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How to stay emotionally healthy during quarantine – Times of India

When we talk about self-isolation and quarantine, we assume that a home is a safe place, however, for a lot of people who are struggling with mental health issues, it becomes difficult to sustain. People often call me and ask why they are feeling emotionally imbalanced even when everything is going good around them- their work, family, friends - yet they are not happy, which is making the home environment toxic. This experience has become very common nowadays. A lot of us are going through a similar situation, but we are not able to figure out the reason behind this. Now let me tell you something. It is totally fine to feel this. Trust me, it is!

Emotions are something which we tend to ignore and therefore they are not accepted universally. In the last 4 years, I have been working with people who have faced a lot of discrete emotional imbalances. They feel emotions are triggered and post which the situation just spirals out of their control.

Because of all these non-existential phenomena happening around, sometimes it leads to an understanding that we all are entitled to an emotion which denotes our personality at large. For example, when you are going through a lot of emotional outbursts, we generally tend to react differently with people around us. Some people become angry, some go into depression, others tend to express their emotions with tears and thats how people around us tag their personality.

This makes us believe that we are acquired within an emotional parameter, but the fact is that no such emotional parameter exist in our brain...so what really are emotions?

Can you ignore emotions? No, right?

Let me explain this to you technically - emotions are complex mechanisms that are uncontrollable hardwired brain reactions. Emotions are just vapours. This volatile substance is constructed by us, the environment we live in and the social situations we experience.

Recall your childhood and the school days. I am sure every one of us went through a different sort of feeling when results were to be announced? Remember those days, when in the classroom, the teacher used to declare our marks in the test, or when we used to get our answer sheets. Can you tell me what you felt then? It was a different kind of stomach pain caused by nervousness and anxiety of knowing your marks. Once you knew the result, it vanished in seconds suddenly, right?

In such situations, billions of brain cells work together, and you do not have control over volatile substances called emotions.

The fact is, emotions are eventually built with the experiences we go through and the situations we indulge in. Believe me or not, there is a core area near your stomach, which is the powerhouse of our emotions. The sudden stomach pain we experience is nothing but STRESS!! The emotion that resides in the core.

Why does this happen?Just like reflex action, our system also reacts to the external stimulus provided. The external stimulus is the kind of environment or the social situation we are prone to and because of this social conditioning, our core experiences an emotional trajectory which may be in the form of excitement, happiness, sadness, anger and many more. Once we develop the emotion because of our social experience, we tend to react or respond to this stimulus, eventually coming out in the form of actions like crying, laughing, fighting, lethargy, unstable moods, etc.

We as human beings are unable to recognize and acknowledge what is going inside us due to which emotions get built up to an extent that at some point it takes the shape of depression, anxiety or any other psychological issues. However, it isnt under our control how to respond to such emotional imbalance and so, we dont acknowledge the same.

This unconscious response predominantly depends on our experience in a similar situation or a similar situation that has been faced by someone near to us.

When we start thinking, how did I react in the past when this situation came, our brain starts working like crazy. Our neurons start firing trying to make meaning out of the emotion that we experienced. At that particular moment, our brain also starts evaluating lifetime experiences, building the probabilities and trying to figure out what you relate it to rather than what it actually is. Moreover, this whole process is happening within a blink of an eye.

Such a state is called experiential blindness, which leads to predictions of reactions; they make sense in a quick and abstract way.

HENCE, OUR REACTION TO THE WORLD IS NOT A MERE REACTION, IT IS A PREDICTION THAT WE CONSTRUCT USING OUR EXPERIENCES OF THE WORLD.

Now, let me give you a solution to this. Like we take care of our physical health, we should also take care of our mental health.

It is very important to acknowledge our emotions and regulate them to live a healthy lifestyle. We should be aware of social situations that act as a trigger for elevating emotions within us. Once we identify them and acknowledge them, we will be aware enough to manage our emotional arousal and henceforth our reactions to such a situation will be in our own hands. To put it simply, start identifying the situations that trigger such feelings, accept your reaction to such situations instead of ignoring and start dealing with them. Once you accept your behavioural change and your pattern of reaction in any sort of condition, you will be more open to yourself and know that this is how I will react, this will not only make you more condensed but also, youll become the boss of your reaction.

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A ‘very healthy’ 19-year-old succumbs to COVID-19 30 minutes after being taken to the hospital – Gentside

Luca Di Nicola, from central Italy, had his whole life ahead of him. Working as an assistant chef in London and maintaining a relatively healthy lifestyle, he was the last person you'd think would become a victim of the COVID-19 coronavirus.

The coronavirus continues to spread on a global scale, and despite original thoughts, it seems to be able to lay claim to any victim in its path. Originating from Wuhan, in the Hubei province of central China, the virus has since spread throughout the globe.

