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Sport touted as the best medicine against heart disease

At the heart of the 'French Healthy Lifestyle Alliance', scientists, politicians and economists suggest innovative solutions to combat cardiovascular diseases and obesity. Excercise is the starting point, they say. EurActiv France reports.

TheFrench Healthy Lifestyle Alliance ("Alliance France pour le Mieux Vivre) recommends a comprehensive approach to improving peoples lifestyles. The group, established by the International Chair on Cardiometabolic Risk (ICCR), a North American organisation, brings together French doctors, economists and politicians, who all agree on the importance of exercise as medical treatment.

Activity for longevity

Inactivity is the number one avoidable cause of death in the world, ahead of tobacco abuse, according to a 2012 medical study cited by Martine Duclos, a university professor and member of the alliance.

The professor declares that physical activity must be placed at the heart of childrens education.

Physical activity is not one of our cultural traits. It is different to northern Europe where physical activity is centre stage in childhood. Time spent sitting down in childhood shapes our behaviour for the rest of our life. Furthermore, cardiovascular diseases start in childhood, which explains the importance of making children aware at such an early stage.

Everyday actions suffice in increasing activity. She highlights that it is important to promote a positive message, and explain that activity does not necessarily have to be intensive exercise, one must simply be active every day. This means choosing the stairs over the escalators or walking short distances instead of driving.

According to Martine Duclos, exercise fends off cardiovascular diseases and lowers cholesterol levels.

The risk of developing cardiovascular diseases is 30% less likely for patients who do exercise, a minimum of 30 minutes five times per week, which is accompanied by a balanced diet low in sugar, salt and fat. For patients suffering from hypercholesterolemia, exercise can sometimes avoid the need for treatment or allow for a reduction of the prescribed doses.

10 billion of potential savings

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'Our products support a healthy lifestyle'

EACH week the Evening Times will turn the spotlight on one of the dozens of local businesses determined to succeed.

Dimitris Kourtoumpelidis and Vassilis Xanthopoulos of Dionysus Quality Products

They are the future for Glasgow and the west of Scotland's economy and are working hard to achieve success in the face of continuing economic hardship. Many businesses are struggling to take off because of the economic downturn, and this column will offer advice for potential start-ups and small businesses.

Each company will answer the same questions about their business and their answers will appear each Wednesday.

This week we talk to Dimitris Kourtoumpelidis and Vassilis Xanthopoulos of Dionysus Quality Products

Who are you?

We are a family of Greek origin now living in Scotland; Vassilis, Desy, and Dimitris.

As children we watched as our grandma gathered herbs from the garden for cooking or to prepare natural remedies, and so from a young age we understood the benefits nature can bring to our everyday life.

What does your

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Amway hosts campaign on wellness of women

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Kolkata, Mar 26 : Direct selling health & beauty FMCG company, Amway India on Tuesday hosted an awareness campaign on the wellness of women, here, in a bid to celebrate the International Women's Month and to educate people about the need of nutrients and healthy lifestyle among women.

The campaign, a part of the series of wellness campaigns across India, aims at creating awareness about the need for a wholesome diet and nutritional supplements for modern day women to ensure proper preventative health care.

Dr. Pritpal Singh, an eminent consultant in nutrition management and preventive measures of lifestyle disorders, elaborated the importance of certain nutrients at the later stages of women's lives like menopause.

While, Dr. Anindita Roy, Head of Nutrition Department, Manindra Chandra College, spoke about the importance of calcium, magnesium and iron at adolescence and pregnancy stages of women.

Dr. Pritpal Singh said, "Women should be cautious choosing their diet in their mid-thirties. Indian women experience menopause earlier than their western countries counterparts and the onset of menopause starts as early as 47 years."

Singh added, "Sometimes, it occurs at a younger age. During this time ovaries have stopped production of eggs and estrogen and progesterone hormone levels start depleting in the premenopausal phase. Soy Protein, Omega 3 fatty acids, Iron, Calcium are some important nutrients a woman should eat more in her mid-thirties."

Speaking of the awareness campaign, Diptarag Bhattacharjee, Vice President, East, Amway India said that, "Today's urban woman, exposed to stress at work and family life ignore a healthy life style and good nutrition in her daily rigmarole of responsibility and encourage in binge eating."

Bhattacharjee said, "Mounting work pressure and growing demands at home leave no time for Indian women for either rest or physical exercise. It is high time to sit back, relax and plan their diet and lifestyle to brace up for the next phase in life."

