKaitlyn BroscoThe Ruth Group646-536-7032 kbrosco@theruthgroup.com

Media Contact Kirsten ThomasThe Ruth Group508-280-6592 kthomas@theruthgroup.com

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SOURCE Clene Nanomedicine, Inc.

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Nanomedicine Market: 2020 Global Industry Growth Prospects and Insights on Future Scenario | Company Profiles Combimatrix, Ablynx, Abraxis Bioscience,…

The Global Nanomedicine Market research report includes various topics like total industry size, key drivers, challenges, growth opportunities, share, growth, demand, outlook etc. it covers key market updates, the impact of regulations and technological updates.

The report addresses the need to stay updated in this competitive industry conditions and this provides and comprehensive data for making strategies and decision so as to stimulate the market growth and profitability.

The report has been compiled through extensive primary research (through interviews, surveys, and observations of seasoned analysts) and secondary research (which entails reputable paid sources, trade journals, and industry body databases). The report also features a complete qualitative and quantitative assessment by analyzing data gathered from industry analysts and market participants across key points within the industrys value chain.

No. of Pages: 124

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Report Covers Market Segment by Manufacturers: Combimatrix Ablynx Abraxis Bioscience Celgene Mallinckrodt Arrowhead Research GE Healthcare Merck

Market Segment by Type, covers: Quantum dots Nanoparticles Nanoshells Nanotubes Nanodevices

Market Segment by Applications, can be divided into: Segmentation encompasses oncology Infectious diseases Cardiology Orthopedics Others

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There are 15 Chapters to deeply display the global Nanomedicine market.Chapter 1: Describe Nanomedicine Introduction, product scope, market overview, market opportunities, market risk, and market driving force.

About UsOrian Research is one of the most comprehensive collections of market intelligence reports on the World Wide Web. Our reports repository boasts of over 500000+ industry and country research reports from over 100 top publishers. We continuously update our repository so as to provide our clients easy access to the worlds most complete and current database of expert insights on global industries, companies, and products. We also specialize in custom research in situations where our syndicate research offerings do not meet the specific requirements of our esteemed clients.

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Biomedical Applications of Zeolitic Nanoparticles, with an Emphasis on | IJN – Dove Medical Press

Hossein Derakhshankhah, 1, 2,* Samira Jafari, 1, 2,* Sajad Sarvari, 3 Ebrahim Barzegari, 4 Faezeh Moakedi, 5 Milad Ghorbani, 6 Behrang Shiri Varnamkhasti, 1 Mehdi Jaymand, 7 Zhila Izadi, 1, 8 Lobat Tayebi 9

1Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran; 2Zistmavad Pharmed Co., Tehran, Iran; 3Department of Pharmaceutical and Pharmacological Science, School of Medicine, West Virginia University, Morgantown, WV, USA; 4Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran; 5Department of Biochemistry and Molecular Biology, School of Medicine, West Virginia University, Morgantown, WV, USA; 6Department of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran; 7Nano Drug Delivery Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran; 8Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran; 9Marquette University School of Dentistry, Milwaukee, WI 53201, USA

*These authors contributed equally to this work

Correspondence: Zhila Izadi; Lobat Tayebi Email izadi_zh@razi.tums.ac.ir; lobat.tayebi@marquette.edu

Abstract: The advent of porous materials, in particular zeolitic nanoparticles, has opened up unprecedented putative research avenues in nanomedicine. Zeolites with intracrystal mesopores are low framework density aluminosilicates possessing a regular porous structure along with intricate channels. Their unique physiochemical as well as physiological parameters necessitate a comprehensive overview on their classifications, fabrication platforms, cellular/macromolecular interactions, and eventually their prospective biomedical applications through illustrating the challenges and opportunities in different integrative medical and pharmaceutical fields. More particularly, an update on recent advances in zeolite-accommodated drug delivery and the prevalent challenges regarding these molecular sieves is to be presented. In conclusion, strategies to accelerate the translation of these porous materials from bench to bedside along with common overlooked physiological and pharmacological factors of zeolite nanoparticles are discussed and debated. Furthermore, for zeolite nanoparticles, it is a matter of crucial importance, in terms of biosafety and nanotoxicology, to appreciate the zeolite-bio interface once the zeolite nanoparticles are exposed to the bio-macromolecules in biological media. We specifically shed light on interactions of zeolite nanoparticles with fibrinogen and amyloid beta which had been comprehensively investigated in our recent reports. Given the significance of zeolite nanoparticles interactions with serum or interstitial proteins conferring them new biological identity, the preliminary approaches for deeper understanding of administration, distribution, metabolism and excretion of zeolite nanoparticles are elucidated.

Keywords: zeolite, mesoporous, nanostructure, biosafety, biomedical applications

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License.By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

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Vigilante furries band together to stop an assault – WTSP.com

SAN JOSE, Calif. Editors note: The picture above is a file image from a 2012 furry convention in Pittsburgh.

When you think of furry crimefighters, sharp-toothed police K-9s usually come to mind.

But the heroes in this story are humans in big furry costumes.

ABC7 reports three people attending FurCon a gathering of people who dress in large and elaborate animal costumes stopped a violent assault on the streets of San Jose, California.

According to the local news station, a dinosaur, a tiger and a cowboy, for some reason saw a car drive up and witnessed a man beating his girlfriend in the front seat.

KTLA reports the anthropomorphic trio pulled 22-year-old Demetri Hardnett out of the car, took him to the ground and restrained him until officers arrived.

The girl driver was yelling for him to get out, as he started trying to fight us off, Robbie Ryans told CNN, which reported Hardnett was booked into the Santa Clara County Jail on a domestic violence charge.

According to ABC7, the furry convention continued uninterrupted with an event-filled weekend including dance programs, a furry boxing workout and a panel discussion on transhumanism the belief that humans can evolve beyond their current limitations.

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Vigilante furries band together to stop an assault - WTSP.com

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