Last week, a 16-year-old French girl was claimed by the virus after displaying only 'mild' symptoms. In addition, the UK saw the virus claim their youngest victim so far, a 13-year-old boy, following the death of a 12-year-old girl from Belgium who is thought to be the youngest victim in Europe.

According to his family, Luca had been unwell for about a week prior to his death. He visited his GP who gave him some paracetamol and told him he "did not have to worry about that bad flu". However, it was reported that yesterday (Tuesday), the young man had collapsed after experiencing some 'chest pains'.

According to one of the family members of the young man, they called the ambulance and we're able to revive him however his lungs had collapsed and were filled with water and blood.

His aunt told the local news:

Davide Di Nicola paid tribute to his late brother via an Instagram post in which he stated:

Our thoughts are with Luca's family as well as all the families who have been tragically touched by this deadly and unforgiving virus.

Currently, according to worldometers.info the UK has 25,150 confirmed cases of coronavirus with just under 1,800 deaths. We hope that the public respect and follow the guidelines set in place by the government regarding the lockdown, social distancing and quarantine practices. We all need to do our part to ensure that control over the spread of this fast-acting virus can be attained.

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Coronavirus anxiety is a thing: Here’s how to handle it – Jakarta Post

The coronavirus pandemic has caused another problem: an anxiety pandemic.

As the world is seemingly in chaos, with news outlets reporting about the pandemic non-stop and doctors spreading information on how to stay safe and protect each other, it can be quite overwhelming for anyone to navigate these difficult times. Coupled with our governments call for social distancing, effectively eliminating any physical social contact, all of this isenough to make any person go through psychological hardship.

If you are suddenly feeling shortness of breath, chest pain, dryness in the throator heart palpitations, especially when thinking or reading news about the coronavirus, then you might be experiencing an anxiety attack. The symptoms might increase the more you worry about the coronavirus and disappear altogether when youre distracted. This is all a sign of a classic anxiety attack.

Dont worry, you are not alone.

People have been reporting instances of coronavirus anxiety. Even in the clinic where I worked as a medical doctor, a lot of people are coming in with symptoms of shortness of breath, dry throatand cough. When asked if they have a fever or history of traveling, which is a telltale criterion necessary to diagnose the coronavirus for us physicians, they all said no. When prodded further, these people would go on to describe that their feelings are exacerbated by reading the news.

It is unlikely that you have the coronavirus. Instead, you might be experiencing an anxiety attack, I said to these patients.

According to psychologists, coronavirus anxiety is increasing in number of cases. Some groups of people are especially vulnerable: people with preexisting anxiety disorders, tendencies toward panic and people with a history of obsessive-compulsive disorder (OCD).

Baruch Fischhoff, a professor at Carnegie Mellon University and expert on public perception of risk, explained why we might be worrying more about new and unknown risks such as the coronavirus than familiar ones.

The coronavirus comes from a group of viruses that includes the famous MERS CoV and SARS CoV, which were reported as an outbreak in 2012 and 2003, respectively. According to data, we know that the coronavirus outbreak is not as deadly as the SARS epidemic, which killed 10 percentof the 8,093 confirmed cases. The coronavirus is even far less deadly than the SARS epidemic, which killed 34 percentof roughly 2,500 confirmed cases.

But this is not necessarily public knowledge. People are still more afraid of the coronavirus.

The reason for this, according to Dr. Fischhoff, might be simply because the number of cases and death tolls of the coronavirus continues to rise every day. With the coronavirus, we dont know where its going, he said in a podcast interview about coronavirus anxiety with the American Psychological Association.

According to Paul Slovic, PhD, a researcher in the field of risk and decision-making at the University of Oregon, another plausible explanation for the rise in coronavirus anxiety might be simply because people use emotions, instead of logical analysis, to evaluate risks. Instead of seeing the data, people make assumptions based on the worst and use a cognitive distortion tactic called catastrophizing, which is an irrational thought where we make something out to be far worse than it actually is.

How to handle coronavirus anxiety

Again, panic and anxiety is not a useful response toward the coronavirus pandemic. However, it might be hard to not feel that way when the news and even your own family are sharing information about coronavirus constantly.

The World Health Organization and Center for Disease Control and Prevention (CDC) recently shared information on how to deal with stress during the coronavirus pandemic.

1. Limit your exposure to media coverage on the coronavirus.

This means taking a break from places where fake information or hoaxes are thriving, such as Facebook, WhatsApp groups or other types of social media without credibility. Instead, stick to two or three trusted sources of information such as the WHO or the CDC.