Bhattacharjee added, "We at Nutrilite have come up with a complete women's range of dietary supplements including Nutrilite Tri Iron Folic, Nutrilite Cal Mag D, Nutrlite Bone Health, Nutrilite Hair, Skin & Nails and Nutrilite Black Cohosh and Soy to cater to various nutritional needs of Indian women."

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Immortality Medicine | Prometheism.net – Transhuman …

Neil deGrasse Tyson is a rock star. Or, maybe its better to compare the countrys most famous astrophysicist to a sports star, the kind wholl spend two hours after every game autographing anything thrust in his direction Continue reading

Recommendation and review posted by Guinevere Smith Continue reading

The Fifth Beatle: The Brian Epstein Story, a meticulously researched, masterfully written and gorgeously illustrated graphic novel by award-winning Broadway producer Vivek J. Tiwary and artist Andrew C. Robinson, was a labor of love Continue reading

Tim Entwisle: Which species can we afford to lose? What crops will help us survive climate change? Continue reading

Community HealthNet Health Centers is committed to offering comprehensive healthcare to adults and children. CHN provides a range of acute, chronic and preventative care Continue reading

Purpose To explore the issue of ethics in medical research and, in particular, the issue of informed consent, in the context of Henrietta Lacks and the HeLa cells. This lesson uses the book, The Immortal Life of Henrietta Lacks, written by Rebecca Skloot, which is one of the winners of the 2011 SB&F Prize for Excellence in Science Books Continue reading

The latest from Immortality Medicine (@ImmortalityDrug). Continue reading

A Reflection on Recent Rome Conference on Aging and Disability Rome, February 27, 2014 (Zenit.org) Fr. Joseph Tham, LC, MD, PhD | 93 hits Aging and Disability was the topic of the 20th General Assembly of the Pontifical Academy for Life held last week in Rome. With the advance of medical technology, there is a longer life expectancy worldwide. Continue reading

[02/21/14 - 11:50 PM] Development Update: Friday, February 21 By The Futon Critic Staff (TFC) LOS ANGELES (thefutoncritic.com) The latest development news, culled from recent wire reports: Looking to keep track of all the various projects in development? Continue reading

Studies show your 60s will probably be your last really good decade of healthy life. Here's how to make the best of it Continue reading

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NANOMEDICINE HANGOUT – Video


NANOMEDICINE HANGOUT

By: John Bennett

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NANOMEDICINE HANGOUT1 – Video


NANOMEDICINE HANGOUT1

By: NanoMedicine

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NANOMEDICINE HANGOUT1 - Video

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Ideas @Davos | Sonia Trigueros | Breakthroughs in Nanomedicine – Video


Ideas @Davos | Sonia Trigueros | Breakthroughs in Nanomedicine
http://www.weforum.org/ Growing tolerance to antibiotics means that there are more people dying of infection than cancer. Breakthrough discoveries in nanomed...

By: World Economic Forum

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Nanomedicine: towards development of patient-friendly drug-delivery systems – Video


Nanomedicine: towards development of patient-friendly drug-delivery systems
ES-Cancer Focus Group. Third Journal Club: Nanomedicine: towards development of patient-friendly drug-delivery systems for oncological applications.

By: Egypt Scholars Inc.

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Nanomedicine – Wikipedia, the free encyclopedia

Nanomedicine is the medical application of nanotechnology.[1] Nanomedicine ranges from the medical applications of nanomaterials, to nanoelectronic biosensors, and even possible future applications of molecular nanotechnology. Current problems for nanomedicine involve understanding the issues related to toxicity and environmental impact of nanoscale materials (materials whose structure is on the scale of nanometers, i.e. billionths of a meter).

Nanomedicine research is receiving funding from the US National Institutes of Health. Of note is the funding in 2005 of a five-year plan to set up four nanomedicine centers. In April 2006, the journal Nature Materials estimated that 130 nanotech-based drugs and delivery systems were being developed worldwide.[2]

The biological and medical research communities have exploited the unique properties of nanomaterials for various applications (e.g., contrast agents for cell imaging and therapeutics for treating cancer). Terms such as biomedical nanotechnology, nanobiotechnology, and nanomedicine are used to describe this hybrid field. Functionalities can be added to nanomaterials by interfacing them with biological molecules or structures. The size of nanomaterials is similar to that of most biological molecules and structures; therefore, nanomaterials can be useful for both in vivo and in vitro biomedical research and applications. Thus far, the integration of nanomaterials with biology has led to the development of diagnostic devices, contrast agents, analytical tools, physical therapy applications, and drug delivery vehicles.