2. Gather only necessary information to take precautions and prepare your plans to protect yourself and your family.

Again, said information must be obtained from trusted sources, such as the WHO, the CDC or your local government agency.

In addition, no need to panic-buy or over-buy. Unless you are a medical officer, then you dont need any protective hazmat suits, boots or face shields. Surgical masks and hand sanitizers are enough as precautions.

3. Stay in contact with your friends, familiesand loved ones.

Social distancing can worsen preexisting anxiousness. Give your friends or family a text or a call. Talk to the people you trust about your feelings.

4. If you are staying at home, work to maintain a healthy lifestyle.

This includes proper diet, sleep and physical exercise. Stick to a daily routine and avoid indulging in idleness like staying in bed all day or locking yourself up in your room.

5. Dont use smoking, alcohol or other drugs to deal with your emotions.

Instead, make plans to seek professional help from a mental counselor if your anxiety still persists.

As the coronavirus pandemic is rampant, the human mind has been another one of its casualties. Coronavirus anxiety is another aspect of the coronavirus pandemic that is overlooked. But actually, theres no need to panic.

If you still find yourself suffering from coronavirus anxiety after applying the aforementioned steps, find a trusted mental health counselor to talk about your worries. (kes)

***

Maria Cellina Wijaya is a medical doctor from Airlangga University with an interest in psychology. She is currently enrolled in a government-mandated one-year internship for physicians in Mojokerto, East Java.

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Disclaimer: The opinions expressed in this article are those of the author and do not reflect the official stance of The Jakarta Post.

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Innovations in Gene Therapy, Microbiome, Robotics, Ribozyme & Protein Therapy – 2019 – ResearchAndMarkets.com – Yahoo Finance

The "Innovations in Gene Therapy, Microbiome, Robotics, Ribozyme, and Protein Therapy" report has been added to ResearchAndMarkets.com's offering.

This edition of the Life Science, Health & Wellness TechVision Opportunity Engine (TOE) encompasses innovation insights across biosimilars, gene therapy, microbiome, robotics, ribozyme, and protein therapy. The TOE also provides technological analysis for recent developments in animal protein applications, microbiome, and cell cultures.

The Life Science, Health & Wellness TOE will feature disruptive technology advances in the global life sciences industry. The technologies and innovations profiled will encompass developments across genetic engineering, drug discovery and development, biomarkers, tissue engineering, synthetic biology, microbiome, disease management, as well as health and wellness among several other platforms.

The Health & Wellness cluster tracks developments in a myriad of areas including genetic engineering, regenerative medicine, drug discovery and development, nanomedicine, nutrition, cosmetic procedures, pain and disease management and therapies, drug delivery, personalized medicine, and smart healthcare.

Key Topics Covered:

Recent Advancements in the Biotech Industry

Key Industry Contacts

For more information about this report visit https://www.researchandmarkets.com/r/2q5ocu

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Contacts

ResearchAndMarkets.comLaura Wood, Senior Press Managerpress@researchandmarkets.com For E.S.T Office Hours Call 1-917-300-0470For U.S./CAN Toll Free Call 1-800-526-8630For GMT Office Hours Call +353-1-416-8900

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Healthcare Nanotechnology (Nanomedicine) Market Forecast to 2027 with Key Companies Profile, Supply, Demand and SWOT Analysis – Jewish Life News

Healthcare Nanotechnology (Nanomedicine) Market report is to provide accurate and strategic analysis of the Profile Projectors industry. The report closely examines each segment and its sub-segmehnt futures before looking at the 360-degree view of the market mentioned above. Market forecasts will provide deep insight into industry parameters by accessing growth, consumption, upcoming market trends and various price fluctuations.

Global Healthcare Nanotechnology (Nanomedicine) Market research reports growth rates and market value based on market dynamics, growth factors. Complete knowledge is based on the latest innovations in the industry, opportunities and trends. In addition to SWOT analysis by key suppliers, the report contains a comprehensive market analysis and major players landscape.

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The report on the Global Healthcare Nanotechnology (Nanomedicine) Market has newly added by The Insight Partners to its huge repository. The market is expected to increase by the end of forecast period. Primary and secondary research methodologies have been used for curating this research report.

The global regions which are scrutinized for a clear understanding of Global Healthcare Nanotechnology (Nanomedicine) Market are North America, Latin America, Asia-Pacific, Africa, Europe, and India. The research on the Global Healthcare Nanotechnology (Nanomedicine) Market will be applicable to investors, business owners, industry experts, and various c level peoples. Profiling of the several top-level industries has been included in this informative report.

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The research study has taken the help of graphical presentation techniques such as info graphics, charts, tables, and pictures. It provides guidelines for both established players and new entrants in the Global Healthcare Nanotechnology (Nanomedicine) Market.

Table of Contents:

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What Might be the Best Way to Delivery Nanoparticle Therapy for Cancer? – Genetic Engineering & Biotechnology News

Scientists in the cancer nanomedicine community debate whether use of nanoparticles can best deliver drug therapy to tumors passively, allowing the nanoparticles to diffuse into tumors and become held in place, or actively, adding a targeted anti-cancer molecule to bind to specific cancer cell receptors and, in theory, keep the nanoparticle in the tumor longer. Now, new research on human and mouse tumors in mice by investigators at the Johns Hopkins Kimmel Cancer Center suggests the question is even more complicated.

Laboratory studies testing both methods in six models of breast cancer; five human cancer cell lines and one mouse cancer in mice with three variants of the immune system found that nanoparticles coated with trastuzumab, a drug that targets human epidermal growth factor receptor 2 (HER2)-positive breast cancer cells, were better retained in the tumors than plain nanoparticles, even in tumors that did not express the pro-growth HER2 protein. However, immune cells of the host exposed to nanoparticles induced an anti-cancer immune response by activating T cells that invaded and slowed tumor growth. The results of the work Nanoparticle interactions with immune cells dominate tumor retention and induce T cellmediated tumor suppression in models of breast cancer, appears in Science Advances.

The factors that influence nanoparticle fate in vivo following systemic delivery remain an area of intense interest. Of particular interest is whether labeling with a cancer-specific antibody ligand (active targeting) is superior to its unlabeled counterpart (passive targeting). Using models of breast cancer in three immune variants of mice, we demonstrate that intratumor retention of antibody-labeled nanoparticles was determined by tumor-associated dendritic cells, neutrophils, monocytes, and macrophages and not by antibody-antigen interactions, write the investigators.

Systemic exposure to either nanoparticle type induced an immune response leading to CD8+ T cell infiltration and tumor growth delay that was independent of antibody therapeutic activity. These results suggest that antitumor immune responses can be induced by systemic exposure to nanoparticles without requiring a therapeutic payload. We conclude that immune status of the host and microenvironment of solid tumors are critical variables for studies in cancer nanomedicine and that nanoparticle technology may harbor potential for cancer immunotherapy.

Its been known for a long time that nanoparticles, when injected into the bloodstream, are picked up by scavenger-like macrophages and other immune system cells, explains senior study author Robert Ivkov, PhD, associate professor of radiation oncology and molecular radiation sciences at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins.

Many researchers in the field have been focused on trying to reduce interactions with immune cells, because they have been trying to increase the circulation time of the nanoparticles and their retention in tumor cells. But our study demonstrates that the immune cells in the tumor collect and react to the particles in such a way to stimulate an anti-cancer response. This may hold potential for advancing beyond drug delivery toward developing cancer immunotherapies.

The investigators conducted a few in vitro experiments in their study. First, they applied some plain starch-coated iron oxide nanoparticles and others coated with trastuzumab to five human breast cancer cell lines, finding that the amount of binding between the trastuzumab-coated nanoparticles and cells depended on how much the cancer cells expressed the oncogene HER2. In people, HER2-positive breast cancers are among the most resistant to standard chemotherapy.

Trastuzumab, sold under the name Herceptin, targets the HER2-positive tumor cells and triggers the immune system as well.

Responses were surprisingly different in animal models, the researchers report. In separate experiments, the team used the nanoparticles in two immune-deficient strains of mice engrafted with cells from five human breast cancer cell linestwo that were HER2 negative and three that were HER2 positive. When they studied the animals tumors 24 hours later, they noticed that nanoparticles coated with trastuzumab were found in a concentration two to five times greater than the plain nanoparticles in all types of tumors, regardless of whether they expressed the HER2 protein. They also found that the number of trastuzumab-coated nanoparticles was even greater (tenfold) in mice that had a fully functional immune system and were bearing mouse-derived tumors.

This led the researchers to suspect that the host animals immune systems were interacting strongly with the nanoparticles and playing a role in determining retention of the particles in the tumor, whether or not a drug was added.

More experiments, the team reports, revealed that tumor-associated immune cells were responsible for collecting the nanoparticles, and that mice bred with an intact immune system retained more of the trastuzumab-coated nanoparticles than mice bred without a fully functioning immune system.

In addition, inflammatory immune cells in the tumors immediate surroundings, or microenvironment, seized more of the coated nanoparticles than the plain ones. Finally, in a series of 30-day experiments, the researchers found that exposure to nanoparticles inhibited tumor growth three to five times more than controls, and increased CD8-positive cancer-killing T cells in the tumors.