Nanomedicine seeks to deliver a valuable set of research tools and clinically useful devices in the near future.[3][4] The National Nanotechnology Initiative expects new commercial applications in the pharmaceutical industry that may include advanced drug delivery systems, new therapies, and in vivo imaging.[5] Neuro-electronic interfaces and other nanoelectronics-based sensors are another active goal of research. Further down the line, the speculative field of molecular nanotechnology believes that cell repair machines could revolutionize medicine and the medical field.

Nanomedicine is a large industry, with nanomedicine sales reaching $6.8 billion in 2004, and with over 200 companies and 38 products worldwide, a minimum of $3.8 billion in nanotechnology R&D is being invested every year.[6] As the nanomedicine industry continues to grow, it is expected to have a significant impact on the economy.

Two forms of nanomedicine that have already been tested in mice and are awaiting human trials that will be using gold nanoshells to help diagnose and treat cancer,[7] and using liposomes as vaccine adjuvants and as vehicles for drug transport.[8][9] Similarly, drug detoxification is also another application for nanomedicine which has shown promising results in rats.[10] A benefit of using nanoscale for medical technologies is that smaller devices are less invasive and can possibly be implanted inside the body, plus biochemical reaction times are much shorter. These devices are faster and more sensitive than typical drug delivery.[11] Advances in Lipid nanotechnology was also instrumental in engineering medical nanodevices and novel drug delivery systems as well as in developing sensing applications.[12]

Nanotechnology has provided the possibility of delivering drugs to specific cells using nanoparticles. The overall drug consumption and side-effects may be lowered significantly by depositing the active agent in the morbid region only and in no higher dose than needed. This highly selective approach would reduce costs and human suffering. An example can be found in dendrimers and nanoporous materials. Another example is to use block co-polymers, which form micelles for drug encapsulation.[13] They could hold small drug molecules transporting them to the desired location. Another vision is based on small electromechanical systems; nanoelectromechanical systems are being investigated for the active release of drugs. Some potentially important applications include cancer treatment with iron nanoparticles or gold shells. Targeted drug delivery is intended to reduce the side effects of drugs with concomitant decreases in consumption and treatment expenses. The increased efficiency of delivery results in overall societal benefit by reducing the amount of drug needed in an equipotent preparation of said therapy, and thus reduced cost to the consumer.

Nanomedical approaches to drug delivery center on developing nanoscale particles or molecules to improve drug bioavailability. Bioavailability refers to the presence of drug molecules where they are needed in the body and where they will do the most good. Drug delivery focuses on maximizing bioavailability both at specific places in the body and over a period of time. This can potentially be achieved by molecular targeting by nanoengineered devices.[14][15] It is all about targeting the molecules and delivering drugs with cell precision. More than $65 billion are wasted each year due to poor bioavailability. In vivo imaging is another area where tools and devices are being developed. Using nanoparticle contrast agents, images such as ultrasound and MRI have a favorable distribution and improved contrast. The new methods of nanoengineered materials that are being developed might be effective in treating illnesses and diseases such as cancer. What nanoscientists will be able to achieve in the future is beyond current imagination. This might be accomplished by self assembled biocompatible nanodevices that will detect, evaluate, treat and report to the clinical doctor automatically.