Surprisingly, Ivkov notes, the anti-cancer immune activating response was equally effective with exposure to either plain or trastuzumab-coated nanoparticles. Mice with defective T cells did not show tumor growth inhibition. The investigators say this demonstrated that systemic exposure to nanoparticles can cause a systemic host immune response that leads to anti-cancer immune stimulation and does not require nanoparticles to be inside the tumors.

Overall, our work suggests that complex interdependencies exist between the host and tumor immune responses to nanoparticle exposure, Ivkov says. These results offer intriguing possibilities for exploring nanoparticle targeting of the tumor immune microenvironment. They also demonstrate exciting new potential to develop nanoparticles as platforms for cancer immune therapies.

The investigators say they also plan to study whether the same types of immune responses can be generated for noncancer conditions, such as infectious diseases.

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Erwachen helps combat repair, rejuvenation and anti-ageing – Cosmetics Business

27-Mar-2020

Ingredients | Skin Care

Ultimate Beauty Revealing Oil is exceptional innovated for combing seven ultimate carrier oils into one solution - Centella Asiatica (Centella) Leaf Oil, Rose rubiginosa (Rose Hip) Fruit Oil, Hippophae Rhamnoides (Sea Buckthorn) Fruit Oil, Calendula officinalis (Calendula) Oil, Prunus Amygdalus Dulcis (Sweet Almond) Oil, Simmondsia Chinensis (Jojoba) Seed Oil, Corylus Avellana (Hazelnut) Seed Oil.

All of the seven ultimate carrier oils are 100% natural that makes users completely immersed in the sensation and feels the energy from those purecarrier oils. It soothes fatigue skin and restores youth, moreover, it also nourishes deeply, hydrates intensively and makes the skin tremendously radiant.

Ultimate Beauty Revealing Oil gave velvety and exquisite touch that can be used for any skin types including sensitive skin, and also pregnant ladies, babies to children. It is favored by women as skin care product from body to face during their pregnancy to prevent stretch marks and fine line wrinkles.

Our Centella Leaf Oil originated from France, also called as Pennywort Herb. It has been a long history to be used as herb medicine in traditional Mandarin therapy for calming down and purifying, and renowned for its effect on skin beauty and restoration.

It is obviously a good remedy for anti-aging, firmness, renewal, and reducing blemishes to maintain skin vitality. Rose hip fruit oil, a must-have skin beauty promoters, is from CO2 Supercritical Fluid Extraction in Germany, reserved the highest possible extraction yield, and associated bioactivity and vitamin C to nourish, soften and repair the skin.

The ingredient has effects on whitening, reducing imperfections and strengthening against harms and blemishes. Sea buckthorn fruit oil is from CO2 Supercritical Fluid Extraction in Germany, and reserved the highest possible extraction yield, associated bioactivity and fruity aroma.

The bright color of yellow-orange oil contains over 190 different types of plant nutrition, including vitamin A, vitamin E and large amount of SOD and the rare omega-7 fatty acid.

Those nutrition benefit skin restoration and protection to keep the skin to be bright, moisture, smooth and away from rough and aging.

Calendula oil originated from Germany are made of the legendary sunny herb calendula and then soak them into the cold pressed sunflower oil. That process brought the oil with plenty of vitamin E, a variety of essential oils, vitamins, flavonoids, and -carotene that comfort and soothe the skin, prevent skin from aging, and reduce fine lines.

Our cold pressed sweet almond oil are from Germany too, and good for all types of skin. This ingredient is used as the key material for skin care cream among ancient European nobles, and has a light texture and nice ductility that makes it the best oil for massaging, especially for babies and expecting mothers.

Jojoba seed oil originated from Israel, is often known as "liquid gold", guarding skin as a barrier moisturised and hydrated. Liquid wax is stable and not easily oxidised, therefore, it is nice to be used for mixture of other carrier oils and blended essential oil with longer and betterpreservation of its bioactivity.

Hazelnut Seed Oil originated from France contains abundant nutrition, which was also honored by ancient Celtic and called Fruit of wisdom". It is even graceful and charming for both decent taste and touch, just like those nuts for desserts.

The above seven premium natural carrier oils achieved this unique ultimate beauty revealing oil, features high level actives with sweet fragrance of fruit scent. It has carried a complete and powerful plant energy that help skin improving the ability of protecting and rejuvenating.

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Antiaging Products and Services Market 2020 Shows Strong Growth by 2025. Top Growing Companies are Elizabeth Arden Inc, Johnson & Johnson, Orlane…

In this report, several aspects about the market research and analysis for the Healthcare industry have been underlined. Antiaging Products and Services market report has been designed by keeping in mind the customer requirements which assist them in increasing their return on investment (ROI). This market research report is formulated with the most excellent and superior tools of collecting, recording, estimating and analysing market data of Healthcare industry. As per the DBMR team predictions cited in this report, the market will grow with a specific CAGR value in the forecast period of 2020 to 2026. A number of business challenges can be conquered with this market research report.

The Antiaging Products and Services market analysis report has been prepared by taking into account several aspects of marketing research and analysis which includes market size estimations, market dynamics, company & market best practices, entry level marketing strategies, positioning and segmentations, competitive landscaping, opportunity analysis, economic forecasting, industry-specific technology solutions, roadmap analysis, targeting key buying criteria, and in-depth benchmarking of vendor offerings. All the parameters of this report can be explored to analyse market status, market share, growth rate, future trends, market drivers, opportunities, challenges, risks, entry barriers, sales channels, and distributors. Market segmentation studies conducted in this report with respect to product type, applications, and geography are valuable in taking any verdict about the products.

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Theglobal antiaging products and services marketis expected to reach USD 859.11 billion by 2025, from USD 347.58 billion in 2017 growing at a CAGR of 11.8% during the forecast period of 2018 to 2025. The upcoming market report contains data for historic year2016, the base year of calculation is 2017 and the forecast period is 2018 to 2025.

Some of the major players operating in the globalantiaging products and services marketareChanel SA, GlaxoSmithKline Plc, Allergan Inc, Neutrogena Corporation, Procter & Gamble, Elizabeth Arden Inc, Johnson & Johnson, Orlane SA, Revlon Inc, Novartis International AG, Unilever PLC, Avon Products Inc, Woodridge Labs Inc, Beiersdorf, LOral SA, Merck & Company Inc, Christian Dior, Valeant Pharmaceuticals International, NeoStrata Company Inc, Bayer Schering Pharma AG, F. Hoffmann-La Roche Ltd among others.

Market Definition:Global Antiaging Products and Services Market

As the skin ages, it loses its natural elasticity and becomes thinner, more fragile and laxer, taking on a wrinkled appearance. In modern society, there is a great increase in the search for eternal youth and an insatiable appetite for methods which could turn back the clock. This has triggered an explosion in the antiaging industry. In addition, technological advances in medicine for the prevention and treatment of deadly diseases help to increase life expectancy.

The aging process of the skin generally has two kinds of forms: natural aging and light aging. There are various factors which directly affect intrinsic aging such as ethnicity, anatomic variations, hormonal changes, extrinsic aging, drugs, smoking and sunlight exposure. These aging conditions can be treated by the antiaging products such as UV absorbers, anti-wrinkle products, anti-stretch products, others and services and therapies. For anti-aging, the cosmetics are commercially available products that can be used to improve the appearance of the skin. People are constantly demanding for more effective products that can essentially beautify the appearance and has resulted in augmented basic science research and product development in the cosmetics industry.

According to news provided by Stempeutics Research Pvt. Ltd., in July 2015, Cipla (India) launched a new anti-aging product which uses human bio-active factors. The product was launched with a brand name Cutisera, developed by Stempeutics. This product will be used for reducing fine lines and wrinkles, lightening dark spots, evening skin tone, improving skin firmness and improving skin hydration.

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Market Segmentation:Global Antiaging Products and Services Market

The global antiaging products and services market is segmented based on product, therapies and services and geographical segments.

Based on product, the market is segmented into UV absorbers, anti-wrinkle products, anti-stretch products and others.

Based on therapies and services, the market is segmented into eye-lid surgery, abdominoplasty, hormone replacement therapy, breast augmentation, liposuction, gene therapy, injectable skin, botox, telomere based therapy, rejuvenation and dermal fillers, sclerotherapy, anti-pigmentation therapy, hair restoration services and chemical peels.

Based on geography, the market report covers data points for 28 countries across multiple geographies namely North America & South America, Europe, Asia-Pacific and, Middle East & Africa. Some of the major countries covered in this report are U.S., Canada, Germany, France, U.K., Netherlands, Switzerland, Turkey, Russia, China, India, South Korea, Japan, Australia, Singapore, Saudi Arabia, South Africa and, Brazil among others.

Major Market Drivers and Restraints:

Key Developments in the Market:

Competitive Analysis:Global Antiaging Products and Services Market

The global antiaging products and services market is highly fragmented and the major players have used various strategies such as new product launches, expansions, agreements, joint ventures, partnerships, acquisitions, and others to increase their footprints in this market. The report includes market shares of antiaging products and services market for global, Europe, North America, Asia Pacific and South America.

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Coronavirus pushes Folding@Homes crowdsourced molecular science to exaflop levels – TechCrunch

The long-running Folding@Home program to crowdsource the enormously complex task of solving molecular interactions has hit a major milestone as thousands of new users sign up to put their computers to work. The network now comprises an exaflop of computing power: 1,000,000,000,000,000,000 operations per second.