Drug delivery systems, lipid- or polymer-based nanoparticles,[13] can be designed to improve the pharmacological and therapeutic properties of drugs.[16] The strength of drug delivery systems is their ability to alter the pharmacokinetics and biodistribution of the drug.[17][18] However, the pharmacokinetics and pharmacodynamics of nanomedicine is highly variable among different patients.[19] When designed to avoid the body's defence mechanisms,[20] nanoparticles have beneficial properties that can be used to improve drug delivery. Where larger particles would have been cleared from the body, cells take up these nanoparticles because of their size. Complex drug delivery mechanisms are being developed, including the ability to get drugs through cell membranes and into cell cytoplasm. Efficiency is important because many diseases depend upon processes within the cell and can only be impeded by drugs that make their way into the cell. Triggered response is one way for drug molecules to be used more efficiently. Drugs are placed in the body and only activate on encountering a particular signal. For example, a drug with poor solubility will be replaced by a drug delivery system where both hydrophilic and hydrophobic environments exist, improving the solubility.[21] Also, a drug may cause tissue damage, but with drug delivery, regulated drug release can eliminate the problem. If a drug is cleared too quickly from the body, this could force a patient to use high doses, but with drug delivery systems clearance can be reduced by altering the pharmacokinetics of the drug. Poor biodistribution is a problem that can affect normal tissues through widespread distribution, but the particulates from drug delivery systems lower the volume of distribution and reduce the effect on non-target tissue. Potential nanodrugs will work by very specific and well-understood mechanisms; one of the major impacts of nanotechnology and nanoscience will be in leading development of completely new drugs with more useful behavior and less side effects. Polymeric nano-particles are a competing technology to lipidic (based mainly on Phospholipids) nano-particles. There is an additional risk of toxicity associated with polymers not widely studied or understood. This toxicity could include (but not limited to) hepatotoxicity, nephrotoxicity etc. and can have long term impacts not easily evaluated in short term in-vivo clinical trials either in animals or humans. Since the degradation of polymers to either their monomers or other degradation products in the body cannot be accurately predicted (unclear metabolic pathway), this is a real risk, specially in medicines intended for long term patient use. Even if the toxicity is ignored, there is additional hepatic load of metabolism, again an area of concern for long term medication. The major advantages of polymers is stability, lower cost and predictable characterisation, so the formulation chemists prefer this. However, in the patient's body this very stability (slow degradation) is a negative factor. Phospholipids on the other hand are membrane lipids (already present in the body and surrounding each cell), have a GRAS (Generally Recognised As Safe) status from FDA and are derived from natural sources without any complex chemistry involved. They are not metabolised but rather absorbed by the body and the degradation products are themselves nutrients (fats or micronutrients). It is greatly observed that[who?] nanoparticles are promising tools for the advancement of drug delivery, medical imaging, and as diagnostic sensors. However, the biodistribution of these nanoparticles is still imperfect due to the complex host's reactions to nano- and microsized materials[14] and the difficulty in targeting specific organs in the body. Nevertheless, a lot of work is still ongoing to optimize and better understand the potential and limitations of nanoparticulate systems. For example, current research in the excretory systems of mice shows the ability of gold composites to selectively target certain organs based on their size and charge. These composites are encapsulated by a dendrimer and assigned a specific charge and size. Positively-charged gold nanoparticles were found to enter the kidneys while negatively-charged gold nanoparticles remained in the liver and spleen. It is suggested that the positive surface charge of the nanoparticle decreases the rate of opsonization of nanoparticles in the liver, thus affecting the excretory pathway. Even at a relatively small size of 5nm, though, these particles can become compartmentalized in the peripheral tissues, and will therefore accumulate in the body over time. While advancement of research proves that targeting and distribution can be augmented by nanoparticles, the dangers of nanotoxicity become an important next step in further understanding of their medical uses.[22]

Nanoparticles are also used to circumvent multidrug resistance (MDR) mechanisms.[23] Mechanisms of MDR include decreased uptake of drugs, reduced intracellular drug concentration by activation of the efflux transporters, modifications in cellular pathways by altering cell cycle checkpoints, increased metabolism of drugs, induced emergency response genes to impair apoptotic pathways and altered DNA repair mechanisms.

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Nanomedicine, Volume 1: Basic Capabilities

Nanomedicine Book Site

1996-2013 Robert A. Freitas Jr. All Rights Reserved

Nanomedicine, Volume IIA: Biocompatibility by Robert A. Freitas Jr. is now available in hardcover for $99 + shipping. Click here to purchase the book at Amazon.com or click here for information or to purchase the book directly from Landes Bioscience.

Nanomedicine, Volume I: Basic Capabilities by Robert A. Freitas Jr. is now available in softcover for $89 + shipping. Click here for information or to purchase the book directly from Landes Bioscience.

About Nanomedicine (the field)

Molecular nanotechnology has been defined as the three-dimensional positional control of molecular structure to create materials and devices to molecular precision. The human body is comprised of molecules, hence the availability of molecular nanotechnology will permit dramatic progress in human medical services. More than just an extension of "molecular medicine," nanomedicine will employ molecular machine systems to address medical problems, and will use molecular knowledge to maintain and improve human health at the molecular scale. Nanomedicine will have extraordinary and far-reaching implications for the medical profession, for the definition of disease, for the diagnosis and treatment of medical conditions including aging, and ultimately for the improvement and extension of natural human biological structure and function.

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