Folding@Home started some 20 years ago as a way then novel, and pioneered by the now-hibernating SETI@Home to break up computation-heavy problems and parcel them out to individuals for execution. It amounts to a crude supercomputer distributed over the globe, and while its not as effective as a real supercomputer in blasting through calculations, it can make short work of complex problems.

The problem in question being addressed by this tool (administrated by a group at Washington University in St. Louis) is that of protein folding. Proteins are one of the many chemical structures that make our biology work, and they range from small, relatively well-understood molecules to truly enormous ones.

The thing about proteins is that they change their shape depending on the conditions temperature, pH, the presence or absence of other molecules. This change in shape is often what makes them useful for example, a kinesin protein changes shape like a pair of legs taking steps to carry a payload across a cell. Another protein like an ion channel will open to let charged atoms through only if another protein is present, which fits into it like a key in a lock.

Image Credits: Voelz et al.

Some such changes, or convolutions, are well-documented, but most by far are totally unknown. But through robust simulation of the molecules and their surroundings we can discover new information about proteins that may lead to important discoveries. For example, what if you could show that once that ion channel is open, another protein could lock it that way for longer than usual, or close it quickly? Finding those kinds of opportunities is what this sort of molecular science is all about.

Unfortunately its also extremely computation-expensive. These inter- and intra-molecular interactions are the kind of thing supercomputers can grind away at endlessly to cover every possibility. Twenty years ago supercomputers were a lot rarer than they are today, so Folding@Home started as a way to do this sort of heavy computing load without buying a $500 million Cray setup.

The program has been chugging along the whole time, and likely got a boost when SETI@Home recommended it as an alternative to its many users. But the coronavirus crisis has made the idea of contributing ones resources to a greater cause highly attractive, and as such there has been a huge increase in users so much so that the servers are struggling to get problems out to everyones computers to solve.

Examples of COVID-19-related proteins as visualized by Folding@Home.

The milestone its celebrating is the achievement of an exaflop of processing power, which is I believe a sextillion (a billion billion) operations per second. An operation is a logical operation, like AND or NOR, and several of them together form mathematical expressions, which eventually add up to useful stuff like saying at temperatures above 38 degrees Celsius this protein deforms to allow a drug to bind at this site and disable it.

Exascale computing is the next goal of supercomputers; Intel and Cray are building exascale computers for the National Laboratories that are expected to come online in the next couple of years but the fastest supercomputers available today operate at a scale of hundreds of petaflops, or about half to a third the speed as an exaflop.

Naturally these two things are not directly comparable Folding@Home is marshaling an exaflops worth of computing power, but it is not operating as a single unit working on a single problem, as the exascale systems are built to. The exa- label is there to give a sense of scale.

Will this kind of analysis lead to coronavirus treatments? Perhaps later, but almost certainly not in the immediate future. Proteomics is basic research in that it is at heart about better understanding the world around (and within) us period.

COVID-19 (like Parkinsons, Alzheimers, ALS and others) isnt a single problem, but a large, poorly bounded set of unknowns; its proteome and related interactions are part of that set. The point isnt to stumble onto a magic bullet but to lay a foundation for understanding so that when we are evaluating potential solutions, we can pick the right one even 1% faster because we know that this molecule in that situation acts like so.

As the project noted in a blog post announcing the release of coronavirus-related work:

This initial wave of projects focuses on better understanding how these coronaviruses interact with the human ACE2 receptor required for viral entry into human host cells, and how researchers might be able to interfere with them through the design of new therapeutic antibodies or small molecules that might disrupt their interaction.

If you want to help, you can download the Folding@Home client and donate your spare CPU and GPU cycles to the cause.

See the article here:
Coronavirus pushes Folding@Homes crowdsourced molecular science to exaflop levels - TechCrunch

Recommendation and review posted by Alexandra Lee Anderson

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How a supercomputer network of 700,000 PCs is helping to find a Covid-19 cure – NS Tech

The race to find a coronavirus vaccine is on, with about 35 companies and academic institutions across the world working feverishly on the case. But Sars-CoV-2, the virus that causes Covid-19, is a novel, as well as a large and complex structure. The process of discovering a vaccine is complemented and accelerated by building a solid ground layer in knowledge about the virus. One of the projects helping to plug the gaps in our understanding is Folding@home, based at Stanford University. Its a distributed computing project that links up the machines of citizen scientists across the world willing to donate excess computing resources from their devices to help run simulations of disease proteins at scale.

For the past 20 years, the project has been mapping disease proteins involved in Alzheimers and cancer, but in late February it began modelling the protein structures of Covid-19 too. This decision prompted the projects biggest ever spike in new volunteers signing up via downloadable software around 600,000 so far, putting it on track to reach one million total users. The network is now operating at an exaflop of computing power: 1,000,000,000,000,000,000 (a billion billion) operations per second.

Historically, vaccines contain enfeebled versions of the virus that trigger specific antibodies priming the human bodys immune system to react effectively to the real thing. But in the case of Covid-19, most research groups around the world are developing newer recombinant nucleic acid vaccines that contain scraps of the virus genetic code (DNA or RNA).

The ball was set rolling in mid-January when Chinese scientists published the full genome of the Covid-19 virus (all 29,903 nucleic bases). Scientists are able to use this information to single out sets of genes that correspond to specific proteins that make up the building blocks of the virus form essential information to formulating a vaccine. But this is only the beginning.

The proteins of Covid-19 are constantly shuffling and rearranging in response to their environment, and its these dynamical motions that Folding@homes molecular simulations are attempting to map. In a nutshell, this means simulating in a computer how each atom in a very large biomolecule wiggles and jiggles over time, says Vincent Voelz, associate professor in theory and computation at Temple University and a member of Folding@home. These movements indicate how the virus functions. As Voelz puts it, Covid-19 proteins are the nanoscale machines that the virus tricks an infected cell into making so it can propagate.

Of particular interest to Folding@home, and research groups investigating Covid-19 more generally, is the S-protein making up the spikes on the virus outer shell, that it uses to gain access to human cells. Folding@home has created a simulation of the spike protein, that is composed of three interlocking proteins, and a pocket that helps the virus bind to human cells and infect them.

The point of mapping proteins is to find out which parts of proteins the immune system might target, says Jim Naismith, professor of structural biology at the University of Oxford. In Covid-19, the spike protein is a particularly popular binding spot for human antibodies, meaning it could be key to developing an effective vaccine. Scientists are mapping all those epitopes [protein segments] where people are mounting good responses to them, and then theyll test those antibodies in trials, says Naismith.

Running computations to produce simulations of this type of biological puzzle is time and energy-intensive. Folding@homes distributed network of computers is able to run calculations with greater speed and efficiency than any single computer could. In effect, large calculations are broken down into smaller ones that are run concurrently on thousands of displaced machines. The power of Folding@homes distributed network is not directly comparable to one supercomputer, because the system is not operating as a single unit on a single problem. But if it was, it would be faster. The fastest supercomputers available today operate at a scale of hundreds of petaflops between a third and a half of the speed of an exaflop.

Folding@home isnt the only project directing vast quantities of computing power towards understanding Covid-19. In the US, a partnership including the US government, IBM, and others has began to grant promising Covid-19 projects access to 16 supercomputers. Summit, the worlds most powerful non-distributed computer system in the world, was tasked with identifying compounds that would be effective in binding to the spike proteins of the Covid-19 organism, thereby preventing the attachment of the virus to host cells. It came up with 77 matches.

Beyond brute computing force, artificial intelligence is also playing an increasingly important role in virus modelling. Traditionally, experiments to determine the structure have taken months or longer. But computational methods can provide a much speedier way to predict protein structures from amino acids sequences. In cases where the structure of a similar protein has already been experimentally defined, algorithms based on template modelling can provide accurate predictions of the protein structure. Googles DeepMind recently announced AlphaFold, a deep learning system that focuses on predicting protein structure accurately when no structures of similar proteins are available, called free modelling.

While Folding@homes work is not pitched directly at creating a vaccine, its useful for modern computational drug discovery, which relies on sampling the many possible conformations of the proteins, and modelling how drug molecules might bind to them. At present, there are not good experimental techniques that can probe these motions at the atomic scale that can be achieved with computational modelling, says Voelz.

Computational mapping complements structural mapping of the virus using laboratory techniques such as cryogenic electron microscopy. What you can do with computing is, if possible, use evolutionarily related proteins that we already know something about the architecture and the active site and then build a computing model using those, says Tom Blundell, biochemist and structural biologist at Cambridge University.

Folding@home has been able to go one further. Voelzs group at Temple University are partnering with researchers at the Diamond Light Source in the UK who have done groundbreaking work in solving over a thousand different crystal structures of the coronavirus main protease, and have discovered several drug fragments that bind to sites on the protein. Based on these initial fragment screening results, the computing power of Folding@home is being used to virtually screen a huge number of potential drug compounds including those from the COVID Moonshot project to prioritise which to synthesise and experimentally test.

Continued here:
How a supercomputer network of 700,000 PCs is helping to find a Covid-19 cure - NS Tech

Recommendation and review posted by Alexandra Lee Anderson

Read the Rest...

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